C Hugh Reynolds

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
  2. ncbi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
  3. ncbi Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
  4. ncbi Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
    Alessia Usardi
    Department of Neuroscience, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
    FEBS J 278:2927-37. 2011
  5. ncbi Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases
    Ritchie Williamson
    Department of Neuroscience, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    J Neurosci 22:10-20. 2002
  6. ncbi Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn
    Timothy Me Scales
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Mol Neurodegener 6:12. 2011
  7. ncbi Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase
    Pascal Derkinderen
    Department of Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 25:6584-93. 2005
  8. ncbi Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons
    Bilal Malik
    KHP Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurochem Int 61:321-33. 2012
  9. ncbi GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
  10. ncbi The microtubule-associated protein tau is phosphorylated by Syk
    Thibaud Lebouvier
    INSERM, U643, Nantes, F 44000, France
    Biochim Biophys Acta 1783:188-92. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
    ..Thus, the three MAP kinases and GSK3beta are importantly all strong candidates as tau kinases that may be involved in the pathogenic hyperphosphorylation of tau in Alzheimer's disease...
  2. ncbi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
    ....
  3. ncbi Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
    ....
  4. ncbi Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
    Alessia Usardi
    Department of Neuroscience, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
    FEBS J 278:2927-37. 2011
    ..These findings may have implications for the development of novel therapeutic strategies aimed at disrupting the tau/Fyn-mediated synaptic dysfunction that occurs in response to elevated Aβ levels in neurodegenerative disease...
  5. ncbi Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases
    Ritchie Williamson
    Department of Neuroscience, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    J Neurosci 22:10-20. 2002
    ..This cascade of signaling events contains the earliest biochemical changes in neurons to be described in response to Abeta exposure and may be critical for subsequent neurodegenerative changes...
  6. ncbi Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn
    Timothy Me Scales
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Mol Neurodegener 6:12. 2011
    ..abstract:..
  7. ncbi Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase
    Pascal Derkinderen
    Department of Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 25:6584-93. 2005
    ..These results show that phosphorylation of tau on Tyr-394 is a physiological event that is potentially part of a signal relay and suggest that Abl could have a pathogenic role in Alzheimer's disease...
  8. ncbi Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons
    Bilal Malik
    KHP Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurochem Int 61:321-33. 2012
    ..These new data suggest that Aβ may influence steroid and lipid metabolism in neurons via multiple gene-expression changes...
  9. ncbi GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
    ..In the light of these findings GSK3alpha warrants further investigation regarding its involvement in Wnt signalling and tauopathies such as Alzheimer's disease...
  10. ncbi The microtubule-associated protein tau is phosphorylated by Syk
    Thibaud Lebouvier
    INSERM, U643, Nantes, F 44000, France
    Biochim Biophys Acta 1783:188-92. 2008
    ..These results bring another clue to the intriguing overlaps between tauopathies and synucleinopathies and provide new insights into the role of Syk in neuronal physiology...