Research Topics
Genomes and GenesSpecies | Theodore ReichSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Diagnosing migraine in research and clinical settings: the validation of the Structured Migraine Interview (SMI)Zainab Samaan
Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
BMC Neurol 10:7. 2010..The aim of this study was to design a short and practical screening tool to identify migraine for clinical and research purposes...
Medical disorders in people with recurrent depressionAnne Farmer
Medical Research Council, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
Br J Psychiatry 192:351-5. 2008..Few studies have examined the rates of physical disorders in those with recurrent depression...
The genetics of bipolar affective disorderAnne Farmer
MRC SGDP Centre, Institute of Psychiatry, Camberwell, London, UK
Curr Opin Psychiatry 20:8-12. 2007..Molecular genetic studies of bipolar affective disorder are beginning to show some positive and reproducible findings. The most relevant of these will be reviewed...- A sib-pair study of the Temperament and Character Inventory scales in major depressionAnne Farmer
Medical Research Council, Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, England
Arch Gen Psychiatry 60:490-6. 2003..A sib-pair method has been used to examine the familiality of the 7 scales of the Temperament and Character Inventory (TCI) and whether this could be related to the genetic vulnerability to develop depression... - A pilot study of positive mood induction in euthymic bipolar subjects compared with healthy controlsAnne Farmer
MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Camberwell, London, UK
Psychol Med 36:1213-8. 2006..This pilot study evaluates the Go task in a reward paradigm as a method for inducing a happy mood state and compares the response of euthymic bipolar subjects and healthy controls... - The Cardiff sib-pair study: suicidal ideation in depressed and healthy subjects and their siblingsA Farmer
MRC SGDP Research Centre, Institute of Psychiatry, London, UK
Crisis 22:71-3. 2001..Suicidal ideation was significantly associated with high neuroticism and psychoticism scores and severe threatening life events... - The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic studyAnne Farmer
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
BMC Psychiatry 4:42. 2004..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America... - Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studiesA Schosser
MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Mol Psychiatry 15:844-9. 2010.... - Sensation-seeking, life events and depression. The Cardiff Depression StudyA Farmer
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK
Br J Psychiatry 178:549-52. 2001..CONCLUSIONS: The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat... - Whole genome linkage scan of recurrent depressive disorder from the depression network studyPeter McGuffin
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
Hum Mol Genet 14:3337-45. 2005..Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined... - NRG1 gene in recurrent major depression: no association in a large-scale case-control association studyA Schosser
MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
Am J Med Genet B Neuropsychiatr Genet 153:141-7. 2010..We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD... - Trajectories of change in depression severity during treatment with antidepressantsR Uher
Medical Research Council Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
Psychol Med 40:1367-77. 2010..We explore alternative categorization of outcome by naturally occurring trajectories of symptom change... - Sense of hyper-positive self, goal-attainment beliefs and coping strategies in bipolar I disorderR Lee
Psychology Department, Institute of Psychiatry, King s College London, UK
Psychol Med 40:967-75. 2010..To promote of our understanding of this group of patients, the present study investigated the relationship between SHPS, preferred internal state, dysfunctional attitudes and coping with hypothetical manic prodromal scenarios... - No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysisD Gaysina
MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Am J Med Genet B Neuropsychiatr Genet 147:699-706. 2008..This was the case in the sample as a whole, and when females and males were considered separately. Our findings suggest that the MTHFR C677T polymorphism is not involved in the etiology of clinically significant recurrent MDD... - What can psychiatric genetics offer suicidology?P McGuffin
MRC SGDP Research Center, Institute of Psychiatry, London, UK
Crisis 22:61-5. 2001..Further progress is likely to come from candidate gene and linkage disequilibrium studies that are capable of detecting multiple genes of small effect... - The effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder and controlsJ Roiser
Institute of Cognitive Neuroscience, London, UK
Psychol Med 39:785-91. 2009..The objective of this study was to investigate the effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder (BD) and controls... - The genetics of affective disorder and suicideP McGuffin
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AF, United Kingdom
Eur Psychiatry 25:275-7. 2010..The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour... - Psychomotor performance: investigating the dose-response relationship for caffeine and theophylline in elderly volunteersC A Bryant
Department of Health Care of the Elderly, King s College School of Medicine and Dentistry, London, UK
Eur J Clin Pharmacol 54:309-13. 1998..The aim of the study was to investigate the dose-response relationship for psychomotor performance, caffeine and theophylline in healthy elderly volunteers... - An investigation of candidate regions for association with bipolar disorderJo Knight
Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
Am J Med Genet B Neuropsychiatr Genet 153:1292-7. 2010..02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP... - Life events and depression in a community sample of siblingsF V Rijsdijk
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
Psychol Med 31:401-10. 2001..Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety... - Measuring depression: comparison and integration of three scales in the GENDEP studyR Uher
Medical Research Council, Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
Psychol Med 38:289-300. 2008..In this study we examined and integrated the psychometric properties of three commonly used rating scales... - Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008.... - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseSheila A Fisher
Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Nat Genet 40:710-2. 2008..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases... - Differences in depressive symptom profile between males and femalesDaniel J Smith
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, CF10 3XQ, UK
J Affect Disord 108:279-84. 2008..Here we compare the clinical profile of major depression for men and women from a sample of almost 600 well-characterized individuals with recurrent major depressive disorder (MDD)... - Clinical differences between bipolar and unipolar depressionLiz Forty
Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
Br J Psychiatry 192:388-9. 2008..Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression... - Sex differences in symptom patterns of recurrent major depression in siblingsValentina Moskvina
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Depress Anxiety 25:527-34. 2008..38, P=0.004) and appetite gain (exp(B)=2.19, P<0.001). Sex significantly modifies clinical features of depression and an earlier onset of depression and atypical depressive symptoms occur more frequently in women... - Neuroticism, extraversion, life events and depression. The Cardiff Depression StudyAnne Farmer
MRC Social Genetic and Developmental Psychiatric Research Centre, Institute of Psychiatry, London, UK
Br J Psychiatry 181:118-22. 2002..CONCLUSIONS: Neither extraversion nor neuroticism measures trait vulnerability to depression, and neuroticism scores mainly reflect symptoms of depression... - Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesEleftheria Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
Science 316:1336-41. 2007..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes... - Familiality of symptom dimensions in depressionAnia Korszun
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Arch Gen Psychiatry 61:468-74. 2004..A dimensional rather than a categorical approach to depressive phenotype definition may be more useful for identification of susceptibility genes... - Prevalence of chronic disabling fatigue in children and adolescentsAnne Farmer
MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, London, UK
Br J Psychiatry 184:477-81. 2004..The epidemiology of chronic fatiguing illnesses in young people is poorly understood... - Personality as a determinant of social functioning in depressionGopinath Ranjith
Affective Disorders Unit, Bethlem Royal Hospital, Beckenham BR3 3BX, UK
J Affect Disord 84:73-6. 2005..CONCLUSIONS: Social functioning as measured by SASS is predicted by extraversion and severity of depression. Personality traits should be taken into account when assessing social functioning in depression... - The relationship of fatigue to mental and physical health in a community sampleRichard J Williamson
Social, Genetic, Developmental Psychiatry Research, Institute of Psychiatry, PO80, 16 De Crespigny Park, Denmark Hill London SE5 8AF, UK
Soc Psychiatry Psychiatr Epidemiol 40:126-32. 2005..The present study seeks to differentiate between fatigue and depression/anxiety and to investigate the familiality/heritability of fatigue using sib-pairs... - Response style, interpersonal difficulties and social functioning in major depressive disorderDominic Lam
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
J Affect Disord 75:279-83. 2003.... - The definition of disabling fatigue in children and adolescentsTom Fowler
Department of Psychological Medicine, Wales College of Medicine, Cardiff University, UK
BMC Fam Pract 6:33. 2005.... - Cognitive style in bipolar disorderLisa Jones
Department of Psychiatry, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
Br J Psychiatry 187:431-7. 2005..Abnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance... - Interrelationship of childhood trauma, neuroticism, and depressive phenotypeValentina Moskvina
Department of Psychological Medicine, University of Cardiff, Cardiff, Wales, United Kingdom
Depress Anxiety 24:163-8. 2007.... - Familiality of postpartum depression in unipolar disorder: results of a family studyLiz Forty
Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Am J Psychiatry 163:1549-53. 2006..They suggest that a postnatal onset definition of within 6-8 weeks of delivery may be optimal in studies of the triggering of depressive illness by childbirth... - Relationship between disabling fatigue and depression in children: genetic studyTom A Fowler
Section of Child and Adolescent Psychiatry, Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, Wales CF14 4XN, UK
Br J Psychiatry 189:247-53. 2006..Medically unexplained disabling fatigue in young people is familial and frequently associated with depressed mood... - Heterogeneity of serum tryptophan concentration and availability to the brain in patients with the chronic fatigue syndromeAbdulla A B Badawy
Cardiff and Vale NHS Trust, Biomedical Research Laboratory, Whitchurch Hospital, Cardiff, Wales, UK
J Psychopharmacol 19:385-91. 2005..The relevance of our findings to, and their implications for, the pharmacological and other therapies of the chronic fatigue syndrome are discussed... - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsPaul R Burton
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Nat Genet 39:1329-37. 2007.... - Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibshipsMatthew W Nash
MRC Social, Genetic and Developmental Psychiatry Research Centre, Section of Epidemiology, Institute of Psychiatry, King's College, London, UK
Hum Mol Genet 13:2173-82. 2004..2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects... - Atypical depression in growth hormone deficient adults, and the beneficial effects of growth hormone treatment on depression and quality of lifeTripti Mahajan
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
Eur J Endocrinol 151:325-32. 2004..We hypothesise that this rapid improvement of symptoms of atypical depression represents a direct central effect of GH therapy... - Current strategies for investigating the genetic and environmental risk factors for affective disordersAnne Farmer
Br J Psychiatry 186:179-81. 2005 - Wake-up call for British psychiatryNick Craddock
Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
Br J Psychiatry 193:6-9. 2008..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients...