Research Topics
| Alberto QuagliaSummaryAffiliation: King's College Hospital Country: UK Publications
| Collaborators
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Detail Information
Publications
Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinomaAlberto Quaglia
Department of Histopathology, Royal Free and University College Medical School, London, UK
Liver Int 26:424-32. 2006..We investigated cell cycle kinetics of nodular lesions in cirrhosis to differentiate hepatocellular carcinoma (HCC) from its precursor lesions...- Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteriaYoh Zen
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Mod Pathol 20:701-9. 2007..This classification should help to advance clinical and research applications... - Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liverA Quaglia
Department of Histopathology, Royal Free and University College Medical School, London NW3 2QG, UK
World J Gastroenterol 11:6262-8. 2005..To design a classification tool for the histological assessment of hepatocellular carcinoma (HCC), dysplastic nodules (DN), and macroregenerative nodules (MRN) in cirrhotic liver... 
Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injurySanjeev Kanoria
Hepato Pancreatico Biliary and Liver Transplant Unit, University Department of Surgery, Royal Free Hospital and RFUCSM, UCL, London, UK
Transpl Int 25:783-91. 2012..03). There was a positive correlation (P = 0.02) between hepatic venous NO(x) levels and mitochondrial oxygenation. RIPC before IRI improves hepatic mitochondrial oxygenation and reduces acidosis and currently undergoing clinical study...- The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injuryMahmoud Abu-Amara
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
Transplantation 93:880-6. 2012..The present study aimed to assess the role of hepatic sGC-cGMP in lower limb RIPC-induced protection against liver IR injury... - Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular studyStratigoula Sakellariou
Institute of Liver Studies, King s College Hospital, London, UK
Histopathology 60:E58-65. 2012..In this retrospective study, our aim was to reclassify according to geno-phenotypic characteristics nodular lesions identified in hepatectomy specimens of such patients transplanted between 1998 and 2008 at our institution... - Immunohistochemical phenotyping of the inflammatory infiltrate in de novo autoimmune hepatitis after liver transplantation in childrenNedim Hadzic
Department of Child Health, King s College Medical School at King s College Hospital, Denmark Hill, London, UK
Pediatr Transplant 16:501-10. 2012..A Th1 polarization of the inflammatory infiltrate characterizes dn-AIH, but also ACR and AIH... - Efficacy of loco-regional ablation therapy of HCC in a population of liver transplanted patientsFilomena Morisco
Liver Transplant and Hepatobiliary Medicine, Royal Free Hospital, London, UK
Dig Dis Sci 53:1131-7. 2008..The aim of this study was: to evaluate if LAT was able to induce complete necrosis of tumour mass; to determine the tumour recurrence rate after LT and factors associated with recurrence... - N-Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosisGiuseppe Fusai
University Department of Surgery and Liver Transplant Unit, Royal Free Hospital, Royal Free and University College Medical School, Pond Street, London NW3 2QG, U.K
Clin Sci (Lond) 109:465-73. 2005..In conclusion, NAC administration decreased the extent of I/R injury in the steatotic liver, particularly during the late phase of reperfusion... - Two distinct pathways of carcinogenesis in primary sclerosing cholangitisYoh Zen
Institute of Liver Studies, King s College Hospital, London, UK
Histopathology 59:1100-10. 2011..To identify clinicopathological characteristics of cholangiocarcinoma and premalignant lesions arising in patients with primary sclerosing cholangitis (PSC)... - Immunosuppression and donor age with respect to severity of HCV recurrence after liver transplantationDimitrios N Samonakis
Royal Free Hospital, Liver Transplantation and Hepatobiliary Unit, London, UK
Liver Transpl 11:386-95. 2005..Maintenance azathioprine gave survival advantage... - Liver transplantation in cirrhotic patients with small hepatocellular carcinoma: an analysis of pre-operative imaging, explant histology and prognostic histologic indicatorsShantanu Bhattacharjya
Department of Surgery, Royal Free Hospital, Royal Free and University College School of Medicine, London, UK
Dig Surg 21:152-9; discussion 159-60. 2004..IOCT and DCT are similar in their ability to detect unifocal or multifocal HCC. Tumour size and number are not predictive of recurrence with these selective criteria, but microscopic vascular invasion is a bad prognostic factor... - The histopathology of regeneration in massive hepatic necrosisClare Elizabeth Honor Craig
Royal Free and University College Medical School, London, United Kingdom
Semin Liver Dis 24:49-64. 2004..Thus, more patients will be able to restore their own livers and avoid liver transplantation... - Serum levels of CK18 M30 and leptin are useful predictors of steatohepatitis and fibrosis in paediatric NAFLDEmer Fitzpatrick
Paediatric Liver, GI, and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
J Pediatr Gastroenterol Nutr 51:500-6. 2010..Our aim was to evaluate a combination of serum biomarkers as a measure of disease activity in paediatric NAFLD... - Vascular invasion and herniation by hepatocellular carcinoma in cirrhosis: A wolf in sheep's clothing?Alberto Quaglia
Department of Histopathology, Royal Free Hospital, London, United Kingdom
Arch Pathol Lab Med 129:639-44. 2005..Intravascular free-floating tumor clusters (IvCs) of HCC are found histologically in the vicinity of HCC. Thrombus formation is not seen morphologically in association with these IvCs, which are usually covered by endothelium... - Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: Implications for follow-up and screeningAndrew D Yeoman
Institute of Liver Studies, King s College Hospital National Health Service NHS Foundation Trust, Denmark Hill, London, UK
Hepatology 48:863-70. 2008..042). CONCLUSION: Cirrhosis in AIH is the sine qua non for HCC development, which subsequently occurs at a rate of 1.1% per year and affects men and women in equal proportions... - Liver disease in pregnancyDeepak Joshi
Institute of Liver Studies, King s College Hospital, London, UK
Lancet 375:594-605. 2010..Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options... - Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liverMahmoud Abu-Amara
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
Liver Transpl 17:610-9. 2011..eNOS exerts its protective effects through the preservation of hepatic MBF. At 2 hours of reperfusion, eNOS protection is likely due to the increased activation of eNOS rather than increased expression... - Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile ductYoh Zen
Institute of Liver Studies, King s College Hospital, London, UK
Mod Pathol 24:1079-89. 2011.... - A comparison of four- versus three-pass transjugular biopsy using a 19-G Tru-Cut needle and a randomized study using a cassette to prevent biopsy fragmentationShusang Vibhakorn
Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK
Cardiovasc Intervent Radiol 32:508-13. 2009..We conclude that at least four passes with TJLB should be performed when liver specimens are needed for grading and staging. Using a supportive cassette did not reduce fragmentation... - Laser microdissection microscopy: application to cell cultureAhlam Mustafa
Institute of Liver Studies, King s College London School of Medicine, London, UK
Methods Mol Biol 806:385-92. 2012..RNA, DNA, and protein isolation is possible from a small number of cells and the material is suitable for further real-time PCR, ELISA, Western Blotting, and protein microarray analysis... - New monoallelic (partial tandem duplication) mutation of HNF1a gene in steatotic hepatocellular adenomaStratigoula Sakellariou
Institute of Liver Studies, King s College Hospital, London, UK
Eur J Gastroenterol Hepatol 23:623-7. 2011..Clinicopathological and molecular investigation of HCA cases with unique features could result in a better understanding of HCAs pathogenesis... - Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cellsMaria Serena Longhi
Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, London, UK
Hepatology 50:130-42. 2009..045 in ID and P = 0.13 in AD). Conclusion: Monocyte overactivation and inability of cT-regs and tT-regs to restrain it may contribute to the loss of immune tolerance and perpetuation of the autoimmune attack in AILD... - Liver after hepatocyte transplantation for liver-based metabolic disorders in childrenAlberto Quaglia
Institute of Liver Studies, King s College Hospital and King s College London School of Medicine, London, UK
Cell Transplant 17:1403-14. 2008..Further studies are needed to monitor donor hepatocytes in vivo, to quantify better the efficacy of the procedure and to find ways of improving engraftment and function... - Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver diseaseEmer Fitzpatrick
Paediatric Liver, GI and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
J Pediatr Gastroenterol Nutr 56:72-6. 2013..The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort... - Effect of ischaemic preconditioning on hepatic oxygenation, microcirculation and function in a rat model of moderate hepatic steatosisRahul S Koti
University Department of Surgery and Liver Transplantation Unit, Royal Free and University College Medical School, The Royal Free Hospital, London NW3 2QG, U.K
Clin Sci (Lond) 108:55-63. 2005..3+/-379.6 units/l respectively; P<0.01]. In conclusion, IPC has a hepatoprotective effect against I/R injury in livers with moderate steatosis. These data may have important clinical implications in liver surgery and transplantation... - Immunoglobulin G4-positive plasma cell infiltration in explanted livers for primary sclerosing cholangitisYoh Zen
Institute of Liver Studies, King s College Hospital, London, UK
Histopathology 58:414-22. 2011..To explore whether immunoglobulin (Ig)G4-related sclerosing cholangitis (IgG4-SC) contributes to end-stage primary sclerosing cholangitis (PSC) in the United Kingdom... - Epithelial colonies cultured from human explanted liver in subacute hepatic failure exhibit hepatocyte, biliary epithelial, and stem cell phenotypic markersClare Selden
Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, Hampstead, London, United Kingdom
Stem Cells 21:624-31. 2003..Proliferating epithelial-like cells with combined hepatocyte- and biliary-epithelial-specific functional markers and a stem cell marker can be isolated from the nonparenchymal fraction of liver cells in subacute hepatic failure... - Expression of c-kit (CD117) in neuroendocrine tumours--a target for therapy?Virginia Kostoula
Department of Medicine, Royal Free Hospital and University of College Medical School, Pond Street, London, NW3 2QG, UK
Oncol Rep 13:643-7. 2005..It is possible that the polyclonal antibody is less specific. Studies need to be performed to determine if c-kit expression by NETs can be translated into therapeutic benefit by agents such as imatinib mesylate... - Parathyroid carcinoma: a report of two cases and a concise review and update of the literatureHumera Babar-Craig
Department of Otorhinolaryngology, Royal Free Hospital, London, UK
J Laryngol Otol 119:577-80. 2005..Most studies in the literature are retrospective but recent trends in presentation, treatment options and complications have been reviewed and are summarized in this paper... - Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosisDimitrios N Samonakis
Liver Transplantation and Hepatobiliary Unit and Histopathology Department, Royal Free Hospital, London, United Kingdom
Liver Transpl 13:1305-11. 2007..In 29 with HVPG <6 mmHg at 1 yr, none decompensated compared to 4 of 13 (31%) with PHT. In conclusion, HVPG correlates with fibrosis and its progression, due to recurrent HCV infection, assessed in TJB... - Hepatocellular carcinoma in a 12-year-old child with PiZZ alpha1-antitrypsin deficiencyNedim Hadzic
Hepatology 43:194. 2006 - Induction of autoimmune hepatitis by pegylated interferon in a liver transplant patient with recurrent hepatitis C virusEvangelos Cholongitas
Transplantation 81:488-90. 2006 - A systematic review of the quality of liver biopsy specimensEvangelos Cholongitas
Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, Pond Street, Hampstead, London, England
Am J Clin Pathol 125:710-21. 2006..New studies are needed based on adequate liver biopsy samples to provide reliable estimation of grading and staging in chronic liver disease... - Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant studyAlessandro Grasso
Liver Transplantation and Hepatobiliary Medicine Unit, London UK, Royal Free Hospital London, United Kingdom
Transplantation 81:1532-41. 2006..New proposals for increasing the diameter of the largest nodule as a selection criteria for LT do not agree with our data, which on the contrary indicate the optimal nodule diameter should be 35 mm or less... - Liver transplantation for HCV cirrhosis: improved survival in recent years and increased severity of recurrent disease in female recipients: results of a long term retrospective studyLuca S Belli
Hepatology and Abdominal Organ Transplantation Unit, Niguarda Hospital, Milan, Italy
Liver Transpl 13:733-40. 2007..The combination of a female recipient receiving an older graft emerged as a strong risk factor for a severe recurrence... - Noninvasive tests in the post-liver transplantation settingEvangelos Cholongitas
Liver Transpl 13:626-7; author reply 628-9. 2007 - Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkersRagai R Mitry
Hepatology 46:2047-8; author reply 2048. 2007 - A morphometric model to minimize subjectivity in the histological assessment of hepatocellular carcinoma and its precursors in cirrhosisMaurizio Vertemati
Department of Human Morphology, University of Milan, Milan, Italy
Microsc Res Tech 71:606-13. 2008..To explore how morphometry can minimize subjectivity in the assessment of liver nodules in cirrhosis using a novel classification tool...