Genomes and Genes
Affiliation: King's College London
- Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD)Petroula Proitsi
King s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, London SE5 8AF, UK
Brain Res Bull 88:394-405. 2012..Larger studies and more systematic approaches will delineate the association of missense substitutions with behavioural symptoms in AD...
- Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variationPetroula Proitsi
King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
Neurobiol Aging 33:1843.e9-17. 2012..Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD...
- Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementiaPetroula Proitsi
Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 33:791-803. 2012..This multiple indicators multiple causes (MIMIC) model efficiently captured the complexity of the interrelations between genetic variation, behavioral symptoms, and clinical variables...
- A blood gene expression marker of early Alzheimer's diseaseKatie Lunnon
King s College London, Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, London, UK
J Alzheimers Dis 33:737-53. 2013..However, we accept these results could also represent a marker of diseases sharing common etiology...
- Entorhinal cortex thickness predicts cognitive decline in Alzheimer's diseaseLatha Velayudhan
King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
J Alzheimers Dis 33:755-66. 2013..Focusing on structural analyses that predict decline can identify those individuals at greatest risk for future cognitive loss. This may have potential for increasing the efficacy of early intervention...
- Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's diseaseMichelle K Lupton
MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 6:e17298. 2011..994, CI 1.105-14.439, p = 0.035). This finding warrants further investigation in a larger cohort and adds weight to the hypothesis that rare variation explains some of genetic heritability still to be identified in Alzheimer's disease...
- Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progressionSimon J Furney
King s College London, Institute of Psychiatry and National Institute of Health Research NIHR Biomedical Research Centre for Mental Health, London, UK
J Alzheimers Dis 26:395-405. 2011....
- Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in bloodPetroula Proitsi
King s College London, Institute of Psychiatry, London, UK
Neurobiol Aging 35:279-90. 2014..Inhibiting MS4A6A may therefore promote a more neuroprotective phenotype, although further work is needed to establish whether this is the case...
- The role of ABCA1 gene sequence variants on risk of Alzheimer's diseaseMichelle K Lupton
Department of Neuroscience, Institute of Psychiatry, King s College London, London, UK QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
J Alzheimers Dis 38:897-906. 2014..In addition they highlight the importance of high throughput sequencing in the identification of rare variation undetected by GWAS, but with the potential to have a strong effect on risk of LOAD. ..
- Complement activation as a biomarker for Alzheimer's diseaseMohammed Aiyaz
Kings College London Institute of Psychiatry, De Crespigny Park, London, UK
Immunobiology 217:204-15. 2012..An accurate biomarker that has sufficient predictive, diagnostic and prognostic value would provide a significant opportunity to develop and test for effective novel therapies in the treatment of AD...
- Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer diseaseMadhav Thambisetty
King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 67:739-48. 2010..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
- Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication studySteven J Kiddle
King s College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK
J Alzheimers Dis 38:515-31. 2014..This suggests that AD pathology does affect the blood proteome with some consistency...
- Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease bloodKatie Lunnon
Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, King s College London, London, UK
J Alzheimers Dis 30:685-710. 2012....
- Evidence of altered phosphatidylcholine metabolism in Alzheimer's diseaseLuke Whiley
Institute of Pharmaceutical Science and Institute of Psychiatry, Kings s College London, London, UK
Neurobiol Aging 35:271-8. 2014....
- Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brainDaniel Condliffe
Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 35:1850-4. 2014..Our study further implicates a role for epigenetic alterations in AD. ..
- Risk of developing dementia in people with diabetes and mild cognitive impairmentLatha Velayudhan
National Institute for Health Research NIHR Biomedical Research Centre for Mental Health, Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
Br J Psychiatry 196:36-40. 2010..Diabetes mellitus is associated with cognitive dysfunction, but it is not clear whether the disorder increases the risk of conversion from mild cognitive impairment to dementia...
- Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4Petroula Proitsi
Department of Psychological Medicine, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 63:13-6. 2008..This diverse evidence suggests that wnt signaling genes, defined as pathway participants, modifiers or targets, are good candidates as susceptibility factors...