Genomes and Genes
Affiliation: King's College London
- Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD)Petroula Proitsi
King s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, London SE5 8AF, UK
Brain Res Bull 88:394-405. 2012..Larger studies and more systematic approaches will delineate the association of missense substitutions with behavioural symptoms in AD...
- Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementiaPetroula Proitsi
Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 33:791-803. 2012..This multiple indicators multiple causes (MIMIC) model efficiently captured the complexity of the interrelations between genetic variation, behavioral symptoms, and clinical variables...
- Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variationPetroula Proitsi
King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
Neurobiol Aging 33:1843.e9-17. 2012..Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD...
- A blood gene expression marker of early Alzheimer's diseaseKatie Lunnon
King s College London, Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, London, UK
J Alzheimers Dis 33:737-53. 2013..However, we accept these results could also represent a marker of diseases sharing common etiology...
- Entorhinal cortex thickness predicts cognitive decline in Alzheimer's diseaseLatha Velayudhan
King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
J Alzheimers Dis 33:755-66. 2013..Focusing on structural analyses that predict decline can identify those individuals at greatest risk for future cognitive loss. This may have potential for increasing the efficacy of early intervention...
- Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's diseaseMichelle K Lupton
MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 6:e17298. 2011..994, CI 1.105-14.439, p = 0.035). This finding warrants further investigation in a larger cohort and adds weight to the hypothesis that rare variation explains some of genetic heritability still to be identified in Alzheimer's disease...
- Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progressionSimon J Furney
King s College London, Institute of Psychiatry and National Institute of Health Research NIHR Biomedical Research Centre for Mental Health, London, UK
J Alzheimers Dis 26:395-405. 2011....
- Complement activation as a biomarker for Alzheimer's diseaseMohammed Aiyaz
Kings College London Institute of Psychiatry, De Crespigny Park, London, UK
Immunobiology 217:204-15. 2012..An accurate biomarker that has sufficient predictive, diagnostic and prognostic value would provide a significant opportunity to develop and test for effective novel therapies in the treatment of AD...
- Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer diseaseMadhav Thambisetty
King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 67:739-48. 2010..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
- Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease bloodKatie Lunnon
Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, King s College London, London, UK
J Alzheimers Dis 30:685-710. 2012....
- Risk of developing dementia in people with diabetes and mild cognitive impairmentLatha Velayudhan
National Institute for Health Research NIHR Biomedical Research Centre for Mental Health, Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
Br J Psychiatry 196:36-40. 2010..Diabetes mellitus is associated with cognitive dysfunction, but it is not clear whether the disorder increases the risk of conversion from mild cognitive impairment to dementia...
- Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4Petroula Proitsi
Department of Psychological Medicine, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 63:13-6. 2008..This diverse evidence suggests that wnt signaling genes, defined as pathway participants, modifiers or targets, are good candidates as susceptibility factors...