L Poston

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc A complex intervention to improve pregnancy outcome in obese women; the UPBEAT randomised controlled trial
    Annette L Briley
    Division of Women s Health, Women s Health Academic Centre, King s College London and King s Health Partners, 10th Floor, North Wing, St, Thomas Hospital, London SE1 7EH, UK
    BMC Pregnancy Childbirth 14:74. 2014
  2. doi request reprint Maternal obesity, gestational weight gain and diet as determinants of offspring long term health
    Lucilla Poston
    Division of Women s Health, Women s Health Academic Centre, King s College London, St Thomas Hospital, London, United Kingdom
    Best Pract Res Clin Endocrinol Metab 26:627-39. 2012
  3. pmc Lifestyle interventions for overweight and obese pregnant women to improve pregnancy outcome: systematic review and meta-analysis
    Eugene Oteng-Ntim
    Department of Women s Health, Guy s and St Thomas NHS Foundation Trust King s Health Partners, St Thomas Hospital, Westminster Bridge Road, London, SE 1 7EH, UK
    BMC Med 10:47. 2012
  4. doi request reprint Gestational weight gain: influences on the long-term health of the child
    Lucilla Poston
    Division of Women s Health, King s College London, St Thomas Hospital, London, UK
    Curr Opin Clin Nutr Metab Care 15:252-7. 2012
  5. pmc Agreement between pedometer and accelerometer in measuring physical activity in overweight and obese pregnant women
    Tarja I Kinnunen
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 11:501. 2011
  6. ncbi request reprint Influences of maternal nutritional status on vascular function in the offspring
    Lucilla Poston
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College, London, UK
    Curr Drug Targets 8:914-22. 2007
  7. ncbi request reprint Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial
    L Poston
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Lancet 367:1145-54. 2006
  8. ncbi request reprint Vitamin E in preeclampsia
    Lucilla Poston
    MFRU, Division of Reproductive Health, Endocrinology and Development, St Thomas Hospital, 10th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, United Kingdom
    Ann N Y Acad Sci 1031:242-8. 2004
  9. doi request reprint Developmental programming and diabetes - The human experience and insight from animal models
    Lucilla Poston
    King s College London, United Kingdom
    Best Pract Res Clin Endocrinol Metab 24:541-52. 2010
  10. doi request reprint Influence of maternal nutritional status on vascular function in the offspring
    Lucilla Poston
    Division of Women s Health, King s College London and King s Health Partners, London, UK
    Microcirculation 18:256-62. 2011

Detail Information

Publications106 found, 100 shown here

  1. pmc A complex intervention to improve pregnancy outcome in obese women; the UPBEAT randomised controlled trial
    Annette L Briley
    Division of Women s Health, Women s Health Academic Centre, King s College London and King s Health Partners, 10th Floor, North Wing, St, Thomas Hospital, London SE1 7EH, UK
    BMC Pregnancy Childbirth 14:74. 2014
    ..A secondary aim is to determine whether the intervention lowers the long term risk of obesity in the offspring...
  2. doi request reprint Maternal obesity, gestational weight gain and diet as determinants of offspring long term health
    Lucilla Poston
    Division of Women s Health, Women s Health Academic Centre, King s College London, St Thomas Hospital, London, United Kingdom
    Best Pract Res Clin Endocrinol Metab 26:627-39. 2012
    ..Importantly, dissection of the mechanism in animals has led to description of novel interactive pathways between maternal environment and fetus which are amenable to investigation in humans...
  3. pmc Lifestyle interventions for overweight and obese pregnant women to improve pregnancy outcome: systematic review and meta-analysis
    Eugene Oteng-Ntim
    Department of Women s Health, Guy s and St Thomas NHS Foundation Trust King s Health Partners, St Thomas Hospital, Westminster Bridge Road, London, SE 1 7EH, UK
    BMC Med 10:47. 2012
    ..Hence the objective of this study is to determine the efficacy of antenatal dietary, activity, behaviour or lifestyle interventions in overweight and obese pregnant women to improve maternal and perinatal outcomes...
  4. doi request reprint Gestational weight gain: influences on the long-term health of the child
    Lucilla Poston
    Division of Women s Health, King s College London, St Thomas Hospital, London, UK
    Curr Opin Clin Nutr Metab Care 15:252-7. 2012
    ..To address the recent evidence which suggests that inappropriate gestational weight gain (GWG) may have consequences that extend to the longer term health of the child...
  5. pmc Agreement between pedometer and accelerometer in measuring physical activity in overweight and obese pregnant women
    Tarja I Kinnunen
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 11:501. 2011
    ..This study compared the number of pedometer step counts with accelerometer data in pregnant women in free-living conditions to assess agreement between these measures...
  6. ncbi request reprint Influences of maternal nutritional status on vascular function in the offspring
    Lucilla Poston
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College, London, UK
    Curr Drug Targets 8:914-22. 2007
    ..Further investigation is required into the intriguing suggestion that early life nutritional imbalance may adversely influence vascular angiogenesis leading to rarefaction and increased peripheral vascular resistance...
  7. ncbi request reprint Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial
    L Poston
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Lancet 367:1145-54. 2006
    ..Our aim was to investigate the potential benefit of these antioxidants in a cohort of women with a range of clinical risk factors...
  8. ncbi request reprint Vitamin E in preeclampsia
    Lucilla Poston
    MFRU, Division of Reproductive Health, Endocrinology and Development, St Thomas Hospital, 10th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, United Kingdom
    Ann N Y Acad Sci 1031:242-8. 2004
    ..Several larger trials are under way to investigate the precise role that vitamins C and E can play in the prevention of preeclampsia...
  9. doi request reprint Developmental programming and diabetes - The human experience and insight from animal models
    Lucilla Poston
    King s College London, United Kingdom
    Best Pract Res Clin Endocrinol Metab 24:541-52. 2010
    ....
  10. doi request reprint Influence of maternal nutritional status on vascular function in the offspring
    Lucilla Poston
    Division of Women s Health, King s College London and King s Health Partners, London, UK
    Microcirculation 18:256-62. 2011
    ..This and several other similarities may indicate commonality of mechanism and could reflect supranormal nutritional status in postnatal life in both conditions...
  11. ncbi request reprint Trophoblast oxidative stress, antioxidants and pregnancy outcome--a review
    L Poston
    Maternal and Fetal Research Unit, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Placenta 25:S72-8. 2004
    ....
  12. ncbi request reprint Endothelial dysfunction in pre-eclampsia
    Lucilla Poston
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, 10th Floor North Wing, St Thomas Hospital, London SE1 7EH, UK
    Pharmacol Rep 58:69-74. 2006
    ..Endothelial dysfunction, unlike pre-eclampsia, does not resolve post-partum, and persistence of the defect may underpin the increased risk of cardiovascular disease in later life...
  13. doi request reprint Intergenerational transmission of insulin resistance and type 2 diabetes
    Lucilla Poston
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Prog Biophys Mol Biol 106:315-22. 2011
    ....
  14. ncbi request reprint Is oxidative stress involved in the aetiology of pre-eclampsia?
    L Poston
    Department of Obstetrics and Gynaecology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London, UK
    Acta Paediatr Suppl 90:3-5. 2001
    ..It was recently shown by the present authors that supplementation with vitamin C and E from early in pregnancy leads to a reduction in the incidence of the disease in "high-risk" women...
  15. doi request reprint Role of oxidative stress and antioxidant supplementation in pregnancy disorders
    Lucilla Poston
    Division of Women s Health, King s College London, Kings Health Partners Women s Health, Clinical Academic Grouping, London, United Kingdom
    Am J Clin Nutr 94:1980S-1985S. 2011
    ..Other potential approaches for preventing preeclampsia through amelioration of oxidative stress include the use of supplements in the preconceptual period, selenium supplements, antiperoxynitrite strategies, and statins...
  16. ncbi request reprint Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring
    Imran Khan
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology, and Development, Kings College, London, UK
    Circulation 110:1097-102. 2004
    ..We have investigated "predictive adaptive" responses in a rodent model in which adult offspring of fat-fed dams develop characteristics of the metabolic syndrome...
  17. pmc Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring
    T Ozaki
    Department of Obstetrics and Gynaecology, University College Hospital, London WC1E 6HX, UK
    J Physiol 530:141-52. 2001
    ..01) were enhanced. Moderate maternal undernutrition in rat gestation adversely affects cardiovascular function in the offspring. These abnormalities increase with age and are more pronounced in males...
  18. ncbi request reprint A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring
    I Y Khan
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College, London, UK
    Am J Physiol Regul Integr Comp Physiol 288:R127-33. 2005
    ..However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling...
  19. ncbi request reprint Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy
    M T M Raijmakers
    MFRU, Division of Reproductive Health, Endocrinology and Development, GKT School of Medicine, St Thomas Hospital, London, UK
    Placenta 27:158-63. 2006
    ..05) when compared to corresponding term placental values. NAD(P)H oxidase mediated superoxide generation could be an important modulator of the antioxidant defence response in early pregnancy...
  20. ncbi request reprint Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role...
  21. doi request reprint Psychological predictors of dietary intentions in pregnancy
    B Gardner
    Health Behaviour Research Centre, University College London, London, UK
    J Hum Nutr Diet 25:345-53. 2012
    ..The present study aimed to model psychological predictors of intentions to reduce intake of high-fat and high-sugar foods, and increase fruit and vegetable consumption, among pregnant women...
  22. pmc Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy
    P Ghosh
    Maternal and Fetal Research Unit, Department of Obstetrics and Gynaecology, Guy's, King's and St Thomas' School of Medicine, St Thomas' Hospital, London SE1 7EH, UK
    J Physiol 533:815-22. 2001
    ..5. This study demonstrates that a high fat diet in pregnant rats produces abnormal vascular function, plasma lipid disturbances and altered vascular fatty acid content in their female offspring during adulthood...
  23. pmc Cardiovascular consequences of life-long exposure to dietary isoflavones in the rat
    G Douglas
    Division of Reproductive Health, Endocrinology and Development, Medical School of Guy s, King s and St Thomas Hospital, Kings College London, St Thomas Hospital, London SE1 7EH, UK
    J Physiol 571:477-87. 2006
    ..In summary, the isoflavone content of soy protein has no influence on blood pressure in healthy rats fed a diet based on soy protein, but influences small artery function...
  24. ncbi request reprint Amino thiols, detoxification and oxidative stress in pre-eclampsia and other disorders of pregnancy
    M T M Raijmakers
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, St Thomas Hospital, London, SE1 7EH, UK
    Curr Pharm Des 11:711-34. 2005
    ....
  25. pmc Impaired EDHF-mediated vasodilatation in adult offspring of rats exposed to a fat-rich diet in pregnancy
    P D Taylor
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, 10th Floor North Wing, St Thomas Hospital, London SE1 7EH, UK
    J Physiol 558:943-51. 2004
    ..In conclusion, reduced endothelium-dependent relaxation in OHF mesenteric arteries is due to impaired EDHF-mediated relaxation. This defect was not apparent in femoral arteries in which EDHF has a less prominent role...
  26. ncbi request reprint Developmental programming of obesity in mammals
    P D Taylor
    Division of Reproduction and Endocrinology, 10 Floor North Wing, St Thomas Hospital, London SE1 7EH, UK
    Exp Physiol 92:287-98. 2007
    ....
  27. ncbi request reprint Calcium homeostatic pathways change with gestation in human myometrium
    R M Tribe
    The London Myometrial Group, Fetal Health Research Group, Department of Obstetrics and Gynaecology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, United Kingdom
    Biol Reprod 63:748-55. 2000
    ..We conclude that the activity of SERCA isoforms becomes increasingly important in the maintenance of regular contractile activity during labor and may compensate for the functional loss of other calcium control pathways at term...
  28. ncbi request reprint Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
    Jude A Oben
    University College London, Centre for Hepatology, Royal Free Hospital, London, UK
    J Hepatol 52:913-20. 2010
    ..Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition to dysmetabolism, obesity and NAFLD...
  29. pmc Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice
    Piran Shelley
    Division of Reproduction and Endocrinology, King s College London, St Thomas s Hospital, London, UK
    Am J Physiol Regul Integr Comp Physiol 297:R675-81. 2009
    ..Sex-related alterations in key insulin-signaling proteins and in mitochondrial ETC may contribute to a state of insulin resistance in offspring of obese mice...
  30. ncbi request reprint Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function
    Lucy C Chappell
    Maternal and Fetal Research Unit, Department of Obstetrics and Gynaecology and Centre for Cardiovascular Biology and Medicine, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Am J Obstet Gynecol 187:777-84. 2002
    ..In this study, we determined whether supplementation in the same cohort was associated with an improvement in indices of placental dysfunction and oxidative stress toward values determined in women who were at low risk of preeclampsia...
  31. ncbi request reprint Placentation, antiphospholipid syndrome and pregnancy outcome
    S Stone
    Lupus Pregnancy Clinic, St Thomas' Hospitals, London, UK
    Lupus 10:67-74. 2001
    ..The evidence for defective placentation in APS pregnancies and involvement of aPLs in this process is summarized. Finally hypotheses based on the interpretation of these studies are discussed...
  32. ncbi request reprint NAD(P)H oxidase associated superoxide production in human placenta from normotensive and pre-eclamptic women
    M T M Raijmakers
    Maternal and Fetal Research Unit, GKT School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    Placenta 25:S85-9. 2004
    ..These data justify more detailed investigation of the role of NAD(P)H oxidase and placental oxidative stress in complicated pregnancies...
  33. ncbi request reprint Functional characterization and sex differences in small mesenteric arteries of the estrogen receptor-beta knockout mouse
    Gillian Douglas
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, Kings College London, London, UK
    Am J Physiol Regul Integr Comp Physiol 294:R112-20. 2008
    ..Further studies in beta-ERKO mice with established hypertension and in alpha-ERKO mice are warranted...
  34. ncbi request reprint Fetal programming for adult disease: where next?
    I Y Khan
    Maternal and Fetal Research Unit, St Thomas Hospital, London, UK
    J Matern Fetal Neonatal Med 13:292-9. 2003
    ....
  35. pmc Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro
    A Ferro
    Department Clinical Pharmacology, King s College London, St Thomas Hospital
    Br J Pharmacol 126:1872-80. 1999
    ..7. These results indicate that endothelial beta2-adrenergic stimulation and cyclic AMP elevation activate the L-arginine/NO system, and give rise to vasorelaxation, in human umbilical vein...
  36. ncbi request reprint Interleukin 8 expression in human myometrium: changes in relation to labor onset and with gestational age
    C L Elliott
    Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
    Am J Reprod Immunol 43:272-7. 2000
    ..The mechanisms involved in the onset of preterm labor are poorly understood, mainly because the mechanisms initiating term labor remain ill-defined...
  37. doi request reprint Clinical and geographical variation in prophylactic and therapeutic treatments for pre-eclampsia in the UK
    L C Chappell
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London School of Biomedical and Health Sciences, London, UK
    BJOG 117:695-700. 2010
    ..To evaluate the clinical and geographical variation in the use of aspirin in women at high risk of pre-eclampsia, and in the use of antihypertensive drugs and magnesium sulphate in women with established pre-eclampsia...
  38. pmc Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy
    James A Armitage
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College London, GKT Department of Women s Health, St Thomas Hospital, UK
    J Physiol 565:171-84. 2005
    ..Despite normal renal stereology, altered renal Na+,K+-ATPase and renin activity offers further insight into the mechanism underlying the increased blood pressure characteristic of this model...
  39. ncbi request reprint Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle
    Rachel M Tribe
    Parturition Research, Maternal and Fetal Research Unit, Department of Women s Health, King s College London, St Thomas Hospital Campus, United Kingdom
    Biol Reprod 68:1842-9. 2003
    ..IL-1beta modulation of calcium mobilization may be an important mechanism in the cascade of events preparing the pregnant uterus for labor...
  40. pmc Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood
    Natalia Igosheva
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Physiol 582:665-74. 2007
    ..We conclude that prenatal stress during late gestation has long-lasting effects on cardiovascular responsiveness and vascular reactivity to neuropeptide Y in the offspring...
  41. pmc Experimental models of developmental programming: consequences of exposure to an energy rich diet during development
    James A Armitage
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, GKT School of Medicine, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Physiol 565:3-8. 2005
    ..These suggest that maternal over-nutrition is deleterious to the health of offspring and can result in a phenotype of the offspring that is characteristic of metabolic syndrome...
  42. doi request reprint Adverse perinatal outcomes and risk factors for preeclampsia in women with chronic hypertension: a prospective study
    Lucy C Chappell
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London School of Biomedical and Health Sciences, London SE1 7EH, UK
    Hypertension 51:1002-9. 2008
    ..Paradoxically, smoking is an independent risk factor for superimposed preeclampsia in chronic hypertension, in contrast to the protective effect in low-risk pregnant women...
  43. pmc Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?
    James A Armitage
    Maternal and Fetal Research Unit, Department of Women s Health, Guy s, King s and St Thomas School of Medicine, King s College London, UK
    J Physiol 561:355-77. 2004
    ..The validity of the different species, diets, feeding regimes and end-point measures used is also discussed...
  44. doi request reprint Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, 10th Floor North Wing, St Thomas Hospital, London SE1 7EH, UK
    Hypertension 55:76-82. 2010
    ..The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development...
  45. doi request reprint Respiratory outcomes in early childhood following antenatal vitamin C and E supplementation
    Anne Greenough
    Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
    Thorax 65:998-1003. 2010
    ....
  46. ncbi request reprint Gender-linked hypertension in offspring of lard-fed pregnant rats
    Imran Y Khan
    Maternal and Fetal Research Unit, GKT Department of Women s Health, St Thomas Hospital, London, UK
    Hypertension 41:168-75. 2003
    ..Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring...
  47. ncbi request reprint Preeclampsia inactivates glucose-6-phosphate dehydrogenase and impairs the redox status of erythrocytes and fetal endothelial cells
    Iram Afzal-Ahmed
    Cardiovascular Division, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, UK
    Free Radic Biol Med 42:1781-90. 2007
    ..The deficiency in G6PD in preeclampsia potentially accounts for the lack of protection against oxidative stress afforded by antioxidant vitamin C/E supplementation in the VIP trial...
  48. ncbi request reprint Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy
    Paul D Taylor
    Division of Reproductive Health, Endocrinology and Development, King s College London, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R134-9. 2005
    ....
  49. doi request reprint Prediction of preeclampsia and delivery of small for gestational age babies based on a combination of clinical risk factors in high-risk women
    Paul T Seed
    Division of Reproduction and Endocrinology, St Thomas Hospital, King s College London, London, UK
    Hypertens Pregnancy 30:58-73. 2011
    ..To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women...
  50. ncbi request reprint Reporting errors, incidence and risk factors for postpartum haemorrhage and progression to severe PPH: a prospective observational study
    A Briley
    Division of Women s Health, Women s Health Academic Centre, King s College London and King s Health Partners, St Thomas Hospital Campus, London, UK
    BJOG 121:876-88. 2014
    ..To quantify reporting errors, measure incidence of postpartum haemorrhage (PPH) and define risk factors for PPH (≥500 ml) and progression to severe PPH (≥1500 ml)...
  51. doi request reprint Changing diet and physical activity to reduce gestational weight gain: a meta-analysis
    B Gardner
    Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK
    Obes Rev 12:e602-20. 2011
    ..We suggest that behaviour-based gestational weight gain reduction interventions be more systematically designed, evaluated and reported to build on insights from behavioural science...
  52. ncbi request reprint The non-invasive biopsy--will urinary proteomics make the renal tissue biopsy redundant?
    K Bramham
    Maternal and Fetal Research Unit, KCL Division of Reproduction and Endocrinology, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    QJM 102:523-38. 2009
    ....
  53. ncbi request reprint Intrauterine vascular development: programming effects of nutrition on vascular function in the new born and adult
    L Poston
    Department of Obstetrics and Gynaecology and Centre for Cardiovascular Biology and Medicine, St Thomas' Hospital, London, UK
    Nutr Health 15:207-12. 2001
    ..The importance of the Barker hypothesis, relating faulty maternal nutrition to low birth weight and subsequent disease in adult life, is examined in relation to vascular function...
  54. ncbi request reprint The placental bed in pregnancies complicated by primary antiphospholipid syndrome
    S Stone
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Placenta 27:457-67. 2006
    ..The aim of this study was to investigate the placental bed in APS pregnancies for evidence of impaired trophoblast invasion, endothelial cell activation (ECA) and macrophage infiltration...
  55. doi request reprint A prospective study of pregnancy outcome and biomarkers of oxidative stress in nulliparous obese women
    Daghni Rajasingam
    Division of Reproduction and Endocrinology, Maternal and Fetal Research Unit, King s College London, London, United Kingdom
    Am J Obstet Gynecol 200:395.e1-9. 2009
    ..We sought to investigate pregnancy outcome and biomarkers of oxidative stress in nulliparous obese pregnant women...
  56. ncbi request reprint Programmed aortic dysfunction and reduced Na+,K+-ATPase activity present in first generation offspring of lard-fed rats does not persist to the second generation
    James A Armitage
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, 10th Floor North Wing, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Exp Physiol 92:583-9. 2007
    ....
  57. pmc Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase
    James A Armitage
    Division of Reproduction and Endocrinology, King s College London, London, UK
    J Physiol 586:5013-22. 2008
    ..In utero and neonatal exposure to a maternal diet rich in saturated fatty acids is associated with altered activity and expression of Na(+),K(+)-ATPase in adulthood, but mechanisms appear tissue specific...
  58. pmc Effect of endothelium-specific insulin resistance on endothelial function in vivo
    Edward R Duncan
    Cardiovascular Division, Department of Cardiology, King s College, London, UK
    Diabetes 57:3307-14. 2008
    ..Insulin resistance is associated with endothelial dysfunction; however, the mechanistic relationship between these abnormalities and the role of impaired endothelial insulin signaling versus global insulin resistance remains unclear...
  59. pmc Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring
    Shona L Kirk
    Division of Reproduction and Endocrinology, King s College London, London, UK
    PLoS ONE 4:e5870. 2009
    ..Such effects may underlie the developmental programming of hyperphagia and obesity in these rats...
  60. ncbi request reprint Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo
    Katharina Mahn
    Cardiovascular Division, School of Biomedical and Health Sciences, King s College London, London, UK
    FASEB J 19:1755-7. 2005
    ..The improvement in endothelial function, increased gene expression, and reduced blood pressure by soy isoflavones have implications for alternative therapy for postmenopausal women and patients at risk of coronary heart disease...
  61. ncbi request reprint A longitudinal study of biochemical variables in women at risk of preeclampsia
    Lucy C Chappell
    Maternal and Fetal Research Unit, Department Cardiovascular Research, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Am J Obstet Gynecol 187:127-36. 2002
    ....
  62. pmc Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep
    Hidenori Nishina
    Department of Obstetrics and Gynaecology, University College London, 86 96 Chenies Mews, London WC1 6HX, UK
    J Physiol 553:637-47. 2003
    ..These changes may precede perturbed late-gestation fetal and postnatal cardiovascular control...
  63. ncbi request reprint Leptin and preeclampsia
    Lucilla Poston
    Maternal and Fetal Research Unit, Guy s Kings and St Thomas School of Medicine, King s College, London, United Kingdom
    Semin Reprod Med 20:131-8. 2002
    ..Further research is needed to determine if the rise in leptin plays a role in preeclampsia or whether it is a secondary and unrelated bystander...
  64. ncbi request reprint Longitudinal evaluation of markers of endothelial cell dysfunction and hemostasis in treated antiphospholipid syndrome and in healthy pregnancy
    Sophia Stone
    Departments of Maternal and Fetal Research Unit Women s Health, Guy s, King s and St Thomas School of Medicine, King s College, London, United Kingdom
    Am J Obstet Gynecol 188:454-60. 2003
    ..The purpose of this study was to determine whether primary antiphospholipid syndrome pregnancies are associated with endothelial cell activation in the maternal circulation...
  65. ncbi request reprint Uterine artery function in pregnant rats fed a diet supplemented with animal lard
    P D Taylor
    Maternal and Fetal Research Unit, GKT Department of Women s Health, King s College London, UK
    Exp Physiol 88:389-98. 2003
    ....
  66. ncbi request reprint Gestational profile of matrix metalloproteinases in rat uterine artery
    B A Kelly
    Maternal and Fetal Research Unit, Department of Womens Health, Guy s, King s and St Thomas School of Medicine, 10th Floor St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Mol Hum Reprod 9:351-8. 2003
    ..Continued elevated levels of some MMPs post-partum may contribute to vessel regression and return to a non-pregnant physiological state...
  67. ncbi request reprint Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation
    B A Kelly
    Maternal and Fetal Research Unit, Department of Women s Health, Guy s, King s and St Thomas School of Medicine, 10th Floor St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Mol Hum Reprod 10:331-7. 2004
    ..These data suggest that MMP-2 and MMP-3 may contribute to adaptive processes in the maternal rat aorta at different gestations and further support a role for this family of enzymes in physiological vascular remodelling...
  68. doi request reprint Low saliva progesterone concentrations are associated with spontaneous early preterm labour (before 34 weeks of gestation) in women at increased risk of preterm delivery
    G C L Lachelin
    Department of Obstetrics and Gynaecology, University College London, London, UK
    BJOG 116:1515-9. 2009
    ..007) or at term (P = 0.009). Measurement of saliva progesterone may be of value in the prediction of early preterm labour and in determining which women might benefit from progesterone supplementation...
  69. ncbi request reprint Validation of the Welch Allyn 'Vital Signs' oscillometric blood pressure monitor
    C R Jones
    Fetal Health Research Group, Department of Obstetrics and Gynaecology, Guy's King's and St. Thomas' School of Medicine, St Thomas' Hospital, London, UK
    J Hum Hypertens 15:191-5. 2001
    ..This is one of the first oscillometric monitors designed for routine use in a hospital environment that has been found to provide an accurate assessment of BP by accepted validation procedures...
  70. ncbi request reprint Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta
    A Dalrymple
    Parturition Research Group, Maternal and Fetal Research Unit, Department of Women s Health, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital Campus, London, SE1 7EH, United Kingdom
    J Clin Endocrinol Metab 89:1291-300. 2004
    ..05). TrpC3 up-regulation was unaffected by cyclooxygenase blockade. These data demonstrate physiological regulation of TrpC mRNA and protein and suggest an important role for TrpC proteins in human myometrium during labor...
  71. ncbi request reprint Association of pulse waveform characteristics with birth weight in young adults
    Christopher Broyd
    Maternal and Fetal Research Unit, Department of Women s Health, GKT School of Medicine, King s College, London, St Thomas Hospital, London, UK
    J Hypertens 23:1391-6. 2005
    ..The objective of this study was to examine the relationship between birth weight and characteristics of the proximal arterial tree determined by pulse wave analysis...
  72. ncbi request reprint Oxidative stress and preeclampsia: rationale for antioxidant clinical trials
    Maarten T M Raijmakers
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology, and Development, King s College Hospital, St Thomas Hospital, London, UK
    Hypertension 44:374-80. 2004
    ..A combination test involving several relevant biomarkers is likely to provide the best predictive potential...
  73. ncbi request reprint Longitudinal analysis of serum insulin-like growth factor-I and insulin-like growth factor binding protein-1 in antiphospholipid syndrome and in healthy pregnancy
    Sophia Stone
    Departments of Maternal and Fetal Research Unit, Guy s, King s and St Thomas School of Medicine, King s College, London, United Kingdom
    Am J Obstet Gynecol 189:274-9. 2003
    ..The purpose of this study was to determine the concentrations of serum insulin-like growth factor-I and insulin-like growth factor binding protein-1 in pregnancies that are complicated with primary antiphospholipid syndrome...
  74. ncbi request reprint Inflationary oscillometry provides accurate measurement of blood pressure in pre-eclampsia
    Moneli Golara
    GKT Department of Obstetrics and Gynaecology, St Thomas Hospital, London, UK
    BJOG 109:1143-7. 2002
    ..To evaluate the accuracy of the OMRON-MIT inflationary oscillometric device for blood pressure measurement in pregnancy and pre-eclampsia...
  75. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction...
  76. doi request reprint Maternal obesity and the developmental programming of hypertension: a role for leptin
    P D Taylor
    Division of Women s Health, Women s Health Academic Centre, King s College London and King s Health Partners, London, UK
    Acta Physiol (Oxf) 210:508-23. 2014
    ..The goal of the review is to highlight the potential importance of leptin in the developmental programming of hypertension in obese pregnancy. ..
  77. ncbi request reprint Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2
    C W Tam
    Cardiovascular Division, King s College London, United Kingdom
    Circ Res 98:262-70. 2006
    ..Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches...
  78. ncbi request reprint Mechanical stretch regulates TRPC expression and calcium entry in human myometrial smooth muscle cells
    A Dalrymple
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    Mol Hum Reprod 13:171-9. 2007
    ..05), respectively. These data support the hypothesis that uterine stretch modulates uterine growth and contractility in pregnancy via alterations in calcium signalling...
  79. ncbi request reprint Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus
    A Dalrymple
    Parturition Research Group, Maternal and Fetal Research Unit, Department of Women s Health, 10th Floor North Wing, Guy s School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
    Mol Hum Reprod 8:946-51. 2002
    ..TrpC protein immunostaining in HMSM cells was distributed in a distinct reticular fashion. TrpC proteins may be candidate proteins forming SOCE channels in term pregnant human myometrium...
  80. ncbi request reprint A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study
    Andrew Shennan
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, St Thomas Hospital, King s College London, UK
    BJOG 113:65-74. 2006
    ..To determine whether metronidazole reduces early preterm labour in asymptomatic women with positive vaginal fetal fibronectin (fFN) in the second trimester of pregnancy...
  81. ncbi request reprint Glutathione S-transferase and liver function in intrahepatic cholestasis of pregnancy and pruritus gravidarum
    Anthony T Dann
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Hepatology 40:1406-14. 2004
    ..Additionally, on the basis of this study, reference ranges for biochemical markers of liver function require reevaluation in pregnancy...
  82. ncbi request reprint Low-protein diet impairs vascular relaxation in virgin and pregnant rats
    Angeliki Koumentaki
    Fetal Origins of Adult Disease Research Division, University of Southampton, Obstetrics and Gynaecology 815, Level F, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Clin Sci (Lond) 102:553-60. 2002
    ..005 respectively). Thus low-protein diets impair vasodilator responses in female rats. These effects may contribute to the poor cardiovascular adaptation to pregnancy and lower fetal weights associated with restricted protein intake...
  83. ncbi request reprint Preeclampsia is associated with altered Ca2+ regulation and NO production in human fetal venous endothelial cells
    Joern R Steinert
    Centre for Cardiovascular Biology and Medicine, Guy s, King s and St Thomas Schools of Biomedical Sciences and Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    FASEB J 16:721-3. 2002
    ..As these changes are sustained in culture in vitro, this may reflect long-term "programming" of the fetal cardiovascular system...
  84. ncbi request reprint Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring
    Lee Brawley
    Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, U K
    Pediatr Res 54:83-90. 2003
    ..Reduced vasodilation may be a potential mechanism underlying the elevated systolic blood pressure observed in this model...
  85. ncbi request reprint Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes
    Andriy E Belevych
    Centre for Cardiovascular Biology and Medicine, King s College London, St Thomas s Campus, SE1 7EH, UK
    Cardiovasc Res 54:152-61. 2002
    ..We therefore investigated changes in the functional characteristics and expression of Kv channels in rat aortic myocytes (RAMs) during early postnatal development...
  86. pmc Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring
    Christopher Torrens
    Centre for Fetal Origins of Adult Disease, University of Southampton, Southampton, SO16 5YA, UK
    J Physiol 547:77-84. 2003
    ..We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries...
  87. doi request reprint Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity
    James Andrew Armitage
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Vic, Australia
    Front Horm Res 36:73-84. 2008
    ..This chapter discusses the effects of maternal obesity on fetal development and birth outcomes as well as the manner in which DOHaD may contribute to the obesity epidemic...
  88. ncbi request reprint In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health
    Peter W Nathanielsz
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, The University of Texas of Health Science Center, 7703 Floyd Curl Drive, MSC 7836, San Antonio, TX 78229, USA
    Clin Perinatol 34:515-26, v. 2007
    ....
  89. ncbi request reprint Diet-induced obesity in the rat: a model for gestational diabetes mellitus
    Kathleen Holemans
    Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 190:858-65. 2004
    ..However, in obese women, it is difficult to disentangle the genetic and environmental contributions. The aim of this study was to investigate whether diet-induced obesity results in GDM in rats with the same genetic background...
  90. pmc Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood
    Jane K Cleal
    Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 104:9529-33. 2007
    ..Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies...
  91. ncbi request reprint In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health
    Peter W Nathanielsz
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, The University of Texas of Health Science Center, 7703 Floyd Curl Drive, MSC 7836, San Antonio, TX 78229, USA
    Obstet Gynecol Clin North Am 34:201-12, vii-viii. 2007
    ....
  92. ncbi request reprint Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function
    Omar A Khan
    Department of Cardiothoracic Surgery, Southampton General Hospital, UK
    Eur J Cardiothorac Surg 28:811-5. 2005
    ..We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model...
  93. ncbi request reprint Vitamins C and E and the prevention of preeclampsia
    Annette L Briley
    N Engl J Med 355:1065-6; author reply 1066. 2006
  94. ncbi request reprint Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death
    Piran Shelley
    Neurochemistry Division, Institute of Neurology, UCL, London WC1N 3BG, UK
    Mech Ageing Dev 128:681-7. 2007
    ....
  95. pmc Molecular, cellular and endocrine signalling in the perinatal cardiovascular system: interplay and developmental programming
    Ronald R Magness
    J Physiol 565:1. 2005
  96. ncbi request reprint Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction
    Christopher Torrens
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
    Hypertension 47:982-7. 2006
    ..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function...
  97. pmc The oestrogen receptor beta contributes to sex related differences in endothelial function of murine small arteries via EDHF
    Leonid Luksha
    Institution for Clinical Science, Intervention and Technology CLINTEC, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    J Physiol 577:945-55. 2006
    ..The data suggest that in WT male mice, ERbeta reduces EDHF-mediated relaxation through gap junction communication...
  98. ncbi request reprint Acute responses to phytoestrogens in small arteries from men with coronary heart disease
    Maria Natalia Cruz
    Department of Obstetrics and Gynaecology, Institutional for Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Huddinge Campus, Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 290:H1969-75. 2006
    ..The contribution of NO to dilatory responses by these compounds is pertinent to arteries from control males, whereas other NO-independent dilatory mechanism(s) are involved in arteries from CHD...
  99. ncbi request reprint Gender-specific alteration of adrenergic responses in small femoral arteries from estrogen receptor-beta knockout mice
    Leonid Luksha
    Department of Obstetrics and Gynecology, Institution for Clinical Science, Intervention, and Technology CLINTEC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Hypertension 46:1163-8. 2005
    ..beta-adrenoceptor-mediated dilatation was also enhanced in estrogen receptor-beta knockout versus wild-type males. We suggest that estrogen receptor-beta modifies the adrenergic control of small artery tone in males but not in females...
  100. ncbi request reprint Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake
    Shigeru Itoh
    Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, University of Southampton, Southampton SO16 5YA, UK
    Pediatr Res 51:485-91. 2002
    ..These results show an attenuated uterine artery vasodilator response to VEGF produced by a low-protein diet in pregnancy, partly because of a reduction of the nitric oxide component of VEGF-mediated relaxation...
  101. ncbi request reprint Dilatory responses to estrogenic compounds in small femoral arteries of male and female estrogen receptor-beta knockout mice
    Maria Natalia Cruz
    Institution for Clinical Science, Intervention, and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Huddinge, 14186 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 290:H823-9. 2006
    ..Because NO appeared to contribute to responses to 17beta-E2 in arteries from beta-ERKO but not WT mice, the presence of ER- apparently inhibits ER--mediated NO relaxation...