Robert Plomin

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Reading exposure: a (largely) environmental risk factor with environmentally-mediated effects on reading performance in the primary school years
    Nicole Harlaar
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1192-9. 2007
  2. pmc Literacy and numeracy are more heritable than intelligence in primary school
    Yulia Kovas
    1Laboratory for Cognitive Investigations and Behavioural Genetics, Department of Psychology, Tomsk State University
    Psychol Sci 24:2048-56. 2013
  3. pmc Commentary: missing heritability, polygenic scores, and gene-environment correlation
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 54:1147-9. 2013
  4. pmc Common DNA markers can account for more than half of the genetic influence on cognitive abilities
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Sci 24:562-8. 2013
  5. pmc Child development and molecular genetics: 14 years later
    Robert Plomin
    King s College London
    Child Dev 84:104-20. 2013
  6. ncbi request reprint Common disorders are quantitative traits
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Nat Rev Genet 10:872-8. 2009
  7. pmc Generalist genes and high cognitive abilities
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre P080, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:437-45. 2009
  8. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
  9. ncbi request reprint Aetiological relationship between language performance and autistic-like traits in childhood: a twin study
    Katharina Dworzynski
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Int J Lang Commun Disord 42:273-92. 2007
  10. pmc Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1318-25. 2009

Detail Information

Publications89

  1. ncbi request reprint Reading exposure: a (largely) environmental risk factor with environmentally-mediated effects on reading performance in the primary school years
    Nicole Harlaar
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1192-9. 2007
    ....
  2. pmc Literacy and numeracy are more heritable than intelligence in primary school
    Yulia Kovas
    1Laboratory for Cognitive Investigations and Behavioural Genetics, Department of Psychology, Tomsk State University
    Psychol Sci 24:2048-56. 2013
    ..In contrast, the heritability of g increases during development as individuals select and create their own environments correlated with their genetic propensities. ..
  3. pmc Commentary: missing heritability, polygenic scores, and gene-environment correlation
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 54:1147-9. 2013
    ..Rather than discussing the many interesting findings and methods in this special issue, I will comment on two cross-cutting issues - one about genes and the other about the environment - that came to mind as I read these articles. ..
  4. pmc Common DNA markers can account for more than half of the genetic influence on cognitive abilities
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Sci 24:562-8. 2013
    ..66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities...
  5. pmc Child development and molecular genetics: 14 years later
    Robert Plomin
    King s College London
    Child Dev 84:104-20. 2013
    ..The present article considers reasons for the missing heritability problem and possible solutions...
  6. ncbi request reprint Common disorders are quantitative traits
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Nat Rev Genet 10:872-8. 2009
    ..Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits...
  7. pmc Generalist genes and high cognitive abilities
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre P080, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:437-45. 2009
    ..However, a smaller proportion of the phenotypic intercorrelations appears to be explained by genetic influences for high abilities...
  8. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
    ..These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed...
  9. ncbi request reprint Aetiological relationship between language performance and autistic-like traits in childhood: a twin study
    Katharina Dworzynski
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Int J Lang Commun Disord 42:273-92. 2007
    ..The basis for this association is poorly understood. How early language is related to each of the triad of impairments characteristic of ASDs is also in need of clarification...
  10. pmc Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1318-25. 2009
    ..Here we assess whether this finding extends to language and general cognitive disabilities, as well as replicating the earlier finding for reading and mathematics in an older and larger sample...
  11. pmc A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Genet 40:31-45. 2010
    ..When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families...
  12. pmc Nonshared environmental influences on teacher-reported behaviour problems: monozygotic twin differences in perceptions of the classroom
    Bonamy R Oliver
    Social, Genetic and Developmental Psychiatry Centre, King s College London, UK
    J Child Psychol Psychiatry 49:646-53. 2008
    ..The identification of specific nonshared environments responsible for the variance in behaviour problems is a key challenge...
  13. ncbi request reprint Increasing heritability of BMI and stronger associations with the FTO gene over childhood
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:2663-8. 2008
    ..01 at age 11. These findings suggest that expression of FTO may become stronger throughout childhood. Increases in heritability may also be due to children increasingly selecting environments correlated with their genetic propensities...
  14. ncbi request reprint Genetic influences in different aspects of language development: the etiology of language skills in 4.5-year-old twins
    Yulia Kovas
    Social, Genetic, and Developmental Psychiatry, Institute of Psychiatry, London England
    Child Dev 76:632-51. 2005
    ..Genetic and environmental influences on language ability and disability are quantitatively and qualitatively similar for males and females...
  15. pmc DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities
    Maciej Trzaskowski
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Genet 43:267-73. 2013
    ..These results indicate that genes related to diverse neurocognitive processes have general rather than specific effects. ..
  16. pmc Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components
    Gráinne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Abnorm Child Psychol 35:999-1008. 2007
    ..This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder...
  17. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
    ..An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools of 100 individuals...
  18. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
    ..We demonstrate that this approach can be effectively applied to the truly genomewide Affymetrix GeneChip Mapping 500 K Array...
  19. pmc The etiology of science performance: decreasing heritability and increasing importance of the shared environment from 9 to 12 years of age
    Claire M A Haworth
    SGDP Centre P080, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Child Dev 80:662-73. 2009
    ..Understanding what these increasingly important shared environmental influences are could lead to interventions that encourage engagement in science throughout the lifespan...
  20. ncbi request reprint Internet cognitive testing of large samples needed in genetic research
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 10:554-63. 2007
    ..We conclude that Internet testing can be reliable and valid for collecting cognitive test data on large samples even for children as young as 10 years...
  21. pmc Gene-environment interaction in the etiology of mathematical ability using SNP sets
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Behav Genet 41:141-54. 2011
    ....
  22. pmc Added value measures in education show genetic as well as environmental influence
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, King s College London, London, United Kingdom
    PLoS ONE 6:e16006. 2011
    ..The pervasiveness of genetic influence in how and how much children learn is compatible with an active view of learning in which children create their own educational experiences in part on the basis of their genetic propensities...
  23. pmc More than just IQ: school achievement is predicted by self-perceived abilities--but for genetic rather than environmental reasons
    Corina U Greven
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Psychol Sci 20:753-62. 2009
    ..It should therefore be possible to identify "SPA genes" that predict school achievement independently of "IQ genes."..
  24. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
    ..The purpose of the present study was to test the developmental origins of some of these associations in a large longitudinal sample of children...
  25. ncbi request reprint Exploring the relation between prenatal and neonatal complications and later autistic-like features in a representative community sample of twins
    Angelica Ronald
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, King s College London, London, UK
    Child Dev 81:166-82. 2010
    ..Differences in identical twins' neonatal problems correlated weakly with their difference scores on autistic-like features (r = .01-.06)...
  26. ncbi request reprint Genetic and environmental influence on language impairment in 4-year-old same-sex and opposite-sex twins
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 45:315-25. 2004
    ..We investigated the aetiology of language impairment in 579 four-year-old twins with low language performance and their co-twins, members of 160 MZ twin pairs, 131 same-sex DZ pairs and 102 opposite-sex DZ pairs...
  27. ncbi request reprint Heritability of antisocial behaviour at 9: do callous-unemotional traits matter?
    Essi Viding
    Department of Psychology, University College London, and SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Dev Sci 11:17-22. 2008
    ..The heritability difference was even more pronounced in magnitude when hyperactive symptoms were controlled. CU traits thus appear to index one valid way of sub-typing children with early-onset AB...
  28. pmc Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Nucleic Acids Res 34:e27. 2006
    ..We conclude that extending the SNP-MaP method to the Affymetrix GeneChip Mapping 100K Array set provides a useful screen of >100,000 SNP markers for QTL association scans...
  29. pmc Developmental origins of low mathematics performance and normal variation in twins from 7 to 9 years
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Twin Res Hum Genet 10:106-17. 2007
    ..We conclude that, despite the considerable differences in mathematics curricula from 7 to 9 years, the same genetic effects largely operate at the two ages...
  30. ncbi request reprint Birthweight-discordance and differences in early parenting relate to monozygotic twin differences in behaviour problems and academic achievement at age 7
    Kathryn Asbury
    SGDP Centre, Institute of Psychiatry, King s College London, UK
    Dev Sci 9:F22-F31. 2006
    ..Higher-risk families generally showed stronger negative associations...
  31. ncbi request reprint Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 49:535-42. 2008
    ..This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population...
  32. pmc Socioeconomic status (SES) and children's intelligence (IQ): in a UK-representative sample SES moderates the environmental, not genetic, effect on IQ
    Ken B Hanscombe
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 7:e30320. 2012
    ..The evidence however is inconsistent. Other studies have reported an effect in the opposite direction (higher heritability in lower SES), or no moderation of the genetic effect on intelligence...
  33. ncbi request reprint A twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlap
    Angelica Ronald
    Social Genetic and Developmental, Psychiatry SGDP Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Eur Child Adolesc Psychiatry 17:473-83. 2008
    ..Genetic overlap was significant but moderate across all raters. These findings are discussed in relation to population screening for autism and future genetic research...
  34. ncbi request reprint Childhood obesity: genetic and environmental overlap with normal-range BMI
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:1585-90. 2008
    ..To understand the overlap between the etiology of obesity and normal variation in BMI in children...
  35. pmc Genetics of callous-unemotional behavior in children
    Essi Viding
    King s College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e65789. 2013
    ..This GCTA ceiling is very low for CU in our study, despite its high twin study heritability estimate. The gap between GCTA and twin study heritabilities will make it challenging to identify genes responsible for the heritability of CU. ..
  36. ncbi request reprint Twins and non-twin siblings: different estimates of shared environmental influence in early childhood
    Gesina Koeppen-Schomerus
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, London SE5 8AF, United Kingdom
    Twin Res 6:97-105. 2003
    ..Although many possibilities exist for explaining the special shared environment effect for twins, we suggest that cognitive-relevant experiences that are not shared by siblings are shared by twins because they are exactly the same age...
  37. ncbi request reprint Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood
    Jonna Kuntsi
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:647-54. 2005
    ....
  38. ncbi request reprint From learning to read to reading to learn: substantial and stable genetic influence
    Nicole Harlaar
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Child Dev 78:116-31. 2007
    ..There was also evidence for age-specific genetic influences at each age. Genetic influences on reading are substantial and stable during the elementary school years despite the shift from "learning to read" to "reading to learn."..
  39. ncbi request reprint Twins' Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence
    Bonamy R Oliver
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    Twin Res Hum Genet 10:96-105. 2007
    ..The TEDS dataset is proving valuable in genome-wide association research that tries to identify some of the many genes responsible for the ubiquitous heritability of behavior...
  40. ncbi request reprint Genetic and environmental influences on sex-typed behavior during the preschool years
    Alessandra C Iervolino
    Social, Genetic, and Developmental Psychiatry Centre, Inistitute of Psychiatry, King s College London, UK
    Child Dev 76:826-40. 2005
    ..The inclusion of non-twin siblings showed that some of the shared environmental influence is specific to twins...
  41. pmc Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months
    Emma L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 12:372-80. 2009
    ..g., eQTLs) and correlates (e.g., psychopathology) of individual differences in gene expression...
  42. pmc First genome-wide association study on anxiety-related behaviours in childhood
    Maciej Trzaskowski
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e58676. 2013
    ....
  43. pmc Chaotic homes and school achievement: a twin study
    Ken B Hanscombe
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 52:1212-20. 2011
    ....
  44. pmc Dramatic increase in heritability of cognitive development from early to middle childhood: an 8-year longitudinal study of 8,700 pairs of twins
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Psychol Sci 20:1301-8. 2009
    ..57 and a shared environmental correlation of .65. These findings set constraints on how genetic and environmental variation affects the developing brain...
  45. pmc Learning abilities and disabilities: generalist genes in early adolescence
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Cogn Neuropsychiatry 14:312-31. 2009
    ..A surprising finding emerging from multivariate quantitative genetic studies across diverse learning abilities is that most genetic influences are shared: they are "generalist", rather than "specialist"...
  46. pmc Chaotic homes and children's disruptive behavior: a longitudinal cross-lagged twin study
    Sara R Jaffee
    Institute of Psychiatry, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, King s College London, England
    Psychol Sci 23:643-50. 2012
    ..However, genetic influences on disruptive behavior did not explain why household chaos was heritable...
  47. ncbi request reprint Genetic influences on specific versus nonspecific language impairment in 4-year-old twins
    Marianna E Hayiou-Thomas
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London
    J Learn Disabil 38:222-32. 2005
    ..18 for SLI and .52 for NLI. Probandwise cross-concordances were suggestive of some genetic overlap between these two groups, but not with a subgroup of children with more severe cognitive delay...
  48. pmc Genetic etiology in cases of recovered and persistent stuttering in an unselected, longitudinal sample of young twins
    Katharina Dworzynski
    Department of Psychology, King s College London, Gower Street, London, UK
    Am J Speech Lang Pathol 16:169-78. 2007
    ..The contribution of genetic factors in the persistence of and early recovery from stuttering was assessed...
  49. ncbi request reprint Individual differences in theory of mind ability in middle childhood and links with verbal ability and autistic traits: a twin study
    Angelica Ronald
    Institute of Psychiatry, King s College London, London, UK
    Soc Neurosci 1:412-25. 2006
    ..The possible neural basis underlying this association is discussed...
  50. ncbi request reprint Phenotypic and genetic overlap between autistic traits at the extremes of the general population
    Angelica Ronald
    Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 45:1206-14. 2006
    ....
  51. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
    ..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
  52. pmc A longitudinal twin study on the association between ADHD symptoms and reading
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 53:234-42. 2012
    ..However, the stability and change of these genetic influences and the predictive relationships underlying this association longitudinally remain unclear...
  53. pmc Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genet 11:61. 2010
    ..The 4927 children in this genotyped sample have also been studied at 7, 9 and 12 years of age on measures of mathematical ability, as well as on other cognitive and learning abilities...
  54. ncbi request reprint A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    J Abnorm Child Psychol 39:623-32. 2011
    ..Thus, hyperactivity-impulsivity may serve to exacerbate inattentiveness over time. Findings are discussed in the context of developmental changes in ADHD symptoms...
  55. pmc A three-stage genome-wide association study of general cognitive ability: hunting the small effects
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 40:759-67. 2010
    ..Larger samples, denser arrays and multiple replications will be necessary in the hunt for the genetic variants that influence human cognitive ability...
  56. doi request reprint The Russian School Twin Registry (RSTR): project PROGRESS
    Yulia Kovas
    Department of Psychology, Tomsk State University, Tomsk, Russia
    Twin Res Hum Genet 16:126-33. 2013
    ..It is hoped that the RSTR will provide an important research platform for national and international educationally relevant research...
  57. ncbi request reprint Nature, nurture and academic achievement: a twin study of teacher assessments of 7-year-olds
    Sheila O Walker
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Br J Educ Psychol 74:323-42. 2004
    ..Twin research has consistently shown substantial genetic influence on individual differences in cognitive ability; however, much less is known about the genetic and environmental aetiologies of school achievement...
  58. pmc The nature of nurture: a genomewide association scan for family chaos
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box Number P082, De Crespigny Park, London, UK
    Behav Genet 38:361-71. 2008
    ..Similar to GWA analyses of other complex traits, it is likely that most of the heritable variation in environmental measures such as family chaos is due to many genes of very small effect size...
  59. pmc Stable genetic influence on anxiety-related behaviours across middle childhood
    Maciej Trzaskowski
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box PO80, De Crespigny Park, London SE5 8AF, UK
    J Abnorm Child Psychol 40:85-94. 2012
    ..In contrast, though more varied, heterotypic continuity between some traits (i.e. the change from one type of anxiety-related behaviour into another over time) was mainly due to shared-environmental factors...
  60. ncbi request reprint Etiologies of associations between childhood sleep and behavioral problems in a large twin sample
    Alice M Gregory
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, England
    J Am Acad Child Adolesc Psychiatry 43:744-51. 2004
    ..To examine the etiologies of covariation of childhood sleep problems and other behavioral/emotional problems in young children...
  61. pmc Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    J Am Acad Child Adolesc Psychiatry 49:783-93. 2010
    ..We focus on findings that go beyond merely estimating heritability. We use learning abilities and disabilities as examples...
  62. pmc Twins Early Development Study (TEDS): a genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood
    Claire M A Haworth
    Institute of Psychiatry, King s College London, London, UK
    Twin Res Hum Genet 16:117-25. 2013
    ..TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond...
  63. ncbi request reprint The etiology of variation in language skills changes with development: a longitudinal twin study of language from 2 to 12 years
    Marianna E Hayiou-Thomas
    Department of Psychology, University of York, Heslington, York YO10 5DD, UK
    Dev Sci 15:233-49. 2012
    ..In contrast, genetic factors remain stable from middle childhood through to early adolescence, and account for the phenotypic continuity in language skills across these two stages...
  64. pmc A twin study of the genetics of high cognitive ability selected from 11,000 twin pairs in six studies from four countries
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:359-70. 2009
    ..41-0.60). Shared environmental influences were moderate (0.28, 0.19-0.37). We conclude that genetic variation contributes substantially to high g in Australia, the Netherlands, the United Kingdom and the United States...
  65. ncbi request reprint Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice
    Michael J Galsworthy
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 35:675-92. 2005
    ..Nevertheless, the factor structure is seen to remain fairly robust across permutations of the battery composition and the current findings fit well with other recent studies...
  66. ncbi request reprint Single-nucleotide polymorphism genotyping in DNA pools
    Ian Craig
    SGDP Centre, Institute of Psychiatry, London, UK
    Methods Mol Biol 311:147-64. 2005
    ....
  67. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  68. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  69. ncbi request reprint A twin study of ADHD symptoms in early adolescence: hyperactivity-impulsivity and inattentiveness show substantial genetic overlap but also genetic specificity
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Abnorm Child Psychol 39:265-75. 2011
    ..Future genetic studies should investigate the ADHD dimensions separately...
  70. ncbi request reprint Sex differences and science: the etiology of science excellence
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1113-20. 2009
    ....
  71. pmc The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Bioinformatics 25:281-3. 2009
    ..We present a set of software tools for processing SNPMaP (SNP microarrays and pooling) data from CEL files to Relative Allele Scores in the rich R statistical computing environment...
  72. pmc Mathematical ability of 10-year-old boys and girls: genetic and environmental etiology of typical and low performance
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Learn Disabil 40:554-67. 2007
    ..We conclude that low mathematical performance is the quantitative extreme of the same genetic and environmental factors responsible for variation throughout the distribution...
  73. pmc Clones in the classroom: a daily diary study of the nonshared environmental relationship between monozygotic twin differences in school experience and achievement
    Kathryn Asbury
    Social, Genetic and Developmental Psychiatry Centre, King s College London, United Kingdom
    Twin Res Hum Genet 11:586-95. 2008
    ..10, p < .05). These results indicate that MZ twins experience the classroom differently and that differences in their experience are associated with differences in their achievement...
  74. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  75. pmc Visualizing genetic similarity at the symptom level: the example of learning disabilities
    Oliver S P Davis
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Behav Brain Sci 33:155-7. 2010
    ..We illustrate this approach using a study of cognitive abilities involving over 5,000 pairs of twins...
  76. pmc Brain correlates of non-symbolic numerosity estimation in low and high mathematical ability children
    Yulia Kovas
    Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 4:e4587. 2009
    ..This suggests that individual differences in mathematical ability are reflected in differential brain response during approximation...
  77. ncbi request reprint Time to give up on a single explanation for autism
    Francesca Happe
    Francesca Happé, Angelica Ronald and Robert Plomin are at the Institute of Psychiatry, Kings College London, De Crispigny Park, London SE5 8AF, UK
    Nat Neurosci 9:1218-20. 2006
    ..Twin data suggest largely nonoverlapping genes acting on each of these traits. At the cognitive level, too, attempts at a single explanation for the symptoms of autism have failed. Implications for research and treatment are discussed...
  78. pmc The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA
    Robert Plomin
    Institute of Psychiatry, King s College, London, UK
    J Child Psychol Psychiatry 50:63-71. 2009
    ..What are the implications of these advances for identifying genes responsible for the high heritability of many behavioural disorders and dimensions in childhood?..
  79. ncbi request reprint Aetiology of the relationship between callous-unemotional traits and conduct problems in childhood
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, P080, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry Suppl 49:s33-8. 2007
    ..A callous and unemotional disposition is an indicator of early-onset antisocial behaviour...
  80. pmc Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin study
    Corina U Greven
    Radboud University Medical Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, the Netherlands King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 55:39-48. 2014
    ..Attention-deficit/hyperactivity disorder (ADHD) symptoms and mathematics ability are associated, but little is known about the genetic and environmental influences underlying this association...
  81. doi request reprint Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy
    Thomas S Price
    SGDP Centre, Institute of Psychiatry, Kings College London, London, UK
    Child Dev 81:101-14. 2010
    ..Future studies should conduct formal tests of Fetal Genotype x Maternal Smoking interactions...
  82. pmc Genetic Overlap between ADHD Symptoms and Reading is largely Driven by Inattentiveness rather than Hyperactivity-Impulsivity
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    J Can Acad Child Adolesc Psychiatry 20:6-14. 2011
    ..To assess the genetic and environmental etiology of the co-occurence of ADHD symptoms and reading difficulties using the largest sample to date, distinguishing two dimensions of ADHD and two of reading...
  83. ncbi request reprint Genetic heterogeneity between the three components of the autism spectrum: a twin study
    Angelica Ronald
    SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 45:691-9. 2006
    ....
  84. pmc Microarrays
    Robert Plomin
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, UK
    Dev Sci 10:19-23. 2007
    ....
  85. ncbi request reprint Generalist genes and cognitive neuroscience
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom
    Curr Opin Neurobiol 16:145-51. 2006
    ....
  86. ncbi request reprint Generalist genes: implications for the cognitive sciences
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Trends Cogn Sci 10:198-203. 2006
    ..That is, the genetic input into brain structure and function is general not specific...
  87. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...