R Plomin

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
  2. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
  3. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
  4. ncbi request reprint DNA
    R Plomin
    Genetic and Developmental Psychiatry Research Centre, King s College London, United Kingdom
    Psychol Bull 126:806-28. 2000
  5. ncbi request reprint Why are children in the same family so different? Nonshared environment a decade later
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, Denmark Hill, London SE5 8AF, UK
    Can J Psychiatry 46:225-33. 2001
  6. ncbi request reprint Genetics and general cognitive ability
    R Plomin
    Institute of Psychiatry, King s College London, UK
    Nature 402:C25-9. 1999
  7. ncbi request reprint Associations between behaviour problems and verbal and nonverbal cognitive abilities and disabilities in early childhood
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 43:619-33. 2002
  8. ncbi request reprint Genetics and educational psychology
    Robert Plomin
    Institute of Psychiatry, King s College London, UK
    Br J Educ Psychol 73:3-14. 2003
  9. ncbi request reprint Intelligence: genetics, genes, and genomics
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, England
    J Pers Soc Psychol 86:112-29. 2004
  10. ncbi request reprint Generalist genes and learning disabilities
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Psychol Bull 131:592-617. 2005

Detail Information

Publications118 found, 100 shown here

  1. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...
  2. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
    ..We demonstrate that this approach can be effectively applied to the truly genomewide Affymetrix GeneChip Mapping 500 K Array...
  3. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
    ..An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools of 100 individuals...
  4. ncbi request reprint DNA
    R Plomin
    Genetic and Developmental Psychiatry Research Centre, King s College London, United Kingdom
    Psychol Bull 126:806-28. 2000
    ..Finally, the authors discuss behavioral genomics and predict that DNA will revolutionize psychological research and treatment early in the 21st century...
  5. ncbi request reprint Why are children in the same family so different? Nonshared environment a decade later
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, Denmark Hill, London SE5 8AF, UK
    Can J Psychiatry 46:225-33. 2001
    ..To review recent developments in the study of nonshared environment; that is, the environmental influences that make children growing up in the same family different, rather than similar...
  6. ncbi request reprint Genetics and general cognitive ability
    R Plomin
    Institute of Psychiatry, King s College London, UK
    Nature 402:C25-9. 1999
    ..g is one of the most heritable behavioural traits, and genes that contribute to the heritability of g will certainly be identified. What are the scientific and social implications of finding genes associated with g?..
  7. ncbi request reprint Associations between behaviour problems and verbal and nonverbal cognitive abilities and disabilities in early childhood
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 43:619-33. 2002
    ....
  8. ncbi request reprint Genetics and educational psychology
    Robert Plomin
    Institute of Psychiatry, King s College London, UK
    Br J Educ Psychol 73:3-14. 2003
    ..Molecular genetics, one of the most energetic and exciting areas of science, is slowly but surely coming to educational psychology...
  9. ncbi request reprint Intelligence: genetics, genes, and genomics
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, England
    J Pers Soc Psychol 86:112-29. 2004
    ..Deoxyribonucleic acid (DNA) will integrate life sciences research on intelligence; bottom-up molecular biological research will meet top-down psychological research in the brain...
  10. ncbi request reprint Generalist genes and learning disabilities
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Psychol Bull 131:592-617. 2005
    ..Third, genes that affect one learning disability are also likely to affect other learning disabilities. These quantitative genetic findings have far-reaching implications for molecular genetics and neuroscience as well as psychology...
  11. ncbi request reprint Psychopathology in the postgenomic era
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AF, UK
    Annu Rev Psychol 54:205-28. 2003
    ..DNA will revolutionize psychological research and treatment during the coming decades...
  12. ncbi request reprint Finding genes in child psychology and psychiatry: when are we going to be there?
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 46:1030-8. 2005
    ..The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet...
  13. ncbi request reprint A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: a five-stage design using DNA pooling and extreme selected groups
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Behav Genet 31:497-509. 2001
    ..Instead we are using the same design to screen markers such as cSNPs and SNPs in regulatory regions that are likely to include functional polymorphisms in which the marker can be presumed to be the QTL...
  14. pmc Microarrays
    Robert Plomin
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, UK
    Dev Sci 10:19-23. 2007
    ....
  15. pmc A genome-wide association study identifies multiple loci associated with mathematics ability and disability
    S J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 9:234-47. 2010
    ....
  16. ncbi request reprint Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 10:384-92. 2005
    ..The present SNP strategy combined with DNA pooling and large samples represents a step towards identifying QTLs of small effect size associated with complex traits in the postgenomic era when all functional polymorphisms will be known...
  17. pmc Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Genes Brain Behav 7:435-46. 2008
    ..11 (P < 0.00000003) with g. This shows that future SNP sets that will incorporate many more SNPs could be useful for predicting genetic risk and for investigating functional systems of effects from genes to brain to behavior...
  18. ncbi request reprint GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Centre, London, UK
    Twin Res 3:316-22. 2000
    ..This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS...
  19. ncbi request reprint Genetic and environmental covariation between verbal and nonverbal cognitive development in infancy
    T S Price
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Child Dev 71:948-59. 2000
    ..The implications of this result for theories of cognitive development are discussed...
  20. pmc Generalist genes and the Internet generation: etiology of learning abilities by web testing at age 10
    O S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Genes Brain Behav 7:455-62. 2008
    ..In this way, generalist genes may prove invaluable in integrating top-down and bottom-up approaches to the systems biology of the brain...
  21. ncbi request reprint Exploring the genetic etiology of low general cognitive ability from 14 to 36 months
    S A Petrill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Dev Psychol 33:544-8. 1997
    ..Although replication is necessary, these results suggest that the genetic etiology of low g during infancy and early childhood is at least as great as the heritability of g in the unselected population...
  22. ncbi request reprint Genetic and environmental origins of verbal and performance components of cognitive delay in 2-year-olds
    T C Eley
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Dev Psychol 35:1122-31. 1999
    ..Because the genetic and environmental origins of V and P delays in infancy differ, they are better considered separately rather than combined into a composite measure of general cognitive delay...
  23. ncbi request reprint Genotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parenting
    T G O'Connor
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Dev Psychol 34:970-81. 1998
    ....
  24. ncbi request reprint Dimensions and disorders of adolescent adjustment: a quantitative genetic analysis of unselected samples and selected extremes
    K Deater-Deckard
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 38:515-25. 1997
    ..Similar estimates were found for unselected individual differences and selected extreme groups. A framework is proposed that focuses on quantifying the etiologies of disorders (QED) as measured on continuous dimensions...
  25. ncbi request reprint Infant zygosity can be assigned by parental report questionnaire data
    T S Price
    Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Twin Res 3:129-33. 2000
    ..The results validate the use of parental report questionnaire data to determine zygosity in infancy...
  26. ncbi request reprint Adoption results for self-reported personality: evidence for nonadditive genetic effects?
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, London, England
    J Pers Soc Psychol 75:211-8. 1998
    ..These findings have important implications for attempts to identify specific genes responsible for genetic influence on personality...
  27. ncbi request reprint A genetic analysis of weight and overweight in 4-year-old twin pairs
    G Koeppen-Schomerus
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, 113 Denmark Hill, London SE5 8AF, UK
    Int J Obes Relat Metab Disord 25:838-44. 2001
    ..We tested the hypothesis that, in early childhood, overweight is as heritable as weight and that weight and overweight are linked genetically...
  28. ncbi request reprint Genetics, environment and cognitive abilities: review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK
    Br J Psychiatry Suppl 40:s41-8. 2001
    ..CONCLUSIONS: These first results of the application of DNA pooling in systematic analysis of allelic association are encouraging...
  29. ncbi request reprint Gene-environment interaction analysis of serotonin system markers with adolescent depression
    T C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Mol Psychiatry 9:908-15. 2004
    ....
  30. ncbi request reprint Developmental associations between traits of autism spectrum disorder and attention deficit hyperactivity disorder: a genetically informative, longitudinal twin study
    M J Taylor
    Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, University of London, London, UK
    Psychol Med 43:1735-46. 2013
    ..This paper provides the first genetically informative, longitudinal analysis of the interaction between traits of ASD and ADHD, and explores their genetic and environmental overlap...
  31. ncbi request reprint Child development, molecular genetics, and what to do with genes once they are found
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Child Dev 69:1223-42. 1998
    ....
  32. ncbi request reprint A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability
    R Plomin
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Mol Psychiatry 9:582-6. 2004
    ..These data suggest that higher SSADH activity is associated with higher intelligence across the general population. The effect is small, with each allele having an effect size translating to about 1.5 IQ points...
  33. ncbi request reprint Quantitative trait loci for IQ and other complex traits: single-nucleotide polymorphism genotyping using pooled DNA and microarrays
    I Craig
    Social, Genetic and Developmental Psychiatry Centre, King s College Londan, Institute of Psychiatry, Denmark Hill, London, UK
    Genes Brain Behav 5:32-7. 2006
    ....
  34. ncbi request reprint DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations
    B Freeman
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Behav Genet 27:251-7. 1997
    ..The purpose of this paper is to recommend this technique to the behavioral genetics community and to present results of our use of this technique to obtain DNA by mail for 114 2-year-olds and 116 adults...
  35. ncbi request reprint Genetic contributions to continuity, change, and co-occurrence of antisocial and depressive symptoms in adolescence
    T G O'Connor
    Institute of Psychiatry, University of London, UK
    J Child Psychol Psychiatry 39:323-36. 1998
    ..Results were discussed in light of the potential contributions of development behavioural genetic research in understanding individual differences in the stability and change of maladjustment...
  36. ncbi request reprint Genetic factors contributing to learning and language delays and disabilities
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom
    Child Adolesc Psychiatr Clin N Am 10:259-77, viii. 2001
    ....
  37. ncbi request reprint Food and activity preferences in children of lean and obese parents
    J Wardle
    Department of Epidemiology and Public Health, University College London, London, UK
    Int J Obes Relat Metab Disord 25:971-7. 2001
    ..Because the children from the families with obese parents were not yet overweight, differences observed in the two types of families are more likely to be causes than effects of obesity...
  38. ncbi request reprint Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
    ..We conclude that QTL effect sizes, even for highly heritable common disorders and quantitative traits such as early reading disability and ability, might be much smaller than previously considered...
  39. ncbi request reprint A model incorporating potential skewed X-inactivation in MZ girls suggests that X-linked QTLs exist for several social behaviours including autism spectrum disorder
    C S Loat
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, England
    Ann Hum Genet 72:742-51. 2008
    ..This emphasises the potential importance of X-linked genes in the developmental trajectories of behaviour and mental health and the need to stratify genetic analysis of behaviours by gender...
  40. ncbi request reprint Evidence for general cognitive ability (g) in heterogeneous stock mice and an analysis of potential confounds
    M J Galsworthy
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:88-95. 2002
    ..A general cognitive ability (g) appears to underlie the performance of HS mice on a battery tapping diverse cognitive demands...
  41. ncbi request reprint Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    C C Y Wong
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Mol Psychiatry 19:495-503. 2014
    ..This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism. ..
  42. pmc Overlap and specificity of genetic and environmental influences on mathematics and reading disability in 10-year-old twins
    Y Kovas
    Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 48:914-22. 2007
    ..However, little is known about the etiology of co-morbidity for the disability extremes of reading and mathematics...
  43. ncbi request reprint An adoption study of depressive symptoms in middle childhood
    T C Eley
    Institute of Psychiatry, London, U K
    J Child Psychol Psychiatry 39:337-45. 1998
    ..Although the power of the sibling data is low, the combined findings from the two designs suggest that genetic effects on depressive symptoms in childhood may be somewhat smaller than previously estimated in twin studies...
  44. ncbi request reprint Chasing behaviour genes into the next millennium
    I W Craig
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Trends Biotechnol 18:22-6. 2000
    ..For the foreseeable future, association studies involving whole-genome scanning will combine strategies using both single-nucleotide and simple-sequence-repeat polymorphisms...
  45. ncbi request reprint The genetics of g in human and mouse
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, 111 Denmark Hill, London SE5 8AF, UK
    Nat Rev Neurosci 2:136-41. 2001
    ..In this article, I argue that a mouse model of g could provide a powerful analytic tool for exploring cognitive processes that are linked functionally by genes...
  46. doi request reprint The FTO gene and measured food intake in children
    J Wardle
    Department of Epidemiology and Public Health, Health Behaviour Research Centre, University College London, Gower Street, 2 16 Torrington Place, London, UK
    Int J Obes (Lond) 33:42-5. 2009
    ....
  47. ncbi request reprint No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene
    S A Petrill
    Institute of Psychiatry, London, England
    Behav Genet 27:29-31. 1997
    ....
  48. pmc Genes and environment in asthma: a study of 4 year old twins
    G Koeppen-Schomerus
    Centre for Research into Social Developmental and Genetic Psychiatry, Institute of Psychiatry, King s College, 113 Denmark Hill, London SE5 8AF, UK
    Arch Dis Child 85:398-400. 2001
    ..Although the genetic and environmental factors of asthma have been investigated in adolescence and adulthood, no previous studies have focused on the early development of asthma...
  49. ncbi request reprint The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
    K Brookes
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, UK
    Mol Psychiatry 11:934-53. 2006
    ..Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples...
  50. pmc Visual analysis of geocoded twin data puts nature and nurture on the map
    O S P Davis
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Mol Psychiatry 17:867-74. 2012
    ..More broadly, our experience demonstrates the potential for collaborative exploratory visualization to act as a lingua franca for large-scale interdisciplinary research...
  51. ncbi request reprint Genetic analyses of emotionality
    T C Eley
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, 113 Denmark Hill, London, SE5 8AF, UK
    Curr Opin Neurobiol 7:279-84. 1997
    ..Molecular genetic research is beginning to identify quantitative trait loci that are associated with the genetically related emotional domains of neuroticism, anxiety and depression...
  52. doi request reprint Genetic influence on appetite in children
    S Carnell
    Department of Epidemiology and Public Health, Cancer Research UK Health Behaviour Research Centre, University College London, London, UK
    Int J Obes (Lond) 32:1468-73. 2008
    ..We assessed the relative contribution of genes and environment for two aspects of appetite that have been implicated in obesity...
  53. pmc The heritability of general cognitive ability increases linearly from childhood to young adulthood
    C M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:1112-20. 2010
    ....
  54. ncbi request reprint From modeling to measurement: Developmental trends in genetic influence on adiposity in childhood
    C H Llewellyn
    Health Behavior Research Center, Department of Epidemiology and Public Health, University College London, UK MRC Social, Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College London, UK
    Obesity (Silver Spring) 22:1756-61. 2014
    ..Evidence of increasing heritability of BMI over childhood can seem paradoxical given longer exposure to environmental influences. Genomic data were used to provide direct evidence of developmental increases in genetic influence...
  55. ncbi request reprint Investigating the relationship between FMR1 allele length and cognitive ability in children: a subtle effect of the normal allele range on the normal ability range?
    C S Loat
    Social, Genetic, and Developmental Psychiatry Centre, P082, Institute of Psychiatry, Kings College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Ann Hum Genet 70:555-65. 2006
    ..002). This suggests that, within the normal spectrum of allele length, increased repeat numbers may have a limiting influence on cognitive performance...
  56. ncbi request reprint Co-occurrence of depressive symptoms and antisocial behavior in adolescence: a common genetic liability
    T G O'Connor
    Genetic and Developmental Psychiatry Research Center, Institute of Psychiatry, London, England
    J Abnorm Psychol 107:27-37. 1998
    ..Results are interpreted in light of contribution of genetic studies to debates on child and adolescent psychopathology...
  57. ncbi request reprint Life events and depression in a community sample of siblings
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Psychol Med 31:401-10. 2001
    ..Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety...
  58. ncbi request reprint Language-impaired children: No sign of the FOXP2 mutation
    E Meaburn
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, 111 Denmark Hill, London SE5 8AF, UK
    Neuroreport 13:1075-7. 2002
    ....
  59. ncbi request reprint Are associations between parental divorce and children's adjustment genetically mediated? An adoption study
    T G O'Connor
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Dev Psychol 36:429-37. 2000
    ....
  60. ncbi request reprint Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity
    J Mill
    Social, Genetic, and Developmental Psychiatric Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:166-73. 2002
    ....
  61. ncbi request reprint DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12
    M Trzaskowski
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London, UK
    Mol Psychiatry 19:380-4. 2014
    ..35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence. ..
  62. pmc Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis
    C H Llewellyn
    1 Department of Epidemiology and Public Health, Health Behaviour Research Centre, University College London, London, UK 2 MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Int J Obes (Lond) 37:1506-9. 2013
    ..02). These results indicate that 37% of the twin-estimated heritability (30/82%) can be explained by additive effects of multiple common SNPs, and provide compelling evidence for strong genetic influence on adiposity in childhood. ..
  63. ncbi request reprint Pathways from science findings to health benefits
    M Rutter
    Institute of Psychiatry, King s College London, London, UK
    Psychol Med 39:529-42. 2009
    ..There are now some opportunities for direct translational research but there is a much greater need for hypothesis-based bridging studies that occupy a crucial mid-phase in the pathway from science findings to health benefits...
  64. pmc The nature of nurture: a genomewide association scan for family chaos
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box Number P082, De Crespigny Park, London, UK
    Behav Genet 38:361-71. 2008
    ..Similar to GWA analyses of other complex traits, it is likely that most of the heritable variation in environmental measures such as family chaos is due to many genes of very small effect size...
  65. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
    ..The purpose of the present study was to test the developmental origins of some of these associations in a large longitudinal sample of children...
  66. ncbi request reprint Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
    Jane Wardle
    Department of Epidemiology and Public Health, Health Behaviour Research Centre, University College London, London, United Kingdom
    Am J Clin Nutr 87:398-404. 2008
    ..Body mass index (BMI) has been shown to be highly heritable, but most studies were carried out in cohorts born before the onset of the "obesity epidemic."..
  67. ncbi request reprint Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 49:535-42. 2008
    ..This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population...
  68. ncbi request reprint Heritability of antisocial behaviour at 9: do callous-unemotional traits matter?
    Essi Viding
    Department of Psychology, University College London, and SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Dev Sci 11:17-22. 2008
    ..The heritability difference was even more pronounced in magnitude when hyperactive symptoms were controlled. CU traits thus appear to index one valid way of sub-typing children with early-onset AB...
  69. ncbi request reprint Reading exposure: a (largely) environmental risk factor with environmentally-mediated effects on reading performance in the primary school years
    Nicole Harlaar
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1192-9. 2007
    ....
  70. ncbi request reprint Genetic and environmental influences in adolescent peer socialization: evidence from two genetically sensitive designs
    Alessandra C Iervolino
    Institute of Psychiatry, Social, Genetic, and Developmental Psychiatry Research Center, London, UK
    Child Dev 73:162-74. 2002
    ..These results suggest that although some dimensions of peers are somewhat mediated by genetic factors, nonshared environmental influence is substantial...
  71. pmc Mathematical ability of 10-year-old boys and girls: genetic and environmental etiology of typical and low performance
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Learn Disabil 40:554-67. 2007
    ..We conclude that low mathematical performance is the quantitative extreme of the same genetic and environmental factors responsible for variation throughout the distribution...
  72. pmc The genetic and environmental origins of learning abilities and disabilities in the early school years
    Yulia Kovas
    Goldsmiths College, University of London and SGDP Centre, Institute of Psychiatry
    Monogr Soc Res Child Dev 72:vii, 1-144. 2007
    ..These conclusions have far-reaching implications for education and child development as well as for molecular genetics and neuroscience...
  73. ncbi request reprint X inactivation as a source of behavioural differences in monozygotic female twins
    Caroline S Loat
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College, London, UK
    Twin Res 7:54-61. 2004
    ....
  74. ncbi request reprint Parental familial vulnerability, family environment, and their interactions as predictors of depressive symptoms in adolescents
    Thalia C Eley
    Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 43:298-306. 2004
    ..Third, the authors explored the influence of family environment variables. Fourth, the authors sought interactions between parental familial vulnerability and family environment...
  75. ncbi request reprint Childhood obesity: genetic and environmental overlap with normal-range BMI
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:1585-90. 2008
    ..To understand the overlap between the etiology of obesity and normal variation in BMI in children...
  76. ncbi request reprint Why do preschool language abilities correlate with later reading? A twin study
    Nicole Harlaar
    King s College London, England
    J Speech Lang Hear Res 51:688-705. 2008
    ..Language acquisition is predictive of successful reading development, but the nature of this link is poorly understood...
  77. ncbi request reprint Profound sex-specific effects on incubation times for transmission of bovine spongiform encephalopathy to mice
    Oduola O Abiola
    Department of Neuroscience, Genetic and Developmental Psychiatry Research Centre, KCL Institute of Psychiatry, London, UK
    Intervirology 45:56-8. 2002
    ..Research into this phenomenon may provide clues to the prophylaxis of BSE and have possible implications for new variant Creutzfeldt-Jakob disease in humans...
  78. ncbi request reprint Heritability of symptom domains in otitis media: a longitudinal study of 1,373 twin pairs
    Maroeska Rovers
    MRC Institute of Hearing Research, University Park, Nottingham, England
    Am J Epidemiol 155:958-64. 2002
    ..72 heritability and 0.10 shared environment). The strong genetic component, which this study confirms, is not unitary but distributes differently across the phenotypic aspects of otitis media and probably across pathogenetic stage...
  79. ncbi request reprint Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood
    Alexandra Trouton
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Twin Res 5:444-8. 2002
    ..DNA has been obtained so far for more than 4000 pairs and is being used initially in molecular genetic studies of language problems and hyperactivity...
  80. ncbi request reprint Association analysis of MAOA and COMT with neuroticism assessed by peers
    Thalia C Eley
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:90-6. 2003
    ..We found weak evidence for association with COMT genotype, when the females and males were considered separately, and for MAOA genotype in males only. There was no significant interaction between COMT and MAOA...
  81. ncbi request reprint Obesity associated genetic variation in FTO is associated with diminished satiety
    Jane Wardle
    Health Behavior Research Centre, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 93:3640-3. 2008
    ..However, to date, it is not known whether the association between genetic variation in FTO and obesity is mediated through effects on energy intake or energy expenditure...
  82. ncbi request reprint Genotype-environment interaction in children's adjustment to parental separation
    Thomas G O'Connor
    Institute of Psychiatry, Department of Child and Adolescent Psychiatry, London, UK
    J Child Psychol Psychiatry 44:849-56. 2003
    ....
  83. ncbi request reprint A twin study of anxiety-related behaviours in pre-school children
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 44:945-60. 2003
    ..However, little is known about the genetics of these categories and especially about the phenotypic and genetic structure of related behaviours in pre-school children...
  84. ncbi request reprint Substantial genetic influence on mild mental impairment in early childhood
    Frank M Spinath
    Department of Psychology, University of Bielefeld, Bielefeld, Germany
    Am J Ment Retard 109:34-43. 2004
    ..49, which is significantly greater than heritability for the rest of the population in early childhood. These results suggest that mild mental impairment is a good target for neuroscience research on global brain function and dysfunction...
  85. ncbi request reprint Outcomes of early language delay: I. Predicting persistent and transient language difficulties at 3 and 4 years
    Philip S Dale
    Communication Sciences and Disorders, University of Missouri Columbia, 65211, USA
    J Speech Lang Hear Res 46:544-60. 2003
    ..Furthermore, measures of parental education and the child's history of ear infections failed to substantially improve the prediction...
  86. ncbi request reprint Genetic and environmental mediation of the relationship between language and nonverbal impairment in 4-year-old twins
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, England
    J Speech Lang Hear Res 46:1271-82. 2003
    ..This finding held even when we excluded those children with language impairment whose nonverbal score indicated general cognitive delay. These results point to a general genetic factor that includes both language and nonverbal problems...
  87. ncbi request reprint Internet cognitive testing of large samples needed in genetic research
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 10:554-63. 2007
    ..We conclude that Internet testing can be reliable and valid for collecting cognitive test data on large samples even for children as young as 10 years...
  88. ncbi request reprint Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour
    Cathy Fernandes
    Social, Genetic and Developmental Psychiatry Centre, PO 82, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur J Neurosci 19:2576-82. 2004
    ....
  89. pmc Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components
    GrĂ¡inne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Abnorm Child Psychol 35:999-1008. 2007
    ..This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder...
  90. ncbi request reprint Common aetiology for diverse language skills in 4 1/2-year-old twins
    Marianna E Hayiou-Thomas
    Department of Psychology, University of York, Heslington
    J Child Lang 33:339-68. 2006
    ..64 and shared environment correlation of 1.00. We conclude that to a large extent, the same genetic and environmental factors underlie the development of individual differences in a wide range of linguistic skills...
  91. ncbi request reprint Genetic heterogeneity between the three components of the autism spectrum: a twin study
    Angelica Ronald
    SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 45:691-9. 2006
    ....
  92. ncbi request reprint Generalist genes: implications for the cognitive sciences
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Trends Cogn Sci 10:198-203. 2006
    ..That is, the genetic input into brain structure and function is general not specific...
  93. ncbi request reprint Generalist genes and cognitive neuroscience
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom
    Curr Opin Neurobiol 16:145-51. 2006
    ....
  94. ncbi request reprint Parental discipline and affection and children's prosocial behavior: genetic and environmental links
    Ariel Knafo
    Psychology Department, Hebrew University of Jerusalem, Jerusalem, Israel
    J Pers Soc Psychol 90:147-64. 2006
    ..This pattern was found both cross-sectionally and longitudinally. The findings point to the importance of children's characteristics and of the parent-child relationship in family processes...
  95. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  96. ncbi request reprint Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice
    Michael J Galsworthy
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 35:675-92. 2005
    ..Nevertheless, the factor structure is seen to remain fairly robust across permutations of the battery composition and the current findings fit well with other recent studies...
  97. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
    ..These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed...
  98. ncbi request reprint Verbal and nonverbal predictors of early language problems: an analysis of twins in early childhood back to infancy
    Bonamy Oliver
    Social, Genetic and Developmental Psychiatry Centre, King s College, London, UK
    J Child Lang 31:609-31. 2004
    ..Bivariate genetic analyses indicated that these predictions are mediated by both genetic and shared environmental links...
  99. ncbi request reprint Continuity and change in preschool ADHD symptoms: longitudinal genetic analysis with contrast effects
    Thomas S Price
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Behav Genet 35:121-32. 2005
    ..Contrast effects acting in the same direction at different ages contributed to the observed continuity:longitudinal correlations were greater for dizygotic than monozygotic twins...
  100. ncbi request reprint The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism
    Angelica Ronald
    Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, UK
    Dev Sci 8:444-58. 2005
    ..Considering these behaviours separately might help clarify gene-brain-behaviour pathways in future research...

Research Grants11

  1. Genetics, School environments and cognitive development
    Robert Plomin; Fiscal Year: 2007
    ..abstract_text> ..
  2. Genetics, School environments and cognitive development
    Robert Plomin; Fiscal Year: 2010
    ....
  3. Reading disability QTLs: pooled DNA on microarrays
    Robert Plomin; Fiscal Year: 2007
    ..Identifying genes associated with reading disability will eventually lead to better diagnoses, individually tailored treatments, and interventions that can prevent the development of reading disability. ..
  4. Reading disability QTLs: pooled DNA on microarrays
    Robert Plomin; Fiscal Year: 2006
    ..Identifying genes associated with reading disability will eventually lead to better diagnoses, individually tailored treatments, and interventions that can prevent the development of reading disability. ..
  5. Genetics, School environments and cognitive development
    Robert Plomin; Fiscal Year: 2006
    ..abstract_text> ..
  6. Genetics, School environments and cognitive development
    Robert Plomin; Fiscal Year: 2011
    ....