J C Pickup

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Glucose sensing based on the intrinsic fluorescence of sol-gel immobilized yeast hexokinase
    Faeiza Hussain
    Department of Chemical Pathology, Guy's, King's, and St. Thomas's School of Medicine, Guy's Hospital, London SE1 9RT, UK
    Anal Biochem 339:137-43. 2005
  2. ncbi Are insulin pumps underutilized in type 1 diabetes? Yes
    John C Pickup
    Diabetes Care 29:1449-52. 2006
  3. ncbi Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetes
    John C Pickup
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Diabetes Care 31:S140-5. 2008
  4. ncbi Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion
    J C Pickup
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London, UK
    Diabet Med 25:765-74. 2008
  5. ncbi Fluorescence intensity- and lifetime-based glucose sensing using glucose/galactose-binding protein
    John C Pickup
    Diabetes Research Group, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    J Diabetes Sci Technol 7:62-71. 2013
  6. ncbi Management of diabetes mellitus: is the pump mightier than the pen?
    John C Pickup
    Diabetes Research Group, King s College London School of Medicine, Guy s Hospital, London SE1 1UL, UK
    Nat Rev Endocrinol 8:425-33. 2012
  7. ncbi Fluorescence-based glucose sensors
    John C Pickup
    Department of Chemical Pathology, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Biosens Bioelectron 20:2555-65. 2005
  8. ncbi In vivo glucose monitoring: the clinical reality and the promise
    John C Pickup
    Metabolic Unit, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, 5th Floor Thomas Guy House, London SE1 9RT, UK
    Biosens Bioelectron 20:1897-902. 2005
  9. ncbi Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    John C Pickup
    Metabolic Unit, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London, UK
    Diabetes Care 27:813-23. 2004
  10. ncbi Nanomedicine and its potential in diabetes research and practice
    John C Pickup
    Unit for Metabolic Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Diabetes Metab Res Rev 24:604-10. 2008

Collaborators

Detail Information

Publications31

  1. ncbi Glucose sensing based on the intrinsic fluorescence of sol-gel immobilized yeast hexokinase
    Faeiza Hussain
    Department of Chemical Pathology, Guy's, King's, and St. Thomas's School of Medicine, Guy's Hospital, London SE1 9RT, UK
    Anal Biochem 339:137-43. 2005
    ..We conclude that fluorescence monitoring of sol-gel entrapped yeast hexokinase is a suitable system for development as an in vivo glucose biosensor...
  2. ncbi Are insulin pumps underutilized in type 1 diabetes? Yes
    John C Pickup
    Diabetes Care 29:1449-52. 2006
  3. ncbi Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetes
    John C Pickup
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Diabetes Care 31:S140-5. 2008
    ..It is possible that CSII will be beneficial in selected patient groups with type 2 diabetes, but this requires further study...
  4. ncbi Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion
    J C Pickup
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London, UK
    Diabet Med 25:765-74. 2008
    ..We therefore conducted a meta-analysis comparing severe hypoglycaemia and glycaemic control during CSII and MDI...
  5. ncbi Fluorescence intensity- and lifetime-based glucose sensing using glucose/galactose-binding protein
    John C Pickup
    Diabetes Research Group, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    J Diabetes Sci Technol 7:62-71. 2013
    ..Measuring fluorescence lifetime rather than intensity has particular potential advantages for in vivo sensing. A prototype fiber-optic-based glucose sensor using this technology is being tested...
  6. ncbi Management of diabetes mellitus: is the pump mightier than the pen?
    John C Pickup
    Diabetes Research Group, King s College London School of Medicine, Guy s Hospital, London SE1 1UL, UK
    Nat Rev Endocrinol 8:425-33. 2012
    ....
  7. ncbi Fluorescence-based glucose sensors
    John C Pickup
    Department of Chemical Pathology, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Biosens Bioelectron 20:2555-65. 2005
    ..Here we review the principles of operation, context and current status of the various approaches to fluorescence-based glucose sensing...
  8. ncbi In vivo glucose monitoring: the clinical reality and the promise
    John C Pickup
    Metabolic Unit, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, 5th Floor Thomas Guy House, London SE1 9RT, UK
    Biosens Bioelectron 20:1897-902. 2005
    ....
  9. ncbi Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    John C Pickup
    Metabolic Unit, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London, UK
    Diabetes Care 27:813-23. 2004
    ....
  10. ncbi Nanomedicine and its potential in diabetes research and practice
    John C Pickup
    Unit for Metabolic Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Diabetes Metab Res Rev 24:604-10. 2008
    ..g. tissue complications) using quantum dots (QDs) or gold nanoparticles, and single-molecule detection for the study of molecular diversity in diabetes pathology...
  11. ncbi Activation of the innate immune system as a predictor of cardiovascular mortality in Type 2 diabetes mellitus
    J C Pickup
    Metabolic Unit, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London, UK
    Diabet Med 20:723-6. 2003
    ....
  12. ncbi Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials
    John Pickup
    Department of Chemical Pathology, Metabolic Unit, Guy s, King s, and St Thomas s Hospitals School of Medicine, Guy s Hospital, London SE1 9RT
    BMJ 324:705. 2002
    ..To compare glycaemic control and insulin dosage in people with type 1 diabetes treated by continuous subcutaneous insulin infusion (insulin infusion pump therapy) or optimised insulin injections...
  13. ncbi Continuous subcutaneous insulin infusion at 25 years: evidence base for the expanding use of insulin pump therapy in type 1 diabetes
    John Pickup
    Department of Chemical Pathology and Metabolic Unit, Guy s King s and St Thomas Hospitals School of Medicine, Guy s Hospital, London, UK
    Diabetes Care 25:593-8. 2002
    ..Their number is relatively small, as would therefore be the demand on funds set aside for this purpose...
  14. ncbi Insulin pumps
    J Pickup
    King s College London School of Medicine, Guy s Hospital, London, UK
    Int J Clin Pract Suppl . 2011
    ..Patients in the clinic usually say that it does, and more evidence for quality of life improvement in pump therapy is reviewed here...
  15. ncbi Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self monitoring of blood glucose: meta-analysis of randomised controlled trials using individual patient data
    John C Pickup
    Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King s College London School of Medicine, Guy s Hospital, London SE1 1UL, UK
    BMJ 343:d3805. 2011
    ..To determine the clinical effectiveness of real time continuous glucose monitoring compared with self monitoring of blood glucose in type 1 diabetes...
  16. ncbi Determinants of glycaemic control in type 1 diabetes during intensified therapy with multiple daily insulin injections or continuous subcutaneous insulin infusion: importance of blood glucose variability
    John C Pickup
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London, UK
    Diabetes Metab Res Rev 22:232-7. 2006
    ..The variability of within-day and between-day blood glucose concentrations was calculated from blood glucose self-monitoring data...
  17. ncbi Performance assessment of the Medtronic-MiniMed Continuous Glucose Monitoring System and its use for measurement of glycaemic control in Type 1 diabetic subjects
    N Sachedina
    Metabolic Unit, Guy's, King's and St Thomas's School of Medicine, Guy's Hospital, London, UK
    Diabet Med 20:1012-5. 2003
    ..CONCLUSIONS: The CGMS has acceptable clinical accuracy. Detection by the CGMS of more hypoglycaemia and post-prandial hyperglycaemia than BGSM promises a valuable tool for control assessment and optimization of treatment...
  18. ncbi Relationship between plasma sialic acid concentration and microvascular and macrovascular complications in type 1 diabetes: the EURODIAB Complications Study
    M A Crook
    Department of Chemical Pathology, Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London, UK
    Diabetes Care 24:316-22. 2001
    ..Further study of acute-phase response markers and mediators as indicators or predictors of diabetic microvascular complications is therefore justified...
  19. ncbi Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes
    Z L Zhi
    King s College London School of Medicine, London, UK
    Diabetologia 55:1081-90. 2012
    ..We aimed to test whether early islet loss can be limited and transplant survival improved by the application of conformal nano-coating layers to islets...
  20. ncbi In vitro testing of a simply constructed, highly stable glucose sensor suitable for implantation in diabetic patients
    G W Shaw
    Division of Chemical Pathology, United Medical School, Guy s Hospital, London, UK
    Biosens Bioelectron 6:401-6. 1991
    ..During continuous operation in 5 mM buffered glucose solutions in vitro, sensors suffered no significant loss of response over periods of up to 60 h. Such electrodes are, therefore, useful for development as in vivo glucose sensors...
  21. ncbi Near-infrared fluorescence lifetime assay for serum glucose based on allophycocyanin-labeled concanavalin A
    L J McCartney
    Department of Chemical Pathology, Guy's Hospital, London, SE1 9RT, United Kingdom
    Anal Biochem 292:216-21. 2001
    ..APC shows promise for incorporation in an implanted glucose sensor which can be interrogated from outside the body...
  22. ncbi Clinicians' requirements for chemical sensors for in vivo monitoring: a multinational survey
    J C Pickup
    Division of Chemical Pathology, United Medical School, Guy s Hospital, London, UK
    Biosens Bioelectron 6:639-46. 1991
    ..This information may help those designing such sensors to match available and new technologies to clinical needs...
  23. ncbi Glucose-dependent changes in NAD(P)H-related fluorescence lifetime of adipocytes and fibroblasts in vitro: potential for non-invasive glucose sensing in diabetes mellitus
    N D Evans
    Department of Chemical Pathology, Guy's, King's and St. Thomas's School of Medicine, King's College, London SE1 9RT, UK
    J Photochem Photobiol B 80:122-9. 2005
    ..Further investigation and development of fluorescence intensity and lifetime sensing is therefore indicated for possible non-invasive metabolic monitoring in human diabetes...
  24. ncbi Novel hexacyanoferrate (III)-modified carbon electrodes: application in miniaturized biosensors with potential for in vivo glucose sensing
    S A Jaffari
    Division of Chemical Pathology, United Medical and Dental Schools, Guy s Hospital, London, UK
    Biosens Bioelectron 11:1167-75. 1996
    ..Also, the relatively large effect of ascorbate and 4-acetamidophenol at the unmodified-carbon base electrode was reduced considerably when the base electrode was coated with glucose oxidase, Nafion and polyurethane membranes...
  25. ncbi Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes
    J C Pickup
    Dept of Chemical Pathology, Guy s, King s and St Thomas s School of Medicine, Guy s Hospital, London, UK
    Life Sci 67:291-300. 2000
    ..Blood has the capacity to produce cytokines in diabetes which contribute to the augmented acute-phase response, but the main source of the increased plasma IL-6 and TNFalpha concentrations may be from non-circulating cells...
  26. ncbi Non-invasive glucose monitoring by NAD(P)H autofluorescence spectroscopy in fibroblasts and adipocytes: a model for skin glucose sensing
    Nicholas D Evans
    Metabolic Unit, Guy's, King's and St Thomas's School of Medicine, Guy's Hospital, London, United Kingdom
    Diabetes Technol Ther 5:807-16. 2003
    ..We conclude that glucose can be sensed non-invasively by cellular fluorescence changes in fibroblasts and adipocytes. This is a model for the further exploration of fluorescence-based non-invasive metabolic monitoring in human diabetes...
  27. ncbi Inflammatory markers and type 2 diabetes
    John C Pickup
    Diabetes Technol Ther 8:1-6. 2006
  28. ncbi Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering
    Colin D McGuinness
    Unit for Metabolic Medicine, Thomas Guy House, Guy s Hospital, St Thomas Street, London, UK SE1 9RT
    Analyst 132:633-4. 2007
    ..The detection limit using the peak height of the 440 cm(-1) band was 1 x 10(-13) mol l(-1), compared to 2 x 10(-12) mol l(-1) for the fluorescence peak at 660 nm...
  29. ncbi Effect of pH on aqueous phenylalanine studied using a 265-nm pulsed light-emitting diode
    Alexander M Macmillan
    Photophysics Research Group, Department of Physics, John Anderson Bldg, University of Strathclyde, 107 Rottenrow, Glasgow G4 0NG, United Kingdom
    Ann N Y Acad Sci 1130:300-4. 2008
    ....
  30. ncbi Innate immunity, insulin resistance and type 2 diabetes
    Jose Manuel Fernandez-Real
    University Hospital of Girona Dr Josep Trueta and CIBER Fisiopatología de la Obesidad CB06 03 010 17007 Girona, Spain
    Trends Endocrinol Metab 19:10-6. 2008
    ..The common characteristics shared among innate immunity activation, obesity and insulin resistance are summarized...
  31. ncbi Fluorescence-based sensing of glucose using engineered glucose/galactose-binding protein: a comparison of fluorescence resonance energy transfer and environmentally sensitive dye labelling strategies
    Faaizah Khan
    Metabolic Unit, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Biochem Biophys Res Commun 365:102-6. 2008
    ....