Stuart Pickering-Brown

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation
    Stuart Pickering-Brown
    Institute of Psychiatry, Section of Old Age Psychiatry, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:79-82. 2004
  2. ncbi request reprint The tau gene locus and frontotemporal dementia
    Stuart Pickering-Brown
    Institute of Psychiatry, London, UK
    Dement Geriatr Cogn Disord 17:258-60. 2004
  3. ncbi request reprint Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
    Victoria Busby
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuromolecular Med 5:133-46. 2004
  4. ncbi request reprint Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease
    Mark Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, England
    Arch Neurol 64:1535-9. 2007
  5. pmc Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada
    Acta Neuropathol 112:539-49. 2006
  6. ncbi request reprint The effect of tau genotype on clinical features in FTDP-17
    Yasuhiko Baba
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 11:205-8. 2005
  7. ncbi request reprint Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Alun Hughes
    Division of Neuroscience, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Exp Neurol 181:12-6. 2003
  8. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  9. ncbi request reprint Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
    Yong Jie Zhang
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 27:10530-4. 2007
  10. ncbi request reprint Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK
    Acta Neuropathol 113:521-33. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation
    Stuart Pickering-Brown
    Institute of Psychiatry, Section of Old Age Psychiatry, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:79-82. 2004
    ..Furthermore, this single large pedigree may be of use in the identification of disease modifying loci in FTD...
  2. ncbi request reprint The tau gene locus and frontotemporal dementia
    Stuart Pickering-Brown
    Institute of Psychiatry, London, UK
    Dement Geriatr Cogn Disord 17:258-60. 2004
    ..The role of the tau locus and tau accumulation in contributing to the neurodegenerative process in chromosome-17-linked families without mutations and in families with tau mutations without insoluble tau is discussed...
  3. ncbi request reprint Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
    Victoria Busby
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuromolecular Med 5:133-46. 2004
    ..None of these SNPs was associated with disease. Although an excellent candidate, we conclude that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10...
  4. ncbi request reprint Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease
    Mark Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, England
    Arch Neurol 64:1535-9. 2007
    ....
  5. pmc Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada
    Acta Neuropathol 112:539-49. 2006
    ....
  6. ncbi request reprint The effect of tau genotype on clinical features in FTDP-17
    Yasuhiko Baba
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 11:205-8. 2005
    ..7; 95% confidence interval, 1.4-98.7; P=0.008). Our results suggest that tau genotype does not influence the disease course. However, it may predispose to a specific clinical sign in the early stage of FTDP-17...
  7. ncbi request reprint Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Alun Hughes
    Division of Neuroscience, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Exp Neurol 181:12-6. 2003
    ..These data are consistent with the hypothesis that the tau gene, or nearby gene on the H1 haplotype, is a risk factor for frontotemporal dementia...
  8. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  9. ncbi request reprint Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
    Yong Jie Zhang
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 27:10530-4. 2007
    ..Altered cleavage and redistribution of TDP-43 in cell culture models are similar to findings in FTLD-U and ALS. The results suggest that abnormal metabolism of TDP-43 mediated by progranulin may play a pivotal role in neurodegeneration...
  10. ncbi request reprint Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK
    Acta Neuropathol 113:521-33. 2007
    ..We conclude that the UBQ-ir lesions of FTLD and MND are defined by the presence of TDP-43, and that these disorders can be subsumed into a single disease entity under the umbrella of TDP-43 proteinopathy...
  11. ncbi request reprint The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver Coastal Health Vancouver, BC, Canada
    Brain 129:3081-90. 2006
    ..These findings suggest that FTD caused by PGRN mutations has a recognizable pathology with the most characteristic feature being ub-ir NII...
  12. pmc Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
    Zbigniew K Wszolek
    Department of Neurology, Mayo Clinic, FL, USA
    Orphanet J Rare Dis 1:30. 2006
    ..The prognosis and rate of the disease's progression vary considerably among individual patients and genetic kindreds, ranging from life expectancies of several months to several years, and, in exceptional cases, as long as two decades...
  13. ncbi request reprint Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation
    Jing Shi
    Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK
    Acta Neuropathol 110:501-12. 2005
    ....
  14. ncbi request reprint Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter
    Victoria Zhukareva
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Ann Neurol 51:730-9. 2002
    ....