Marco Picchioni

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Schizophrenia
    Marco M Picchioni
    King s College London, Institute of Psychiatry, Division of Psychological Medicine, London SE5 8AF
    BMJ 335:91-5. 2007
  2. ncbi request reprint Medial temporal lobe activity at recognition increases with the duration of mnemonic delay during an object working memory task
    Marco Picchioni
    King s College London, Institute of Psychiatry, Section of Neuroimaging, London, United Kingdom
    Hum Brain Mapp 28:1235-50. 2007
  3. ncbi request reprint Neurological abnormalities in schizophrenic twins
    Marco M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
    Biol Psychiatry 59:341-8. 2006
  4. ncbi request reprint Substantial shared genetic influences on schizophrenia and event-related potentials
    Mei Hua Hall
    Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 164:804-12. 2007
  5. pmc Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, De Crespigny Park, London UK
    BMC Psychiatry 11:18. 2011
  6. doi request reprint Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
    Andreina Pauli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 34:2244-58. 2013
  7. doi request reprint Impaired intellect and memory: a missing link between genetic risk and schizophrenia?
    Timothea Toulopoulou
    King s College London, United Kingdom
    Arch Gen Psychiatry 67:905-13. 2010
  8. doi request reprint Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls
    Sergio Alessandro Papagni
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, UK
    Neuroimage 56:2283-91. 2011
  9. doi request reprint The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
  10. doi request reprint Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
    Diana P Prata
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Hum Brain Mapp 33:143-53. 2012

Detail Information

Publications34

  1. pmc Schizophrenia
    Marco M Picchioni
    King s College London, Institute of Psychiatry, Division of Psychological Medicine, London SE5 8AF
    BMJ 335:91-5. 2007
  2. ncbi request reprint Medial temporal lobe activity at recognition increases with the duration of mnemonic delay during an object working memory task
    Marco Picchioni
    King s College London, Institute of Psychiatry, Section of Neuroimaging, London, United Kingdom
    Hum Brain Mapp 28:1235-50. 2007
    ..These results confirm the components of an object WM network required for successful recognition, and suggest that parts of this network, including the medial temporal cortex, are sensitive to the duration of mnemonic delay...
  3. ncbi request reprint Neurological abnormalities in schizophrenic twins
    Marco M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
    Biol Psychiatry 59:341-8. 2006
    ..Neurological abnormalities (NAs) are well recognized in schizophrenia, though their genetic and environmental determinants, and pathophysiological significance, are poorly understood...
  4. ncbi request reprint Substantial shared genetic influences on schizophrenia and event-related potentials
    Mei Hua Hall
    Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 164:804-12. 2007
    ..The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia...
  5. pmc Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, De Crespigny Park, London UK
    BMC Psychiatry 11:18. 2011
    ..Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses...
  6. doi request reprint Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
    Andreina Pauli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 34:2244-58. 2013
    ..This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation...
  7. doi request reprint Impaired intellect and memory: a missing link between genetic risk and schizophrenia?
    Timothea Toulopoulou
    King s College London, United Kingdom
    Arch Gen Psychiatry 67:905-13. 2010
    ..Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia...
  8. doi request reprint Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls
    Sergio Alessandro Papagni
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, UK
    Neuroimage 56:2283-91. 2011
    ..Our results suggest that genetic variation in DAAO has a significant impact on both regional activation and functional connectivity, and provide evidence for a diagnosis-dependent pattern of gene action...
  9. doi request reprint The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
    ..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex...
  10. doi request reprint Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
    Diana P Prata
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Hum Brain Mapp 33:143-53. 2012
    ..Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder...
  11. ncbi request reprint Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 65:473-80. 2009
    ..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects...
  12. doi request reprint Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3287-98. 2009
    ..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia...
  13. pmc Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating
    Rachel H Flomen
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Eur J Hum Genet 21:76-81. 2013
    ..Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele...
  14. ncbi request reprint Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF UK
    Curr Pharm Des 18:510-7. 2012
    ..Future studies could explore the effects of DAAO and G72 in individuals with prodromal symptoms of psychosis, in order to elucidate glutamate dysfunction in this critical phase of the disorder...
  15. ncbi request reprint Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 64:401-9. 2007
    ..However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia...
  16. doi request reprint Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
    Evangelos Vassos
    King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
    J Psychiatr Res 44:795-8. 2010
    ..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals...
  17. doi request reprint Altered integrity of perisylvian language pathways in schizophrenia: relationship to auditory hallucinations
    Marco Catani
    Department of Forensic and Neurodevelopmental Sciences, King s College London, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 70:1143-50. 2011
    ....
  18. pmc Gender differences in white matter microstructure
    Richard A Kanaan
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, London, United Kingdom
    PLoS ONE 7:e38272. 2012
    ..We used diffusion tensor imaging to explore differences in fractional anisotropy (FA), an index of microstructural integrity...
  19. doi request reprint Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state
    Stefania Benetti
    Division of Psychological Medicine and Psychiatry, Section of Neuroimaging, Institute of Psychiatry, De Crespigny Park, King s College London, London, UK
    Brain 132:2426-36. 2009
    ..This suggests that it may be a correlate of increased vulnerability to psychosis and that it is not attributable to an effect of chronic illness or its treatment...
  20. ncbi request reprint Heritability and reliability of P300, P50 and duration mismatch negativity
    Mei Hua Hall
    Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 36:845-57. 2006
    ..Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs...
  21. ncbi request reprint Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Am J Psychiatry 163:543-5. 2006
    ..Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype...
  22. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    ..Overall, our data provide further evidence to support a role for DNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD...
  23. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  24. pmc White matter microstructure in schizophrenia: effects of disorder, duration and medication
    Richard Kanaan
    Institute of Psychiatry, Department of Psychological Medicine, King s College London, PO 62, Denmark Hill, London SE5 9RJ, UK
    Br J Psychiatry 194:236-42. 2009
    ..Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure...
  25. doi request reprint White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder
    Frederick Sundram
    King s College London, Institute of Psychiatry, Department of Forensic and Neurodevelopmental Science, London, UK Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cortex 48:216-29. 2012
    ..Also in the right frontal lobe, increased MD was found in the IFOF and UF, and the corpus callosum and anterior corona radiata. There was a significant positive correlation between MD and psychopathy scores...
  26. ncbi request reprint COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia
    Irene Rebollo-Mesa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Psychiatr Genet 21:98-105. 2011
    ..In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia...
  27. ncbi request reprint Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples
    Timothea Toulopoulou
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 64:1348-55. 2007
    ..Neurocognitive deficits are among the most promising indicators of increased risk for schizophrenia; however, it is not clear to what extent these deficits are genetically linked to the disorder...
  28. doi request reprint A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young women
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Horm Behav 54:47-59. 2008
    ..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM...
  29. doi request reprint Regional gray matter volume in monozygotic twins concordant and discordant for schizophrenia
    Stefan J Borgwardt
    Section of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 67:956-64. 2010
    ..We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia...
  30. doi request reprint Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
    ..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...
  31. ncbi request reprint Acoustic noise and functional magnetic resonance imaging: current strategies and future prospects
    Edson Amaro
    Institute of Psychiatry, King s College, University College, London, UK
    J Magn Reson Imaging 16:497-510. 2002
    ..We also provide new data, using a silent event-related (SER) design, which demonstrate higher blood oxygen level-dependent (BOLD) response to a simple auditory cue when compared to a conventional image acquisition...
  32. doi request reprint Microstructural organization of cerebellar tracts in schizophrenia
    Richard A A Kanaan
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 66:1067-9. 2009
    ..However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error...
  33. ncbi request reprint Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    Araceli Rosa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008
    ....
  34. ncbi request reprint A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...