Research Topics
Genomes and GenesSpecies | Marco PicchioniSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
SchizophreniaMarco M Picchioni
King's College London, Institute of Psychiatry, Division of Psychological Medicine, London SE5 8AF
BMJ 335:91-5. 2007
Medial temporal lobe activity at recognition increases with the duration of mnemonic delay during an object working memory taskMarco Picchioni
King s College London, Institute of Psychiatry, Section of Neuroimaging, London, United Kingdom
Hum Brain Mapp 28:1235-50. 2007..These results confirm the components of an object WM network required for successful recognition, and suggest that parts of this network, including the medial temporal cortex, are sensitive to the duration of mnemonic delay...- Neurological abnormalities in schizophrenic twinsMarco M Picchioni
Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
Biol Psychiatry 59:341-8. 2006..Neurological abnormalities (NAs) are well recognized in schizophrenia, though their genetic and environmental determinants, and pathophysiological significance, are poorly understood... - Substantial shared genetic influences on schizophrenia and event-related potentialsMei Hua Hall
Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
Am J Psychiatry 164:804-12. 2007..The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia... - Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorderSergi G Costafreda
Institute of Psychiatry, King s College London, De Crespigny Park, London UK
BMC Psychiatry 11:18. 2011..Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses... 
The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorderAndrea Mechelli
Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
Neuroimage 42:817-26. 2008..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex...- Impaired intellect and memory: a missing link between genetic risk and schizophrenia?Timothea Toulopoulou
King s College London, United Kingdom
Arch Gen Psychiatry 67:905-13. 2010..Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia... - Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controlsSergio Alessandro Papagni
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, UK
Neuroimage 56:2283-91. 2011..Our results suggest that genetic variation in DAAO has a significant impact on both regional activation and functional connectivity, and provide evidence for a diagnosis-dependent pattern of gene action... - Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluencyDiana P Prata
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Hum Brain Mapp 33:143-53. 2012..Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder... - Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 65:473-80. 2009..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects... - Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?Sergi G Costafreda
Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 30:3287-98. 2009..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia... - Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72Andrea Mechelli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF UK
Curr Pharm Des 18:510-7. 2012..Future studies could explore the effects of DAAO and G72 in individuals with prodromal symptoms of psychosis, in order to elucidate glutamate dysfunction in this critical phase of the disorder... - Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophreniaUlrich Ettinger
Centre for Neuroimaging Sciences, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, England
Arch Gen Psychiatry 64:401-9. 2007..However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia... - Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controlsEvangelos Vassos
King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
J Psychiatr Res 44:795-8. 2010..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals... - Altered integrity of perisylvian language pathways in schizophrenia: relationship to auditory hallucinationsMarco Catani
Department of Forensic and Neurodevelopmental Sciences, King s College London, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 70:1143-50. 2011.... - Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gatingRachel H Flomen
Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
Eur J Hum Genet 21:76-81. 2013..Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele... - Gender differences in white matter microstructureRichard A Kanaan
Department of Psychological Medicine, King s College London, Institute of Psychiatry, London, United Kingdom
PLoS ONE 7:e38272. 2012..We used diffusion tensor imaging to explore differences in fractional anisotropy (FA), an index of microstructural integrity... - Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin studyUlrich Ettinger
Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Am J Psychiatry 163:543-5. 2006..Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype... - Heritability and reliability of P300, P50 and duration mismatch negativityMei Hua Hall
Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, De Crespigny Park, London, SE5 8AF, UK
Behav Genet 36:845-57. 2006..Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs... - Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental stateStefania Benetti
Division of Psychological Medicine and Psychiatry, Section of Neuroimaging, Institute of Psychiatry, De Crespigny Park, King s College London, London, UK
Brain 132:2426-36. 2009..This suggests that it may be a correlate of increased vulnerability to psychosis and that it is not attributable to an effect of chronic illness or its treatment... - Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorderEmma L Dempster
MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Hum Mol Genet 20:4786-96. 2011..Overall, our data provide further evidence to support a role for DNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD... - Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
Proc Natl Acad Sci U S A 106:13600-5. 2009.... - White matter microstructure in schizophrenia: effects of disorder, duration and medicationRichard Kanaan
Institute of Psychiatry, Department of Psychological Medicine, King s College London, PO 62, Denmark Hill, London SE5 9RJ, UK
Br J Psychiatry 194:236-42. 2009..Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure... - White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorderFrederick Sundram
King s College London, Institute of Psychiatry, Department of Forensic and Neurodevelopmental Science, London, UK Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
Cortex 48:216-29. 2012..Hence, we provide evidence of significant WM microstructural abnormalities in frontal brain regions in ASPD and psychopathy... - COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophreniaIrene Rebollo-Mesa
Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Psychiatr Genet 21:98-105. 2011..In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia... - Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samplesTimothea Toulopoulou
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 64:1348-55. 2007..Neurocognitive deficits are among the most promising indicators of increased risk for schizophrenia; however, it is not clear to what extent these deficits are genetically linked to the disorder... - A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Horm Behav 54:47-59. 2008..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM... - Regional gray matter volume in monozygotic twins concordant and discordant for schizophreniaStefan J Borgwardt
Section of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
Biol Psychiatry 67:956-64. 2010..We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia... - Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 66:1162-72. 2009..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia... - Acoustic noise and functional magnetic resonance imaging: current strategies and future prospectsEdson Amaro
Institute of Psychiatry, King s College, University College, London, UK
J Magn Reson Imaging 16:497-510. 2002..We also provide new data, using a silent event-related (SER) design, which demonstrate higher blood oxygen level-dependent (BOLD) response to a simple auditory cue when compared to a conventional image acquisition... - Microstructural organization of cerebellar tracts in schizophreniaRichard A A Kanaan
Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 66:1067-9. 2009..However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error... - Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twinsAraceli Rosa
Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008.... - A controlled study of brain structure in monozygotic twins concordant and discordant for schizophreniaNeeltje E M van Haren
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
Biol Psychiatry 56:454-61. 2004..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...