Alkystis Phinikaridou

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, King s College London, London, United Kingdom
    J Am Heart Assoc 2:e000402. 2013
  2. pmc In vivo magnetization transfer and diffusion-weighted magnetic resonance imaging detects thrombus composition in a mouse model of deep vein thrombosis
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, Cardiovascular Division, BHF Centre of Excellence, King s College London, London, UK
    Circ Cardiovasc Imaging 6:433-40. 2013
  3. pmc Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, King s College London, United Kingdom
    Am J Physiol Heart Circ Physiol 303:H1397-410. 2012
  4. pmc Detection of thrombus size and protein content by ex vivo magnetization transfer and diffusion weighted MRI
    Alkystis Phinikaridou
    Division of Imaging Sciences and Biomedical Engineering, King s College London, London, UK
    J Cardiovasc Magn Reson 14:45. 2012
  5. doi request reprint Noninvasive magnetic resonance imaging evaluation of endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent
    Alkystis Phinikaridou
    King s College London, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, United Kingdom
    Circulation 126:707-19. 2012
  6. ncbi request reprint Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis
    Marcelo E Andia
    From the Division of Imaging Sciences and Biomedical Engineering, School of Medicine, St Thomas Hospital, King s College London, London, United Kingdom M E A, A J W, A P, T S, R M B Academic Department of Surgery, Cardiovascular Division P S, J J, B M, S P G, A S P, A s, Wellcome Trust and EPSRC Medical Engineering Centre T S, R M B, BHF Centre of Excellence, Cardiovascular Division T S, A s, R M B, and NIHR Biomedical Research Centre, GSTT T S, A s, R M B, School of Medicine, King s College London, London, United Kingdom and Radiology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile M E A
    Arterioscler Thromb Vasc Biol 34:1193-8. 2014
  7. ncbi request reprint Vascular remodeling and plaque vulnerability in a rabbit model of atherosclerosis: comparison of delayed-enhancement MR imaging with an elastin-specific contrast agent and unenhanced black-blood MR imaging
    Alkystis Phinikaridou
    From the Division of Imaging Science and Biomedical Engineering A P, M E A, A I, R M B, Academic Department of Surgery, Cardiovascular Division A S, P S, BHF Centre of Excellence, Cardiovascular Division A P, A s, P S, R M B, and Wellcome Trust and EPSRC Medical Engineering Center R M B, King s College London, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, England and Lantheus Medical Imaging, North Billerica, Mass D C O, R R C, S P R
    Radiology 271:390-9. 2014
  8. pmc Magnetic resonance T1 relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis
    Prakash Saha
    Academic Department of Surgery, Cardiovascular Division, King s College London, 1st Floor North Wing, St Thomas Hospital, Westminster Bridge Rd, London, UK, SE1 7EH
    Circulation 128:729-36. 2013
  9. ncbi request reprint Molecular imaging of myocardial infarction
    Naheed Jivraj
    Division of Imaging Sciences and Biomedical Engineering, King s College London, St Thomas Hospital, 4th Floor, Lambeth Wing, London, SE1 7EH, UK
    Basic Res Cardiol 109:397. 2014
  10. ncbi request reprint Molecular MRI of atherosclerosis
    Alkystis Phinikaridou
    Division of Imaging Sciences and Biomedical Engineering, King s College London, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    Molecules 18:14042-69. 2013

Collaborators

Detail Information

Publications16

  1. pmc Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, King s College London, London, United Kingdom
    J Am Heart Assoc 2:e000402. 2013
    ....
  2. pmc In vivo magnetization transfer and diffusion-weighted magnetic resonance imaging detects thrombus composition in a mouse model of deep vein thrombosis
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, Cardiovascular Division, BHF Centre of Excellence, King s College London, London, UK
    Circ Cardiovasc Imaging 6:433-40. 2013
    ..We tested the feasibility of in vivo magnetization transfer (MT) and diffusion-weighted magnetic resonance imaging to detect thrombus organization in a murine model of deep vein thrombosis...
  3. pmc Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology
    Alkystis Phinikaridou
    Division of Imaging Science and Biomedical Engineering, King s College London, United Kingdom
    Am J Physiol Heart Circ Physiol 303:H1397-410. 2012
    ..In this review, we will concentrate on the major accomplishments and advances in the field of molecular imaging of atherosclerosis and myocardial infarction with a special focus on magnetic resonance imaging...
  4. pmc Detection of thrombus size and protein content by ex vivo magnetization transfer and diffusion weighted MRI
    Alkystis Phinikaridou
    Division of Imaging Sciences and Biomedical Engineering, King s College London, London, UK
    J Cardiovasc Magn Reson 14:45. 2012
    ..7 T for the ex vivo detection of size and composition of thrombus associated with disrupted plaques...
  5. doi request reprint Noninvasive magnetic resonance imaging evaluation of endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent
    Alkystis Phinikaridou
    King s College London, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, United Kingdom
    Circulation 126:707-19. 2012
    ..Furthermore, we tested whether magnetic resonance imaging could noninvasively assess endothelial function by measuring the endothelial-dependent vasodilation in response to acetylcholine...
  6. ncbi request reprint Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis
    Marcelo E Andia
    From the Division of Imaging Sciences and Biomedical Engineering, School of Medicine, St Thomas Hospital, King s College London, London, United Kingdom M E A, A J W, A P, T S, R M B Academic Department of Surgery, Cardiovascular Division P S, J J, B M, S P G, A S P, A s, Wellcome Trust and EPSRC Medical Engineering Centre T S, R M B, BHF Centre of Excellence, Cardiovascular Division T S, A s, R M B, and NIHR Biomedical Research Centre, GSTT T S, A s, R M B, School of Medicine, King s College London, London, United Kingdom and Radiology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile M E A
    Arterioscler Thromb Vasc Biol 34:1193-8. 2014
    ..The aim of this study was to investigate a fibrin-specific MRI contrast agent (EP-2104R) for the accurate quantification of thrombus' fibrin content in vivo and for the identification of thrombus suitable for thrombolysis...
  7. ncbi request reprint Vascular remodeling and plaque vulnerability in a rabbit model of atherosclerosis: comparison of delayed-enhancement MR imaging with an elastin-specific contrast agent and unenhanced black-blood MR imaging
    Alkystis Phinikaridou
    From the Division of Imaging Science and Biomedical Engineering A P, M E A, A I, R M B, Academic Department of Surgery, Cardiovascular Division A S, P S, BHF Centre of Excellence, Cardiovascular Division A P, A s, P S, R M B, and Wellcome Trust and EPSRC Medical Engineering Center R M B, King s College London, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, England and Lantheus Medical Imaging, North Billerica, Mass D C O, R R C, S P R
    Radiology 271:390-9. 2014
    ....
  8. pmc Magnetic resonance T1 relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis
    Prakash Saha
    Academic Department of Surgery, Cardiovascular Division, King s College London, 1st Floor North Wing, St Thomas Hospital, Westminster Bridge Rd, London, UK, SE1 7EH
    Circulation 128:729-36. 2013
    ..In this study, we investigate the possible mechanisms that give rise to the T1 signal in venous thrombi and whether changes in T1 relaxation time are informative of the susceptibility to lysis...
  9. ncbi request reprint Molecular imaging of myocardial infarction
    Naheed Jivraj
    Division of Imaging Sciences and Biomedical Engineering, King s College London, St Thomas Hospital, 4th Floor, Lambeth Wing, London, SE1 7EH, UK
    Basic Res Cardiol 109:397. 2014
    ..Translating this work to the bedside in a cost-effective, clinically beneficial manner remains a significant challenge. This article reviews these new imaging techniques as well as the corresponding pathophysiology...
  10. ncbi request reprint Molecular MRI of atherosclerosis
    Alkystis Phinikaridou
    Division of Imaging Sciences and Biomedical Engineering, King s College London, 4th Floor, Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    Molecules 18:14042-69. 2013
    ..Compared to other imaging modalities; MRI can provide excellent spatial resolution; high soft tissue contrast and has the ability to simultaneously image anatomy; function as well as biological tissue composition and activity. ..
  11. ncbi request reprint Assessment of inflammation with a very small iron-oxide particle in a murine model of reperfused myocardial infarction
    Andrea Protti
    King s College London British Heart Foundation Centre of Excellence, Cardiovascular Division, King s College London, London, United Kingdom King s College London British Heart Foundation Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, King s College London, London, United Kingdom
    J Magn Reson Imaging 39:598-608. 2014
    ..To investigate a very small iron-oxide particle (VSOP) in a mouse model of acute ischemia-reperfusion to access the mechanism of such particles in areas of myocardial inflammation...
  12. pmc Bisphosphonate-anchored PEGylation and radiolabeling of superparamagnetic iron oxide: long-circulating nanoparticles for in vivo multimodal (T1 MRI-SPECT) imaging
    Lydia Sandiford
    Division of Imaging Sciences and Biomedical Engineering, King s College London, St Thomas Hospital, London, SE1 7EH, UK
    ACS Nano 7:500-12. 2013
    ..The SPECT studies confirmed low RES uptake and long blood circulation times (t(1/2) = 2.97 h). These results demonstrate the potential of PEG(5)-BP-USPIOs for the development of targeted multimodal imaging agents for molecular imaging...
  13. doi request reprint Flow-independent 3D whole-heart vessel wall imaging using an interleaved T2-preparation acquisition
    Marcelo E Andia
    Division of Imaging Sciences and Biomedical Engineering, King s College London, St Thomas Hospital, London, United Kingdom
    Magn Reson Med 69:150-7. 2013
    ..In this article, we present the technique and preliminary results in healthy subjects...
  14. ncbi request reprint Gd-containing conjugated polymer nanoparticles: bimodal nanoparticles for fluorescence and MRI imaging
    Zeina Hashim
    Department of Physics, King s College London, Strand, London, WC2R 2LS, UK
    Nanoscale 6:8376-86. 2014
    ....
  15. pmc Protein kinase G oxidation is a major cause of injury during sepsis
    Olena Rudyk
    Cardiovascular Division, King s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    Proc Natl Acad Sci U S A 110:9909-13. 2013
    ..We conclude that oxidative activation of PKG Iα is a key mediator of hypotension and consequential organ injury during sepsis...
  16. ncbi request reprint Regions of low endothelial shear stress colocalize with positive vascular remodeling and atherosclerotic plaque disruption: an in vivo magnetic resonance imaging study
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Cardiovasc Imaging 6:302-10. 2013
    ..We used in vivo MRI to investigate the role of the magnitude of ESS on vascular remodeling, plaque burden, and disruption using a rabbit model of controlled atherothrombosis...