Mary L Phillips

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, 121 Meyran Ave, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:1041-52. 2008
  2. ncbi request reprint Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures
    Erwin Lemche
    Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 27:623-35. 2006
  3. ncbi request reprint The development of emotion-processing in children: effects of age, emotion, and intensity
    Catherine M Herba
    Department of Psychological Medicine, Institute of Psychiatry, KCL, UK
    J Child Psychol Psychiatry 47:1098-106. 2006
  4. ncbi request reprint Differential neural responses to overt and covert presentations of facial expressions of fear and disgust
    Mary L Phillips
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, KCL, London, UK
    Neuroimage 21:1484-96. 2004
  5. ncbi request reprint Depersonalization disorder: a functional neuroanatomical perspective
    Mary L Phillips
    Institute of Psychiatry, Denmark Hill, London, UK
    Stress 6:157-65. 2003
  6. ncbi request reprint The neural basis of mood dysregulation in bipolar disorder
    Mary L Phillips
    Institute of Psychiatry, London, UK
    Cogn Neuropsychiatry 11:233-49. 2006
  7. doi request reprint Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli
    David Mataix-Cols
    King s College London, Institute of Psychiatry, London, UK
    Eur J Neurosci 27:3050-8. 2008
  8. ncbi request reprint A preferential increase in the extrastriate response to signals of danger
    Simon A Surguladze
    Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 19:1317-28. 2003
  9. ncbi request reprint A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia
    Simon Surguladze
    Division of Psychological Medicine, Kings College London Institute and Brain Image Analysis Unit of Psychiatry, London, UK
    Biol Psychiatry 60:423-31. 2006
  10. ncbi request reprint Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders
    Xavier Caseras
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, United Kingdom
    Biol Psychiatry 62:464-71. 2007

Research Grants

Detail Information

Publications70

  1. pmc Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, 121 Meyran Ave, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:1041-52. 2008
    ....
  2. ncbi request reprint Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures
    Erwin Lemche
    Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 27:623-35. 2006
    ..We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity...
  3. ncbi request reprint The development of emotion-processing in children: effects of age, emotion, and intensity
    Catherine M Herba
    Department of Psychological Medicine, Institute of Psychiatry, KCL, UK
    J Child Psychol Psychiatry 47:1098-106. 2006
    ..This study examined the effects of age and two novel factors (intensity and emotion category) on healthy children's developing emotion-processing from 4 to 15 years using two matching paradigms...
  4. ncbi request reprint Differential neural responses to overt and covert presentations of facial expressions of fear and disgust
    Mary L Phillips
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, KCL, London, UK
    Neuroimage 21:1484-96. 2004
    ..These results therefore suggest distinct neural correlates of conscious and unconscious emotion perception...
  5. ncbi request reprint Depersonalization disorder: a functional neuroanatomical perspective
    Mary L Phillips
    Institute of Psychiatry, Denmark Hill, London, UK
    Stress 6:157-65. 2003
    ..Taken together, these finding suggest that symptoms of depersonalization, and in particular emotional numbing, may be related to a reversal of normal patterns of autonomic and neural response to emotive stimuli...
  6. ncbi request reprint The neural basis of mood dysregulation in bipolar disorder
    Mary L Phillips
    Institute of Psychiatry, London, UK
    Cogn Neuropsychiatry 11:233-49. 2006
    ....
  7. doi request reprint Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli
    David Mataix-Cols
    King s College London, Institute of Psychiatry, London, UK
    Eur J Neurosci 27:3050-8. 2008
    ..The results have implications for disgust-related psychiatric disorders...
  8. ncbi request reprint A preferential increase in the extrastriate response to signals of danger
    Simon A Surguladze
    Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 19:1317-28. 2003
    ..We suggest that this differential pattern of response to different categories of emotional signals allows the preferential direction of visual attention to signals of imminent danger than to other, less-salient emotional stimuli...
  9. ncbi request reprint A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia
    Simon Surguladze
    Division of Psychological Medicine, Kings College London Institute and Brain Image Analysis Unit of Psychiatry, London, UK
    Biol Psychiatry 60:423-31. 2006
    ..The neural mechanisms underlying this deficit and the relationship with different symptoms remain poorly understood...
  10. ncbi request reprint Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders
    Xavier Caseras
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, United Kingdom
    Biol Psychiatry 62:464-71. 2007
    ..The aim of this functional magnetic resonance imaging (fMRI) study was to examine possible sex differences in neural responses to disgust-inducing stimuli that might help explain this female predominance...
  11. ncbi request reprint A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder
    Simon Surguladze
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 57:201-9. 2005
    ..In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals...
  12. ncbi request reprint Limbic and prefrontal responses to facial emotion expressions in depersonalization
    Erwin Lemche
    Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuroreport 18:473-7. 2007
    ....
  13. doi request reprint Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication
    Simon A Surguladze
    Division of Psychological Medicine and Psychiatry, King s College London Institute of Psychiatry, London, UK
    J Psychopharmacol 25:722-33. 2011
    ..Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI...
  14. doi request reprint Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder
    Erwin Lemche
    Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 193:222-8. 2008
    ..Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood...
  15. ncbi request reprint The neural correlates of anhedonia in major depressive disorder
    Paul A Keedwell
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, London, United Kingdom
    Biol Psychiatry 58:843-53. 2005
    ....
  16. ncbi request reprint Emotional memory in depersonalization disorder: a functional MRI study
    Nicholas Medford
    Division of Psychological Medicine, P O Box 68, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
    Psychiatry Res 148:93-102. 2006
    ..This study provides further evidence that patients with DPD do not process emotionally salient material in the same way as healthy controls, in accordance with their subjective descriptions of reduced or absent emotional responses...
  17. doi request reprint Changes in male brain responses to emotional faces from adolescence to middle age
    Quinton Deeley
    Section of Brain Maturation, King s College London Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroimage 40:389-97. 2008
    ....
  18. ncbi request reprint An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome
    Quinton Deeley
    Section of Brain Maturation, De Crespigny Park, London, UK
    Biol Psychiatry 62:207-17. 2007
    ..However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities...
  19. doi request reprint Neural response to specific components of fearful faces in healthy and schizophrenic adults
    Joaquim Radua
    King s College London Institute of Psychiatry, London, UK
    Neuroimage 49:939-46. 2010
    ..PCA-based analysis could be useful in isolating brain response to salient facial features in psychiatric populations...
  20. ncbi request reprint Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder
    David Mataix-Cols
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 61:564-76. 2004
    ....
  21. ncbi request reprint Task instructions modulate neural responses to fearful facial expressions
    Kezia Lange
    Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:226-32. 2003
    ..Little is known, however, about the effect of task instructions upon the intensity of responses within these regions to fear-inducing stimuli...
  22. ncbi request reprint Recognition accuracy and response bias to happy and sad facial expressions in patients with major depression
    Simon A Surguladze
    Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Neuropsychology 18:212-8. 2004
    ..The authors suggest that, in depressed patients, the inability to accurately identify subtle changes in facial expression displayed by others in social situations may underlie the impaired interpersonal functioning...
  23. ncbi request reprint Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, England
    Neuropsychology 20:409-19. 2006
    ..These results help explain previous inconsistent findings in neuropsychological research in OCD and support recent neuroimaging data showing dissociable neural mechanisms involved in mediating the different OCD symptom dimensions...
  24. ncbi request reprint A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals
    Paul A Keedwell
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Biol Psychiatry 58:495-503. 2005
    ..We wished to corroborate these results by examining neural responses to personally relevant happy and sad stimuli in MDD and healthy individuals within the same paradigm...
  25. ncbi request reprint Functional neuroanatomy of body shape perception in healthy and eating-disordered women
    Rudolf Uher
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 58:990-7. 2005
    ..Abnormalities in perception and evaluation of body shape are a hallmark of eating disorders...
  26. ncbi request reprint Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD
    Natalia S Lawrence
    Division of Psychological Medicine, Section of Neuroscience and Emotion, King s College London, London, United Kingdom
    Biol Psychiatry 61:1072-80. 2007
    ..This study explored neural systems underlying sensitivity to symptom-unrelated disgust and fear in OCD using functional neuroimaging...
  27. doi request reprint Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humans
    Eileen Daly
    Section of Brain Maturation, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Psychopharmacology (Berl) 210:499-510. 2010
    ..Acute tryptophan depletion (ATD) temporarily lowers brain serotonin (5-HT) synthesis, and behavioral studies have shown that this alters the processing of facial expressions of emotion...
  28. ncbi request reprint Lamotrigine as an add-on treatment for depersonalization disorder: a retrospective study of 32 cases
    Mauricio Sierra
    Depersonalisation Research Unit, Psychological Medicine, Institute of Psychiatry, London, UK
    Clin Neuropharmacol 29:253-8. 2006
    ..Lamotrigine as sole agent was not found to be effective in a previous small double-blind, randomized crossover trial. However, evidence from open trials suggests that it may be beneficial as an add-on medication with antidepressants...
  29. pmc Withdrawal-associated increases and decreases in functional neural connectivity associated with altered emotional regulation in alcoholism
    Owen G O'Daly
    Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuropsychopharmacology 37:2267-76. 2012
    ..Such changes may confer increased sensitivity to emotional stress and impaired social competence, contributing to relapse...
  30. ncbi request reprint Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 55:578-87. 2004
    ..We compared responses within subcortical and prefrontal cortical regions to emotionally salient material in patients with BP and MDD using functional magnetic resonance imaging...
  31. ncbi request reprint Autonomic response in the perception of disgust and happiness in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, Denmark Hill, London, UK
    Psychiatry Res 145:225-31. 2006
    ..The findings of this study provide further support to the idea that patients with depersonalization have a selective impairment in the processing of threatening or unpleasant emotional stimuli...
  32. doi request reprint Distinct roles of prefrontal cortical subregions in the Iowa Gambling Task
    Natalia S Lawrence
    King s College London, Section of Neuroscience and Emotion, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Cereb Cortex 19:1134-43. 2009
    ..They reveal that deciding advantageously under initially ambiguous conditions may require both continuous and dynamic processes involving both the ventral and dorsal prefrontal cortex...
  33. ncbi request reprint Emotional memory: separating content and context
    Nicholas Medford
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, King s College, London SE5 8AF, UK
    Psychiatry Res 138:247-58. 2005
    ..These findings, if applicable to the wider population, may have application in a range of psychiatric disorders where interactions between emotion and cognition are relevant...
  34. ncbi request reprint Facial emotion processing in criminal psychopathy. Preliminary functional magnetic resonance imaging study
    Quinton Deeley
    Section of Brain Maturation, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 189:533-9. 2006
    ..It has been suggested that people with psychopathic disorders lack empathy because they have deficits in processing distress cues (e.g. fearful facial expressions)...
  35. ncbi request reprint Perception of facial and vocal affect by people with schizophrenia in early and late stages of illness
    Katarzyna Kucharska-Pietura
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 187:523-8. 2005
    ..Emotion recognition impairments have been demonstrated in schizophrenia, but few studies have examined whether these reflect generalised or specific perceptual deficits or are associated with illness course...
  36. ncbi request reprint Disgusting smells activate human anterior insula and ventral striatum
    Maike Heining
    Department of Psychology, Institute of Psychiatry, Kings College London, London, UK
    Ann N Y Acad Sci 1000:380-4. 2003
  37. ncbi request reprint A pilot study to investigate the effectiveness of emotion recognition remediation in schizophrenia using the micro-expression training tool
    Tamara A Russell
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, UK
    Br J Clin Psychol 45:579-83. 2006
    ..Emotion recognition impairments are a common feature of schizophrenia. This pilot study investigates the effectiveness of the 'micro-expressions training tool' (METT) to help improve this skill...
  38. ncbi request reprint Neurobiology of emotion perception II: Implications for major psychiatric disorders
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:515-28. 2003
    ..We suggest that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder...
  39. ncbi request reprint Cognitive-behaviour therapy for depersonalisation disorder: an open study
    Elaine C M Hunter
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Res Ther 43:1121-30. 2005
    ..These initial results suggest that a CBT approach to DPD may be effective, but further trials with larger sample sizes and more rigorous research methodology are needed to determine the specificity of this approach...
  40. pmc Pattern recognition analyses of brain activation elicited by happy and neutral faces in unipolar and bipolar depression
    Janaina Mourao-Miranda
    Department of Computer Science, Centre for Computational Statistics and Machine Learning, University College London, London, UK
    Bipolar Disord 14:451-60. 2012
    ..Only a few studies have applied similar methods to functional MRI (fMRI) data...
  41. ncbi request reprint A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, Department of Psychological Medicine, Kings College, London University, London UK
    J Psychopharmacol 17:103-5. 2003
    ..None of the nine patients was deemed a responder to the lamotrigine arm of the cross-over. Lamotrigine does not seem to be useful as a sole medication in the treatment of depersonalization disorder...
  42. ncbi request reprint Autonomic response in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, England
    Arch Gen Psychiatry 59:833-8. 2002
    ..In this study, we tested the prediction that autonomic response to emotional stimuli would be reduced in patients with depersonalization disorder...
  43. doi request reprint Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging study
    Simon A Surguladze
    Department of Psychosis, King s College London Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 44:894-902. 2010
    ..Enhanced activation to facial expressions of disgust may reflect an emotion processing bias that suggests high relevance of emotion of disgust to depression...
  44. doi request reprint The Maudsley Obsessive-Compulsive Stimuli Set: validation of a standardized paradigm for symptom-specific provocation in obsessive-compulsive disorder
    David Mataix-Cols
    Departments of Psychological Medicine and Psychology, King s College London, Institute of Psychiatry, United Kingdom
    Psychiatry Res 168:238-41. 2009
    ..The Maudsley Obsessive-Compulsive Stimuli Set has excellent convergent and discriminant validity, and it will be a useful resource for OCD researchers...
  45. ncbi request reprint Medial prefrontal cortex activity associated with symptom provocation in eating disorders
    Rudolf Uher
    Institute of Psychiatry PO59, Eating Disorders Unit, King s College London, De Crespigny Park, London SE5 8AF, UK
    Am J Psychiatry 161:1238-46. 2004
    ..The authors sought to identify neural correlates of eating disorders in order to contribute to the debate on the genesis and classification of eating disorders and provide endophenotypes for genetic research...
  46. ncbi request reprint The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation
    Mary L Phillips
    Division of Psychological Medicine, Guy s, St Thomas and King s College School of Clinical Medicine and Institute of Psychiatry, London, UK
    Brain 126:669-84. 2003
    ....
  47. ncbi request reprint Chronic depersonalization following illicit drug use: a controlled analysis of 40 cases
    Nicholas Medford
    Depersonalization Research Unit and Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Addiction 98:1731-6. 2003
    ....
  48. doi request reprint Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior
    Fabrice Jollant
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Neuroimage 51:1275-81. 2010
    ..These results also add to our growing understanding of the role of the orbitofrontal cortex in decision-making and psychopathology...
  49. ncbi request reprint Ketamine and fMRI BOLD signal: distinguishing between effects mediated by change in blood flow versus change in cognitive state
    Kathryn M Abel
    Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 18:135-45. 2003
    ....
  50. ncbi request reprint Neurobiology of emotion perception I: The neural basis of normal emotion perception
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:504-14. 2003
    ..We suggest that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems...
  51. doi request reprint Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies
    Sudhakar Selvaraj
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Bipolar Disord 14:135-45. 2012
    ..We sought to address this issue using meta-analytic techniques applied for the first time in bipolar disorder at the level of the individual voxel...
  52. ncbi request reprint Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of obsessive-compulsive disorder
    Mary L Phillips
    Division of Psychological Medicine, Guy s King s and St Thomas School of Medicine and Institute of Psychiatry, London, UK
    CNS Spectr 9:275-83. 2004
    ....
  53. ncbi request reprint The spectrum of organic depersonalization: a review plus four new cases
    Michelle V Lambert
    Depersonalisation Research Unit of the Division of Psychological Medicine, Institute of Psychiatry, London
    J Neuropsychiatry Clin Neurosci 14:141-54. 2002
    ..The introduction to the DSM-IV of an organic subtype of depersonalization disorder would facilitate research in this area...
  54. ncbi request reprint Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study
    Kathryn M Abel
    Department of Psychiatry and Behavioural Sciences, Manchester University, 7th Floor, Williamson Building, Oxford Road, Manchester M13 9PL Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 14:387-91. 2003
    ..Emotional blunting may be associated with reduced limbic responses to emotional stimuli and a relative increase in the visual cortical response to neutral stimuli...
  55. ncbi request reprint Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers
    David Mataix-Cols
    Division of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:482-93. 2003
    ..The neural correlates of anxiety associated with obsessive-compulsive symptomlike provocation in normal volunteers are unknown...
  56. ncbi request reprint Perception of emotions from faces and voices following unilateral brain damage
    Katarzyna Kucharska-Pietura
    Section of Cognitive Neuropsychiatry, Division of Psychological Medicine, Institute of Psychiatry P068, De Crespigny Park, London SE5 8AF, UK
    Neuropsychologia 41:1082-90. 2003
    ..It is possible that the left hemisphere has a particular role in the perception of emotion conveyed through meaningful speech...
  57. ncbi request reprint Facial processing deficits and social dysfunction: how are they related?
    Mary L Phillips
    Brain 127:1691-2. 2004
  58. doi request reprint Orbitofrontal cortex response to angry faces in men with histories of suicide attempts
    Fabrice Jollant
    Universite Montpellier I, Institut National de la Santé et de la Recherche Médicale U 888, Centre Hospitalier Universitaire, Montpellier, France
    Am J Psychiatry 165:740-8. 2008
    ..The authors sought to elucidate the functional neural basis of the neurobiological abnormalities underlying the vulnerability to suicidal behavior...
  59. ncbi request reprint Social threat perception and the evolution of paranoia
    Melissa J Green
    Macquarie Centre for Cognitive Science, Division of Linguistics and Psychology, Macquarie University, Sydney, 2109, Australia
    Neurosci Biobehav Rev 28:333-42. 2004
    ..As such, clinical levels of paranoia may represent the inevitable cost of efficient threat perception--or 'justified' suspicion--that is necessary for survival of the human species...
  60. ncbi request reprint Depersonalisation disorder: clinical features of 204 cases
    Dawn Baker
    Hartside Unit, St Nicholas Hospital, Gosforth, Newcastle NE3 3XT, London
    Br J Psychiatry 182:428-33. 2003
    ..Depersonalisation disorder is a poorly understood and underresearched syndrome...
  61. pmc Neuroimaging in bipolar disorder: a critical review of current findings
    Matthew T Keener
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Curr Psychiatry Rep 9:512-20. 2007
    ....
  62. ncbi request reprint Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  63. pmc Identifying functional neuroimaging biomarkers of bipolar disorder: toward DSM-V
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA, USA
    Schizophr Bull 33:893-904. 2007
    ..Current and future research in bipolar disorder should focus on identification of disorder biomarkers to improve diagnostic accuracy and the mental heath of those with the disorder...
  64. ncbi request reprint Stroop performance in bipolar disorder: further evidence for abnormalities in the ventral prefrontal cortex
    Dina M Kronhaus
    Institute for Adaptive and Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh, UK
    Bipolar Disord 8:28-39. 2006
    ..We aimed to examine the relationship between functional abnormalities, impaired task performance and the severity of depressive symptoms in bipolar patients...
  65. ncbi request reprint Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW, Australia
    Am J Psychiatry 161:480-9. 2004
    ..It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and medial prefrontal activity relative to both healthy comparison subjects and patients with nonparanoid schizophrenia...
  66. pmc Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:532-9. 2008
    ..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD...
  67. ncbi request reprint Redefining bipolar disorder: toward DSM-V
    Mary L Phillips
    Am J Psychiatry 163:1135-6. 2006
  68. pmc Medication effects in neuroimaging studies of bipolar disorder
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:313-20. 2008
    ..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable...
  69. pmc Deconstructing bipolar disorder: a critical review of its diagnostic validity and a proposal for DSM-V and ICD-11
    Eduard Vieta
    Bipolar Disorders Program, Institute of Neuroscience, University of Barcelona Hospital Clinic, Barcelona, Spain
    Schizophr Bull 33:886-92. 2007
    ....
  70. doi request reprint Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
    J Affect Disord 109:117-26. 2008
    ..Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume...

Research Grants1