Genomes and Genes
Affiliation: King's College London
- Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP projectNader Perroud
MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College Lodon, London, UK
Neuropsychopharmacology 34:2517-28. 2009..Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality...
- Genome-wide pharmacogenetics of antidepressant response in the GENDEP projectRudolf Uher
Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, SE5 8AF, London, United Kingdom
Am J Psychiatry 167:555-64. 2010..The authors performed a genome-wide association analysis of improvement of depression severity with two antidepressant drugs...
- Genetic predictors of response to antidepressants in the GENDEP projectRudolf Uher
MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College London, London, UK
Pharmacogenomics J 9:225-33. 2009..The single marker associations explained only a small proportion of variance in response to antidepressants, indicating a need for a multivariate approach to prediction...
- Moderation of antidepressant response by the serotonin transporter genePatricia Huezo-Diaz
Institute of Psychiatry, King s College London, UK
Br J Psychiatry 195:30-8. 2009..We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene...
- CYP2C19 genotype predicts steady state escitalopram concentration in GENDEPPatricia Huezo-Diaz
MRC SGDP Centre, Institute of Psychiatry at King s College London, London, UK
J Psychopharmacol 26:398-407. 2012..0003; p = 0.0012 Bonferroni corrected). In conclusion, we have demonstrated an association between CYP2C19 genotype, including the CYP2C19*17 allele, and steady state escitalopram concentration...
- Adverse reactions to antidepressantsRudolf Uher
P080 SGDP, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Br J Psychiatry 195:202-10. 2009..Adverse drug reactions are important determinants of non-adherence to antidepressant treatment, but their assessment is complicated by overlap with depressive symptoms and lack of reliable self-report measures...
- Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysisKatherine E Tansey
Institute of Psychiatry, King s College London, London, UK
PLoS Med 9:e1001326. 2012..This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way...
- Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring studyNiamh Mullins
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 165:428-37. 2014..Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis...
- Genomewide association scan of suicidal thoughts and behaviour in major depressionAlexandra Schosser
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 6:e20690. 2011..Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT...
- Body weight as a predictor of antidepressant efficacy in the GENDEP projectRudolf Uher
Institute of Psychiatry, King s College London, United Kingdom
J Affect Disord 118:147-54. 2009..The present report explores the moderation of antidepressant response by body weight to establish the specificity to antidepressant mode of action, type of depressive symptoms and gender...
- Prevalence and heritability of compulsive hoarding: a twin studyAlessandra C Iervolino
Department of Psychology, King s College London, Institute of Psychiatry, London SE5 8AF, UK
Am J Psychiatry 166:1156-61. 2009..It appears to be highly prevalent and to run in families. However, this familiality could be due to genetic or environmental factors. This study examined the prevalence and heritability of compulsive hoarding in a large sample of twins...