Carmine M Pariante

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint The effects of antidepressants on the hypothalamic-pituitary-adrenal axis
    Brittany L Mason
    Institute of Psychiatry King s College London, London, UK
    Drug News Perspect 19:603-8. 2006
  2. ncbi request reprint Do antidepressants regulate how cortisol affects the brain?
    Carmine M Pariante
    Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK
    Psychoneuroendocrinology 29:423-47. 2004
  3. ncbi request reprint The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones
    Carmine M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 28:1553-61. 2003
  4. ncbi request reprint Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, PO 51, London, SE5 8AF, UK
    Psychopharmacology (Berl) 177:200-6. 2004
  5. ncbi request reprint Pituitary volume in psychosis
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:5-10. 2004
  6. pmc Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF
    Br J Pharmacol 134:1335-43. 2001
  7. doi request reprint Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
    Martino Belvederi Murri
    Institute of Psychiatry, King s College London, Department of Psychological Medicine, London, UK
    Psychoneuroendocrinology 37:629-44. 2012
  8. ncbi request reprint Different responses to dexamethasone and prednisolone in the same depressed patients
    Mario F Juruena
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Psychopharmacology (Berl) 189:225-35. 2006
  9. pmc Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression
    Livia A Carvalho
    King s College London, Section for Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Neuropsychopharmacology 33:3182-9. 2008
  10. pmc Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment
    Valeria Mondelli
    Institute of Psychiatry, King s College London, Division of Psychological Medicine, London, United Kingdom
    Schizophr Res 116:234-42. 2010

Detail Information

Publications87

  1. ncbi request reprint The effects of antidepressants on the hypothalamic-pituitary-adrenal axis
    Brittany L Mason
    Institute of Psychiatry King s College London, London, UK
    Drug News Perspect 19:603-8. 2006
    ..Finding relationships between antidepressant action and HPA regulation leads to the conclusion that the disruption of the HPA may be more a contributing factor to depression than other biological abnormalities...
  2. ncbi request reprint Do antidepressants regulate how cortisol affects the brain?
    Carmine M Pariante
    Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK
    Psychoneuroendocrinology 29:423-47. 2004
    ..Enhanced cortisol action in the brain might prove to be a successful approach to maximise therapeutic antidepressant effects...
  3. ncbi request reprint The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones
    Carmine M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 28:1553-61. 2003
    ..This work further supports the hypothesis that membrane steroid transporters regulating the access of glucocorticoids to the brain in vivo are a fundamental target for antidepressant action...
  4. ncbi request reprint Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, PO 51, London, SE5 8AF, UK
    Psychopharmacology (Berl) 177:200-6. 2004
    ..In contrast, acute antidepressant treatment induces an activation of basal HPA axis activity...
  5. ncbi request reprint Pituitary volume in psychosis
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:5-10. 2004
    ..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown...
  6. pmc Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF
    Br J Pharmacol 134:1335-43. 2001
    ..5. The membrane steroid transporters that regulate access of glucocorticoids to the brain in vivo, like the multiple drug resistance p-glycoprotein, could be a fundamental target for antidepressant action...
  7. doi request reprint Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
    Martino Belvederi Murri
    Institute of Psychiatry, King s College London, Department of Psychological Medicine, London, UK
    Psychoneuroendocrinology 37:629-44. 2012
    ..The aim of this study was to investigate the association between HPA axis activity and clinical symptoms in first-episode psychosis, taking into account diagnosis and illness phase...
  8. ncbi request reprint Different responses to dexamethasone and prednisolone in the same depressed patients
    Mario F Juruena
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Psychopharmacology (Berl) 189:225-35. 2006
    ..Patients with major depression show hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, but the mechanisms underlying this abnormality are still unclear...
  9. pmc Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression
    Livia A Carvalho
    King s College London, Section for Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Neuropsychopharmacology 33:3182-9. 2008
    ..Upcoming studies shall test whether assessing the effects of antidepressants in vitro on GR function could predict future treatment response in a clinical setting...
  10. pmc Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment
    Valeria Mondelli
    Institute of Psychiatry, King s College London, Division of Psychological Medicine, London, United Kingdom
    Schizophr Res 116:234-42. 2010
    ..Our study shows that antipsychotics normalize diurnal cortisol hyper-secretion but not the blunted cortisol awakening response in FEP; factors other than the excess of psychosocial stress explain HPA axis abnormalities in FEP...
  11. doi request reprint Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance
    Mario F Juruena
    Section of Neurobiology of Mood Disorders, PO 74, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 194:342-9. 2009
    ..People with severe depressive illness have raised levels of cortisol and reduced glucocorticoid receptor function...
  12. doi request reprint Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
    Monica Aas
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 137:73-9. 2012
    ..This points to a complex relationship between childhood trauma exposure, cognitive function and amygdala volume in first-episode psychosis...
  13. doi request reprint Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attention
    Kaylita Chantiluke
    Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Biol Psychiatry 71:59-67. 2012
    ..In this study, we investigated the neurofunctional correlates of the interplay between attention and motivation in medication-naive pediatric MDD using a rewarded sustained attention task...
  14. ncbi request reprint A novel prednisolone suppression test for the hypothalamic-pituitary-adrenal axis
    Carmine M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 51:922-30. 2002
    ....
  15. pmc Serum and gene expression profile of cytokines in first-episode psychosis
    Marco Di Nicola
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Brain Behav Immun 31:90-5. 2013
    ..002). In conclusion, first-episode psychosis is characterised by a pro-inflammatory state supported, at least in part, by activation of leukocytes. Past and recent stressors contribute to this pro-inflammatory state...
  16. pmc Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis
    Christoph Anacker
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology SPI Lab, Institute of Psychiatry, Department of Psychological Medicine, King s College London, London, UK
    Neuropsychopharmacology 38:872-83. 2013
    ..In conclusion, our data demonstrate novel molecular signaling pathways that are regulated by glucocorticoids in vitro, in human hippocampal progenitor cells, and by stress in vivo, in the rat hippocampus...
  17. pmc Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis
    Christoph Anacker
    Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 9NU, United Kingdom
    Proc Natl Acad Sci U S A 110:8708-13. 2013
    ..Our findings identify SGK1 as a mediator for the effects of cortisol on neurogenesis and GR function, with particular relevance to stress and depression...
  18. doi request reprint Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume
    Valeria Mondelli
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London
    J Clin Psychiatry 72:1677-84. 2011
    ....
  19. pmc The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment
    Mario F Juruena
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology, Institute of Psychiatry, King s College London, Department of Psychological Medicine, London, UK
    Psychoneuroendocrinology 35:1486-91. 2010
    ..Thus, we propose that the prednisolone suppression test may offer specific biological and clinical information, related to its action at both the GR and the MR...
  20. pmc A discordant monozygotic twin design shows blunted cortisol reactivity among bullied children
    Isabelle Ouellet-Morin
    Institute of Psychiatry, King s College London, London
    J Am Acad Child Adolesc Psychiatry 50:574-582.e3. 2011
    ....
  21. pmc Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids
    Carmine M Pariante
    Sections of Perinatal Psychiatry and Stress, Psychiatry and Immunology, Division of Psychological Medicine and Psychiatry Institute of Psychiatry, King s College London, London, United Kingdom
    Ann N Y Acad Sci 1179:144-52. 2009
    ..These studies do not support the notion that "high levels of glucocorticoids" always have a depressogenic effect, nor that decreasing the effects of these hormones always has an antidepressant effects...
  22. pmc Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice
    Brittany L Mason
    Institute of Pharmaceutical Science, King s College London, London, UK
    Psychoneuroendocrinology 36:1351-60. 2011
    ..Overall, under the conditions tested, these results do not support the hypothesis that treatment with desipramine can inhibit P-gp at the BBB and subsequently increase the accumulation of glucocorticoids in the brain...
  23. pmc A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice
    Brittany L Mason
    Pharmaceutical Science Research Division, King s College London, London, UK
    Endocrinology 149:5244-53. 2008
    ..Therefore, our current understanding of the role of P-gp in hypothalamic-pituitary-adrenal regulation in mice requires revision...
  24. doi request reprint The ratio of cortisol/DHEA in treatment resistant depression
    Kalypso Markopoulou
    King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, United Kingdom
    Psychoneuroendocrinology 34:19-26. 2009
    ..This study measured cortisol, DHEA and their ratio in treatment resistant depression (TRD) and healthy controls and also related these measures to treatment outcome...
  25. doi request reprint Childhood trauma and cognitive function in first-episode affective and non-affective psychosis
    Monica Aas
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Schizophr Res 129:12-9. 2011
    ..The potential impact of diagnosis (schizophrenia or affective psychosis) and gender on this association was also examined...
  26. pmc Elevated inflammation levels in depressed adults with a history of childhood maltreatment
    Andrea Danese
    Social, Genetic, and Developmental Psychiatry Centre, PO Box 080, Institute of Psychiatry, King s College London, London SE5 8AF, England
    Arch Gen Psychiatry 65:409-15. 2008
    ..The association between depression and inflammation is inconsistent across research samples...
  27. ncbi request reprint [The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression]
    Mario F Juruena
    Division of Psychological Medicine, Section of Neurobiology of Mood Disorders, Institute of Psychiatry, University of London, London, UK
    Rev Bras Psiquiatr 26:189-201. 2004
    ..Because the effects of glucocorticoids are mediated by intracellular receptors including, most notably, the glucocorticoid receptor (GR), several studies have examined the number and/or function of GRs in depressed patients...
  28. doi request reprint In vitro modulation of the glucocorticoid receptor by antidepressants
    Livia A Carvalho
    Section and Laboratory of Stress, Psychiatry and Immunology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Stress 11:411-24. 2008
    ..We suggest that the study of the effects of antidepressants on glucocorticoid function might help clarify the therapeutic action of these drugs...
  29. doi request reprint Stress abnormalities in individuals at risk for psychosis: a review of studies in subjects with familial risk or with "at risk" mental state
    Giuliano Aiello
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Psychoneuroendocrinology 37:1600-13. 2012
    ..Possible causes and consequences of HPA axis impairment in risk for psychosis are discussed...
  30. doi request reprint Maternal psychopathology and infant development at 18 months: the impact of maternal personality disorder and depression
    Susan Conroy
    Kings College London, Institute of Psychiatry, London SE5 8AF, U K
    J Am Acad Child Adolesc Psychiatry 51:51-61. 2012
    ..We set out to examine whether maternal PD and depression assessed at 2 months post partum would be independently associated with adverse developmental outcomes at 18 months of age...
  31. pmc Glucocorticoids, cytokines and brain abnormalities in depression
    Patricia A Zunszain
    Stress, Psychiatry and Immunology Laboratory SPI Lab, Department of Psychological Medicine, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, SE59NU London, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 35:722-9. 2011
    ..However, further studies are needed to clarify the relative contribution of glucocorticoids and inflammatory signals to MD and other disorders...
  32. pmc Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
    Valeria Mondelli
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 119:75-8. 2010
    ..Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion...
  33. pmc Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters
    Carmine M Pariante
    Section of Clinical Neuropharmacology, PO 51, Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, London, SE5 8AF
    Br J Pharmacol 139:1111-8. 2003
    ..Moreover, fluoxetine (10 micro M) induces approximately 30% inhibition of PGP activity in Caco-2 cells. 4. Our results show that fluoxetine, like other antidepressants, inhibits membrane steroid transporters...
  34. ncbi request reprint The glucocorticoid receptor: part of the solution or part of the problem?
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK c pariante kcl ac uk
    J Psychopharmacol 20:79-84. 2006
    ..On the contrary, this paper concludes that a lack of the 'positive' effects of cortisol on the brain, because of glucocorticoid resistance, is likely to be involved in the pathogenesis of depression...
  35. doi request reprint Antenatal depression and offspring psychopathology: the influence of childhood maltreatment
    Susan Pawlby
    Section of Perinatal Psychiatry, PO Box 71, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 199:106-12. 2011
    ..Antenatal depression and childhood maltreatment have each been associated with offspring psychopathology, but have never been examined in the same sample...
  36. doi request reprint The role of immune genes in the association between depression and inflammation: a review of recent clinical studies
    Chiara Bufalino
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Brain Behav Immun 31:31-47. 2013
    ..However, future studies are necessary to identify the molecular mechanisms underlying these associations...
  37. doi request reprint The role of mineralocorticoid receptor function in treatment-resistant depression
    Mario F Juruena
    1King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, London, UK
    J Psychopharmacol 27:1169-79. 2013
    ..This study aimed to evaluate the functional activity of the mineralocorticoid receptor system in regulating the hypothalamic-pituitary-adrenal axis in well-defined treatment-resistant depression patients...
  38. pmc Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
    Nilay Hepgul
    Section of Perinatal Psychiatry and Stress, Department of Psychological Medicine, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, London, SE5 9NU, UK
    BMC Med 11:28. 2013
    ..Taken together, these findings highlight the use of peripheral blood gene expression as a clinically relevant biomarker approach...
  39. doi request reprint Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review
    Sara Baraldi
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, England
    J Clin Psychopharmacol 32:531-43. 2012
    ..The main limitation of our review is that the quality of the findings varied across the reviewed studies. Our observations may help clinicians with managing IFN-α-induced depression...
  40. pmc Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis
    Patricia A Zunszain
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology SPI Lab, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 37:939-49. 2012
    ..Our results suggest that inhibition of the kynurenine pathway may provide a new therapy to revert inflammatory-induced reduction in neurogenesis...
  41. doi request reprint Pharmacogenetic studies of change in cortisol on ecstasy (MDMA) consumption
    Kim Wolff
    King s College London, Institute of Psychiatry, Addiction Department, London, UK
    J Psychopharmacol 26:419-28. 2012
    ....
  42. pmc Association Between Symptom Dimensions and Categorical Diagnoses of Psychosis: A Cross-sectional and Longitudinal Investigation
    Manuela Russo
    The work was carried out at the Department of Psychosis Studies, Institute of Psychiatry, King s College London
    Schizophr Bull 40:111-9. 2014
    ..This hierarchical model was stable over time and showed good concordance with categorical diagnoses. The combined use of dimensional and categorical approach to psychotic disorders would be of clinical and research utility. ..
  43. doi request reprint White matter integrity as a predictor of response to treatment in first episode psychosis
    Tiago Reis Marques
    1 Department of Psychosis Studies, Institute of Psychiatry, King s College London, UK
    Brain 137:172-82. 2014
    ..These findings can inform patient stratification to anticipate care needs, and raise the possibility that antipsychotics may restore white matter integrity as part of the therapeutic response. ..
  44. doi request reprint Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain
    Rowena Handley
    Department of Psychosis Studies, King s College London, Institute of Psychiatry, United Kingdom
    Hum Brain Mapp 34:272-82. 2013
    ....
  45. ncbi request reprint Glucocorticoid receptor function in vitro in patients with major depression
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
    Stress 7:209-19. 2004
    ....
  46. doi request reprint Pituitary volume in unaffected relatives of patients with schizophrenia and bipolar disorder
    Valeria Mondelli
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Psychoneuroendocrinology 33:1004-12. 2008
    ..The aim of this study was to assess the contribution of familial liability to pituitary volume in schizophrenia and bipolar disorder. Pituitary volume may be an indirect measure of HPA axis activity...
  47. doi request reprint The HPA axis in major depression: classical theories and new developments
    Carmine M Pariante
    Institute of Psychiatry, King s College London, Division of Psychological Medicine and Psychiatry, Centre for the Cellular Basis of Behaviour, London, UK
    Trends Neurosci 31:464-8. 2008
    ....
  48. ncbi request reprint Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Division of Psychological Medicine, Clinical Neuropharmacology PO51, Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK
    Neuropsychopharmacology 30:1923-31. 2005
    ..This activation of the hormonal stress response could participate to the important metabolic abnormalities observed in patients with psychosis...
  49. ncbi request reprint Neuroendocrine effects of citalopram infusion in anorexia nervosa
    Valeria Mondelli
    Section of Psychiatry, Department of Neuroscience, University of Turin, Italy
    Psychoneuroendocrinology 31:1139-48. 2006
    ....
  50. doi request reprint The role of multi-drug resistance p-glycoprotein in glucocorticoid function: studies in animals and relevance in humans
    Carmine M Pariante
    Section and Laboratory of Stress, Psychiatry and Immunology SPI Lab, Institute of Psychiatry, Kings College London, United Kingdom
    Eur J Pharmacol 583:263-71. 2008
    ..We believe that the interaction between antidepressants and multi-drug resistance p-glycoprotein is one of the most potentially exciting developments in psychopharmacological research...
  51. doi request reprint Mind-mindedness and maternal responsiveness in infant-mother interactions in mothers with severe mental illness
    S Pawlby
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1861-9. 2010
    ..Previous cross-diagnosis studies of interaction between mothers with severe mental illness and their babies have concluded that mothers with schizophrenia have deficits in interaction, but these studies have not included healthy controls...
  52. ncbi request reprint Glial cell abnormalities in major psychiatric disorders: the evidence and implications
    D R Cotter
    Section of Experimental Neuropathology and Psychiatry, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
    Brain Res Bull 55:585-95. 2001
    ..The potential therapeutic impact of agents which up-regulate glial activity or normalise glial cell numbers is also discussed...
  53. ncbi request reprint Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  54. pmc Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms
    L A Carvalho
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology Laboratory, King s College London, Institute of Psychiatry, London, UK
    Eur Neuropsychopharmacol 20:379-87. 2010
    ..Furthermore, it also points towards a possible mechanism by which one maybe able to overcome treatment-resistant depression. Research in this field will lead to new insights into the pathophysiology and treatment of affective disorders...
  55. doi request reprint Inflammation and depression
    Patricia A Zunszain
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Curr Top Behav Neurosci 14:135-51. 2013
    ..Further understanding of pathways involved is still needed. This will be vital for the identification of new drug targets and preventative strategies...
  56. doi request reprint Understanding clinical risk decision making regarding development of depression during interferon-alpha treatment for hepatitis-C: a qualitative interview study
    Nilay Hepgul
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Int J Nurs Stud 49:1480-8. 2012
    ..However, little is known about how clinical nurse specialists identify patients at risk of developing interferon-alpha-induced depression, and monitor those receiving antiviral treatment for the occurrence of depression...
  57. doi request reprint The dietary pattern of patients with schizophrenia: a systematic review
    Salvatore Dipasquale
    Institute of Psychiatry, King s College London, Department of Psychological Medicine, London, UK
    J Psychiatr Res 47:197-207. 2013
    ....
  58. doi request reprint Central glucocorticoid receptor-mediated effects of the antidepressant, citalopram, in humans: a study using EEG and cognitive testing
    Carmine M Pariante
    Department of Psychological Medicine, Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology Laboratory SPI Lab, Institute of Psychiatry, King s College London, London, UK
    Psychoneuroendocrinology 37:618-28. 2012
    ..Our study further emphasizes the importance of the GR as a target for antidepressant action in humans...
  59. ncbi request reprint Pituitary volume in psychosis: the first review of the evidence
    Carmine M Pariante
    Section and Laboratory of Stress, Psychiatry and Immunology SPI Lab, Department of Psychological Medicine, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, London, UK
    J Psychopharmacol 22:76-81. 2008
    ..Future studies should address these issues that are relevant in improving the care of patients with psychosis...
  60. pmc The glucocorticoid receptor: pivot of depression and of antidepressant treatment?
    Christoph Anacker
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour CCBB, Department of Psychological Medicine, Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology SPI Lab, 125 Coldharbour Lane, London SE5 9NU, UK
    Psychoneuroendocrinology 36:415-25. 2011
    ..We will review some of the evidence for modulation of the GR by antidepressants and we will provide further insight into how antidepressants may regulate the GR to overcome depressive symptoms...
  61. ncbi request reprint The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, London, United Kingdom
    Endocrinology 140:4359-66. 1999
    ....
  62. ncbi request reprint The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, UK
    J Endocrinol 169:309-20. 2001
    ..Moreover, RU40555, like RU486, is an effective GR antagonist. Finally, there is no evidence that the intracellular concentrations of RU40555 or RU486 are regulated by the steroids membrane transporter in L929 cells...
  63. doi request reprint Mother-infant interaction in mother and baby unit patients: before and after treatment
    Maeve Kenny
    PO 71, Section of Perinatal Psychiatry, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Psychiatr Res 47:1192-8. 2013
    ....
  64. ncbi request reprint Psychopharmacological treatment of depression, anxiety, irritability and insomnia in patients receiving interferon-alpha: a prospective case series and a discussion of biological mechanisms
    Clementine Maddock
    Maudsley Hospital, London, UK
    J Psychopharmacol 18:41-6. 2004
    ..Thus, psychopharmacological management can successfully treat psychiatric symptoms in patients who are receiving IFN-alpha...
  65. ncbi request reprint Depression, stress and the adrenal axis
    Carmine M Pariante
    Institute of Psychiatry, King s College London, London, UK
    J Neuroendocrinol 15:811-2. 2003
    ..Moreover, antidepressants directly regulate HPA axis function. These novel findings are reshaping our understanding of the causes and treatment of this disabling disorder...
  66. ncbi request reprint The metabolic implications of long term cannabis use in patients with psychosis
    Farrah Mushtaq
    Institute of Psychiatry, King s College London, Division of Psychological Medicine, London, United Kingdom
    Epidemiol Psichiatr Soc 17:221-6. 2008
    ....
  67. doi request reprint Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers
    Izabela Guimarães Barbosa
    Programa de Pós Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Affect Disord 137:151-5. 2012
    ..We aimed to investigate the executive performance of BD type I euthymic patients and its relation with the plasma levels of BDNF, TNF-α and its related soluble receptors (sTNFR1 and sTNFR2)...
  68. pmc Up-beat UK: a programme of research into the relationship between coronary heart disease and depression in primary care patients
    Andre Tylee
    Health Services and Population Research Dept, Institute of Psychiatry, King s College London, UK
    BMC Fam Pract 12:38. 2011
    ..We aim to explore the relationship between coronary heart disease and depression in a primary care population and to develop an intervention for patients with coronary heart disease and depression...
  69. doi request reprint Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls
    Rozmin Halari
    Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 50:307-16. 2009
    ..This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control...
  70. pmc Childhood maltreatment predicts adult inflammation in a life-course study
    Andrea Danese
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre and Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 104:1319-24. 2007
    ..Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult health...
  71. pmc Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment
    S J Bull
    King s College London, Section and Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Mol Psychiatry 14:1095-104. 2009
    ....
  72. doi request reprint Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line
    K Sugden
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1253-9. 2010
    ..In conclusion, care must be taken when choosing reference transcripts for analysis in qPCR. For in-vitro pharmacological studies, it should not be assumed that 'housekeeping' genes are stable...
  73. ncbi request reprint Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..We examined pituitary volume before the onset of psychosis in subjects who were at ultra-high risk (UHR) for developing psychosis...
  74. ncbi request reprint [Depression and stress: is there an endophenotype?]
    Andrea Feijo Mello
    Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil, and Programa de Pesquisas em Transtornos do Humor, Hospital Butler, USA
    Rev Bras Psiquiatr 29:S13-8. 2007
    ..To review the new findings about stress, hypothalamic-pituitary-adrenal axis and depression trying to explain a possible endophenotype prone to depression...
  75. ncbi request reprint The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    Joyce L W Yau
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 32:2520-9. 2007
    ..These data support the notion that the MDR PGP is one of the molecular targets through which antidepressants regulate the HPA axis...
  76. ncbi request reprint Manic episode associated with citalopram therapy for interferon-induced depression in a patient with chronic hepatitis C infection
    Po Lun Wu
    Gen Hosp Psychiatry 29:374-6. 2007
  77. ncbi request reprint A crossover study of prolactin changes associated with risperidone and olanzapine
    Cher Yeang Lin
    J Clin Psychiatry 67:1470. 2006
  78. ncbi request reprint Stress and the progression of the developmental hypothesis of schizophrenia
    David Cotter
    Br J Psychiatry 181:363-5. 2002
  79. ncbi request reprint Interferon alfa-induced adverse effects in patients with a psychiatric diagnosis
    Carmine M Pariante
    N Engl J Med 347:148-9. 2002
  80. ncbi request reprint Perception of psychosis in patients, therapists, and the public
    Carmine M Pariante
    Epidemiol Psichiatr Soc 13:211-2. 2004
  81. ncbi request reprint Depression and liver diseases
    M Germana Orrù
    Psychiatric Cinic, University of Cagliari, Italy
    Dig Liver Dis 37:564-5. 2005
  82. ncbi request reprint Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial
    Kuan Pin Su
    Department of Psychiatry and Mind Body Interface Research Centre, China Medical University Hospital, Taichung, Taiwan
    J Clin Psychiatry 69:644-51. 2008
    ..In this study, we examined the efficacy of omega-3 PUFA monotherapy for the treatment of depression during pregnancy...
  83. ncbi request reprint Controversies in antidepressant therapy
    Carmine M Pariante
    Epidemiol Psichiatr Soc 14:51-4. 2005
  84. ncbi request reprint A crossover study on lipid and weight changes associated with olanzapine and risperidone
    Kuan Pin Su
    Department of General Psychiatry, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Psychopharmacology (Berl) 183:383-6. 2005
    ..The crossover design can minimize the influence of individual variation in metabolic profiles and demographic variables, such as age, sex, concomitant medication use and personal life styles...
  85. ncbi request reprint [Interferon-alpha-induced psychiatric side effects in patients with chronic viral hepatitis: a prospective, observational, controlled study]
    M Germana Orrù
    Clinica Psichiatrica, Universita degli Studi di Cagliari, Cagliari, Italy
    Epidemiol Psichiatr Soc 14:145-53. 2005
    ..They also examined the psychopharmacological management of the interferon-alpha-induced psychiatric side effects...
  86. ncbi request reprint Different cutoff points for different trimesters? The use of Edinburgh Postnatal Depression Scale and Beck Depression Inventory to screen for depression in pregnant Taiwanese women
    Kuan Pin Su
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Gen Hosp Psychiatry 29:436-41. 2007
    ....
  87. ncbi request reprint A pilot observational crossover study of QTc interval changes associated with switching between olanzapine and risperidone
    Chieh Liang Huang
    J Clin Psychiatry 68:803-5. 2007