José L Orgaz
Affiliation: King's College London
- Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factorJosé L Orgaz
Department of Biochemistry, Universidad Autónoma de Madrid UAM and Instituto de Investigaciones Biomédicas Alberto Sols, CSIC UAM, Madrid, Spain
Melanoma Res 21:285-97. 2011..Our study identifies new molecular targets and signaling pathways that may potentially contribute to determine PEDF's ability to restrict the aggressiveness of A375 human melanoma cells...
- (V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanismPablo Baquero
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
Cancer Lett 335:232-41. 2013..These results reveal a novel (V600E)BRAF-induced mechanism in thyroid tumours progression and provides a rationale for using the PLX4720 inhibitor to target (V600E)BRAF signalling to effectively control progression of thyroid cancer...