John O'Grady

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Treatment options for other hepatic malignancies
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 6:S23-9. 2000
  2. doi Liver transplantation for acute liver failure
    John O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    Best Pract Res Clin Gastroenterol 26:27-33. 2012
  3. ncbi Personal view: current role of artificial liver support devices
    J O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Aliment Pharmacol Ther 23:1549-57. 2006
  4. ncbi Corticosteroid-free strategies in liver transplantation
    John G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Drugs 66:1853-62. 2006
  5. pmc Liver transplantation alcohol related liver disease: (deliberately) stirring a hornet's nest!
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Gut 55:1529-31. 2006
  6. ncbi Randomized controlled trial of tacrolimus versus microemulsified cyclosporin (TMC) in liver transplantation: poststudy surveillance to 3 years
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Am J Transplant 7:137-41. 2007
  7. ncbi Modern management of acute liver failure
    John O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    Clin Liver Dis 11:291-303. 2007
  8. doi Multidisciplinary insights into optimizing adherence after solid organ transplantation
    John G M O'Grady
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Transplantation 89:627-32. 2010
  9. doi Postoperative issues and outcome for acute liver failure
    John G O'Grady
    King s College Hospital, Denmark Hill, London, United Kingdom
    Liver Transpl 14:S97-101. 2008
  10. doi The immunoreactive patient: Rejection and autoimmune disease
    John O'Grady
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 17:S29-33. 2011

Collaborators

Detail Information

Publications42

  1. ncbi Treatment options for other hepatic malignancies
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 6:S23-9. 2000
    ..5. Liver transplantation has been successfully applied to a range of rare hepatic malignancies, but small numbers preclude strong recommendations on the appropriateness of this practice...
  2. doi Liver transplantation for acute liver failure
    John O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    Best Pract Res Clin Gastroenterol 26:27-33. 2012
    ..Although the outcomes after liver transplantation are good the survival rates do not quite match those achieved after elective transplantation...
  3. ncbi Personal view: current role of artificial liver support devices
    J O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Aliment Pharmacol Ther 23:1549-57. 2006
    ..It is very clear that randomized controlled trials are mandatory to establish clinical efficacy, but it is less clear how the ideal trial should be constructed...
  4. ncbi Corticosteroid-free strategies in liver transplantation
    John G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Drugs 66:1853-62. 2006
    ..The effect of corticosteroid-free immunosuppression in hepatitis C liver transplant recipients is yet to be resolved...
  5. pmc Liver transplantation alcohol related liver disease: (deliberately) stirring a hornet's nest!
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Gut 55:1529-31. 2006
    ..A better understanding of the issues influencing these outcomes should decrease the tension that currently exists between patient expectations, professional opinion, and the attitude of the general public who gift organs for donation...
  6. ncbi Randomized controlled trial of tacrolimus versus microemulsified cyclosporin (TMC) in liver transplantation: poststudy surveillance to 3 years
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, London, UK
    Am J Transplant 7:137-41. 2007
    ..The TMC study confirms after 3 years of follow-up the benefits of tacrolimus-based immunosuppression over cyclosporin using C(0) monitoring...
  7. ncbi Modern management of acute liver failure
    John O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    Clin Liver Dis 11:291-303. 2007
    ..The potential for liver support devices to have an impact on the need for liver transplantation and outcomes after transplantation remains exciting...
  8. doi Multidisciplinary insights into optimizing adherence after solid organ transplantation
    John G M O'Grady
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Transplantation 89:627-32. 2010
    ..Despite its importance, there is a lack of common understanding across the disciplines involved of the key issues driving nonadherence...
  9. doi Postoperative issues and outcome for acute liver failure
    John G O'Grady
    King s College Hospital, Denmark Hill, London, United Kingdom
    Liver Transpl 14:S97-101. 2008
    ..5. Multiple factors have an influence on outcome, and risk stratification is beginning to emerge...
  10. doi The immunoreactive patient: Rejection and autoimmune disease
    John O'Grady
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 17:S29-33. 2011
    ..5. Patterns of primary sclerosing cholangitis recurrence are not affected by immunosuppression. 6. Autoimmune hepatitis recurrence and de novo autoimmune hepatitis are corticosteroid-responsive in most cases...
  11. pmc Acute liver failure
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9PJ, UK
    Postgrad Med J 81:148-54. 2005
    ..The optimal care is multidisciplinary and up to half of the cases receive liver transplants, with survival rates around 75%-90%. Artificial liver support devices remain unproven in efficacy in acute liver failure...
  12. ncbi Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial
    J G O'Grady
    Institute of Liver Studies, King s College Hospital, Denmark Hill, SE5 9RS, London, UK
    Lancet 360:1119-25. 2002
    ..The aim of our study was to compare tacrolimus with microemulsified ciclosporin, in a regimen with standardised concomitant immunosuppressive therapy...
  13. doi Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 19:383-94. 2013
    ..Selected miRNAs may serve as intragraft and serum biomarkers for recurrent HCV after LT and help to distinguish between ACR and recurrent HCV...
  14. doi The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 33:53-61. 2013
    ..An association between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) is well recognized. However, the disease course of IBD following liver transplantation (LT) for PSC remains ill-defined...
  15. ncbi Evidence of differential risk for posttransplantation malignancy based on pretransplantation cause in patients undergoing liver transplantation
    Sanjiv Saigal
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 8:482-7. 2002
    ..Although the incidence of de novo nonlymphoid malignancy after liver transplantation is low, patients who underwent transplantation for alcoholic cirrhosis appear to have an increased risk for developing posttransplantation malignancy...
  16. ncbi Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B
    Sanjiv Saigal
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Transpl Int 15:369-73. 2002
    ..Auxiliary partial orthotopic liver transplantation is an attractive treatment option in acute liver failure due to hepatitis B infection and allows a life free of long-term immunosuppression...
  17. ncbi Hepatitis B virus genotype A and D and clinical outcomes of liver transplantation for HBV-related disease
    Raffaele Girlanda
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London
    Liver Transpl 10:58-64. 2004
    ..In conclusion, HBV genotype A and D did not have a significant impact on clinical outcomes of LT for HBV-related liver disease in patients of European origin. These data do not support routine HBV genotyping in liver transplantation...
  18. doi Simultaneous combined liver and kidney transplantation: a single center experience
    Srinivas P Chava
    Institute of Liver Studies, King s College Hospital, Denmark Hill, SE5 9RS London, UK
    Clin Transplant 24:E62-8. 2010
    ..The rate of acute rejection episodes of kidney is low. Significant proportion develops long-term mild/moderate renal dysfunction. Careful attention to immunosuppression to minimize nephrotoxicity may help...
  19. pmc Single-center experience with liver transplantation from controlled non-heartbeating donors: a viable source of grafts
    Paolo Muiesan
    Department of Liver Transplantation and HPB Surgery, King s College Hospital, London, UK
    Ann Surg 242:732-8. 2005
    ..To increase the number of livers available for transplantation a non-heartbeating donor (NHBD) liver transplant program was started after obtaining hospital ethical committee approval...
  20. ncbi Liver transplantation for Budd-Chiari syndrome
    Parthi Srinivasan
    Institute of Liver Studies, Kings College Hospital, London SE5 9RS, United Kingdom
    Transplantation 73:973-7. 2002
    ..Budd-Chiari syndrome (BCS) is a clinical condition characterized by hepatic venous outflow obstruction secondary to an underlying systemic predisposition to thrombosis...
  21. doi Liver transplantation in human immunodeficiency virus-infected patients: procoagulant, but is antithrombotic prophylaxis required?
    P Thomas Cherian
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 18:82-8. 2012
    ..2%, P = 0.016 (Fisher's exact test)]. The minimization of complex arterial reconstruction, coagulopathy screening, and risk-adapted antithrombotic chemoprophylaxis appear to be reasonable precautions...
  22. doi Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study
    Constantine J Karvellas
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 30:826-33. 2010
    ..Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK. Patients often consume the drug with suicidal intent or with a background of substance dependence...
  23. ncbi Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT
    Ioannis Kyrlagkitsis
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Am J Gastroenterol 98:1588-93. 2003
    ..We performed a retrospective review of patients with chronic HCV infection and persistently normal ALT to compare clinical and histological features with those in patients with abnormal liver biochemistry...
  24. ncbi Bile duct strictures after adult liver transplantation: a role for biliary reconstructive surgery?
    Robert Sutcliffe
    Liver Transplant Unit, King s College Hospital, London, UK
    Liver Transpl 10:928-34. 2004
    ..In patients presenting with bile duct strictures late after transplantation, surgery should be reserved for selected patients without histological evidence of graft fibrosis (moderate-severe) or significant nonbiliary pathology...
  25. doi Hereditary fibrinogen A alpha-chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation
    Arie J Stangou
    Institute of Liver Studies and Amyloidosis Treatment Centre, King s College Hospital, London SE5 9RS, United Kingdom
    Blood 115:2998-3007. 2010
    ..Our data encourage evaluation of preemptive solitary liver transplantation early in the course of amyloid nephropathy to prevent hemodialysis and kidney transplantation...
  26. pmc Outcome of liver transplantation for haemophilia
    Satoshi Yokoyama
    King s College London School of Medicine at King s College Hospital, Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    HPB (Oxford) 13:40-5. 2011
    ..Prior to routine screening of blood products many patients with haemophilia were infected with hepatitis C virus (HCV) and have subsequently gone on to develop end-stage liver disease (ESLD)...
  27. doi Liver transplantation in human immunodeficiency virus-positive patients
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, SE5 9RS, UK
    Liver Transpl 17:881-90. 2011
    ..Because the burden of liver disease in this cohort is likely to increase, this review addresses the key etiologies and the management strategies available for HIV-positive patients undergoing LT...
  28. ncbi How we treat sickle hepatopathy and liver transplantation in adults
    Kate Gardner
    Division of Cancer Studies, Molecular Haematology, King s College London School of Medicine, London, United Kingdom
    Blood 123:2302-7. 2014
    ..Future work must concentrate on not only investigating the underlying pathogenesis, but also identifying in whom and when to intervene with the 2 treatment modalities available: EBT and liver transplantation...
  29. ncbi Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis--a randomised clinical trial
    Martin Phillips
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 44:784-90. 2006
    ..The perceived need for alternative treatments together with the theoretical benefits of anti-oxidant therapy triggered the design of a randomised clinical trial comparing these treatment modalities...
  30. doi Spontaneous rupture of hepatocellular carcinoma: a Western experience
    Narendra Battula
    Institute of Liver Studies, King s College London School of Medicine, King s College Hospital, Denmark Hill, Camberwell, London, UK
    Am J Surg 197:164-7. 2009
    ..The reported overall mortality is < or =50% in Asian countries, where the incidence is 12% to 14%. The aim of this study was to report a single center's experience of patients with ruptured HCC during a 11-year period...
  31. doi Iron and acetaminophen a fatal combination?
    Vinod K Audimoolam
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 24:e85-8. 2011
    ..Despite maximum supportive care including liver transplantation in two cases, all patients died. Iron poisoning may have an additive toxic effect in drug-induced acute liver failure and worsen outcome...
  32. ncbi CXCL10 levels identify individuals with rapid fibrosis at 12 months post-transplant for hepatitis C virus and predict treatment response
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Clin Transplant 28:569-78. 2014
    ..We hypothesized that CXCL10 levels can distinguish between slow and fast fibrosis progression at 12 months, development of F ≥ 4 post-transplantation, and help predict treatment response in patients undergoing AVT...
  33. doi Donor-transmitted malignancy confirmed by quantitative fluorescence polymerase chain reaction genotype analysis: a rare indication for liver retransplantation
    Katie Snape
    Department of Neurology, Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
    Liver Transpl 14:155-8. 2008
  34. ncbi Treatment of refractory cerebral aspergillosis in a liver transplant recipient with voriconazole: case report and review of the literature
    Thomas Cherian
    Institute of Liver Studies, King s College Hospital, London, UK
    Exp Clin Transplant 10:482-6. 2012
    ..Voriconazole yields fungicidal drug concentrations within the central nervous system, but use of this drug is limited in liver transplant recipients because of hepatotoxicity and drug interactions...
  35. doi Mixed phenotype hepatocellular carcinoma after transarterial chemoembolization and liver transplantation
    Chikako Zen
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 17:943-54. 2011
    ..Further studies are needed to investigate the potential relationships between TACE and HCC subpopulations with a chemoembolization-resistant phenotype and their clinical significance...
  36. ncbi Outcome of liver transplantation in hereditary hemochromatosis
    Faisal S Dar
    Kings College London School of Medicine, Institute of Liver Studies, Kings College Hospital, London, SE5 9RS, UK
    Transpl Int 22:717-24. 2009
    ..Improved survival post-LT reflects changes in selection, disease modification through venesection, and improvement in immunosuppression...
  37. doi Increasing burden of liver disease in patients with HIV infection
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 377:1198-209. 2011
    ..We provide an overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation...
  38. ncbi Liver transplantation for HCV-related cirrhosis in a patient with gastric mucosa-associated lymphoma (MALToma) pretreated with rituximab
    Matthew R Foxton
    Institute of Liver Studies, King s College Hospital, London SE5 9RS, UK
    Liver Transpl 11:839-42. 2005
    ..Rituximab may be useful in preventing progression of NHL until surgical extirpation is possible...
  39. ncbi Piperacillin-tazobactam versus ciprofloxacin plus amoxicillin in the treatment of infective episodes after liver transplantation
    John Philpott-Howard
    Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, Bessemer Road, London SE5 9PJ, UK
    J Antimicrob Chemother 52:993-1000. 2003
    ..Empirical monotherapy with piperacillin-tazobactam is an effective treatment for infective episodes in liver transplant patients...
  40. ncbi Hepatic expression of IL-15 mRNA is associated with liver graft acceptance
    Sharon Cookson
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    Transpl Immunol 11:39-48. 2003
    ..The aim of this study was to investigate the local expression of a range of immunomodulatory molecules which may be mediating rejection of, or tolerance to, liver allografts...
  41. ncbi Human plasma fibrinogen is synthesized in the liver
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    Blood 109:1971-4. 2007
    ..After transplantation, only the wild-type sequence was detected, and the liver is thus the source of at least 98% of the circulation fibrinogen...
  42. ncbi Acute hepatitis A virus infection: a review of prognostic factors from 25 years experience in a tertiary referral center
    Ioannis Kyrlagkitsis
    Institute of Liver Studies, King s College Hospital, London SE5 9RS, UK
    Hepatogastroenterology 49:524-8. 2002
    ..Hepatitis A is usually a mild, self-limiting illness but can result in severe or fatal disease. We reviewed 25 years experience to determine what factors predispose to severe or fatal disease...