P J Norman

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Genes Immun 3:86-95. 2002
  2. ncbi request reprint Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Immunogenetics 52:195-205. 2001
  3. ncbi request reprint DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
    Immunogenetics 55:165-71. 2003
  4. pmc Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations
    M A Hall
    Molecular Immunogenetics Unit, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 70:1172-82. 2002
  5. ncbi request reprint Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters
    S J Moodie
    Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
    Eur J Immunogenet 29:287-91. 2002
  6. ncbi request reprint Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 39:1092-9. 2007
  7. ncbi request reprint High KIR diversity in Amerindians is maintained using few gene-content haplotypes
    Ketevan Gendzekhadze
    Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
    Immunogenetics 58:474-80. 2006
  8. ncbi request reprint SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
    Immunogenetics 56:225-37. 2004
  9. pmc Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
  10. ncbi request reprint A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry
    Christine V F Carrington
    Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
    Hum Immunol 63:1045-54. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Genes Immun 3:86-95. 2002
    ..0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations...
  2. ncbi request reprint Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Immunogenetics 52:195-205. 2001
    ..The A haplotype was always the most prevalent, but the ratio of A to B varied between populations. The frequency of B haplotype was highest in the Palestinians and lowest in the Thais (Pc<0.0001)...
  3. ncbi request reprint DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
    Immunogenetics 55:165-71. 2003
    ..Six alleles were present in this group but they were unevenly distributed, as three alleles accounted for 88% of the studied chromosomes...
  4. pmc Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations
    M A Hall
    Molecular Immunogenetics Unit, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 70:1172-82. 2002
    ..More generally, these data show the power of an integrated human gene-mapping approach for heritable molecular phenotypes, using large pedigrees that have been extensively genotyped...
  5. ncbi request reprint Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters
    S J Moodie
    Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
    Eur J Immunogenet 29:287-91. 2002
    ..A transmission disequilibrium test also found no association of the A and B KIR haplotypes or the LILRA3 gene deletion with coeliac disease...
  6. ncbi request reprint Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 39:1092-9. 2007
    ..Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression...
  7. ncbi request reprint High KIR diversity in Amerindians is maintained using few gene-content haplotypes
    Ketevan Gendzekhadze
    Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
    Immunogenetics 58:474-80. 2006
    ..Here is clear evidence for balancing selection on the KIR system and the biological importance of both A and B haplotypes for the survival of human populations...
  8. ncbi request reprint SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
    Immunogenetics 56:225-37. 2004
    ..The different natural selection pressures acting on each locus may have contributed to a lack of linkage disequilibrium between them...
  9. pmc Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
    ..These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity...
  10. ncbi request reprint A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry
    Christine V F Carrington
    Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
    Hum Immunol 63:1045-54. 2002
    ..Trinidad South Asians displayed similar allele frequencies and associations to other populations from Northern India...
  11. ncbi request reprint Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors
    Paul J Norman
    Departments of Structural Biology and Microbiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    Semin Hematol 42:65-75. 2005
    ..The functional variety of natural immune responses that are controlled by HLA and KIR interactions is genetically determined and maintained by natural selection...
  12. ncbi request reprint A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines
    Mark A Cook
    Cancer Research, UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Hum Immunol 64:567-71. 2003
    ..Further improvements in typing may be required if population and clinical studies are to produce accurate results...
  13. ncbi request reprint Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins
    Laurent Abi-Rached
    Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:7943-54. 2007
    ..A cluster of positively selected residues presents a putative binding site for unknown IgA-binding factors...
  14. ncbi request reprint Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3
    Achim K Moesta
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 180:3969-79. 2008
    ..This study demonstrates how allelic polymorphism at sites distal to the ligand-binding site of KIR2DL2/3 has diversified this receptor's interactions with HLA-C...
  15. ncbi request reprint Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch
    Maria Luisa Vampa
    Department of Nephrology and Transplantation, Guy s Hospital, London, United Kingdom
    Transplantation 76:1220-8. 2003
    ..This provides us with a unique opportunity to dissect the influence of KIR on NK-cell function after transplantation...