P J Norman

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Genes Immun 3:86-95. 2002
  2. ncbi Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Immunogenetics 52:195-205. 2001
  3. ncbi DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
    Immunogenetics 55:165-71. 2003
  4. ncbi Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations
    M A Hall
    Molecular Immunogenetics Unit, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 70:1172-82. 2002
  5. ncbi Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters
    S J Moodie
    Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
    Eur J Immunogenet 29:287-91. 2002
  6. ncbi Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 39:1092-9. 2007
  7. ncbi High KIR diversity in Amerindians is maintained using few gene-content haplotypes
    Ketevan Gendzekhadze
    Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
    Immunogenetics 58:474-80. 2006
  8. ncbi SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
    Immunogenetics 56:225-37. 2004
  9. ncbi Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
  10. ncbi A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry
    Christine V F Carrington
    Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
    Hum Immunol 63:1045-54. 2002

Collaborators

Detail Information

Publications15

  1. ncbi Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Genes Immun 3:86-95. 2002
    ..0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations...
  2. ncbi Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Immunogenetics 52:195-205. 2001
    ..The A haplotype was always the most prevalent, but the ratio of A to B varied between populations. The frequency of B haplotype was highest in the Palestinians and lowest in the Thais (Pc<0.0001)...
  3. ncbi DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
    Immunogenetics 55:165-71. 2003
    ..Six alleles were present in this group but they were unevenly distributed, as three alleles accounted for 88% of the studied chromosomes...
  4. ncbi Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations
    M A Hall
    Molecular Immunogenetics Unit, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 70:1172-82. 2002
    ..More generally, these data show the power of an integrated human gene-mapping approach for heritable molecular phenotypes, using large pedigrees that have been extensively genotyped...
  5. ncbi Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters
    S J Moodie
    Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
    Eur J Immunogenet 29:287-91. 2002
    ..A transmission disequilibrium test also found no association of the A and B KIR haplotypes or the LILRA3 gene deletion with coeliac disease...
  6. ncbi Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
    Paul J Norman
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 39:1092-9. 2007
    ..Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression...
  7. ncbi High KIR diversity in Amerindians is maintained using few gene-content haplotypes
    Ketevan Gendzekhadze
    Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
    Immunogenetics 58:474-80. 2006
    ..Here is clear evidence for balancing selection on the KIR system and the biological importance of both A and B haplotypes for the survival of human populations...
  8. ncbi SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex
    Paul J Norman
    Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
    Immunogenetics 56:225-37. 2004
    ..The different natural selection pressures acting on each locus may have contributed to a lack of linkage disequilibrium between them...
  9. ncbi Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
    ..These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity...
  10. ncbi A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry
    Christine V F Carrington
    Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
    Hum Immunol 63:1045-54. 2002
    ..Trinidad South Asians displayed similar allele frequencies and associations to other populations from Northern India...
  11. ncbi Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors
    Paul J Norman
    Departments of Structural Biology and Microbiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    Semin Hematol 42:65-75. 2005
    ..The functional variety of natural immune responses that are controlled by HLA and KIR interactions is genetically determined and maintained by natural selection...
  12. ncbi A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines
    Mark A Cook
    Cancer Research, UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Hum Immunol 64:567-71. 2003
    ..Further improvements in typing may be required if population and clinical studies are to produce accurate results...
  13. ncbi Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins
    Laurent Abi-Rached
    Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:7943-54. 2007
    ..A cluster of positively selected residues presents a putative binding site for unknown IgA-binding factors...
  14. ncbi Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3
    Achim K Moesta
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 180:3969-79. 2008
    ..This study demonstrates how allelic polymorphism at sites distal to the ligand-binding site of KIR2DL2/3 has diversified this receptor's interactions with HLA-C...
  15. ncbi Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch
    Maria Luisa Vampa
    Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom
    Transplantation 76:1220-8. 2003
    ....