P J Norman
Affiliation: King's College London
- Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populationsP J Norman
South Thames Tissue Typing, Guy s Hospital, London, UK
Genes Immun 3:86-95. 2002..0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations...
- Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groupsP J Norman
South Thames Tissue Typing, Guy s Hospital, London, UK
Immunogenetics 52:195-205. 2001..The A haplotype was always the most prevalent, but the ratio of A to B varied between populations. The frequency of B haplotype was highest in the Palestinians and lowest in the Thais (Pc<0.0001)...
- DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3Paul J Norman
Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
Immunogenetics 55:165-71. 2003..Six alleles were present in this group but they were unevenly distributed, as three alleles accounted for 88% of the studied chromosomes...
- Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulationsM A Hall
Molecular Immunogenetics Unit, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, United Kingdom
Am J Hum Genet 70:1172-82. 2002..More generally, these data show the power of an integrated human gene-mapping approach for heritable molecular phenotypes, using large pedigrees that have been extensively genotyped...
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clustersS J Moodie
Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
Eur J Immunogenet 29:287-91. 2002..A transmission disequilibrium test also found no association of the A and B KIR haplotypes or the LILRA3 gene deletion with coeliac disease...
- Unusual selection on the KIR3DL1/S1 natural killer cell receptor in AfricansPaul J Norman
Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Genet 39:1092-9. 2007..Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression...
- High KIR diversity in Amerindians is maintained using few gene-content haplotypesKetevan Gendzekhadze
Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA
Immunogenetics 58:474-80. 2006..Here is clear evidence for balancing selection on the KIR system and the biological importance of both A and B haplotypes for the survival of human populations...
- SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complexPaul J Norman
Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
Immunogenetics 56:225-37. 2004..The different natural selection pressures acting on each locus may have contributed to a lack of linkage disequilibrium between them...
- Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?Rasmi Thomas
Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 180:6743-50. 2008..These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity...
- A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestryChristine V F Carrington
Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
Hum Immunol 63:1045-54. 2002..Trinidad South Asians displayed similar allele frequencies and associations to other populations from Northern India...
- Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptorsPaul J Norman
Departments of Structural Biology and Microbiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
Semin Hematol 42:65-75. 2005..The functional variety of natural immune responses that are controlled by HLA and KIR interactions is genetically determined and maintained by natural selection...
- A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell linesMark A Cook
Cancer Research, UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
Hum Immunol 64:567-71. 2003..Further improvements in typing may be required if population and clinical studies are to produce accurate results...
- Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteinsLaurent Abi-Rached
Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 178:7943-54. 2007..A cluster of positively selected residues presents a putative binding site for unknown IgA-binding factors...
- Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3Achim K Moesta
Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
J Immunol 180:3969-79. 2008..This study demonstrates how allelic polymorphism at sites distal to the ligand-binding site of KIR2DL2/3 has diversified this receptor's interactions with HLA-C...
- Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatchMaria Luisa Vampa
Department of Nephrology and Transplantation, Guy s Hospital, London, United Kingdom
Transplantation 76:1220-8. 2003..This provides us with a unique opportunity to dissect the influence of KIR on NK-cell function after transplantation...