Kypros H Nicolaides

Summary

Affiliation: King's College
Country: UK

Publications

  1. ncbi request reprint Nasal bone in first-trimester screening for trisomy 21
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 195:109-14. 2006
  2. ncbi request reprint Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College, London University, Denmark Hill, London SE5 8RX
    Am J Obstet Gynecol 191:45-67. 2004
  3. ncbi request reprint First-trimester screening for chromosomal abnormalities
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College, London University, London, UK
    Semin Perinatol 29:190-4. 2005
  4. ncbi request reprint [Increased nuchal translucency with normal karyotype]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ginekol Pol 76:593-601. 2005
  5. ncbi request reprint [Sonographic features of chromosomal defects in the second trimester of pregnancy]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
    Ginekol Pol 76:528-35. 2005
  6. pmc Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down's syndrome, preterm delivery and preeclampsia
    Anne E Chambers
    Department of Clinical Biochemistry, Heartlands Hospital, Birmingham, UK
    Reprod Biol Endocrinol 10:113. 2012
  7. ncbi request reprint First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing
    K H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 42:41-50. 2013
  8. doi request reprint Validation of targeted sequencing of single-nucleotide polymorphisms for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X, and Y
    K H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 33:575-9. 2013
  9. pmc A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies
    Subhasis Banerjee
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London SE5 9RS, UK
    Reprod Biol Endocrinol 3:25. 2005
  10. ncbi request reprint Maternal plasma inhibin A at 11-13 weeks of gestation in hypertensive disorders of pregnancy
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Prenat Diagn 29:753-60. 2009

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Nasal bone in first-trimester screening for trisomy 21
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 195:109-14. 2006
    ..This study was undertaken to investigate the impact of incorporating assessment of the nasal bone into first-trimester combined screening by fetal nuchal translucency (NT) thickness and maternal serum biochemistry...
  2. ncbi request reprint Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College, London University, Denmark Hill, London SE5 8RX
    Am J Obstet Gynecol 191:45-67. 2004
    ..As with all aspects of good clinical practice, those care givers who perform first-trimester screening should be trained appropriately, and their results should be subjected to external quality assurance...
  3. ncbi request reprint First-trimester screening for chromosomal abnormalities
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College, London University, London, UK
    Semin Perinatol 29:190-4. 2005
    ..This process was well established by the Fetal Medical Foundation several years ago and is widely accepted internationally...
  4. ncbi request reprint [Increased nuchal translucency with normal karyotype]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ginekol Pol 76:593-601. 2005
    ..After 14 weeks, increased NT usually resolves but in some cases it evolves into nuchal edema or cystic hygromas...
  5. ncbi request reprint [Sonographic features of chromosomal defects in the second trimester of pregnancy]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
    Ginekol Pol 76:528-35. 2005
    ....
  6. pmc Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down's syndrome, preterm delivery and preeclampsia
    Anne E Chambers
    Department of Clinical Biochemistry, Heartlands Hospital, Birmingham, UK
    Reprod Biol Endocrinol 10:113. 2012
    ..To determine whether sLHCGR has diagnostic potential, quantitative ELISAs were developed and tested to examine the correlation between pregnancy outcome and levels of serum sLHCGR and hCG-sLHCGR complex...
  7. ncbi request reprint First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing
    K H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 42:41-50. 2013
    ....
  8. doi request reprint Validation of targeted sequencing of single-nucleotide polymorphisms for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X, and Y
    K H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 33:575-9. 2013
    ..To assess the performance of cell-free DNA (cfDNA) testing in maternal blood for detection of fetal aneuploidy of chromosomes 13, 18, 21, X, and Y using targeted sequencing of single-nucleotide polymorphisms...
  9. pmc A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies
    Subhasis Banerjee
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London SE5 9RS, UK
    Reprod Biol Endocrinol 3:25. 2005
    ..However, the synthesis of high molecular weight mature LHCGR proteins was significantly reduced in DS compared to uncompromised pregnancies, suggesting a lack of utilization of circulating hCG in DS pregnancies...
  10. ncbi request reprint Maternal plasma inhibin A at 11-13 weeks of gestation in hypertensive disorders of pregnancy
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Prenat Diagn 29:753-60. 2009
    ..To investigate the potential value of maternal plasma inhibin A in first-trimester screening for preeclampsia (PE)...
  11. ncbi request reprint Increased fetal nuchal translucency at 11-14 weeks
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, King s College London, UK
    Prenat Diagn 22:308-15. 2002
    ..As with the introduction of any new technology into routine clinical practice, it is essential that those undertaking the 11-14-week scan are adequately trained and their results are subjected to rigorous audit...
  12. doi request reprint Ductus venosus Doppler at 11 to 13 weeks of gestation in the prediction of outcome in twin pregnancies
    Nerea Maiz
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 113:860-5. 2009
    ..To examine the independent contribution of abnormal flow in the ductus venosus at 11 to 13 weeks of gestation in the prediction of adverse pregnancy outcome in relation to chorionicity...
  13. doi request reprint First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 112:1082-90. 2008
    ....
  14. doi request reprint Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age
    Catalina De Paco
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 111:292-300. 2008
    ..To investigate maternal cardiac output in the first trimester as a predictor of preeclampsia and delivery of small for gestational age (SGA) infants...
  15. doi request reprint Maternal serum placental protein 13 at eleven to thirteen weeks in chromosomally abnormal pregnancies
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 27:72-7. 2010
    ....
  16. doi request reprint Maternal thyroid function at 11-13 weeks of gestation in fetal trisomies 21 and 18
    Ghalia Ashoor
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:33-7. 2011
    ....
  17. ncbi request reprint Maternal cardiac function during pregnancy at high altitude
    Nikos A Kametas
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    BJOG 111:1051-8. 2004
    ..To investigate the maternal cardiovascular adaptation in pregnancy at high altitude, compared with that at sea level...
  18. doi request reprint Maternal arterial stiffness in pregnancies complicated by gestational and type 2 diabetes mellitus
    Makrina D Savvidou
    Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK
    Am J Obstet Gynecol 203:274.e1-7. 2010
    ..We sought to investigate whether maternal arterial stiffness is altered in pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes compared to normoglycemic women...
  19. ncbi request reprint Maternal serum biochemistry at 11-13(+6) weeks in relation to the presence or absence of the fetal nasal bone on ultrasonography in chromosomally abnormal fetuses: an updated analysis of integrated ultrasound and biochemical screening
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Prenat Diagn 25:977-83. 2005
    ....
  20. doi request reprint Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Am J Obstet Gynecol 200:508.e1-6. 2009
    ..The objective of this study was to investigate the potential value of ADAM12 (A disintegrin and metalloprotease) in first-trimester screening for trisomy 21 and other major chromosomal abnormalities...
  21. doi request reprint Combined screening for preeclampsia and small for gestational age at 11-13 weeks
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 33:16-27. 2013
    ..To combine a specific algorithm for small for gestational age (SGA) without preeclampsia (PE) and another algorithm for PE in the prediction of SGA and PE...
  22. doi request reprint Maternal thyroid function at eleven to thirteen weeks of gestation and subsequent delivery of small for gestational age neonates
    George Karagiannis
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Thyroid 21:1127-31. 2011
    ..Our hypothesis is that maternal thyroid function in the first trimester is altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates...
  23. doi request reprint Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia
    Surabhi Nanda
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:479-83. 2011
    ..To examine the potential role of maternal serum level of adiponectin in the first trimester of pregnancy in the prediction of neonatal macrosomia...
  24. doi request reprint First-trimester uterine artery Doppler and serum pregnancy-associated plasma protein-a in preeclampsia and chromosomal defects
    Ismini Staboulidou
    Harris Birthright Research Centre for Foetal Medicine, King s College Hospital, London SE5 9RS, UK
    Fetal Diagn Ther 25:336-9. 2009
    ....
  25. ncbi request reprint Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11(+0) to 13(+6) weeks of gestation
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 28:1110-5. 2008
    ..To investigate the pathogenesis of pregnancies delivering small for gestational age (SGA) neonates by examining biochemical and Doppler indices of placental development during the first trimester of pregnancy...
  26. doi request reprint Prediction of miscarriage and stillbirth at 11-13 weeks and the contribution of chorionic villus sampling
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:38-45. 2011
    ....
  27. ncbi request reprint Maternal arterial stiffness in pregnancies affected by preeclampsia
    Christina Kaihura
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Am J Physiol Heart Circ Physiol 297:H759-64. 2009
    ..9, IQR 0.7-1.1 MoM vs. 1.0, IQR 0.5-1.8 MoM; P = 0.46). In conclusion, we found that established PE is characterized by increased maternal arterial stiffness but not altered maternal wave reflection...
  28. ncbi request reprint Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free beta-hCG and PAPP-A at 11 to 14 weeks
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Prenat Diagn 23:306-10. 2003
    ....
  29. doi request reprint Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks' gestation: effect of maternal and fetal factors
    Ghalia Ashoor
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 31:237-43. 2012
    ..It was the aim of this study to examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell-free DNA (cfDNA) at 11-13 weeks' gestation...
  30. doi request reprint Maternal serum vitamin D at 11-13 weeks in pregnancies delivering small for gestational age neonates
    Rebecca Ertl
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 31:103-8. 2012
    ....
  31. doi request reprint Maternal serum placental growth factor in prospective screening for aneuploidies at 8-13 weeks' gestation
    Pranav Pandya
    Department of Fetal Medicine, University College Hospital, London, UK
    Fetal Diagn Ther 31:87-93. 2012
    ....
  32. doi request reprint Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11-13 weeks
    Ranjit Akolekar
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:66-74. 2011
    ..To develop models for prediction of pre-eclampsia (PE) based on maternal factors and biophysical and biochemical markers at 11-13 weeks' gestation...
  33. ncbi request reprint Free fetal DNA in maternal circulation: a potential prognostic marker for chromosomal abnormalities?
    Ageliki Gerovassili
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Prenat Diagn 27:104-10. 2007
    ..We aimed to quantify the levels of fetal and total cfDNA on prospectively collected samples, to understand their correlation with other variables and to clarify their diagnostic value...
  34. doi request reprint Maternal plasma soluble fms-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia
    Ranjit Akolekar
    Department of Fetal Medicine, Kings College Hospital, London, UK
    Prenat Diagn 30:191-7. 2010
    ....
  35. doi request reprint Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia
    Ranjit Akolekar
    Harris Birthright Research Centre, King s College Hospital, London SE5 9RS, UK
    Prenat Diagn 29:1103-8. 2009
    ..To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE)...
  36. doi request reprint First-trimester prediction of hypertensive disorders in pregnancy
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    Hypertension 53:812-8. 2009
    ..This method of screening is far superior to the traditional approach, which relies entirely on maternal history...
  37. ncbi request reprint Relation between increased fetal nuchal translucency thickness and chromosomal defects
    Karl Oliver Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Obstet Gynecol 107:6-10. 2006
    ..To examine the prevalence and distribution of all chromosomal defects in fetuses with increased nuchal translucency thickness...
  38. doi request reprint Competing risks model in early screening for preeclampsia by biophysical and biochemical markers
    Ranjit Akolekar
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 33:8-15. 2013
    ....
  39. doi request reprint First-trimester screening for spontaneous preterm delivery with maternal characteristics and cervical length
    Elena Greco
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 31:154-61. 2012
    ..It was the aim of this study to examine the potential value of cervical length at 11-13 weeks' gestation in the prediction of spontaneous preterm delivery...
  40. doi request reprint Hypertensive disorders in pregnancy: combined screening by uterine artery Doppler, blood pressure and serum PAPP-A at 11-13 weeks
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 30:216-23. 2010
    ..To explore if the addition of pregnancy-associated plasma protein-A (PAPP-A) to maternal factors and biophysical markers yields a significant improvement in the detection of hypertensive disorders before the clinical onset of disease...
  41. ncbi request reprint Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies
    Kyriaki Avgidou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Am J Obstet Gynecol 192:1761-7. 2005
    ....
  42. ncbi request reprint [Fetal nuchal translucency thickness and risk for chromosomal defects]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Ginekol Pol 76:257-63. 2005
    ..It is therefore essential that, in screening, attention is paid to the provision of high quality sonographic and biochemical services for early diagnosis of chromosomal defects...
  43. doi request reprint Maternal thyroid function at 11-13 weeks of gestation in women with hypothyroidism treated by thyroxine
    Ghalia Ashoor
    Harris Birthright Research Centre, King s College Hospital, London, UK
    Fetal Diagn Ther 28:22-7. 2010
    ....
  44. doi request reprint Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death
    Ghalia Ashoor
    Harris Birthright Research Centre, King s College Hospital, London, United Kingdom
    Thyroid 20:989-93. 2010
    ..Our hypothesis is that maternal thyroid function in the first trimester is altered in pregnancies ending in miscarriage or fetal death...
  45. doi request reprint Reference range of birth weight with gestation and first-trimester prediction of small-for-gestation neonates
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Prenat Diagn 31:58-65. 2011
    ....
  46. doi request reprint Maternal thyroid function at 11 to 13 weeks of gestation and subsequent development of preeclampsia
    Ghalia Ashoor
    Harris Birthright Research Centre, King s College Hospital, London, UK
    Prenat Diagn 30:1032-8. 2010
    ..To determine if maternal thyroid function in the first trimester is altered in pregnancies that subsequently develop preeclampsia (PE)...
  47. ncbi request reprint [Multiple pregnancy at 11+0 - 13+6 weeks]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom Wielka Brytania
    Ginekol Pol 77:175-83. 2006
    ....
  48. doi request reprint Ultrasonographic prediction of early miscarriage
    George I Papaioannou
    King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Hum Reprod 26:1685-92. 2011
    ..The aim of this retrospective study was to assess the value of maternal history and ultrasound scan findings at 6-10 weeks for predicting early miscarriage...
  49. doi request reprint Prediction of spontaneous preterm delivery from maternal factors, obstetric history and placental perfusion and function at 11-13 weeks
    Jarek Beta
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:75-83. 2011
    ..To develop a model for prediction of spontaneous delivery before 34 weeks based on maternal factors, placental perfusion and function at 11-13 weeks' gestation...
  50. ncbi request reprint Screening for chromosomal defects by fetal nuchal translucency at 11 to 14 weeks
    Renu Bindra
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, King s College, Denamark Hill, London, United Kingdom
    Clin Obstet Gynecol 45:661-70; discussion 730-2. 2002
  51. doi request reprint Birthweight with gestation and maternal characteristics in live births and stillbirths
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 32:156-65. 2012
    ..To establish a normal range of birthweight with gestational age (GA) at delivery and examine the contribution of maternal characteristics in defining growth restriction in stillbirths...
  52. doi request reprint First-trimester screening for trisomy 21 using alpha-fetoprotein
    Foteini E Bredaki
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 30:215-8. 2011
    ..To investigate the potential value of adding maternal serum alpha-fetoprotein (AFP) to free β-human chorionic gonadotropin (β-hCG) and PAPP-A and fetal nuchal translucency (NT) thickness in first-trimester screening for trisomy 21...
  53. doi request reprint Body mass index at 11-13 weeks' gestation and pregnancy complications
    Argyro Syngelaki
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 30:250-65. 2011
    ..To examine the association between body mass index (BMI) at 11-13 weeks' gestation and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics...
  54. doi request reprint Prediction of small-for-gestation neonates from biophysical and biochemical markers at 11-13 weeks
    George Karagiannis
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Fetal Diagn Ther 29:148-54. 2011
    ..To develop a model for prediction of small-for-gestational age (SGA) neonates in the absence of preeclampsia (PE) based on maternal factors and biophysical and biochemical markers at 11-13 weeks' gestation...
  55. doi request reprint Maternal plasma pentraxin 3 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 29:934-8. 2009
    ....
  56. doi request reprint Effect of chorionic villus sampling on uterine artery Doppler
    Asma Khalil
    Department of Fetal Medicine, Institute for Women s Health, University College Hospital, London, UK
    Fetal Diagn Ther 28:9-13. 2010
    ..The aim of this study was to examine the potential effect of chorionic villus sampling (CVS) on placental perfusion by examining the change in uterine artery pulsatility index (PI) between the first and second trimesters of pregnancy...
  57. ncbi request reprint [First trimester diagnosis of chromosomal defects]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ginekol Pol 76:1-8. 2005
    ....
  58. ncbi request reprint Maternal characteristics and cervical length in the prediction of spontaneous early preterm delivery in twins
    Meekai S To
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Am J Obstet Gynecol 194:1360-5. 2006
    ..The purpose of this study was to examine the value of combining maternal characteristics and measurement of cervical length at 22 to 24 weeks in the prediction of spontaneous early preterm delivery...
  59. doi request reprint Screening for triploidy by the risk algorithms for trisomies 21, 18 and 13 at 11 weeks to 13 weeks and 6 days of gestation
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 28:1209-13. 2008
    ....
  60. ncbi request reprint Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia
    Makrina D Savvidou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Lancet 361:1511-7. 2003
    ....
  61. doi request reprint Hepatic artery Doppler in trisomy 21 and euploid fetuses at 11-13 weeks
    Mona Zvanca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 31:22-7. 2011
    ..To determine possible differences in hepatic artery flow between trisomy 21 and euploid fetuses at 11-13 weeks' gestation...
  62. doi request reprint First-trimester maternal serum matrix metalloproteinase-9 (MMP-9) and adverse pregnancy outcome
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 29:553-9. 2009
    ..To investigate the potential value of maternal serum matrix metalloproteinase-9 (MMP-9) in first-trimester screening for preeclampsia and spontaneous early preterm delivery...
  63. doi request reprint Contribution of ductus venosus Doppler in first-trimester screening for major cardiac defects
    Teodora Chelemen
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 29:127-34. 2011
    ..To determine whether assessment of ductus venosus flow at 11-13 weeks' gestation improves the detection rate of cardiac defects achieved by screening with nuchal translucency (NT) thickness...
  64. doi request reprint First-trimester prediction of macrosomia
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, University College Hospital, London, UK
    Fetal Diagn Ther 29:139-47. 2011
    ..To determine if combinations of maternal characteristics and measurements of parameters used in screening for aneuploidies at 11-13 weeks provide significant prediction of macrosomia...
  65. ncbi request reprint [Sonographic features of chromosomal defects at 11(+0) to 13(+6) weeks of gestation]
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Ginekol Pol 76:423-30. 2005
    ..In triploidy, there is early onset asymmetrical fetal growth restriction, bradycardia, holoprosencephaly, exomphalos, posterior fossa cyst and molar changes in the placenta...
  66. doi request reprint Screening for adverse pregnancy outcome by ductus venosus Doppler at 11-13+6 weeks of gestation
    Nerea Maiz
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 112:598-605. 2008
    ..To estimate the independent contribution of abnormal flow in the ductus venosus at 11 to 13+6 weeks of gestation in the prediction of major fetal abnormalities and fetal death...
  67. doi request reprint Assisted conception and placental perfusion assessed by uterine artery Doppler at 11-13 weeks' gestation
    Ilma F Carbone
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Hum Reprod 26:1659-64. 2011
    ..This study examines the potential mechanism for such association by examining the effect of method of conception on placentation as assessed by uterine artery Doppler at 11-13 weeks' gestation...
  68. ncbi request reprint Maternal cardiac function in twin pregnancy
    Nikos A Kametas
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 102:806-15. 2003
    ..To investigate maternal cardiac function in twin pregnancy...
  69. doi request reprint Maternal serum angiopoietin-2 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 29:847-51. 2009
    ..The objective of this study is to determine if the decrease in serum Ang-2 is evident from the first trimester of pregnancy before the clinical onset of PE...
  70. ncbi request reprint An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk women
    Christina K H Yu
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
    Am J Obstet Gynecol 193:429-36. 2005
    ..The purpose of this study was to develop a predictive model for preeclampsia...
  71. ncbi request reprint Evidence-based obstetric ethics and informed decision-making by pregnant women about invasive diagnosis after first-trimester assessment of risk for trisomy 21
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Am J Obstet Gynecol 193:322-6. 2005
    ..The purpose of this study was to determine the ability of pregnant women to incorporate sophisticated screening information about risk assessment into their decisions about invasive testing in an appropriate way...
  72. pmc Maternal arterial stiffness in women who subsequently develop pre-eclampsia
    Makrina D Savvidou
    Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK
    PLoS ONE 6:e18703. 2011
    ..Pre-eclampsia (PE) is associated with profound changes in the maternal cardiovascular system. The aim of the present study was to assess whether alterations in the maternal arterial stiffness precede the onset of PE in at risk women...
  73. ncbi request reprint Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction
    Makrina D Savvidou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 195:1668-73. 2006
    ....
  74. ncbi request reprint Assessment of risk for the development of pre-eclampsia by maternal characteristics and uterine artery Doppler
    Aris T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    BJOG 112:703-9. 2005
    ..To develop a method for the estimation of patient-specific risk for the development of pre-eclampsia by combining maternal history and uterine artery Doppler...
  75. ncbi request reprint Prevalence and outcome of absence of ductus venosus at 11(+0) to 13(+6) weeks
    Ismini Staboulidou
    Harris Birthright Research Centre of Fetal Medicine, King s College Hospital, London, UK
    Fetal Diagn Ther 30:35-40. 2011
    ..To examine the prevalence and outcome of absent ductus venosus (DV) diagnosed at 11-13 weeks' gestation...
  76. ncbi request reprint Fetal lung volume after endoscopic tracheal occlusion in the prediction of postnatal outcome
    Cleisson F A Peralta
    Department of Obstetrics and Gynecology, Fetal Medicine Units, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 198:60.e1-5. 2008
    ..The objective of the study was to investigate the volume response of the contralateral lung in the prediction of postnatal outcome in fetuses with congenital diaphragmatic hernia (CDH) treated by fetoscopic endotracheal occlusion (FETO)...
  77. doi request reprint Prediction of outcome in dichorionic twin pregnancies at 6-10 weeks' gestation
    George I Papaioannou
    Fetal Medicine Unit, King s College Hospital, London, England, UK
    Am J Obstet Gynecol 205:348.e1-5. 2011
    ..The objective of the study was to predict the outcome of dichorionic (DC) twin pregnancies at 6-10 weeks' gestation from intertwin discordance in crown-rump length (CRL), heart rate (HR), and gestational sac diameter (GSD)...
  78. ncbi request reprint Cystic hygromas, nuchal edema, and nuchal translucency at 11-14 weeks of gestation
    Francisca S Molina
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Obstet Gynecol 107:678-83. 2006
    ....
  79. ncbi request reprint Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 8RX, UK
    Hum Reprod 23:1968-75. 2008
    ....
  80. doi request reprint Maternal serum activin a at 11-13 weeks of gestation in hypertensive disorders of pregnancy
    Ranjit Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London SE5 9RS, UK
    Fetal Diagn Ther 25:320-7. 2009
    ....
  81. doi request reprint First-trimester maternal plasma cell-free fetal DNA and preeclampsia
    Stavros Sifakis
    Harris Birthright Research Center for Fetal Medicine, King s College Hospital, London, UK
    Am J Obstet Gynecol 201:472.e1-7. 2009
    ....
  82. ncbi request reprint Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction
    Makrina D Savvidou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 8RS, UK
    Clin Sci (Lond) 115:219-24. 2008
    ....
  83. ncbi request reprint Flow-mediated dilatation of the brachial artery in pregnancy at high altitude
    Nikos A Kametas
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    BJOG 109:930-7. 2002
    ..The aim of this study was to examine the effect of high altitude (4370 m above sea level) on endothelial function during pregnancy as assessed by a non-invasive method...
  84. ncbi request reprint Ultrasound findings before amniocentesis in selecting the method of analysing the sample
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Prenat Diagn 27:34-9. 2007
    ....
  85. ncbi request reprint The role of uterine artery Doppler in predicting adverse pregnancy outcome
    Aris T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London SE5 8RX, UK
    Best Pract Res Clin Obstet Gynaecol 18:383-96. 2004
    ....
  86. ncbi request reprint Sonographic screening for trisomy 13 at 11 to 13(+6) weeks of gestation
    Aris T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, United Kingdom
    Am J Obstet Gynecol 194:397-401. 2006
    ..The purpose of this study was to examine the sonographic features of trisomy 13 at 11 to 13(+6) weeks of gestation...
  87. ncbi request reprint Maternal serum soluble adhesion molecule levels at 11+0-13+6 weeks and subsequent development of pre-eclampsia
    Mauro Parra-Cordero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    J Matern Fetal Neonatal Med 20:793-6. 2007
    ....
  88. ncbi request reprint First trimester sex hormone-binding globulin and subsequent development of preeclampsia or other adverse pregnancy outcomes
    Kevin Spencer
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
    Hypertens Pregnancy 24:303-11. 2005
    ..To investigate whether first trimester maternal serum sex hormone-binding globulin (SHBG) concentrations are altered in women who subsequently develop preeclampsia or other pregnancy complications...
  89. doi request reprint Maternal wave reflections and arterial stiffness in normal pregnancy as assessed by applanation tonometry
    Maria L Macedo
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 8RS, UK
    Hypertension 51:1047-51. 2008
    ..2 for carotid-radial, P=0.5 for carotid-femoral). In summary, we found that normal pregnancy is associated with a reduction in central BP and wave reflection...
  90. doi request reprint Mean arterial pressure at 11(+0) to 13(+6) weeks in the prediction of preeclampsia
    Leona C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    Hypertension 51:1027-33. 2008
    ..5% for a false-positive rate of 10%. Maternal variables, together with MAP, at 11(+0) to 13(+6) weeks identify a group at high risk for development of PE...
  91. ncbi request reprint Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
    ..Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women...
  92. doi request reprint Angiotensin II type 1 and 2 receptors gene polymorphisms in pre-eclampsia and normal pregnancy in three different populations
    Syed Ali Akbar
    Department of Fetal Medicine, Harris Birthright Research Centre, King s College Hospital, London, UK
    Acta Obstet Gynecol Scand 88:606-11. 2009
    ..To investigate a possible association between pre-eclampsia (PE) and the genotype for the angiotensin II type-1 receptor (AT1R) and the angiotensin type-2 receptor (AT2R) in various population groups...
  93. ncbi request reprint Maternal left ventricular diastolic and systolic long-axis function during normal pregnancy
    Jacqueline E A K Bamfo
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, Golden Jubilee Wing, London SE5 9RS, UK
    Eur J Echocardiogr 8:360-8. 2007
    ..The aim of this study was to evaluate left ventricular (LV) function during normal pregnancy and investigate the effect of maternal factors. Little information about LV diastolic and long-axis systolic function in normal pregnancy exists...
  94. doi request reprint Screening for fetal aneuploidies at 11 to 13 weeks
    Kypros H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK and Department of Fetal Medicine, University College Hospital, London, UK
    Prenat Diagn 31:7-15. 2011
    ....
  95. ncbi request reprint Increased nuchal translucency with normal karyotype
    Athena P Souka
    Harris Birthright Research Centre for Fetal Medicine, King s College, London University, London, UK
    Am J Obstet Gynecol 192:1005-21. 2005
    ....
  96. ncbi request reprint Ultrasonographic occiput position in early labour in the prediction of caesarean section
    Serap Akmal
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    BJOG 111:532-6. 2004
    ....
  97. ncbi request reprint Aneuploidy screening in coelomic samples using fluorescence in situ hybridisation (FISH)
    Katerina Chatzimeletiou
    Harris Birthright Centre for Fetal Medicine, King s College Hospital, London, UK
    Prenat Diagn 25:919-26. 2005
    ..The aim of this study was to extend previous studies and investigate the feasibility of analysing uncultured coelomic fluid samples for 11 chromosomes using fluorescence in situ hybridisation (FISH)...
  98. ncbi request reprint Cell-free DNA levels in pregnancies at risk of sickle-cell disease and significant ethnic variation
    Ageliki Gerovassili
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, King s College Hospital, London, UK
    Br J Haematol 135:738-41. 2006
    ..A significant variation in cf-DNA was found between ethnic groups, which should be taken into consideration in future studies measuring cf-DNA...
  99. doi request reprint Maternal thyroid function at 11-13 weeks of gestation
    Ghalia Ashoor
    Harris Birthright Research Centre, King s College Hospital, Denmark Hill, London, UK
    Fetal Diagn Ther 27:156-63. 2010
    ..To establish normal ranges of maternal serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) at 11-13 weeks of gestation...
  100. ncbi request reprint The influence of medical and psychological interventions on women's distress after miscarriage
    Ana V Nikčević
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical, School, London, United Kingdom
    J Psychosom Res 63:283-90. 2007
    ..The aim of this study was to examine the impact of medical and psychological interventions on women's distress after early miscarriage...
  101. doi request reprint The outcome of twin reversed arterial perfusion sequence diagnosed in the first trimester
    Liesbeth Lewi
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Am J Obstet Gynecol 203:213.e1-4. 2010
    ..The aim of this study was to document the mortality of twin reversed arterial perfusion (TRAP) sequence from the first trimester to planned intervention at 16-18 weeks...