Frank O Nestle

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Psoriasis
    Frank O Nestle
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine at Guy s, Guy s Hospital, London, UK
    Curr Dir Autoimmun 10:65-75. 2008
  2. pmc Deepening our understanding of immune sentinels in the skin
    Frank O Nestle
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, United Kingdom
    J Clin Invest 117:2382-5. 2007
  3. pmc Skin immune sentinels in health and disease
    Frank O Nestle
    St John s Institute of Dermatology, King s College London, UK
    Nat Rev Immunol 9:679-91. 2009
  4. pmc Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis
    Ute Laggner
    Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
    J Immunol 187:2783-93. 2011
  5. pmc Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis
    Christian Hundhausen
    St John s Institute of Dermatology, King s College London, Guy s Hospital, London, UK
    J Invest Dermatol 132:635-41. 2012
  6. pmc The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients
    Paola Di Meglio
    St John s Institute of Dermatology, NIHR Biomedical Research Centre, King s College London, London, UK
    J Invest Dermatol 133:2381-9. 2013
  7. pmc IgG4 subclass antibodies impair antitumor immunity in melanoma
    Panagiotis Karagiannis
    National Institute for Health Research Biomedical Research Centre at Guy s and St Thomas Hospitals and King s College London, Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, King s College London, London, United Kingdom
    J Clin Invest 123:1457-74. 2013
  8. ncbi request reprint Toward prediction of immune mechanisms and design of immunotherapies in melanoma
    Sophia Tsoka
    Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King s College London, United Kingdom
    Crit Rev Biomed Eng 40:279-94. 2012
  9. pmc An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element
    Alex Clop
    Division of Genetics and Molecular Medicine, King s College London, London, United Kingdom
    PLoS ONE 8:e71690. 2013
  10. pmc Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
    Chung Ching Chu
    St John s Institute of Dermatology, King s College London and National Institutes for Health Research Biomedical Research Centre, London, UK
    J Exp Med 209:935-45. 2012

Collaborators

Detail Information

Publications51

  1. doi request reprint Psoriasis
    Frank O Nestle
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine at Guy s, Guy s Hospital, London, UK
    Curr Dir Autoimmun 10:65-75. 2008
    ..The success of these therapies has validated insights into disease pathogenesis and also provides the opportunity to increase our understanding about the pathways underpinning autoimmune-type inflammation in the skin...
  2. pmc Deepening our understanding of immune sentinels in the skin
    Frank O Nestle
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, United Kingdom
    J Clin Invest 117:2382-5. 2007
    ..These studies provide the basis for better insight into the role of important immune sentinels contributing to the maintenance of skin tissue homeostasis and lay the foundation for future studies of the skin immune system...
  3. pmc Skin immune sentinels in health and disease
    Frank O Nestle
    St John s Institute of Dermatology, King s College London, UK
    Nat Rev Immunol 9:679-91. 2009
    ..This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease...
  4. pmc Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis
    Ute Laggner
    Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
    J Immunol 187:2783-93. 2011
    ..In summary, we report a novel human proinflammatory γδ T cell involved in skin immune surveillance with immediate response characteristics and with potential clinical relevance in inflammatory skin disease...
  5. pmc Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis
    Christian Hundhausen
    St John s Institute of Dermatology, King s College London, Guy s Hospital, London, UK
    J Invest Dermatol 132:635-41. 2012
    ..These data pave the way for functional studies into the pathogenic role of the major psoriasis susceptibility allele...
  6. pmc The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients
    Paola Di Meglio
    St John s Institute of Dermatology, NIHR Biomedical Research Centre, King s College London, London, UK
    J Invest Dermatol 133:2381-9. 2013
    ....
  7. pmc IgG4 subclass antibodies impair antitumor immunity in melanoma
    Panagiotis Karagiannis
    National Institute for Health Research Biomedical Research Centre at Guy s and St Thomas Hospitals and King s College London, Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, King s College London, London, United Kingdom
    J Clin Invest 123:1457-74. 2013
    ....
  8. ncbi request reprint Toward prediction of immune mechanisms and design of immunotherapies in melanoma
    Sophia Tsoka
    Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King s College London, United Kingdom
    Crit Rev Biomed Eng 40:279-94. 2012
    ..We propose that efforts in this direction may realize the potential of personalized medicine and facilitate development of the next generation of efficacious tools to treat patients...
  9. pmc An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element
    Alex Clop
    Division of Genetics and Molecular Medicine, King s College London, London, United Kingdom
    PLoS ONE 8:e71690. 2013
    ....
  10. pmc Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
    Chung Ching Chu
    St John s Institute of Dermatology, King s College London and National Institutes for Health Research Biomedical Research Centre, London, UK
    J Exp Med 209:935-45. 2012
    ..Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance...
  11. pmc Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene
    Francesca Capon
    Division of Genetics and Molecular Medicine, Infection and Inflammatory Disease, King s College London, London, UK
    Hum Mol Genet 17:1938-45. 2008
    ..These findings collectively identify a novel psoriasis susceptibility gene, with a putative role in the regulation of immune responses...
  12. doi request reprint Psoriasis
    Gayathri K Perera
    St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
    Annu Rev Pathol 7:385-422. 2012
    ..We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies...
  13. pmc Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype
    Niwa Ali
    St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, London, United Kingdom
    PLoS ONE 7:e44219. 2012
    ..Characterization of Hu-PBMC mice provides a strong preclinical platform for the application of novel immunotherapies targeting T(EM)-cell driven GvHD...
  14. pmc Harnessing dendritic cells in inflammatory skin diseases
    Chung Ching Chu
    St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, Guy s and St Thomas Hospitals, 9th floor Tower Wing, Guy s Hospital, London SE1 9RT, United Kingdom
    Semin Immunol 23:28-41. 2011
    ..In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies...
  15. pmc Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
    Alexandros Onoufriadis
    Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, UK
    Am J Hum Genet 89:432-7. 2011
    ....
  16. pmc Cutting edge: A critical functional role for IL-23 in psoriasis
    Giulia Tonel
    St John s Institute of Dermatology, National Institute for Health Research Biomedical Research Centre, King s College London, London, United Kingdom
    J Immunol 185:5688-91. 2010
    ..Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders...
  17. doi request reprint What on "irf" is this gene 4? Irf4 transcription-factor-dependent dendritic cells are required for T helper 2 cell responses in murine skin
    Barry Flutter
    St John s Institute of Dermatology, King s College London, London SE1 9RT, UK
    Immunity 39:625-7. 2013
    ..In this issue of Immunity, Kumamoto et al. (2013) and Gao et al. (2013) identify an Irf4-dependent migratory dendritic cell subset required for T helper 2 cell polarization following cutaneous challenge. ..
  18. pmc The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans
    Paola Di Meglio
    St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, London, United Kingdom
    PLoS ONE 6:e17160. 2011
    ....
  19. pmc A systems model for immune cell interactions unravels the mechanism of inflammation in human skin
    Najl V Valeyev
    St John s Institute of Dermatology, King s College London, London, United Kingdom
    PLoS Comput Biol 6:e1001024. 2010
    ....
  20. pmc Transcriptome classification reveals molecular subtypes in psoriasis
    Chrysanthi Ainali
    Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King s College London, Strand, London WC2R 2LS, UK
    BMC Genomics 13:472. 2012
    ..Although certain clinical phenotypes, such as plaque psoriasis, are well defined, it is currently unclear whether there are molecular subtypes that might impact on prognosis or treatment outcomes...
  21. doi request reprint Biomarkers in psoriasis and psoriatic arthritis
    Federica Villanova
    St John s Institute of Dermatology, King s College London, London, UK
    Ann Rheum Dis 72:ii104-10. 2013
    ..In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery...
  22. doi request reprint The multitasking organ: recent insights into skin immune function
    Paola Di Meglio
    St John s Institute of Dermatology, King s College London and National Institute for Health Research Biomedical Research Center, Guy s and St Thomas s Hospitals, London SE1 9RT, UK
    Immunity 35:857-69. 2011
    ..Finally, we look at the skin as an interacting network of immune signaling pathways exemplified by the development of a disease interactome for psoriasis...
  23. doi request reprint Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application
    Sophia N Karagiannis
    NIHR Biomedical Research Centre at Guy s and St Thomas s Hospitals and King s College London, London, UK
    Cancer Immunol Immunother 61:1547-64. 2012
    ..On-going efficacy, safety evaluations and future first-in-man clinical studies of IgE therapeutics constitute key metrics for this concept, providing new scope for antibody immunotherapies for solid tumours...
  24. doi request reprint The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    Antonella Di Cesare
    St John s Institute of Dermatology, King s College London School of Medicine and NIHR Biomedical Research Centre, London, UK
    J Invest Dermatol 129:1339-50. 2009
    ..We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis...
  25. doi request reprint TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis
    Barry Flutter
    St John s Institute of Dermatology, King s College London, London, UK
    Eur J Immunol 43:3138-46. 2013
    ..In this review, we will dissect the findings of the imiquimod model to date and ask how this model can inform us about the immunological aspects of human disease. ..
  26. pmc Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery
    Federica Villanova
    St John s Institute of Dermatology, King s College London, London, United Kingdom
    PLoS ONE 8:e65485. 2013
    ..Our results establish a new flow cytometry platform for standardized and rapid immunological biomarker discovery with wide application to immune-mediated diseases. ..
  27. pmc Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity
    Martin Kreutz
    Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, United Kingdom
    PLoS ONE 7:e40208. 2012
    ..A better understanding of the role of the antibody moiety is required to inform future conjugate vaccination strategies for efficient induction of anti-tumour responses...
  28. ncbi request reprint Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
    Francesca Capon
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College, London, UK
    Hum Genet 122:201-6. 2007
    ..0001) and rs3212227 (P = 0.036). Altogether, these findings indicate that genes participating in IL23 signalling play a significant role in the pathogenesis of chronic epithelial inflammation...
  29. ncbi request reprint Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
    Michel Gilliet
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Arch Dermatol 140:1490-5. 2004
    ..It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this...
  30. ncbi request reprint Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  31. ncbi request reprint Immunopathogenesis of psoriasis
    Brian J Nickoloff
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Clin Rev Allergy Immunol 33:45-56. 2007
    ....
  32. ncbi request reprint Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen
    Michel Gilliet
    Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Blood 102:36-42. 2003
    ..Our results indicate that intranodal vaccination with semimature DCs can prime strong, long-lasting CD4 T-cell responses with a TH1-type cytokine profile in cancer patients...
  33. ncbi request reprint Dendritic cell vaccination for the treatment of skin cancer
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Recent Results Cancer Res 160:165-9. 2002
    ..In recent years an enormous increase in our understanding of DC biology has opened up new ways of applying these cells for immunotherapy of cancer...
  34. ncbi request reprint The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse, Zurich, Switzerland
    J Invest Dermatol 123:xiv-xv. 2004
  35. pmc Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
    Brian J Nickoloff
    Skin Disease Research Laboratory and Cardinal Bernardin Cancer Center, Loyola University of Chicago, Medical Center, Maywood, Illinois 60153, USA
    J Clin Invest 113:1664-75. 2004
    ..Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease...
  36. pmc Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha
    Onur Boyman
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091, Switzerland
    J Exp Med 199:731-6. 2004
    ..These findings underline the importance of resident immune cells in psoriasis and will have implications for new therapeutic strategies for psoriasis and other T cell-mediated diseases...
  37. pmc Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions
    Gianni Gerlini
    Department of Dermatological Sciences, University of Florence Medical School, Florence, Italy
    Am J Pathol 165:1853-63. 2004
    ..Our findings suggest that metastatic but not primary melanomas can down-regulate CD1 molecules on infiltrating dendritic cells by secreting IL-10 which may represent a novel way to escape the immune response directed against the tumor...
  38. ncbi request reprint Dendritic cell-based cancer therapy
    Curdin Conrad
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Curr Opin Mol Ther 5:405-12. 2003
    ....
  39. ncbi request reprint Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells
    Tanja Maier
    Department of Dermatology, University Hospital Zurich, Switzerland
    Blood 102:2338-44. 2003
    ..Intranodal injection of autologous tumor-lysate-pulsed DCs is well-tolerated and achieves immunologic and objective clinical responses in selected CTCL patients...
  40. ncbi request reprint Dendritic-cell-based therapeutic vaccination against cancer
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Curr Opin Immunol 17:163-9. 2005
    ..This explains the current need for innovative well designed trials with defined endpoints that induce robust anti-tumor immunity...
  41. ncbi request reprint Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year
    Phoebe Rich
    Oregon Health Sciences University, Dermatology and Clinical Research, Portland, Oregon 97210, USA
    J Am Acad Dermatol 58:224-31. 2008
    ..Although nail psoriasis occurs frequently in patients with psoriatic skin lesions, effective treatments are limited...
  42. ncbi request reprint Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
    Curdin Conrad
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Nat Med 13:836-42. 2007
    ....
  43. ncbi request reprint The pathogenic role of tissue-resident immune cells in psoriasis
    Onur Boyman
    Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
    Trends Immunol 28:51-7. 2007
    ..This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases...
  44. ncbi request reprint A new lease on life for dendritic cell vaccines?
    Frank O Nestle
    Nat Biotechnol 24:1483-4. 2006
  45. ncbi request reprint Infliximab treatment improves productivity among patients with moderate-to-severe psoriasis
    Kristian Reich
    Department of Dermatology, Georg August University Von SieboldStrasse 3, 37075, Gottingen, Germany
    Eur J Dermatol 17:381-6. 2007
    ..In placebo patients who crossed over to infliximab, these scores improved and approached those seen with infliximab at week 50. Infliximab significantly improved productivity and ability to work in psoriasis patients...
  46. ncbi request reprint Animal models of psoriasis and psoriatic arthritis: an update
    Curdin Conrad
    Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland
    Curr Rheumatol Rep 8:342-7. 2006
    ..Every mouse model has strengths and weaknesses, with room for improvement. Still, these models will accelerate knowledge of psoriasis pathogenesis and aid in the development of new therapeutics...
  47. ncbi request reprint Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alpha
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    J Invest Dermatol 125:xiv-xv. 2005
  48. ncbi request reprint Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial
    Kristian Reich
    Department of Dermatology, Georg August University, Gottingen, Germany
    Lancet 366:1367-74. 2005
    ..We assessed the efficacy and safety of continuous treatment with infliximab, a monoclonal antibody that binds to and neutralises the activity of TNFalpha, in patients with psoriasis...
  49. pmc Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Exp Med 202:135-43. 2005
    ..These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis...
  50. ncbi request reprint Antigen specific immunotherapy: Quo vadis?
    Frank O Nestle
    Swiss Med Wkly 135:211. 2005
  51. ncbi request reprint The cytokine and chemokine network in psoriasis
    Brian J Nickoloff
    Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    Clin Dermatol 25:568-73. 2007
    ..These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions...