Research Topics
Genomes and Genes | Frank O NestleSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
PsoriasisFrank O Nestle
St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine at Guy s, Guy s Hospital, London, UK
Curr Dir Autoimmun 10:65-75. 2008..The success of these therapies has validated insights into disease pathogenesis and also provides the opportunity to increase our understanding about the pathways underpinning autoimmune-type inflammation in the skin...- Biomarkers in psoriasis and psoriatic arthritisFederica Villanova
Correspondence to Professor Frank O Nestle, St John s Institute of Dermatology, King s College London, London SE1 9RT, UK
Ann Rheum Dis 72:ii104-ii110. 2013..In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery... 
Deepening our understanding of immune sentinels in the skinFrank O Nestle
St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, United Kingdom
J Clin Invest 117:2382-5. 2007..These studies provide the basis for better insight into the role of important immune sentinels contributing to the maintenance of skin tissue homeostasis and lay the foundation for future studies of the skin immune system...- Skin immune sentinels in health and diseaseFrank O Nestle
St John s Institute of Dermatology, King s College London, UK
Nat Rev Immunol 9:679-91. 2009..This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease... - Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasisUte Laggner
Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
J Immunol 187:2783-93. 2011..In summary, we report a novel human proinflammatory γδ T cell involved in skin immune surveillance with immediate response characteristics and with potential clinical relevance in inflammatory skin disease... - Allele-specific cytokine responses at the HLA-C locus: implications for psoriasisChristian Hundhausen
St John s Institute of Dermatology, King s College London, Guy s Hospital, London, UK
J Invest Dermatol 132:635-41. 2012..These data pave the way for functional studies into the pathogenic role of the major psoriasis susceptibility allele... 
Toward prediction of immune mechanisms and design of immunotherapies in melanomaSophia Tsoka
Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King s College London, United Kingdom
Crit Rev Biomed Eng 40:279-94. 2012..We propose that efforts in this direction may realize the potential of personalized medicine and facilitate development of the next generation of efficacious tools to treat patients...- Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammationChung Ching Chu
St John s Institute of Dermatology, King s College London and National Institutes for Health Research Biomedical Research Centre, London, UK
J Exp Med 209:935-45. 2012..Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance... - IgG4 subclass antibodies impair antitumor immunity in melanomaPanagiotis Karagiannis
National Institute for Health Research Biomedical Research Centre at Guy s and St Thomas Hospitals and King s College London, Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, King s College London, London, United Kingdom
J Clin Invest 123:1457-74. 2013.... - Identification of ZNF313/RNF114 as a novel psoriasis susceptibility geneFrancesca Capon
Division of Genetics and Molecular Medicine, Infection and Inflammatory Disease, King s College London, London, UK
Hum Mol Genet 17:1938-45. 2008..These findings collectively identify a novel psoriasis susceptibility gene, with a putative role in the regulation of immune responses... - PsoriasisGayathri K Perera
St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
Annu Rev Pathol 7:385-422. 2012..We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies... - The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humansPaola Di Meglio
St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, London, United Kingdom
PLoS ONE 6:e17160. 2011.... - Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotypeNiwa Ali
St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, London, United Kingdom
PLoS ONE 7:e44219. 2012..Characterization of Hu-PBMC mice provides a strong preclinical platform for the application of novel immunotherapies targeting T(EM)-cell driven GvHD... - Harnessing dendritic cells in inflammatory skin diseasesChung Ching Chu
St John s Institute of Dermatology, King s College London and NIHR Biomedical Research Centre, Guy s and St Thomas Hospitals, 9th floor Tower Wing, Guy s Hospital, London SE1 9RT, United Kingdom
Semin Immunol 23:28-41. 2011..In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies... - Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasisAlexandros Onoufriadis
Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, UK
Am J Hum Genet 89:432-7. 2011.... - Cutting edge: A critical functional role for IL-23 in psoriasisGiulia Tonel
St John s Institute of Dermatology, National Institute for Health Research Biomedical Research Centre, King s College London, London, United Kingdom
J Immunol 185:5688-91. 2010..Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders... - Transcriptome classification reveals molecular subtypes in psoriasisChrysanthi Ainali
Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King s College London, Strand, London WC2R 2LS, UK
BMC Genomics 13:472. 2012..Although certain clinical phenotypes, such as plaque psoriasis, are well defined, it is currently unclear whether there are molecular subtypes that might impact on prognosis or treatment outcomes... - A systems model for immune cell interactions unravels the mechanism of inflammation in human skinNajl V Valeyev
St John s Institute of Dermatology, King s College London, London, United Kingdom
PLoS Comput Biol 6:e1001024. 2010.... - The multitasking organ: recent insights into skin immune functionPaola Di Meglio
St John s Institute of Dermatology, King s College London and National Institute for Health Research Biomedical Research Center, Guy s and St Thomas s Hospitals, London SE1 9RT, UK
Immunity 35:857-69. 2011..Finally, we look at the skin as an interacting network of immune signaling pathways exemplified by the development of a disease interactome for psoriasis... - Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical applicationSophia N Karagiannis
NIHR Biomedical Research Centre at Guy s and St Thomas s Hospitals and King s College London, London, UK
Cancer Immunol Immunother 61:1547-64. 2012..On-going efficacy, safety evaluations and future first-in-man clinical studies of IgE therapeutics constitute key metrics for this concept, providing new scope for antibody immunotherapies for solid tumours... - The IL-23/Th17 axis in the immunopathogenesis of psoriasisAntonella Di Cesare
St John s Institute of Dermatology, King s College London School of Medicine and NIHR Biomedical Research Centre, London, UK
J Invest Dermatol 129:1339-50. 2009..We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis... - Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificityMartin Kreutz
Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, United Kingdom
PLoS ONE 7:e40208. 2012..A better understanding of the role of the antibody moiety is required to inform future conjugate vaccination strategies for efficient induction of anti-tumour responses... - Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasisFrancesca Capon
Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College, London, UK
Hum Genet 122:201-6. 2007..0001) and rs3212227 (P = 0.036). Altogether, these findings indicate that genes participating in IL23 signalling play a significant role in the pathogenesis of chronic epithelial inflammation... - Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideRoberto Lande
Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Nature 449:564-9. 2007..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis... - Immunopathogenesis of psoriasisBrian J Nickoloff
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
Clin Rev Allergy Immunol 33:45-56. 2007.... - Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursorsMichel Gilliet
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Arch Dermatol 140:1490-5. 2004..It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this... - Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasisCurdin Conrad
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
Nat Med 13:836-42. 2007.... - Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunitiesBrian J Nickoloff
Skin Disease Research Laboratory and Cardinal Bernardin Cancer Center, Loyola University of Chicago, Medical Center, Maywood, Illinois 60153, USA
J Clin Invest 113:1664-75. 2004..Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease... - Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 yearPhoebe Rich
Oregon Health Sciences University, Dermatology and Clinical Research, Portland, Oregon 97210, USA
J Am Acad Dermatol 58:224-31. 2008..Although nail psoriasis occurs frequently in patients with psoriatic skin lesions, effective treatments are limited... - Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigenMichel Gilliet
Department of Dermatology, , Gloriastrasse 31, , Switzerland
Blood 102:36-42. 2003..Our results indicate that intranodal vaccination with semimature DCs can prime strong, long-lasting CD4 T-cell responses with a TH1-type cytokine profile in cancer patients... - Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cellsTanja Maier
Department of Dermatology, , Switzerland
Blood 102:2338-44. 2003..Intranodal injection of autologous tumor-lysate-pulsed DCs is well-tolerated and achieves immunologic and objective clinical responses in selected CTCL patients... - Dendritic cell-based cancer therapyCurdin Conrad
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
Curr Opin Mol Ther 5:405-12. 2003.... - Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alphaOnur Boyman
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091, Switzerland
J Exp Med 199:731-6. 2004..These findings underline the importance of resident immune cells in psoriasis and will have implications for new therapeutic strategies for psoriasis and other T cell-mediated diseases... - Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesionsGianni Gerlini
Department of Dermatological Sciences, University of Florence Medical School, Florence, Italy
Am J Pathol 165:1853-63. 2004..Our findings suggest that metastatic but not primary melanomas can down-regulate CD1 molecules on infiltrating dendritic cells by secreting IL-10 which may represent a novel way to escape the immune response directed against the tumor... - The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasisFrank O Nestle
Department of Dermatology, University Hospital of Zurich, Gloriastrasse, Zurich, Switzerland
J Invest Dermatol 123:xiv-xv. 2004 - Dendritic-cell-based therapeutic vaccination against cancerFrank O Nestle
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
Curr Opin Immunol 17:163-9. 2005..This explains the current need for innovative well designed trials with defined endpoints that induce robust anti-tumor immunity... - Antigen specific immunotherapy: Quo vadis?Frank O Nestle
Swiss Med Wkly 135:211. 2005 - Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha productionFrank O Nestle
Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
J Exp Med 202:135-43. 2005..These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis... - Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trialKristian Reich
Department of Dermatology, Georg-August University, , Germany
Lancet 366:1367-74. 2005.... - Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alphaFrank O Nestle
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
J Invest Dermatol 125:xiv-xv. 2005 - Animal models of psoriasis and psoriatic arthritis: an updateCurdin Conrad
Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland
Curr Rheumatol Rep 8:342-7. 2006..Every mouse model has strengths and weaknesses, with room for improvement. Still, these models will accelerate knowledge of psoriasis pathogenesis and aid in the development of new therapeutics... - A new lease on life for dendritic cell vaccines?Frank O Nestle
Nat Biotechnol 24:1483-4. 2006 - The pathogenic role of tissue-resident immune cells in psoriasisOnur Boyman
Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
Trends Immunol 28:51-7. 2007..This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases... - Infliximab treatment improves productivity among patients with moderate-to-severe psoriasisKristian Reich
Department of Dermatology, Georg August University Von SieboldStrasse 3, 37075, Gottingen, Germany
Eur J Dermatol 17:381-6. 2007..In placebo patients who crossed over to infliximab, these scores improved and approached those seen with infliximab at week 50. Infliximab significantly improved productivity and ability to work in psoriasis patients... - The cytokine and chemokine network in psoriasisBrian J Nickoloff
Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
Clin Dermatol 25:568-73. 2007..These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions... - Dendritic cell vaccination for the treatment of skin cancerFrank O Nestle
Department of Dermatology, University Hospital of Zurich, , Switzerland
Recent Results Cancer Res 160:165-9. 2002..In recent years an enormous increase in our understanding of DC biology has opened up new ways of applying these cells for immunotherapy of cancer...