Research Topics
Species | Kieran C MurphySummaryAffiliation: King's College London Country: UK Publications
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Publications
High rates of schizophrenia in adults with velo-cardio-facial syndromeK C Murphy
Division of Psychological Medicine, University of Wales College of Medicine, Cardiff
Arch Gen Psychiatry 56:940-5. 1999..Velo-cardio-facial syndrome (VCFS), a syndrome characterized by an increased frequency of schizophrenia and bipolar disorder, is associated with small interstitial deletions of chromosome 22q11...- Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophreniaK C Murphy
Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 179:397-402. 2001..Individuals with velocardio-facial syndrome (VCFS), a genetic disorder associated with microdeletions of chromosome 22q11, are reported to have high rates of psychiatric disorder, particularly schizophrenia... - Schizophrenia and velo-cardio-facial syndromeKieran C Murphy
Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Lancet 359:426-30. 2002..Furthermore, the strength of the association between schizophrenia and VCFS has important implications for the clinical management of these disorders... 
Executive functions and memory abilities in children with 22q11.2 deletion syndromeLinda E Campbell
Institute of Psychiatry, King s College London, UK
Aust N Z J Psychiatry 44:364-71. 2010....- Brain structural differences associated with the behavioural phenotype in children with Williams syndromeLinda E Campbell
King s College London, Institute of Psychiatry, UK
Brain Res 1258:96-107. 2009..We investigated structural brain morphology of intellectually disabled children with Williams (WS) syndrome and its relationship to the behavioural phenotype... - Phenotype evaluation and genomewide linkage study of clinical variables in schizophreniaMarian L Hamshere
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation... 
White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescentsFrederick Sundram
Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, PO Box 50, De Crespigny Park, London, SE5 8AF, UK
J Neurodev Disord 2:77-92. 2010..Also, there is preliminary evidence that within 22q11DS, some regional differences in FA are associated with allelic variation in COMT and may perhaps also be associated with schizotypy...- Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI studyRayna Azuma
Psychological Medicine, Institute of Psychiatry, King s College London, Section of Brain Maturation PO50, DeCrespigny Park, London, SE5 8AF, UK
J Neurodev Disord 1:46-60. 2009..Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders... - In vivo brain anatomy of adult males with Fragile X syndrome: an MRI studyBrian P Hallahan
Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Neuroimage 54:16-24. 2011..People with FraX have regionally specific differences in brain anatomy from healthy controls with enlargement of the caudate nuclei that persists into adulthood... - Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)?Linda E Campbell
Institute of Psychiatry, King s College London, University of London, London, UK
J Neurodev Disord 3:152-61. 2011..These results are discussed in relation to the importance of a better delineation of social competence in this population... - The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomyCaroline J Moore
Division of Psychological Medicine, Department of Neurology, Institute of Psychiatry, King s College London, DeCrespigny Park, UK
Brain 127:2672-81. 2004..Moreover, our findings suggest, for the first time, an association between voxel density reduction and genetic variation in FraX... - A neuropsychological investigation of male premutation carriers of fragile X syndromeCaroline J Moore
Division of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
Neuropsychologia 42:1934-47. 2004.... - Asperger syndrome: a proton magnetic resonance spectroscopy study of brainDeclan G M Murphy
Department of Psychological Medicine, St George s Hospital Medical School, London, England
Arch Gen Psychiatry 59:885-91. 2002..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS... - Schizophrenia two-hit hypothesis in velo-cardio facial syndromeHywel J Williams
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
Am J Med Genet B Neuropsychiatr Genet 162:177-82. 2013..Our results suggest the two-hit hypothesis may be relevant to a proportion of VCFS patients with psychosis but sample sizes are small and further studies warranted... - Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibilityBeate Glaser
Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
Schizophr Res 87:21-7. 2006..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia... - White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adultsOswald J N Bloemen
Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
Autism Res 3:203-13. 2010..However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome... - Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's diseaseMelissa Lamar
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, London, England, UK
Neuroimage 57:63-8. 2011..mI] may modify risk for dementia in this vulnerable population... - The new genetics of schizophreniaColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Psychiatr Clin North Am 26:41-63. 2003.... - A comparative study of cognition and brain anatomy between two neurodevelopmental disorders: 22q11.2 deletion syndrome and Williams syndromeLinda E Campbell
Section of Brain Maturation, Institute of Psychiatry, King s College London, UK
Neuropsychologia 47:1034-44. 2009..Hence, it is difficult to know if the observed features of 22q11DS are simply due to a non-specific effect of having a genetic disorder or are specific to 22q11DS... - No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samplesBeate Glaser
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
Biol Psychiatry 58:78-80. 2005..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()... - Discriminating power of localized three-dimensional facial morphologyPeter Hammond
Eastman Dental Institute, University College London, London, WC1X 8LD, United Kingdom
Am J Hum Genet 77:999-1010. 2005.... - Candidate genes and the behavioral phenotype in 22q11.2 deletion syndromeSarah E Prasad
Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Republic of Ireland
Dev Disabil Res Rev 14:26-34. 2008..The study of 22q11.2DS provides an attractive model to increase our understanding of the development and pathogenesis of schizophrenia and other psychiatric disorders in 22q11.2DS and in wider population... - In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autismLisa A Page
Section of Brain Maturation, Institute of Psychiatry, London
Am J Psychiatry 163:2189-92. 2006..CONCLUSIONS: Abnormalities in glutamate/glutamine may partially underpin the pathophysiology of autistic spectrum disorders, and the authors confirm earlier reports that limbic areas are metabolically aberrant in these disorders... - Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndromeRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:7729-34. 2006..Thus, Tbx1 and Gnb1l are strong candidates for psychiatric disease in 22q11DS patients and candidate susceptibility genes for psychiatric disease in the wider population... - Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging studyTherese Van Amelsvoort
Department of Psychological Medicine, Institute of Psychiatry, London, England
Arch Gen Psychiatry 61:1085-96. 2004..The biological basis for this increased risk for schizophrenia is unknown, but people with velocardiofacial syndrome may have genetically determined differences in brain anatomy that predispose to the development of schizophrenia... - Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophreniaStanley Zammit
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior... - 3D analysis of facial morphologyPeter Hammond
Eastman Dental Institute, UCL, London, United Kingdom
Am J Med Genet A 126:339-48. 2004..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html... - Strong evidence that GNB1L is associated with schizophreniaNigel M Williams
Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Hum Mol Genet 17:555-66. 2008..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...