Kieran C Murphy

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint High rates of schizophrenia in adults with velo-cardio-facial syndrome
    K C Murphy
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 56:940-5. 1999
  2. ncbi request reprint Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia
    K C Murphy
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 179:397-402. 2001
  3. ncbi request reprint Schizophrenia and velo-cardio-facial syndrome
    Kieran C Murphy
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Lancet 359:426-30. 2002
  4. doi request reprint Executive functions and memory abilities in children with 22q11.2 deletion syndrome
    Linda E Campbell
    Institute of Psychiatry, King s College London, UK
    Aust N Z J Psychiatry 44:364-71. 2010
  5. doi request reprint Brain structural differences associated with the behavioural phenotype in children with Williams syndrome
    Linda E Campbell
    King s College London, Institute of Psychiatry, UK
    Brain Res 1258:96-107. 2009
  6. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
  7. pmc White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents
    Frederick Sundram
    Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, PO Box 50, De Crespigny Park, London, SE5 8AF, UK
    J Neurodev Disord 2:77-92. 2010
  8. pmc Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study
    Rayna Azuma
    Psychological Medicine, Institute of Psychiatry, King s College London, Section of Brain Maturation PO50, DeCrespigny Park, London, SE5 8AF, UK
    J Neurodev Disord 1:46-60. 2009
  9. doi request reprint In vivo brain anatomy of adult males with Fragile X syndrome: an MRI study
    Brian P Hallahan
    Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Neuroimage 54:16-24. 2011
  10. pmc Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)?
    Linda E Campbell
    Institute of Psychiatry, King s College London, University of London, London, UK
    J Neurodev Disord 3:152-61. 2011

Collaborators

Detail Information

Publications28

  1. ncbi request reprint High rates of schizophrenia in adults with velo-cardio-facial syndrome
    K C Murphy
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 56:940-5. 1999
    ..Velo-cardio-facial syndrome (VCFS), a syndrome characterized by an increased frequency of schizophrenia and bipolar disorder, is associated with small interstitial deletions of chromosome 22q11...
  2. ncbi request reprint Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia
    K C Murphy
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 179:397-402. 2001
    ..Individuals with velocardio-facial syndrome (VCFS), a genetic disorder associated with microdeletions of chromosome 22q11, are reported to have high rates of psychiatric disorder, particularly schizophrenia...
  3. ncbi request reprint Schizophrenia and velo-cardio-facial syndrome
    Kieran C Murphy
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Lancet 359:426-30. 2002
    ..Furthermore, the strength of the association between schizophrenia and VCFS has important implications for the clinical management of these disorders...
  4. doi request reprint Executive functions and memory abilities in children with 22q11.2 deletion syndrome
    Linda E Campbell
    Institute of Psychiatry, King s College London, UK
    Aust N Z J Psychiatry 44:364-71. 2010
    ....
  5. doi request reprint Brain structural differences associated with the behavioural phenotype in children with Williams syndrome
    Linda E Campbell
    King s College London, Institute of Psychiatry, UK
    Brain Res 1258:96-107. 2009
    ..We investigated structural brain morphology of intellectually disabled children with Williams (WS) syndrome and its relationship to the behavioural phenotype...
  6. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
    ..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation...
  7. pmc White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents
    Frederick Sundram
    Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, PO Box 50, De Crespigny Park, London, SE5 8AF, UK
    J Neurodev Disord 2:77-92. 2010
    ..Also, there is preliminary evidence that within 22q11DS, some regional differences in FA are associated with allelic variation in COMT and may perhaps also be associated with schizotypy...
  8. pmc Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study
    Rayna Azuma
    Psychological Medicine, Institute of Psychiatry, King s College London, Section of Brain Maturation PO50, DeCrespigny Park, London, SE5 8AF, UK
    J Neurodev Disord 1:46-60. 2009
    ..Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders...
  9. doi request reprint In vivo brain anatomy of adult males with Fragile X syndrome: an MRI study
    Brian P Hallahan
    Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Neuroimage 54:16-24. 2011
    ..People with FraX have regionally specific differences in brain anatomy from healthy controls with enlargement of the caudate nuclei that persists into adulthood...
  10. pmc Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)?
    Linda E Campbell
    Institute of Psychiatry, King s College London, University of London, London, UK
    J Neurodev Disord 3:152-61. 2011
    ..These results are discussed in relation to the importance of a better delineation of social competence in this population...
  11. ncbi request reprint The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy
    Caroline J Moore
    Division of Psychological Medicine, Department of Neurology, Institute of Psychiatry, King s College London, DeCrespigny Park, UK
    Brain 127:2672-81. 2004
    ..Moreover, our findings suggest, for the first time, an association between voxel density reduction and genetic variation in FraX...
  12. ncbi request reprint A neuropsychological investigation of male premutation carriers of fragile X syndrome
    Caroline J Moore
    Division of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
    Neuropsychologia 42:1934-47. 2004
    ....
  13. ncbi request reprint Asperger syndrome: a proton magnetic resonance spectroscopy study of brain
    Declan G M Murphy
    Department of Psychological Medicine, St George s Hospital Medical School, London, England
    Arch Gen Psychiatry 59:885-91. 2002
    ..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS...
  14. doi request reprint Schizophrenia two-hit hypothesis in velo-cardio facial syndrome
    Hywel J Williams
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 162:177-82. 2013
    ..Our results suggest the two-hit hypothesis may be relevant to a proportion of VCFS patients with psychosis but sample sizes are small and further studies warranted...
  15. ncbi request reprint Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia...
  16. doi request reprint White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults
    Oswald J N Bloemen
    Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Autism Res 3:203-13. 2010
    ..However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome...
  17. doi request reprint Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's disease
    Melissa Lamar
    Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, London, England, UK
    Neuroimage 57:63-8. 2011
    ..mI] may modify risk for dementia in this vulnerable population...
  18. ncbi request reprint The new genetics of schizophrenia
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Psychiatr Clin North Am 26:41-63. 2003
    ....
  19. doi request reprint A comparative study of cognition and brain anatomy between two neurodevelopmental disorders: 22q11.2 deletion syndrome and Williams syndrome
    Linda E Campbell
    Section of Brain Maturation, Institute of Psychiatry, King s College London, UK
    Neuropsychologia 47:1034-44. 2009
    ..Hence, it is difficult to know if the observed features of 22q11DS are simply due to a non-specific effect of having a genetic disorder or are specific to 22q11DS...
  20. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  21. pmc Discriminating power of localized three-dimensional facial morphology
    Peter Hammond
    Eastman Dental Institute, University College London, London, WC1X 8LD, United Kingdom
    Am J Hum Genet 77:999-1010. 2005
    ....
  22. doi request reprint Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome
    Sarah E Prasad
    Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Republic of Ireland
    Dev Disabil Res Rev 14:26-34. 2008
    ..The study of 22q11.2DS provides an attractive model to increase our understanding of the development and pathogenesis of schizophrenia and other psychiatric disorders in 22q11.2DS and in wider population...
  23. ncbi request reprint In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism
    Lisa A Page
    Section of Brain Maturation, Institute of Psychiatry, London
    Am J Psychiatry 163:2189-92. 2006
    ..However, the concentration of glutamate/glutamine in brain regions implicated in autistic spectrum disorders has not yet been examined in vivo...
  24. pmc Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:7729-34. 2006
    ..Thus, Tbx1 and Gnb1l are strong candidates for psychiatric disease in 22q11DS patients and candidate susceptibility genes for psychiatric disease in the wider population...
  25. ncbi request reprint Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study
    Therese Van Amelsvoort
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 61:1085-96. 2004
    ..The biological basis for this increased risk for schizophrenia is unknown, but people with velocardiofacial syndrome may have genetically determined differences in brain anatomy that predispose to the development of schizophrenia...
  26. ncbi request reprint Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  27. ncbi request reprint 3D analysis of facial morphology
    Peter Hammond
    Eastman Dental Institute, UCL, London, United Kingdom
    Am J Med Genet A 126:339-48. 2004
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html...
  28. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...