Research Topics
Genomes and GenesSpecies | Declan G M MurphySummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Autism in adults. New biologicial findings and their translational implications to the cost of clinical servicesDeclan G M Murphy
Department of Forensic and Developmental Sciences, Institute of Psychiatry, Kings College London, London, UK
Brain Res 1380:22-33. 2011....
Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletionEileen M Daly
Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King s College London, London, England
Arch Gen Psychiatry 69:1003-13. 2012....
Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairmentCatherine M L Foy
Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King s College London, London, UK
Brain Topogr 24:316-22. 2011..Reductions in [NAA] can be detected in the hippocampi of subjects with MCI and hippocampal [NAA] and [Cr + PCr] can distinguish between mild AD and normal elderly controls...
White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorderFrederick Sundram
King s College London, Institute of Psychiatry, Department of Forensic and Neurodevelopmental Science, London, UK Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
Cortex 48:216-29. 2012..Hence, we provide evidence of significant WM microstructural abnormalities in frontal brain regions in ASPD and psychopathy...
The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography studyLuca Pugliese
Section of Brain Maturation, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Neuroimage 47:427-34. 2009..05) (p=.02). Our preliminary findings suggest that people with Asperger syndrome have significant differences in the anatomy, and maturation, of some (but not all) limbic tracts...
An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndromeQuinton Deeley
Section of Brain Maturation, De Crespigny Park, London, UK
Biol Psychiatry 62:207-17. 2007..However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities...
A lateralized brain network for visuospatial attentionMichel Thiebaut de Schotten
Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, UK
Nat Neurosci 14:1245-6. 2011..Our results suggest that hemispheric specialization is associated with an unbalanced speed of visuospatial processing...
Early specialization for voice and emotion processing in the infant brainAnna Blasi
Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Curr Biol 21:1220-4. 2011..These results suggest remarkably early functional specialization for processing human voice and negative emotions...
Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's diseaseMelissa Lamar
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, London, England, UK
Neuroimage 57:63-8. 2011..mI] may modify risk for dementia in this vulnerable population...
Brain anatomy and sensorimotor gating in Asperger's syndromeGrainne M McAlonan
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Brain 125:1594-606. 2002....
Fronto-striatal circuitry and inhibitory control in autism: findings from diffusion tensor imaging tractographyMarieke Langen
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK
Cortex 48:183-93. 2012..There are few studies, however, that have measured the micro-structural organisation of white matter tracts connecting striatum and frontal cortex...
White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adultsOswald J N Bloemen
Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
Autism Res 3:203-13. 2010..However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome...
White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescentsFrederick Sundram
Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, PO Box 50, De Crespigny Park, London, SE5 8AF, UK
J Neurodev Disord 2:77-92. 2010..Also, there is preliminary evidence that within 22q11DS, some regional differences in FA are associated with allelic variation in COMT and may perhaps also be associated with schizotypy...
Neural correlates of executive function in autistic spectrum disordersNicole Schmitz
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King College London, UK
Biol Psychiatry 59:7-16. 2006..However, to date, no functional imaging study on ASD has investigated inhibition and cognitive flexibility and no one has related EF brain activation to brain structure...
The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomyCaroline J Moore
Division of Psychological Medicine, Department of Neurology, Institute of Psychiatry, King s College London, DeCrespigny Park, UK
Brain 127:2672-81. 2004..Moreover, our findings suggest, for the first time, an association between voxel density reduction and genetic variation in FraX...
In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autismLisa A Page
Section of Brain Maturation, Institute of Psychiatry, London
Am J Psychiatry 163:2189-92. 2006..CONCLUSIONS: Abnormalities in glutamate/glutamine may partially underpin the pathophysiology of autistic spectrum disorders, and the authors confirm earlier reports that limbic areas are metabolically aberrant in these disorders...
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imagingFinian M O'Brien
Department of Psychological Medicine, Kings College London, UK
Psychiatry Res 184:77-85. 2010..We therefore suggest that people with AS have significant differences in neuronal and lipid membrane integrity and maturation of the AHC...
Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging studyTherese Van Amelsvoort
Department of Psychological Medicine, Institute of Psychiatry, London, England
Arch Gen Psychiatry 61:1085-96. 2004..The biological basis for this increased risk for schizophrenia is unknown, but people with velocardiofacial syndrome may have genetically determined differences in brain anatomy that predispose to the development of schizophrenia...
Executive functions and memory abilities in children with 22q11.2 deletion syndromeLinda E Campbell
Institute of Psychiatry, King s College London, UK
Aust N Z J Psychiatry 44:364-71. 2010....
Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)?Linda E Campbell
Institute of Psychiatry, King s College London, University of London, London, UK
J Neurodev Disord 3:152-61. 2011..These results are discussed in relation to the importance of a better delineation of social competence in this population...
The Women's Health Initiative Memory Study: findings and implications for treatmentMichael C Craig
Psychological Medicine, Institute of Psychiatry, London, UK
Lancet Neurol 4:190-4. 2005....
Serotonin transporter genotype and neuroanatomy in autism spectrum disordersArmin Raznahan
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, KCL, UK
Psychiatr Genet 19:147-50. 2009....
Is there a common underlying mechanism for age-related decline in cortical thickness?Christine Ecker
Section of Brain Maturation, PO50, Institute of Psychiatry, De Crespigny Park, London SE58AF, UK
Neuroreport 20:1155-60. 2009..This model reconciles two seemingly mutually exclusive hypotheses, namely, the existence of different decay functions being caused by the same underlying mechanism...
Microstructural organization of cerebellar tracts in schizophreniaRichard A A Kanaan
Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 66:1067-9. 2009..However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error...
A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorderLisa A Page
King s College London, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Room 3 14, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK
Psychiatry Res 174:202-9. 2009..OCD is associated with task-relevant fronto-striatal dysfunction during motor inhibition and cognitive switching. In addition, parieto-temporal dysfunction was observed during tasks with a higher attentional load...
Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approachChristine Ecker
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, Brain Image Analysis Unit, Centre for Neuroimaging Sciences, King s College, London SE5 8AF, United Kingdom
J Neurosci 30:10612-23. 2010..The spatial patterns detected using SVM may help further exploration of the specific genetic and neuropathological underpinnings of ASD, and provide new insights into the most likely multifactorial etiology of the condition...
Alzheimer's disease in womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Best Pract Res Clin Obstet Gynaecol 23:53-61. 2009..However, it may have a negative or neutral effect if it is prescribed to women after this time. This chapter will discuss some of the putative biological mechanisms that may underlie these effects...
Reversibility of the effects of acute ovarian hormone suppression on verbal memory and prefrontal function in pre-menopausal womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Psychoneuroendocrinology 33:1426-31. 2008..To do this we carried out a further imaging study using the same verbal memory recognition task after cessation of GnRHa-induced ovarian suppression...
Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT studyDeclan G M Murphy
Institute of Psychiatry, Department of Psychological Medicine, London, UK
Am J Psychiatry 163:934-6. 2006..e., autism and Asperger's syndrome) is unknown. The serotonergic (5-HT) system may be especially implicated. However, cortical 5-HT2A receptor density in adults with the disorder has not been examined, to the authors' knowledge...
Neuropsychological functioning in adults with Asperger syndromeFiona Z Ambery
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Autism 10:551-64. 2006..There was no significant difference between verbal and performance IQ. Our results suggest that impairments on tests requiring flexibility of thought and generation occur at all ages and across a range of autistic disorders including AS...
Influence of X chromosome and hormones on human brain development: a magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndromeWilliam J Cutter
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Biol Psychiatry 59:273-83. 2006..Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development...
Effects of acute ovarian hormone suppression on the human brain: an in vivo 1H MRS studyMichael C Craig
Department of Psychological Medicine, Institute of Psychiatry, Section of Brain Maturation, London, UK
Psychoneuroendocrinology 32:1128-32. 2007..They also showed a trend to a significant increase in Cho concentration in the hippocampus. This supports our previous findings and adds to the evidence that neuronal/glial membrane metabolism is affected by sex hormones in women...
Obsessions and compulsions in Asperger syndrome and high-functioning autismAilsa J Russell
Department of Psychology, Institute of Psychiatry, King s College, London, UK
Br J Psychiatry 186:525-8. 2005..Obsessive-compulsive behaviours are common and disabling in autistic-spectrum disorders (ASD) but little is known about how they compare with those experienced by people with obsessive-compulsive disorder (OCD)...
Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomyMichael C Craig
PO Box 50, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Br J Psychiatry 191:224-8. 2007..Our understanding of anatomical differences in people with autistic-spectrum disorder, is based on mixed-gender or male samples...
People with learning disabilities in a low secure in-patient unit: comparison of offenders and non-offendersSuzie Reed
Maudsley Centre for Behavioural Disorders, South London and Maudsley NHS Trust, and Health Services Research Department, Institute of Psychiatry, London SE5 8AF, UK
Br J Psychiatry 185:499-504. 2004....
Gonadotropin hormone releasing hormone agonists alter prefrontal function during verbal encoding in young womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, 16 De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Psychoneuroendocrinology 32:1116-27. 2007....
Oestrogen: brain ageing, cognition and neuropsychiatric disorderRay Norbury
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
J Br Menopause Soc 10:118-22. 2004..Here we review research into the effects of oestrogen on brain maturation and function and discuss the role for oestrogen replacement therapy (ERT) as a therapeutic tool...
5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletionMelissa Lamar
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 30:1135-46. 2009..Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement...
A neuropsychological investigation of male premutation carriers of fragile X syndromeCaroline J Moore
Division of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
Neuropsychologia 42:1934-47. 2004....
Changes in male brain responses to emotional faces from adolescence to middle ageQuinton Deeley
Section of Brain Maturation, King s College London Institute of Psychiatry, De Crespigny Park, London, UK
Neuroimage 40:389-97. 2008....
Physiological variation in estradiol and brain function: a functional magnetic resonance imaging study of verbal memory across the follicular phase of the menstrual cycleMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, Kings College, London, SE5 8AF, UK
Horm Behav 53:503-8. 2008..Although we did not find a significant relationship between plasma estradiol concentration and verbal recall performance, we report a positive correlation between brain function and estradiol concentration at the LIFG...
A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Horm Behav 54:47-59. 2008..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM...
Altered cerebellar feedback projections in Asperger syndromeMarco Catani
Section of Brain Maturation, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, SE58AF, UK
Neuroimage 41:1184-91. 2008..The localised abnormalities in the main cerebellar outflow pathway may prevent the cerebral cortex from receiving those cerebellar feedback inputs necessary for a successful adaptive social behaviour...
The interactive effect of the cholinergic system and acute ovarian suppression on the brain: an fMRI studyM C Craig
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
Horm Behav 55:41-9. 2009..Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy...
Asperger syndrome: a proton magnetic resonance spectroscopy study of brainDeclan G M Murphy
Department of Psychological Medicine, St George s Hospital Medical School, London, England
Arch Gen Psychiatry 59:885-91. 2002..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS...
Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI studyLinda E Campbell
King s College London, Institute of Psychiatry, London, UK
Brain 129:1218-28. 2006..We suggest that there is preliminary evidence for specific vulnerability of the frontostriatal and cerebellar-cortical networks in 22qDS...
A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorderArmin Raznahan
Department of Child and Adolescent Psychiatry, Institute of Psychiatry IOP, Kings College London KCL, 16 De Crespigny Park, London, SE5 8AF, UK
J Neurodev Disord 1:215-23. 2009..If correct, this suggests ASD is associated with a distorted relationship between BDNF val66met genotype and the determinants of regional cortical surface area - gyrification and/or sulcal positioning...
Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy studyFelix Beacher
Section of Brain Maturation, Department of Psychological Medicine, Neuroimaging Research Group, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, England, UK
Arch Gen Psychiatry 62:1360-5. 2005..Future studies are required to relate myo-inositol concentration in people with DS to brain development and increased risk for developing Alzheimer disease...
In vivo brain anatomy of adult males with Fragile X syndrome: an MRI studyBrian P Hallahan
Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Neuroimage 54:16-24. 2011..People with FraX have regionally specific differences in brain anatomy from healthy controls with enlargement of the caudate nuclei that persists into adulthood...
Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI studyRayna Azuma
Psychological Medicine, Institute of Psychiatry, King s College London, Section of Brain Maturation PO50, DeCrespigny Park, London, SE5 8AF, UK
J Neurodev Disord 1:46-60. 2009..Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders...
The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young womenM C Craig
Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
Psychoneuroendocrinology 35:987-1000. 2010..Overall, our findings point to a neural network by which acute loss of ovarian function may interact to negatively impact encoding...
Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractographyMichel Thiebaut de Schotten
Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, UK
Neuroimage 54:49-59. 2011..This study suggests that DTI-derived maps can be used together with a previous histological atlas to establish the relationship of focal lesions with nearby tracts and improve clinico-anatomical correlation...
Brain structural differences associated with the behavioural phenotype in children with Williams syndromeLinda E Campbell
King s College London, Institute of Psychiatry, UK
Brain Res 1258:96-107. 2009..We investigated structural brain morphology of intellectually disabled children with Williams (WS) syndrome and its relationship to the behavioural phenotype...
A comparative study of cognition and brain anatomy between two neurodevelopmental disorders: 22q11.2 deletion syndrome and Williams syndromeLinda E Campbell
Section of Brain Maturation, Institute of Psychiatry, King s College London, UK
Neuropsychologia 47:1034-44. 2009..Hence, it is difficult to know if the observed features of 22q11DS are simply due to a non-specific effect of having a genetic disorder or are specific to 22q11DS...
Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging studyChristine Ecker
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, De Crespigny Park, London, England
Arch Gen Psychiatry 69:195-209. 2012..There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well as how these relate to behavioral variation, remain poorly understood...
Cortical anatomy in autism spectrum disorder: an in vivo MRI study on the effect of ageArmin Raznahan
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
Cereb Cortex 20:1332-40. 2010..This may reflect primary abnormalities in cortical plasticity and/or be secondary to disturbed interactions between individuals with ASD and their environment...
Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humansEileen Daly
Section of Brain Maturation, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
Psychopharmacology (Berl) 210:499-510. 2010..Acute tryptophan depletion (ATD) temporarily lowers brain serotonin (5-HT) synthesis, and behavioral studies have shown that this alters the processing of facial expressions of emotion...
Mapping infant brain myelination with magnetic resonance imagingSean C L Deoni
Centre for Neuroimaging Sciences, Institute of Psychiatry, London SE5 8AF, UK
J Neurosci 31:784-91. 2011..This work represents a significant step forward in our ability to appreciate the fundamental process of myelination, and provides the first ever in vivo visualization of myelin maturation in healthy human infancy...
