Paul D Morrison
Affiliation: King's College London
- SchizophreniaPaul D Morrison
Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Curr Biol 15:R980-4. 2005
- Cannabis, the mind and society: the hash realitiesRobin M Murray
Institute of Psychiatry, Psychological Medicine, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Nat Rev Neurosci 8:885-95. 2007....
- Cannabis use and psychiatric and cogitive disorders: the chicken or the egg?Marta Di Forti
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Curr Opin Psychiatry 20:228-34. 2007..Cannabis is the world's most commonly used illicit drug. In this review, we consider the recent literature on the effects of cannabis on mental health and on cognition...
- Does intravenous Δ9-tetrahydrocannabinol increase dopamine release? A SPET studyEmma Barkus
Institute of Psychiatry, Kings College London, London, UK
J Psychopharmacol 25:1462-8. 2011..THC did not lead to a significant increase in DA release even though the dose was sufficient for participants to have psychotic symptoms. These findings do not support a central role for striatal DA in THC-elicited psychosis...
- Synthetic delta-9-tetrahydrocannabinol elicits schizophrenia-like negative symptoms which are distinct from sedationP D Morrison
Kings College London, The Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Hum Psychopharmacol 26:77-80. 2011..It is unknown if cannabis recreates the negative symptoms of schizophrenia...
- Disruption of frontal θ coherence by Δ9-tetrahydrocannabinol is associated with positive psychotic symptomsPaul D Morrison
The Biomedical Research Centre, Institute of Psychiatry, King s College London, Denmark Hill, UK
Neuropsychopharmacology 36:827-36. 2011..The results reveal that the pro-psychotic effects of THC might be related to impaired network dynamics with impaired communication between the right and left frontal lobes...
- From real-world events to psychosis: the emerging neuropharmacology of delusionsPaul D Morrison
Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Bull 35:668-74. 2009..Here, we discuss how the 3 modulators regulate learning within the striatum and how their dysfunction may lead to delusional thinking...
- The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioningP D Morrison
Institute of Psychiatry, The Biomedical Research Centre, King s College London, UK
Psychol Med 39:1607-16. 2009..In a study of intravenous (i.v.) synthetic THC in healthy humans, we aimed to study the relationship of the psychotic symptoms induced by THC to the consequent anxiety and neuropsychological impairment...
- Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairmentAmir Englund
The Biomedical Research Centre, Institute of Psychiatry, King s College London, UK
J Psychopharmacol 27:19-27. 2013..6 ± 18.9%) compared with the CBD group (-0.4% ± 9.7 %) (t=2.39, p<0.05). These findings support the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health...
- What is the mechanism whereby cannabis use increases risk of psychosis?Sonija Luzi
Institute of Psychiatry, Division of Psychological Medicine, Denmark Hill, London, SE5 8AF, UK
Neurotox Res 14:105-12. 2008..This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis...
- What can we learn about schizophrenia from studying the human model, drug-induced psychosis?Robin M Murray
Department of Psychosis Studies, Institute of Psychiatry, Kings College London, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 162:661-70. 2013..Determining the different molecular effects of those drugs whose pharmacological effects do and do not mimic the various aspects of schizophrenia has much to teach us concerning the pathogenesis of the illness...
- Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathologySagnik Bhattacharyya
Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 35:764-74. 2010..Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC...
- Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective reviewJames M Stone
King s College London Institute of Psychiatry, London, UK
J Psychopharmacol 21:440-52. 2007..We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition...
- Delta-9-tetrahydrocannabinol, neural oscillations above 20 Hz and induced acute psychosisJudith F Nottage
Institute of Psychiatry, King s College London, P089 DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK
Psychopharmacology (Berl) 232:519-28. 2015..An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia...
- A novel method for reducing the effect of tonic muscle activity on the gamma band of the scalp EEGJudith F Nottage
Department of Neuroimaging, Institute of Psychiatry, King s College London, London, UK
Brain Topogr 26:50-61. 2013..05). The reduction of EMG contamination by fitting and subtraction of individual spikes shows promise as a method of improving the signal to noise ratio of high frequency neural oscillations in scalp EEG...
- Cannabis in the arm: what can we learn from intravenous cannabinoid studies?Amir Englund
King s College London, Institute of Psychiatry, Denmark Hill, London SE5 8AF
Curr Pharm Des 18:4906-14. 2012..Here in a critical review, we appraise the major findings from recent intravenous cannabinoid studies in humans and trace the historical roots of this work back to the 1970's...
- Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of lightAlessandra Paparelli
Division of Psychological Medicine, Institute of Psychiatry, King s College London London, UK
Front Behav Neurosci 5:1. 2011..In this review we examine the main hypotheses resulting from the link observed between the most common psychotomimetic drugs (lysergic acid diethylamide, amphetamines, cannabis, phencyclidine) and schizophrenia...
- Schizophrenia: more evidence for less glutamatePaul D Morrison
Institute of Psychiatry, De Crespigny Hill, London SE5 8AF, UK
Expert Rev Neurother 7:29-31. 2007..These findings underscore the importance of NMDA receptors in schizophrenia and support therapeutic strategies aimed at boosting glutamate transmission...