Jonathan Mill

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
    Jonathan Mill
    Institute of Psychiatry, SGDP Research Centre, London, UK
    J Child Psychol Psychiatry 49:1020-30. 2008
  2. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
  3. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
  4. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
  5. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
  6. pmc Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    Matthew N Davies
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genome Biol 13:R43. 2012
  7. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
  8. pmc A data-driven approach to preprocessing Illumina 450K methylation array data
    Ruth Pidsley
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    BMC Genomics 14:293. 2013
  9. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
  10. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005

Collaborators

Detail Information

Publications26

  1. doi request reprint Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
    Jonathan Mill
    Institute of Psychiatry, SGDP Research Centre, London, UK
    J Child Psychol Psychiatry 49:1020-30. 2008
    ..We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention...
  2. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
    ..Previously we reported evidence of a negative correlation between DNA methylation in this region and cerebellum weight in humans...
  3. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  4. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  5. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  6. pmc Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    Matthew N Davies
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genome Biol 13:R43. 2012
    ..We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors...
  7. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
    ..Only few studies have reported association between promoter polymorphisms of the gene and ADHD...
  8. pmc A data-driven approach to preprocessing Illumina 450K methylation array data
    Ruth Pidsley
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    BMC Genomics 14:293. 2013
    ..These metrics also have potential utility as quality scores for datasets...
  9. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  10. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  11. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
    ..Previous research has suggested that activity and expression of COMT is altered in schizophrenia, and is mediated by one or more polymorphisms within the gene, including the functional Val158Met polymorphism...
  12. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
    ..Although we found some evidence for the preferential transmission of a rare haplotype (long-allele/9-repeat-allele/T-allele; chi2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone...
  13. doi request reprint Stochastic choice of allelic expression in human neural stem cells
    Aaron R Jeffries
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, Department of Neuroscience, London, United Kingdom
    Stem Cells 30:1938-47. 2012
    ..We conclude that stochastic allelic expression is prevalent in neural stem cells, providing clonal diversity to developing tissues such as the human brain...
  14. pmc Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight
    Ruth Pidsley
    Institute of Psychiatry, King s College London, London, UK
    Epigenetics 7:155-63. 2012
    ....
  15. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
    ..A principal aim of genetic research is to provide new information that can resolve such clinical heterogeneity and that can be incorporated into diagnostic practice...
  16. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
    ....
  17. pmc A longitudinal study of epigenetic variation in twins
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Epigenetics 5:516-26. 2010
    ..The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research...
  18. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010
    ....
  19. pmc A longitudinal twin study of skewed X chromosome-inactivation
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e17873. 2011
    ..These data have implications for our understanding about sex differences in complex disease, and the potential causes of phenotypic discordance between MZ female twins...
  20. doi request reprint Drugs and addiction: an introduction to epigenetics
    Chloe C Y Wong
    Institute of Psychiatry, SGDP Research Centre, King s College London, De Crespigny Park, Denmark Hill, UK
    Addiction 106:480-9. 2011
    ..The implications of these findings for molecular studies of addiction and the future development of novel therapeutic interventions are also discussed...
  21. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  22. ncbi request reprint Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene
    Jonathan Mill
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:421-5. 2006
    ..Such epigenetic variation between genetically identical individuals may play a key role in the etiology of psychopathology, and explain the incomplete phenotypic concordance observed in MZ twins...
  23. doi request reprint Epigenetics, genomic mutations and cognitive function
    Abraham Reichenberg
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 14:377-90. 2009
    ..However, there is accumulating evidence that dynamic genomic and epigenetic alterations can modulate complex cognitive processes, and influence susceptibility to disorders associated with impaired cognitive functioning...
  24. doi request reprint Toward an integrated genetic and epigenetic approach to Alzheimer's disease
    Jonathan Mill
    Institute of Psychiatry, King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, London, UK
    Neurobiol Aging 32:1188-91. 2011
    ..Here, we briefly describe some methodological issues related to epigenomic studies using postmortem brain tissue in Alzheimer's disease, and argue for an integrated genetic-epigenetic approach to disease etiology...
  25. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...
  26. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004
    ..A global test incorporating all alleles of this marker, however, was not significant and thus this finding needs replication before any conclusions can be made...