J Mill

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet 114:269-71. 2002
  2. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
  3. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
  4. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
  5. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
  6. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
  7. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
  8. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004
  9. ncbi request reprint Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity
    J Mill
    Social, Genetic, and Developmental Psychiatric Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:166-73. 2002
  10. ncbi request reprint Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet 114:269-71. 2002
    ..Within-family tests of linkage and association confirmed these findings. Further work is needed to ascertain the role of SNAP-25 in ADHD and assess the functional significance of this polymorphism...
  2. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
    ..Previous research has suggested that activity and expression of COMT is altered in schizophrenia, and is mediated by one or more polymorphisms within the gene, including the functional Val158Met polymorphism...
  3. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  4. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
    ..Only few studies have reported association between promoter polymorphisms of the gene and ADHD...
  5. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
    ....
  6. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  7. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...
  8. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004
    ..A global test incorporating all alleles of this marker, however, was not significant and thus this finding needs replication before any conclusions can be made...
  9. ncbi request reprint Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity
    J Mill
    Social, Genetic, and Developmental Psychiatric Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:166-73. 2002
    ....
  10. ncbi request reprint Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002
    ..These data provide direct evidence that the VNTR, or another polymorphism in linkage disequilibrium with the VNTR, is involved in regulating expression of this gene...
  11. ncbi request reprint The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study
    J S Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, SE5 8AF, UK
    Mol Psychiatry 7:383-91. 2002
    ..We found no evidence to support this association...
  12. ncbi request reprint Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples
    S Curran
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 6:425-8. 2001
    ..45, P = 0.06, OR = 1.15), however we find significant evidence of heterogeneity between the combined dataset (chi(2) = 22.64, df = 8, P = 0.004)...
  13. ncbi request reprint QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms
    S Curran
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet 105:387-93. 2001
    ..We found a significant relationship between DRD4-7 and high-scoring individuals [chi-square = 8.63; P = 0.003; OR = 2.09 (95% CI 1.24 < OR < 3.54), F-statistic = 7.245; P = 0.008]...
  14. ncbi request reprint Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD
    J Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College, London, UK
    Mol Psychiatry 9:801-10. 2004
    ..Overall our data provide some evidence for a role of this gene in ADHD, although the precise causal functional variant is yet to be ascertained...
  15. ncbi request reprint Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample
    J Mill
    Social, Genetic, and Development Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 6:440-4. 2001
    ..We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation...
  16. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
    ..Although we found some evidence for the preferential transmission of a rare haplotype (long-allele/9-repeat-allele/T-allele; chi2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone...
  17. ncbi request reprint Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup...
  18. ncbi request reprint Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth
    K J Brookes
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:94-9. 2008
    ..We conclude that the DRD4 7-repeat allele is associated with ADHD but there is no association or interaction with SOB for increased risk for ADHD. Our findings suggest that we can refute a possible effect of SOB for ADHD...
  19. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
    ..A principal aim of genetic research is to provide new information that can resolve such clinical heterogeneity and that can be incorporated into diagnostic practice...
  20. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  21. doi request reprint Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
    Jonathan Mill
    Institute of Psychiatry, SGDP Research Centre, London, UK
    J Child Psychol Psychiatry 49:1020-30. 2008
    ..We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention...
  22. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  23. doi request reprint Epigenetics, genomic mutations and cognitive function
    Abraham Reichenberg
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 14:377-90. 2009
    ..However, there is accumulating evidence that dynamic genomic and epigenetic alterations can modulate complex cognitive processes, and influence susceptibility to disorders associated with impaired cognitive functioning...
  24. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  25. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
    ..The location of the polymorphism in the 5'regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles...
  26. ncbi request reprint Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neuroreport 14:1463-6. 2003
    ....
  27. ncbi request reprint Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes
    Ian W Craig
    SGDP Centre, Institute of Psychiatry, Box PO 82, Denmark Hill, London SE5, UK
    Eur J Hum Genet 12:639-46. 2004
    ..Six of the targets were represented by more than one probe set, which gave independent support for the conclusions reached...
  28. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  29. pmc DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP
    T R Powell
    King s College London, MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Transl Psychiatry 3:e300. 2013
    ..Our results suggest that DNA methylation in IL11 might be useful in identifying those patients likely to respond to antidepressants, and if so, the best drug suited to each individual. ..
  30. ncbi request reprint DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping
    B Freeman
    Institute of Psychiatry, SGDP Research Centre, Box P O 82, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Behav Genet 33:67-72. 2003
    ..The availability of this technology is of considerable significance in planning DNA banks from population collections and cohorts...
  31. ncbi request reprint Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene
    Jonathan Mill
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:421-5. 2006
    ..Such epigenetic variation between genetically identical individuals may play a key role in the etiology of psychopathology, and explain the incomplete phenotypic concordance observed in MZ twins...
  32. ncbi request reprint Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  33. doi request reprint Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders
    Jonathan Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:1323-6. 2008
    ..These results suggest the existence of sex-specific etiological factors in depressive disorders, related to estrogen, with onset in childhood...
  34. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    ..Our data are consistent with the epigenetic theory of major psychosis and suggest that DNA-methylation changes are important to the etiology of schizophrenia and bipolar disorder...
  35. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
  36. ncbi request reprint Rodent models: utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD)
    Jonathan Mill
    Centre for Addiction and Mental Health, Toronto, Canada
    J Neurosci Methods 166:294-305. 2007
    ....
  37. ncbi request reprint Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources
    Jonathan Mill
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Biotechniques 41:603-7. 2006
    ..The average difference in methylation percentage calculated from the two sets of template using MS-SNuPE was 4%. If our results are replicated on other genomic loci, WGA may become a useful technique in DNA methylation studies...

Research Grants2

  1. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2009
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  2. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..