A Mechelli

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc The impact of second language learning on semantic and nonsemantic first language reading
    Chiara Nosarti
    Department of Psychiatry, Biomedical Research Centre for Mental Health, Institute of Psychiatry, King s College London, UK
    Cereb Cortex 20:315-27. 2010
  2. doi Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, PO Box 67, Division of Psychological Medicine and Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 66:231-7. 2009
  3. ncbi Semantic relevance explains category effects in medial fusiform gyri
    Andrea Mechelli
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Neuroimage 30:992-1002. 2006
  4. doi Genetic variation in neuregulin1 is associated with differences in prefrontal engagement in children
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3934-43. 2009
  5. pmc Dissociating stimulus-driven semantic and phonological effect during reading and naming
    Andrea Mechelli
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 28:205-17. 2007
  6. ncbi Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
    Andrea Mechelli
    Division of Psychological Medicine, Section of Neuroimaging, King s College London, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 28:1213-22. 2007
  7. doi The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
  8. doi Dysbindin modulates brain function during visual processing in children
    A Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, UK
    Neuroimage 49:817-22. 2010
  9. ncbi The effects of presentation rate during word and pseudoword reading: a comparison of PET and fMRI
    A Mechelli
    Institute of Neurology, London, UK
    J Cogn Neurosci 12:145-56. 2000
  10. ncbi Exact and approximate judgements of visual and auditory numerosity: an fMRI study
    Manuela Piazza
    Institute of Cognitive Neuroscience, University College London, London, UK
    Brain Res 1106:177-88. 2006

Detail Information

Publications53

  1. pmc The impact of second language learning on semantic and nonsemantic first language reading
    Chiara Nosarti
    Department of Psychiatry, Biomedical Research Centre for Mental Health, Institute of Psychiatry, King s College London, UK
    Cereb Cortex 20:315-27. 2010
    ..Our observations were in a context that required participants to switch between languages. They motivate future fMRI studies to test whether first language reading is also altered in contexts when the second language is not in use...
  2. doi Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, PO Box 67, Division of Psychological Medicine and Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 66:231-7. 2009
    ....
  3. ncbi Semantic relevance explains category effects in medial fusiform gyri
    Andrea Mechelli
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Neuroimage 30:992-1002. 2006
    ..It also suggests that increased activation in the medial fusiform gyrus typically found for artefacts > animals can be explained by different semantic relevance for animal and artefact items...
  4. doi Genetic variation in neuregulin1 is associated with differences in prefrontal engagement in children
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3934-43. 2009
    ..Our investigation provides support to the idea that genetic factors may affect brain function to moderate vulnerability to psychopathology from childhood...
  5. pmc Dissociating stimulus-driven semantic and phonological effect during reading and naming
    Andrea Mechelli
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 28:205-17. 2007
    ..In conclusion, this study dissociates the effects of semantic and phonological relatedness between successive items during reading and naming aloud...
  6. ncbi Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
    Andrea Mechelli
    Division of Psychological Medicine, Section of Neuroimaging, King s College London, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 28:1213-22. 2007
    ..Although this finding is based on external rather than internal speech, the same mechanism may contribute to the faulty appraisal of inner speech that putatively underlies AVH...
  7. doi The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
    ..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex...
  8. doi Dysbindin modulates brain function during visual processing in children
    A Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, UK
    Neuroimage 49:817-22. 2010
    ..These findings are consistent with the notion that the DTNBP1 gene influences brain development and can thereby modulate vulnerability to schizophrenia...
  9. ncbi The effects of presentation rate during word and pseudoword reading: a comparison of PET and fMRI
    A Mechelli
    Institute of Neurology, London, UK
    J Cogn Neurosci 12:145-56. 2000
    ..However, for negative effects of rate, fMRI did not replicate the effects seen in PET, suggesting some form of hemodynamic "rectification." The discussion focuses on differences between evoked rCBF and BOLD signals...
  10. ncbi Exact and approximate judgements of visual and auditory numerosity: an fMRI study
    Manuela Piazza
    Institute of Cognitive Neuroscience, University College London, London, UK
    Brain Res 1106:177-88. 2006
    ..Counting activates additional left prefrontal, parietal, and bilateral premotor areas, again independently from stimulus modality. These results dissociate two neuronal systems that underlie different numerosity judgements...
  11. ncbi Effective connectivity and intersubject variability: using a multisubject network to test differences and commonalities
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WCIN 3BG, United Kingdom
    Neuroimage 17:1459-69. 2002
    ..The discussion focuses on the implications of our findings and on further applications of the multisubject network analysis...
  12. ncbi Dissociating reading processes on the basis of neuronal interactions
    Andrea Mechelli
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    J Cogn Neurosci 17:1753-65. 2005
    ..The present investigation is the first to identify distinct neuronal mechanisms for semantic and phonological contributions to reading...
  13. ncbi Neuroimaging studies of word and pseudoword reading: consistencies, inconsistencies, and limitations
    Andrea Mechelli
    Institute of Neurology, London, UK
    J Cogn Neurosci 15:260-71. 2003
    ..Furthermore, (iii) they suggest that inconsistencies observed in the previous literature may result from effects arising from a small number of subjects only...
  14. ncbi Comparing event-related and epoch analysis in blocked design fMRI
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WCIN 3BG, UK
    Neuroimage 18:806-10. 2003
    ..In addition, we show that the advantage of the event-related over epoch model was engendered by its early onset rather than its late offset, relative to the epoch model...
  15. ncbi Estimating efficiency a priori: a comparison of blocked and randomized designs
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 18:798-805. 2003
    ..Furthermore, we show that the error variance can change with the experimental design. This highlights a problem with a priori comparison of efficiency for two or more experimental designs, which usually assumes identical error variance...
  16. doi Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Int J Neuropsychopharmacol 13:421-32. 2010
    ..This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties...
  17. doi No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder
    D P Prata
    Division of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    Genes Brain Behav 10:276-85. 2011
    ..The absence of an effect in patients may reflect interactions of the effects of DISC1 genotype with the effects of other genes associated with these disorders, and/or with the effects of the disorders on brain function...
  18. pmc Differential effects of word length and visual contrast in the fusiform and lingual gyri during reading
    A Mechelli
    Wellcome Department of Cognitive Neurology, London, UK
    Proc Biol Sci 267:1909-13. 2000
    ....
  19. doi Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 68:881-90. 2011
    ..Alterations in glutamatergic neurotransmission and cerebral cortical dysfunction are thought to be central to the pathophysiology of psychosis, but the relationship between these 2 factors is unclear...
  20. ncbi Nonlinear coupling between evoked rCBF and BOLD signals: a simulation study of hemodynamic responses
    A Mechelli
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 14:862-72. 2001
    ....
  21. pmc Selective activation around the left occipito-temporal sulcus for words relative to pictures: individual variability or false positives?
    Nicholas D Wright
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    Hum Brain Mapp 29:986-1000. 2008
    ..More generally, they show that studies using low statistical thresholds in single subject analyses should correct the statistical threshold for the number of comparisons made or replicate effects within subject...
  22. doi Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Arch Gen Psychiatry 68:489-95. 2011
    ..However, the samples examined to date have been small, and the findings have been inconsistent...
  23. doi Fronto-temporal interactions during overt verbal initiation and suppression
    Paul Allen
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    J Cogn Neurosci 20:1656-69. 2008
    ....
  24. doi Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state
    Stefania Benetti
    Division of Psychological Medicine and Psychiatry, Section of Neuroimaging, Institute of Psychiatry, De Crespigny Park, King s College London, London, UK
    Brain 132:2426-36. 2009
    ..This suggests that it may be a correlate of increased vulnerability to psychosis and that it is not attributable to an effect of chronic illness or its treatment...
  25. doi Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits
    Stephane A De Brito
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College, London, UK
    Brain 132:843-52. 2009
    ..These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callous-unemotional conduct problems...
  26. doi Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, Box P067, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:442-51. 2009
    ..Cannabis sativa use can impair verbal learning, provoke acute psychosis, and increase the risk of schizophrenia. It is unclear where C. sativa acts in the human brain to modulate verbal learning and to induce psychotic symptoms...
  27. doi Psychoanalysis on the couch: can neuroscience provide the answers?
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Med Hypotheses 75:594-9. 2010
    ....
  28. doi Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 65:473-80. 2009
    ..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects...
  29. doi Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis
    Nicolas A Crossley
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:4129-37. 2009
    ..However, the stage of the disorder at which these functional alterations occur is unclear. We addressed this issue by using functional MRI (fMRI) to study subjects in the prodromal and first episode phases of schizophrenia...
  30. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  31. pmc Cingulate activity and fronto-temporal connectivity in people with prodromal signs of psychosis
    Paul Allen
    Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park 16, London, UK
    Neuroimage 49:947-55. 2010
    ..Although task related fronto-temporal integration in the ARMS was intact, this may depend on increased engagement of the ACC which was not observed in healthy control subjects...
  32. doi Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
    ..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...
  33. doi Influence of neuregulin1 genotype on neural substrate of perceptual matching in children
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, PO Box 67, London, SE5 8AF, UK
    Behav Genet 40:157-66. 2010
    ..These results indicate that genetic variation in NRG1 significantly affects cortical function during perceptual and monitoring processes in healthy children as young as 10-12 years of age...
  34. ncbi More than words: a common neural basis for reading and naming deficits in developmental dyslexia?
    Eamon J McCrory
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, U
    Brain 128:261-7. 2005
    ..Our investigation points to a common neurological basis for deficits in word reading and picture naming in developmental dyslexia...
  35. doi Heritable variations in gray matter concentration as a potential endophenotype for psychopathic traits
    Fruhling V Rijsdijsk
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Arch Gen Psychiatry 67:406-13. 2010
    ..Genetic vulnerability to psychopathic traits is likely to also manifest at the neural level. We have recently reported increased gray matter concentration in several brain areas in boys with psychopathic traits...
  36. pmc Using genetic, cognitive and multi-modal neuroimaging data to identify ultra-high-risk and first-episode psychosis at the individual level
    W Pettersson-Yeo
    Department of Psychosis Studies, King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
    Psychol Med 43:2547-62. 2013
    ....
  37. ncbi Modelling functional integration: a comparison of structural equation and dynamic causal models
    W D Penny
    Wellcome Department of Imaging Neuroscience, University College London, London, United Kingdom
    Neuroimage 23:S264-74. 2004
    ..This review focuses on the underlying assumptions and limitations of each model and demonstrates their application to data from a study of attention to visual motion...
  38. ncbi Are subitizing and counting implemented as separate or functionally overlapping processes?
    Manuela Piazza
    Institute of Cognitive Neuroscience, London, United Kingdom
    Neuroimage 15:435-46. 2002
    ..Results speak against the idea of the two processes being implemented in separable neural systems...
  39. ncbi Normal and pathological reading: converging data from lesion and imaging studies
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, University College, London, WC1N 3BG, UK
    Neuroimage 20:S30-41. 2003
    ..Future studies are required to examine the connectivity between these areas during normal and abnormal reading...
  40. ncbi Where bottom-up meets top-down: neuronal interactions during perception and imagery
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, UK
    Cereb Cortex 14:1256-65. 2004
    ..Additionally non-selective, top-down processes, originating in superior parietal areas, contribute to the generation of mental images, regardless of their content, and their maintenance in the 'mind's eye'...
  41. pmc Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
    S Tognin
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 44:489-98. 2014
    ..The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis...
  42. ncbi A dynamic causal modeling study on category effects: bottom-up or top-down mediation?
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    J Cogn Neurosci 15:925-34. 2003
    ..These findings indicate that category effects in the occipital and temporal cortex can be mediated by bottom-up mechanisms-a finding that needs to be embraced by models of category specificity...
  43. ncbi Reading and reading disturbance
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12, Queen Square, London, WC1N 3BG, UK
    Curr Opin Neurobiol 15:231-8. 2005
    ..Together, these findings have implications for cognitive models of reading that have previously relied on input from behavioural data...
  44. ncbi Neurolinguistics: structural plasticity in the bilingual brain
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 431:757. 2004
    ..This relation between grey-matter density and performance may represent a general principle of brain organization...
  45. ncbi Brain activation for lexical decision and reading aloud: two sides of the same coin?
    Manuel Carreiras
    Universidad de La Laguna, Tenerife, Spain
    J Cogn Neurosci 19:433-44. 2007
    ..We attribute these effects to differences in the demands on speech production and decision-making processes, respectively...
  46. pmc Effect of word and syllable frequency on activation during lexical decision and reading aloud
    Manuel Carreiras
    Universidad de La Laguna, Tenerife, Spain
    Hum Brain Mapp 27:963-72. 2006
    ..Specifically, words with high-frequency syllables may increase lexical competition in the inferior temporal lobe while facilitating articulatory planning in the left anterior insula...
  47. ncbi The importance of distributed sampling in blocked functional magnetic resonance imaging designs
    Dick J Veltman
    PET Center, Vrije Universiteit Medical Center De Boelelaan 1117, Amsterdam, The Netherlands
    Neuroimage 17:1203-6. 2002
    ..These effects, induced by simply shifting stimulus presentation by a fraction of the interscan interval, suggest that fixed sampling does indeed bias estimated responses, even in blocked designs...
  48. ncbi Structural covariance in the human cortex
    Andrea Mechelli
    Wellcome Department of Imaging Neuroscience, London WC1N 3BG, United Kingdom
    J Neurosci 25:8303-10. 2005
    ..The coordinated variations we report are likely to be determined by both genetic and environmental factors and may be the basis for differences in individual behavior...
  49. ncbi Anterior temporal cortex and semantic memory: reconciling findings from neuropsychology and functional imaging
    Timothy T Rogers
    MRC Cognition and Brain Sciences Unit, Cambridge, England, USA
    Cogn Affect Behav Neurosci 6:201-13. 2006
    ..Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information...
  50. ncbi Fusiform activation to animals is driven by the process, not the stimulus
    Timothy T Rogers
    MRC Cognition and Brain Sciences, Cambridge, UK
    J Cogn Neurosci 17:434-45. 2005
    ..Apparent category effects arise because, at an intermediate level of specificity, animals have more visual and semantic competitors than do artifacts...
  51. ncbi Exploring brain connectivity: a new frontier in systems neuroscience. Functional Brain Connectivity, 4-6 April 2002, Dusseldorf, Germany
    Narender Ramnani
    Centre for fMRI of the Brain, University of Oxford, UK
    Trends Neurosci 25:496-7. 2002
    ..Functional Brain Connectivity, held on 4-6 April 2002, Dusseldorf, Germany...
  52. ncbi A report of the functional connectivity workshop, Dusseldorf 2002
    Lucy Lee
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
    Neuroimage 19:457-65. 2003
    ....
  53. ncbi The Functional Brain Connectivity Workshop: report and commentary
    Lucy Lee
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Network 14:R1-15. 2003
    ....