Emma L Meaburn

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Nucleic Acids Res 34:e27. 2006
  2. pmc Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months
    Emma L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 12:372-80. 2009
  3. ncbi request reprint Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
  4. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
  5. pmc Genetics of callous-unemotional behavior in children
    Essi Viding
    King s College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e65789. 2013
  6. pmc Common DNA markers can account for more than half of the genetic influence on cognitive abilities
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Sci 24:562-8. 2013
  7. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
  8. pmc A three-stage genome-wide association study of general cognitive ability: hunting the small effects
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 40:759-67. 2010
  9. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010
  10. pmc First genome-wide association study on anxiety-related behaviours in childhood
    Maciej Trzaskowski
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e58676. 2013

Detail Information

Publications19

  1. pmc Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Nucleic Acids Res 34:e27. 2006
    ..We conclude that extending the SNP-MaP method to the Affymetrix GeneChip Mapping 100K Array set provides a useful screen of >100,000 SNP markers for QTL association scans...
  2. pmc Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months
    Emma L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 12:372-80. 2009
    ..g., eQTLs) and correlates (e.g., psychopathology) of individual differences in gene expression...
  3. ncbi request reprint Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
    ..We conclude that QTL effect sizes, even for highly heritable common disorders and quantitative traits such as early reading disability and ability, might be much smaller than previously considered...
  4. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
    ..An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools of 100 individuals...
  5. pmc Genetics of callous-unemotional behavior in children
    Essi Viding
    King s College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e65789. 2013
    ..This GCTA ceiling is very low for CU in our study, despite its high twin study heritability estimate. The gap between GCTA and twin study heritabilities will make it challenging to identify genes responsible for the heritability of CU. ..
  6. pmc Common DNA markers can account for more than half of the genetic influence on cognitive abilities
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Sci 24:562-8. 2013
    ..66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities...
  7. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  8. pmc A three-stage genome-wide association study of general cognitive ability: hunting the small effects
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 40:759-67. 2010
    ..Larger samples, denser arrays and multiple replications will be necessary in the hunt for the genetic variants that influence human cognitive ability...
  9. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010
    ....
  10. pmc First genome-wide association study on anxiety-related behaviours in childhood
    Maciej Trzaskowski
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e58676. 2013
    ....
  11. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
    ..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
  12. pmc Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays
    Alexandra Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    BMC Res Notes 3:274. 2010
    ..The genotyping assay using the Affymetrix SNP 6.0 array is highly demanding on sample quality due to the small feature size, low redundancy, and lack of mismatch probes...
  13. pmc Gene set enrichment; a problem of pathways
    Matthew N Davies
    Institute of Psychiatry, Kings College London, UK
    Brief Funct Genomics 9:385-90. 2010
    ..They provide a powerful and functionally meaningful way in which to mine genomewide association and next generation sequencing data in order to identify disease-associated variants and pathways...
  14. ncbi request reprint Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 34:549-55. 2004
    ..Thus, genotyping pooled DNA on microarrays can provide a systematic and powerful approach for identifying QTL associations for complex traits including behavioral dimensions and disorders...
  15. ncbi request reprint Single-nucleotide polymorphism genotyping in DNA pools
    Ian Craig
    SGDP Centre, Institute of Psychiatry, London, UK
    Methods Mol Biol 311:147-64. 2005
    ....
  16. doi request reprint Increasing heritability of BMI and stronger associations with the FTO gene over childhood
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:2663-8. 2008
    ..01 at age 11. These findings suggest that expression of FTO may become stronger throughout childhood. Increases in heritability may also be due to children increasingly selecting environments correlated with their genetic propensities...
  17. doi request reprint Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?
    Dominika Sieradzka
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, United Kingdom
    PLoS ONE 9:e94398. 2014
    ..The challenges of relating adult clinical diagnostic constructs such as schizophrenia to adolescent psychotic experiences at a genetic level are discussed. ..
  18. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
    ..These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed...
  19. pmc A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays
    Claire L Simpson
    Department of Neurology, PO43, Institute of Psychiatry London SE5 8AF, UK
    Nucleic Acids Res 33:e25. 2005
    ....