P McGuffin

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Gene polymorphisms and behavior
    Peter McGuffin
    Medical Research Council MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College London, London, United Kingdom
    Pediatr Blood Cancer 48:736-7. 2007
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  3. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
  4. pmc Diagnosing migraine in research and clinical settings: the validation of the Structured Migraine Interview (SMI)
    Zainab Samaan
    Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    BMC Neurol 10:7. 2010
  5. ncbi request reprint The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
    Peter McGuffin
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 60:497-502. 2003
  6. ncbi request reprint What can psychiatric genetics offer suicidology?
    P McGuffin
    MRC SGDP Research Center, Institute of Psychiatry, London, UK
    Crisis 22:61-5. 2001
  7. ncbi request reprint Fifty years of the double helix and its impact on psychiatry
    Peter McGuffin
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s Colllege, London, De Crespigny Park, UK
    Aust N Z J Psychiatry 37:657-61. 2003
  8. ncbi request reprint Whole genome linkage scan of recurrent depressive disorder from the depression network study
    Peter McGuffin
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Hum Mol Genet 14:3337-45. 2005
  9. doi request reprint Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:844-9. 2010
  10. doi request reprint Non-steroidal anti-inflammatory drugs and efficacy of antidepressants in major depressive disorder
    R Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 42:2027-35. 2012

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Gene polymorphisms and behavior
    Peter McGuffin
    Medical Research Council MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College London, London, United Kingdom
    Pediatr Blood Cancer 48:736-7. 2007
    ..The first susceptibility genes involved in major psychiatric disorders have been identified and more will soon follow with the exploitation of emerging technologies that allow whole genome association studies...
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  3. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
    ..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America...
  4. pmc Diagnosing migraine in research and clinical settings: the validation of the Structured Migraine Interview (SMI)
    Zainab Samaan
    Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    BMC Neurol 10:7. 2010
    ..The aim of this study was to design a short and practical screening tool to identify migraine for clinical and research purposes...
  5. ncbi request reprint The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
    Peter McGuffin
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 60:497-502. 2003
    ..There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD)...
  6. ncbi request reprint What can psychiatric genetics offer suicidology?
    P McGuffin
    MRC SGDP Research Center, Institute of Psychiatry, London, UK
    Crisis 22:61-5. 2001
    ..Further progress is likely to come from candidate gene and linkage disequilibrium studies that are capable of detecting multiple genes of small effect...
  7. ncbi request reprint Fifty years of the double helix and its impact on psychiatry
    Peter McGuffin
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s Colllege, London, De Crespigny Park, UK
    Aust N Z J Psychiatry 37:657-61. 2003
    ..To discuss the impact of Watson and Crick's double helix discovery on the field of psychiatry...
  8. ncbi request reprint Whole genome linkage scan of recurrent depressive disorder from the depression network study
    Peter McGuffin
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Hum Mol Genet 14:3337-45. 2005
    ..Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined...
  9. doi request reprint Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:844-9. 2010
    ....
  10. doi request reprint Non-steroidal anti-inflammatory drugs and efficacy of antidepressants in major depressive disorder
    R Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 42:2027-35. 2012
    ..This effect requires replication and a test of whether it is specific to serotonin-reuptake inhibiting (SRI) antidepressants...
  11. pmc Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms
    R Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 42:967-80. 2012
    ..Symptom dimensions have not yet been comprehensively tested as predictors of the substantial heterogeneity in outcomes of antidepressant treatment in major depressive disorder...
  12. ncbi request reprint The lymphoblast beta-adrenergic receptor in bipolar depressed patients: characterization and down-regulation
    G Kay
    Department of Pharmacology, St Mary s Hospital Medical School, London, UK
    J Affect Disord 27:163-72. 1993
    ..The functional implications of this effect are discussed...
  13. doi request reprint Genome-wide association analysis of copy number variation in recurrent depressive disorder
    J J H Rucker
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 18:183-9. 2013
    ..This may suggest that the absence of deletion CNVs, especially in genes, is associated with resilience to recurrent depression...
  14. doi request reprint A follow-up case-control association study of tractable (druggable) genes in recurrent major depression
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, UK
    Am J Med Genet B Neuropsychiatr Genet 156:640-50. 2011
    ..In the combined sample of 2,170 MDD cases and 1,810 controls, there were positive findings in the Nitric Oxide Synthase 2A (NOS2A) gene both using single SNP analysis and haplotype analysis...
  15. doi request reprint Trajectories of change in depression severity during treatment with antidepressants
    R Uher
    Medical Research Council Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 40:1367-77. 2010
    ..We explore alternative categorization of outcome by naturally occurring trajectories of symptom change...
  16. doi request reprint No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis
    D Gaysina
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:699-706. 2008
    ..This was the case in the sample as a whole, and when females and males were considered separately. Our findings suggest that the MTHFR C677T polymorphism is not involved in the etiology of clinically significant recurrent MDD...
  17. ncbi request reprint The Cardiff sib-pair study: suicidal ideation in depressed and healthy subjects and their siblings
    A Farmer
    MRC SGDP Research Centre, Institute of Psychiatry, London, UK
    Crisis 22:71-3. 2001
    ..Suicidal ideation was significantly associated with high neuroticism and psychoticism scores and severe threatening life events...
  18. doi request reprint NRG1 gene in recurrent major depression: no association in a large-scale case-control association study
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 153:141-7. 2010
    ..We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD...
  19. doi request reprint Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project
    R Keers
    MRC SGDP, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 11:138-45. 2011
    ..Gene-environment interactions including life events may therefore be important not only in the aetiology of depression, but also in predicting response to antidepressant medication...
  20. doi request reprint Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project
    N Perroud
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 12:68-77. 2012
    ..Limited power precludes definitive conclusions and replication in larger sample is warranted...
  21. doi request reprint Adverse life event reporting and worst illness episodes in unipolar and bipolar affective disorders: measuring environmental risk for genetic research
    G M Hosang
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1829-37. 2010
    ....
  22. doi request reprint Estimating the heritability of reporting stressful life events captured by common genetic variants
    R A Power
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 43:1965-71. 2013
    ..Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic variance tagged by single nucleotide polymorphisms (SNPs). We also performed a GWAS on the number of SLEs, and looked at correlations between siblings...
  23. ncbi request reprint A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: a five-stage design using DNA pooling and extreme selected groups
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Behav Genet 31:497-509. 2001
    ..Instead we are using the same design to screen markers such as cSNPs and SNPs in regulatory regions that are likely to include functional polymorphisms in which the marker can be presumed to be the QTL...
  24. doi request reprint Depressive disorder moderates the effect of the FTO gene on body mass index
    M Rivera
    MRC SGDP Centre, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Mol Psychiatry 17:604-11. 2012
    ..This finding suggests that FTO is involved in the mechanism underlying the association between mood disorders and obesity...
  25. doi request reprint Depression, migraine with aura and migraine without aura: their familiality and interrelatedness
    H A Ball
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Cephalalgia 29:848-54. 2009
    ..Implications for our understanding of the relationship between migraine and depression are discussed...
  26. doi request reprint The genetics of affective disorder and suicide
    P McGuffin
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AF, United Kingdom
    Eur Psychiatry 25:275-7. 2010
    ..The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour...
  27. ncbi request reprint Linkage analysis between bipolar affective disorder and markers on chromosome X
    H P Vallada
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatr Genet 8:183-6. 1998
    ..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families...
  28. doi request reprint The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
    R Uher
    King s College London, Institute of Psychiatry, London, UK
    Mol Psychiatry 15:18-22. 2010
    ..These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression...
  29. ncbi request reprint No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene
    S A Petrill
    Institute of Psychiatry, London, England
    Behav Genet 27:29-31. 1997
    ....
  30. pmc The effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder and controls
    J Roiser
    Institute of Cognitive Neuroscience, London, UK
    Psychol Med 39:785-91. 2009
    ..The objective of this study was to investigate the effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder (BD) and controls...
  31. ncbi request reprint Sensation-seeking, life events and depression. The Cardiff Depression Study
    A Farmer
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK
    Br J Psychiatry 178:549-52. 2001
    ..CONCLUSIONS: The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat...
  32. pmc The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder
    H L Fisher
    Institute of Psychiatry, King s College London, UK
    Psychol Med 40:1967-78. 2010
    ..Therefore, we sought to explore the prevalence of more specific adverse childhood experiences amongst those with and without psychotic disorders using detailed assessments in a large epidemiological case-control sample (AESOP)...
  33. ncbi request reprint Gene-environment interaction analysis of serotonin system markers with adolescent depression
    T C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Mol Psychiatry 9:908-15. 2004
    ....
  34. ncbi request reprint The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study
    J S Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, SE5 8AF, UK
    Mol Psychiatry 7:383-91. 2002
    ..We found no evidence to support this association...
  35. ncbi request reprint Familiality of symptom dimensions in schizophrenia
    H Wickham
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8A, UK
    Schizophr Res 47:223-32. 2001
    ..The familiality of the psychomotor poverty, disorganisation, and manic dimensions supports their use in the delineation of homogeneous subsets for genetic studies...
  36. doi request reprint From age correction to genome-wide association
    S Cohen-Woods
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Acta Psychiatr Scand 120:355-62. 2009
    ..There has now been an explosion of interest in this field and research progress, including linkage and association studies, whole genome genotyping, copy number variants and epigenetics is reviewed here...
  37. doi request reprint Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces
    S A Surguladze
    Institute of Psychiatry, King s College London, London, United Kingdom
    Genes Brain Behav 7:543-51. 2008
    ..These effects may underlie the vulnerability to mood and anxiety disorders potentially triggered by socially salient, emotional cues in individuals with the S allele of 5-HTTLPR...
  38. ncbi request reprint Measuring depression: comparison and integration of three scales in the GENDEP study
    R Uher
    Medical Research Council, Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 38:289-300. 2008
    ..In this study we examined and integrated the psychometric properties of three commonly used rating scales...
  39. ncbi request reprint Linkage and associated studies of schizophrenia
    B P Riley
    MRC Research Fellow, Department of Psychological Medicien and the Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College, London
    Am J Med Genet 97:23-44. 2000
    ..Reasons for the difficulty in obtaining consistent results and possible strategies for overcoming them are discussed. Am. J. Med. Genet. (Semin. Med. Genet.) 97:23-44, 2000...
  40. doi request reprint The current state of play on the molecular genetics of depression
    S Cohen-Woods
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 43:673-87. 2013
    ..These were combined in a variety of permutations...
  41. pmc No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression
    J Cole
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Genes Brain Behav 10:756-64. 2011
    ..In this study, there was no evidence of a genetic effect for 5HTTLPR or BDNF Val66Met on hippocampal morphology in either healthy individuals or MDD patients despite the relatively large sample sizes and sensitive methodology...
  42. ncbi request reprint The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
    K Brookes
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, UK
    Mol Psychiatry 11:934-53. 2006
    ..Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples...
  43. ncbi request reprint Life events and depression in a community sample of siblings
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Psychol Med 31:401-10. 2001
    ..Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety...
  44. ncbi request reprint Polydiagnostic approaches to measuring and classifying psychopathology
    P McGuffin
    Institute of Psychiatry, Kings College London, United Kingdom
    Am J Med Genet 105:39-41. 2001
    ..This is necessary if psychiatric diagnoses are ultimately going to be refined and validated against biological criteria...
  45. ncbi request reprint Psychiatric genetics: recent advances and clinical implications
    A Corsico
    Social Genetic and Developmental Psychiatry SGDP Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Epidemiol Psichiatr Soc 10:253-9. 2001
    ..To present an overview on current progress and future directions in psychiatric genetics...
  46. ncbi request reprint Relationship between antisocial behaviour, attention-deficit hyperactivity disorder and maternal prenatal smoking
    T M M Button
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Br J Psychiatry 187:155-60. 2005
    ..However, it is not clear whether maternal smoking during pregnancy is independently associated with antisocial behaviour or whether the association arises because antisocial behaviour and ADHD covary...
  47. pmc DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP
    T R Powell
    King s College London, MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Transl Psychiatry 3:e300. 2013
    ..Our results suggest that DNA methylation in IL11 might be useful in identifying those patients likely to respond to antidepressants, and if so, the best drug suited to each individual. ..
  48. doi request reprint Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line
    K Sugden
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1253-9. 2010
    ..In conclusion, care must be taken when choosing reference transcripts for analysis in qPCR. For in-vitro pharmacological studies, it should not be assumed that 'housekeeping' genes are stable...
  49. ncbi request reprint The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
    R Uher
    Medical Research Council MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 13:131-46. 2008
    ..Biological and behavioural intermediate phenotypes are yet to be exploited to understand the mechanisms underlying the G x E...
  50. ncbi request reprint The lymphoblast beta-adrenergic receptor in bipolar depressed patients: effect of chronic incubation with lithium chloride
    G Kay
    Department of Pharmacology, St Mary s Hospital Medical School, London, UK
    J Affect Disord 30:185-92. 1994
    ..The functional significance of this result and the potential biochemical mechanisms responsible for this effect are discussed...
  51. ncbi request reprint Pathways to childhood depressive symptoms: the role of social, cognitive, and genetic risk factors
    Jennifer Y F Lau
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Dev Psychol 43:1402-14. 2007
    ..Together, these routes accounted for approximately 13% of total phenotypic variance in depressive symptoms. Theoretical and analytical implications of these results are discussed in the context of several design-related caveats...
  52. ncbi request reprint Genetic and environmental influences on interpersonal cognitions and associations with depressive symptoms in 8-year-old twins
    Alice M Gregory
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Abnorm Psychol 116:762-75. 2007
    ..These latter findings may result from interpersonal cognitions in young children, reflecting life experiences as opposed to trait-like cognitive biases...
  53. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  54. ncbi request reprint Differences in depressive symptom profile between males and females
    Daniel J Smith
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, CF10 3XQ, UK
    J Affect Disord 108:279-84. 2008
    ..Here we compare the clinical profile of major depression for men and women from a sample of almost 600 well-characterized individuals with recurrent major depressive disorder (MDD)...
  55. ncbi request reprint Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    Araceli Rosa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008
    ....
  56. doi request reprint Association of the serotonin transporter gene, neuroticism and smoking behaviours
    Colin O'Gara
    MRC Social Genetic and Developmental Psychiatry Research Centre, King s College London, Institute of Psychiatry, London, UK
    J Hum Genet 53:239-46. 2008
    ..Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings...
  57. ncbi request reprint The classification of depression: are we still confused?
    James Cole
    Br J Psychiatry 192:83-5. 2008
    ..Particularly, the institution of operational diagnoses along with the contentious issues of subdividing major depressive disorder and its characterisation on a dimensional as opposed to a categorical scale...
  58. pmc Colombo Twin and Singleton Study (CoTASS): a description of a population based twin study of mental disorders in Sri Lanka
    Sisira H Siribaddana
    Sri Lanka Twin Registry, Institute of Research and Development, Battaramulla, Sri Lanka
    BMC Psychiatry 8:49. 2008
    ..This paper presents the rationale for the study, describes its context, and the methods for twin ascertainment and data collection...
  59. doi request reprint Clinical differences between bipolar and unipolar depression
    Liz Forty
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 192:388-9. 2008
    ..Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression...
  60. doi request reprint Medical disorders in people with recurrent depression
    Anne Farmer
    Medical Research Council, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Br J Psychiatry 192:351-5. 2008
    ..Few studies have examined the rates of physical disorders in those with recurrent depression...
  61. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  62. ncbi request reprint Association of DRD4 in children with ADHD and comorbid conduct problems
    Jane Holmes
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, United Kingdom
    Am J Med Genet 114:150-3. 2002
    ..Further work is needed to examine these phenotype issues...
  63. doi request reprint Twin study refining psychotic symptom dimensions as phenotypes for genetic research
    Alastair G Cardno
    Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, Leeds, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1213-21. 2008
    ..None of the dimensions were significant predictors of psychosis risk in co-twins. We conclude that, of the dimensions analyzed, the narrow disorganized dimension shows most promise as a phenotype for molecular genetic research...
  64. doi request reprint Attributional style and depression
    Harriet A Ball
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Br J Psychiatry 192:275-8. 2008
    ..Few studies have examined whether attributional style (an individual's explanation of why events happen) is a genetically influenced vulnerability factor for depression...
  65. doi request reprint Wake-up call for British psychiatry
    Nick Craddock
    Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 193:6-9. 2008
    ..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients...
  66. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  67. ncbi request reprint Heritability of Schneider's first-rank symptoms
    Alastair G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, UK
    Br J Psychiatry 180:35-8. 2002
    ..Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability...
  68. ncbi request reprint Do aggressive and non-aggressive antisocial behaviors in adolescents result from the same genetic and environmental effects?
    Tanya M M Button
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London
    Am J Med Genet B Neuropsychiatr Genet 129:59-63. 2004
    ..Our results suggest a partial genetic overlap with a specific genetic effect contributing to the variance of aggressive ASB and a stronger genetic effect on aggression in females than in males...
  69. ncbi request reprint The development of prosocial behaviour in children and adolescents: a twin study
    Jane Scourfield
    Department of Psychological Medicine, University of Wales College of Medicine, London, UK
    J Child Psychol Psychiatry 45:927-35. 2004
    ..The influences on these individual differences have not previously been examined in children and adolescents using multiple raters in a genetically informative design...
  70. ncbi request reprint Conduct problems in children and adolescents: a twin study
    Jane Scourfield
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
    Arch Gen Psychiatry 61:489-96. 2004
    ..However, there is a lack of studies using a genetically informative design combined with several different informants and different settings...
  71. ncbi request reprint Familiality of symptom dimensions in depression
    Ania Korszun
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 61:468-74. 2004
    ..A dimensional rather than a categorical approach to depressive phenotype definition may be more useful for identification of susceptibility genes...
  72. ncbi request reprint The genetic relationship between social cognition and conduct problems
    Jane Scourfield
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Behav Genet 34:377-83. 2004
    ..Each phenotype was subject to its own environmental influences that were not shared...
  73. ncbi request reprint Humiliation, loss and other types of life events and difficulties: a comparison of depressed subjects, healthy controls and their siblings
    Anne E Farmer
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
    Psychol Med 33:1169-75. 2003
    ..We have also previously suggested that experiencing high rates of non-severe events may play a role in the development of resilience to the impact of severe threatening events when these occur...
  74. ncbi request reprint Depressive symptoms in children and adolescents: changing aetiological influences with development
    Jane Scourfield
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    J Child Psychol Psychiatry 44:968-76. 2003
    ..However, the literature is not entirely consistent in this respect and existing longitudinal twin studies have examined changes within adolescence only...
  75. ncbi request reprint A sib-pair study of the Temperament and Character Inventory scales in major depression
    Anne Farmer
    Medical Research Council, Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 60:490-6. 2003
    ..A sib-pair method has been used to examine the familiality of the 7 scales of the Temperament and Character Inventory (TCI) and whether this could be related to the genetic vulnerability to develop depression...
  76. ncbi request reprint Linkage and association studies of schizophrenia
    Peter McGuffin
    SGDP Research Centre, Institute of Psychiatry, King s College London, De Crepigny Park, London SE5 8AF, UK
    Curr Psychiatry Rep 5:121-7. 2003
    ..3, and proline dehydrogenase, which is a gene that maps to chromosome 22q11. In addition, there is renewed interest in a fifth gene, catechol-O-methyltransferase, also on chromosome 22q11...
  77. ncbi request reprint Can the social environment cause schizophrenia?
    Jim Van Os
    Department of Psychiatry and Neuropsychology, azM Mondriaan Riagg Vijverdal Academic Centre, Maastricht University, European Graduate School of Neuroscience, Maastricht, The Netherlands
    Br J Psychiatry 182:291-2. 2003
  78. ncbi request reprint Clinical variables and genetic loading for schizophrenia: analysis of published Danish adoption study data
    Alastair G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Schizophr Bull 28:393-9. 2002
    ..These clinical variables may be useful for refining phenotypic definitions of schizophrenia in molecular genetic studies...
  79. ncbi request reprint The genetic basis for psychiatric illness in man
    Kopal Tandon
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, London SE5 8AF, UK
    Eur J Neurosci 16:403-7. 2002
    ..This article will discuss techniques that have been used in psychiatric genetics, and how they have advanced our understanding of complex behaviour...
  80. ncbi request reprint Psychopathology in the postgenomic era
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AF, UK
    Annu Rev Psychol 54:205-28. 2003
    ..DNA will revolutionize psychological research and treatment during the coming decades...
  81. ncbi request reprint Neuroticism, extraversion, life events and depression. The Cardiff Depression Study
    Anne Farmer
    MRC Social Genetic and Developmental Psychiatric Research Centre, Institute of Psychiatry, London, UK
    Br J Psychiatry 181:118-22. 2002
    ..Certain personality traits may mediate the relationship between familiality and adversity in causing depression...
  82. ncbi request reprint Familiality of clinical characteristics in schizophrenia
    Harvey Wickham
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, UK
    J Psychiatr Res 36:325-9. 2002
    ..The familiality of these clinical characteristics supports their use in the delineation of homogeneous subsets for future genetic studies...
  83. ncbi request reprint A twin study of genetic relationships between psychotic symptoms
    Alastair G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Am J Psychiatry 159:539-45. 2002
    ..Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors...
  84. ncbi request reprint Observer effects and heritability of childhood attention-deficit hyperactivity disorder symptoms
    Neilson Martin
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Br J Psychiatry 180:260-5. 2002
    ..Estimates of heritability, the extent of non-additive genetic effects and of 'sibling contrast' effects vary between different studies...
  85. ncbi request reprint Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships
    Matthew W Nash
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Section of Epidemiology, Institute of Psychiatry, King s College, London, UK
    Hum Mol Genet 13:2173-82. 2004
    ..2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects...
  86. ncbi request reprint A decade of the Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry
    Peter McGuffin
    Br J Psychiatry 185:280-2. 2004
  87. ncbi request reprint The Social, Genetic and Developmental Psychiatry Centre: its origins, conception and initial accomplishments
    Michael Rutter
    SGDP Centre, Institute of Psychiatry, King s College, London, UK
    Psychol Med 34:933-47. 2004
    ..The Social, Genetic and Developmental Psychiatry Centre was established by the Medical Research Council, in partnership with the Institute of Psychiatry, King's College London, in 1994...
  88. ncbi request reprint A pilot study of positive mood induction in euthymic bipolar subjects compared with healthy controls
    Anne Farmer
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Camberwell, London, UK
    Psychol Med 36:1213-8. 2006
    ..This pilot study evaluates the Go task in a reward paradigm as a method for inducing a happy mood state and compares the response of euthymic bipolar subjects and healthy controls...
  89. ncbi request reprint Interrelationship of childhood trauma, neuroticism, and depressive phenotype
    Valentina Moskvina
    Department of Psychological Medicine, University of Cardiff, Cardiff, Wales, United Kingdom
    Depress Anxiety 24:163-8. 2007
    ....
  90. ncbi request reprint Familiality of postpartum depression in unipolar disorder: results of a family study
    Liz Forty
    Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 163:1549-53. 2006
    ..The authors here examine whether vulnerability to postpartum triggering of depressive episodes aggregates in families and assess how this aggregation varies with the definition of postpartum onset...
  91. ncbi request reprint Associations between sleep problems, anxiety, and depression in twins at 8 years of age
    Alice M Gregory
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Pediatrics 118:1124-32. 2006
    ..Associations between sleep and internalizing problems are complex and poorly understood. To better understand these covarying difficulties, genetic and environmental influences were estimated by using a twin design...
  92. ncbi request reprint The genetics of bipolar affective disorder
    Anne Farmer
    MRC SGDP Centre, Institute of Psychiatry, Camberwell, London, UK
    Curr Opin Psychiatry 20:8-12. 2007
    ..Molecular genetic studies of bipolar affective disorder are beginning to show some positive and reproducible findings. The most relevant of these will be reviewed...
  93. ncbi request reprint Homing in on depression genes
    Peter McGuffin
    Am J Psychiatry 164:195-7. 2007
  94. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  95. ncbi request reprint In the face of uncertainty: a twin study of ambiguous information, anxiety and depression in children
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, P O Box P080, London, SE5 8AF, UK
    J Abnorm Child Psychol 36:55-65. 2008
    ..The data also support a role for genetic influence on threat interpretations, which may mediate responses to stress...
  96. ncbi request reprint Genetics and delusional disorder
    Alastair G Cardno
    Academic Unit of Psychiatry and Behavioural Sciences, School of Medicine, University of Leeds, 15 Hyde Terrace, Leeds LS2 9LT, UK
    Behav Sci Law 24:257-76. 2006
    ..A range of considerably larger, epidemiologically rigorous studies is required, but the uncommonness and other features of the disorder put strong limitations on the prospects for ascertaining adequate samples...
  97. ncbi request reprint Cognitive style in bipolar disorder
    Lisa Jones
    Department of Psychiatry, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
    Br J Psychiatry 187:431-7. 2005
    ..Abnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance...
  98. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
    ..The location of the polymorphism in the 5'regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles...
  99. ncbi request reprint Nature and nurture interplay: schizophrenia
    Peter McGuffin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry London, Great Britain
    Psychiatr Prax 31:S189-93. 2004
    ....
  100. ncbi request reprint Personality as a determinant of social functioning in depression
    Gopinath Ranjith
    Affective Disorders Unit, Bethlem Royal Hospital, Beckenham BR3 3BX, UK
    J Affect Disord 84:73-6. 2005
    ..We investigated the personality dimensions of neuroticism and extraversion as determinants of social functioning measured by SASS in patients with depression...
  101. ncbi request reprint Family dysfunction interacts with genes in the causation of antisocial symptoms
    Tanya Maria May Button
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Behav Genet 35:115-20. 2005
    ..It was concluded that a risk genotype conferring susceptibility to family dysfunction is responsible for most of the variance in antisocial symptoms in childhood and adolescence...