Research Topics
Species | Colm McDonaldSummaryAffiliation: King's College London Country: UK Publications
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Publications
Brain volumes in familial and non-familial schizophrenic probands and their unaffected relativesColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
Am J Med Genet 114:616-25. 2002..Individuals inheriting the susceptibility to schizophrenia appear particularly prone to develop ventricular enlargement in response to obstetric complications...- Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypesColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, London
Arch Gen Psychiatry 61:974-84. 2004..For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates... - Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorderColm McDonald
Division of Psychological Medicine, Institute if Psychiatry, London, United Kingdom
Biol Psychiatry 56:411-7. 2004..Our aim was to complete a meta-analysis of regional morphometry in bipolar disorder as assessed using magnetic resonance imaging (MRI)... - Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: computational morphometry studyColm McDonald
Division of Psychological Medicine, Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 186:369-77. 2005..It is unclear whether schizophrenia and psychotic bipolar disorder are associated with similar deviations of brain morphometry... - The new genetics of schizophreniaColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Psychiatr Clin North Am 26:41-63. 2003.... 
Memory functioning in familial bipolar I disorder patients and their relativesSeema Quraishi
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Foundation NHS Trust and Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Bipolar Disord 11:209-14. 2009..The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls...- Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relativesColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Am J Psychiatry 163:478-87. 2006..The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder... - Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotypeElvira Bramon
Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
Schizophr Res 103:178-85. 2008..Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype... - The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorderAndrea Mechelli
Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
Neuroimage 42:817-26. 2008..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex... - Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?Sergi G Costafreda
Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 30:3287-98. 2009..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia... 
Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorderSergi G Costafreda
Institute of Psychiatry, King s College London, De Crespigny Park, London UK
BMC Psychiatry 11:18. 2011..Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses...- Executive functioning in familial bipolar I disorder patients and their unaffected relativesKatja K Schulze
King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and Department of Psychology, King s College London, NIHR Biomedical Research Centre, London, UK
Bipolar Disord 13:208-16. 2011..To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls... - Stroop-test interference in bipolar disorderEugenia Kravariti
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 194:285-6. 2009..Having a first-degree relative with bipolar disorder, even a familial, psychotic form, did not confer risk for enhanced susceptibility to interference in our studies... - P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relativesKatja K Schulze
Section of General Psychiatry, Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK, and Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
Biol Psychiatry 62:121-8. 2007..We therefore assessed whether diminished P50 suppression is associated with familial risk for psychotic bipolar disorder... - Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophreniaEugenia Kravariti
Institute of Psychiatry, Department of Psychiatry, Division of Psychological Medicine, Box 63, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 188:186-7. 2006..Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia... - The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relativesKatja Schulze
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Psychiatr Res 40:589-98. 2006..28, p=0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry... - Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controlsEvangelos Vassos
King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
J Psychiatr Res 44:795-8. 2010..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals... - Auditory P300 in patients with bipolar disorder and their unaffected relativesKatja K Schulze
Division of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Bipolar Disord 10:377-86. 2008.... - Familial liability to schizophrenia and premorbid adjustmentMuriel Walshe
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 191:260-1. 2007..Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect... - Association between hippocampal volume and P300 event related potential in psychosis: support for the Kraepelinian divideAnirban Dutt
NIHR Biomedical Research Centre, Institute of Psychiatry King s College London South London and Maudsley NHS Foundation Trust, London, UK
Neuroimage 59:997-1003. 2012.... - Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relativesJolanta Zanelli
Institute of Psychiatry, Psychological Medicine and Psychiatry, Denmark Hill, DeCrespigny Park, London SE5 8AF, United Kingdom
Psychiatry Res 168:193-7. 2009..Smooth pursuit performance was unrelated to any neuropsychological measure. Our study suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia... - Genetic liability for bipolar disorder is characterized by excess frontal activation in response to a working memory taskDominique Drapier
Section of Neuroscience and Emotion, Psychological Medicine and Psychiatry, King s College London Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 64:513-20. 2008..We utilized functional magnetic resonance imaging (fMRI) to investigate neural activity in samples of bipolar disorder patients and their unaffected first-degree relatives while performing working memory tasks of increasing difficulty... - A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorderRobin M Murray
Institute of Psychiatry, Psychological Medicine, Denmark Hill, DeCrespigny Park, London SE5 8AF, UK
Schizophr Res 71:405-16. 2004.... - Prefrontal deviations in function but not volume are putative endophenotypes for schizophreniaSheena F Owens
Department of Psychosis Studies, Institute of Psychiatry, Kings College, London, UK
Brain 135:2231-44. 2012.... - Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluencyDiana P Prata
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Hum Brain Mapp 33:143-53. 2012..Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder... - White matter microstructural impairments and genetic liability to familial bipolar I disorderChristopher A Chaddock
Department of Psychiatry, PO 63, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 194:527-34. 2009..Subtle abnormalities in frontal white matter have been reported in bipolar disorder... - Eye tracking in schizophrenia: does the antisaccade task measure anything that the smooth pursuit task does not?Jolanta Zanelli
Division of Psychological Medicine, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Psychiatry Res 136:181-8. 2005..The finding may reflect a shared genetic liability, that affects both eye-tracking phenotypes. It is likely that both measures reflect frontal cortical dysfunction... - Long-term maternal recall of obstetric complications in schizophrenia researchMuriel Walshe
King s College London, King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and NIHR Biomedical Research Centre, London, SE5 8AF, UK
Psychiatry Res 187:335-40. 2011..Assessing the cognition of participants in retrospective studies may allow future studies to increase the reliability of their data... - Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 65:473-80. 2009..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects... - Pituitary volume in unaffected relatives of patients with schizophrenia and bipolar disorderValeria Mondelli
Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
Psychoneuroendocrinology 33:1004-12. 2008..The aim of this study was to assess the contribution of familial liability to pituitary volume in schizophrenia and bipolar disorder. Pituitary volume may be an indirect measure of HPA axis activity... - Association between BDNF val66 met genotype and episodic memoryEmma Dempster
Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005..When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings... - The relationship between volumetric brain changes and cognitive function: a family study on schizophreniaTimothea Toulopoulou
Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 56:447-53. 2004.... - Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family studyElvira Bramon
Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
Neuroimage 27:960-8. 2005..We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study... - Cognitive performance in presumed obligate carriers for psychosisTimothea Toulopoulou
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Br J Psychiatry 187:284-5. 2005.... - Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge countElvira Bramon
Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 75:399-404. 2005..However, the severity or the origin of these ABRC changes has not been established... - The Maudsley Family Study: premorbid and current general intellectual function levels in familial bipolar I disorder and schizophreniaTimothea Toulopoulou
Division of Psychological Medicine, Institute of Psychiatry, De Crespingy Park, London, UK
J Clin Exp Neuropsychol 28:243-59. 2006..The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods... - Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medicationSimon A Surguladze
Division of Psychological Medicine and Psychiatry, King s College London Institute of Psychiatry, London, UK
J Psychopharmacol 25:722-33. 2011..Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI... - Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relativesBen Chapple
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 67:33-40. 2004.... - Distribution of symptom dimensions across Kraepelinian divisionsDimitris G Dikeos
Institute of Psychiatry, SGDP Building, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Br J Psychiatry 189:346-53. 2006..Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups... - Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relativesKatja Schulze
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 53:562-70. 2003..CONCLUSIONS: We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications... - Selective attention deficits reflect increased genetic vulnerability to schizophreniaFrancesca M Filbey
Department of Psychiatry, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF London, UK
Schizophr Res 101:169-75. 2008..Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease... - Mismatch negativity in schizophrenia: a family studyElvira Bramon
Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Res 67:1-10. 2004..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls... - Sustained attention in bipolar I disorder patients with familial psychosis and their first-degree relativesMuriel Walshe
Department of Psychosis Studies, PO Box 63, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Psychiatry Res 199:70-3. 2012..Patients were impaired compared to relatives, but the latter did not differ from controls. Having a relative with familial, psychotic BD does not confer risk for SA deficits... - COMT gene polymorphism and corpus callosum morphometry in preterm born adultsAnirban Dutt
NIHR Biomedical Research Centre, Institute of Psychiatry King s College London, London, UK
Neuroimage 54:148-53. 2011..It is not known whether this polymorphism is associated with CC morphometry in individuals born preterm... - Neural response to specific components of fearful faces in healthy and schizophrenic adultsJoaquim Radua
King s College London Institute of Psychiatry, London, UK
Neuroimage 49:939-46. 2010..PCA-based analysis could be useful in isolating brain response to salient facial features in psychiatric populations... - Pathways to schizophrenia: the impact of environmental factorsOliver D Howes
Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Int J Neuropsychopharmacol 7:S7-S13. 2004..Thus, stresses, such as drug use and social adversity, in adolescence or early adult life may propel the neurodevelopmentally impaired individual over a threshold into frank psychosis... - A controlled study of brain structure in monozygotic twins concordant and discordant for schizophreniaNeeltje E M van Haren
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
Biol Psychiatry 56:454-61. 2004..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities... - Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit geneEmma L Dempster
Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, McLaughlin Pavillion, 6th Floor Room 415, 399 Bathurst St, Toronto, Ont M5T 2S8, Canada
Am J Psychiatry 163:1832-4. 2006..CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia... - Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family studyMei Hua Hall
Psychology Research Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Am J Med Genet B Neuropsychiatr Genet 147:619-27. 2008..The non-specificity of impaired P50 suppression may reflect the impact of shared psychosis susceptibility genes... - Meta-analysis of brain volumes in unaffected first-degree relatives of patients with schizophrenia overemphasizes hippocampal deficitsColm McDonald
Arch Gen Psychiatry 65:603-4; author reply 604-5. 2008