Anthony M Marinaki

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians
    Anthony M Marinaki
    Purine Research and Department of Gastroenterology, Guy s and St Thomas Hospital, London SE1 9RT, UK
    Pharmacogenetics 13:97-105. 2003
  2. pmc The diagnosis of inherited metabolic diseases by microarray gene expression profiling
    Monica Arenas Hernandez
    Purine Research Laboratory, GSTS Pathology, Guy s and St, Thomas Hospitals, London, UK
    Orphanet J Rare Dis 5:34. 2010
  3. ncbi request reprint Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity
    Monica Arenas
    Purine Research Laboratory, Department of Chemical Pathology, Guy s and St Thomas Hospital NHS Trust, London, UK
    Clin Chem 51:2371-4. 2005
  4. ncbi request reprint Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    Anthony M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology and Department of Gastroenterology, Guy s and St Thomas Hospital, London, UK
    Pharmacogenetics 14:181-7. 2004
  5. doi request reprint Pharmacogenomics in the treatment of inflammatory bowel disease
    Melissa A Smith
    Department of Gastroenterology, 1st Floor, College House, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Pharmacogenomics 11:421-37. 2010
  6. ncbi request reprint Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis
    Emanuela Campalani
    King s College, Skin Therapy Research Unit, St John s Institute of Dermatology, London, UK
    J Invest Dermatol 127:1860-7. 2007
  7. doi request reprint The contribution of deleterious DPYD gene sequence variants to fluoropyrimidine toxicity in British cancer patients
    Aathavan Loganayagam
    Department of Gastroenterology, Guy s and St Thomas Hospital NHS Foundation Trust, College House, St Thomas Hospital, London, UK
    Cancer Chemother Pharmacol 65:403-6. 2010
  8. doi request reprint Adenylosuccinate lyase deficiency in the United Kingdom pediatric population: first three cases
    Claire T Lundy
    Department of Paediatric Neurology, Evelina Children s Hospital, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Pediatr Neurol 43:351-4. 2010

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians
    Anthony M Marinaki
    Purine Research and Department of Gastroenterology, Guy s and St Thomas Hospital, London SE1 9RT, UK
    Pharmacogenetics 13:97-105. 2003
    ..Here we present the allele frequencies of genetic modifiers of TPMT activity in a British Asian population, as well as the concordance between intermediate TPMT activity and ORF and VNTR genotypes in a predominantly Caucasian population...
  2. pmc The diagnosis of inherited metabolic diseases by microarray gene expression profiling
    Monica Arenas Hernandez
    Purine Research Laboratory, GSTS Pathology, Guy s and St, Thomas Hospitals, London, UK
    Orphanet J Rare Dis 5:34. 2010
    ..We aimed to define gene expression signatures characteristic of defective metabolic pathways...
  3. ncbi request reprint Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity
    Monica Arenas
    Purine Research Laboratory, Department of Chemical Pathology, Guy s and St Thomas Hospital NHS Trust, London, UK
    Clin Chem 51:2371-4. 2005
  4. ncbi request reprint Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    Anthony M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology and Department of Gastroenterology, Guy s and St Thomas Hospital, London, UK
    Pharmacogenetics 14:181-7. 2004
    ..5, 95% CI 1.4-21.3, P = 0.0206). Polymorphism in the ITPA gene predicts AZA intolerance. Alternative immunosuppressive drugs, particularly 6-thioguanine, should be considered for AZA-intolerant patients with ITPase deficiency...
  5. doi request reprint Pharmacogenomics in the treatment of inflammatory bowel disease
    Melissa A Smith
    Department of Gastroenterology, 1st Floor, College House, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Pharmacogenomics 11:421-37. 2010
    ....
  6. ncbi request reprint Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis
    Emanuela Campalani
    King s College, Skin Therapy Research Unit, St John s Institute of Dermatology, London, UK
    J Invest Dermatol 127:1860-7. 2007
    ..We have demonstrated preliminary evidence that specific polymorphisms of enzymes involved in folate, pyrimidine, and purine metabolism could be useful in predicting clinical response to methotrexate in patients with psoriasis...
  7. doi request reprint The contribution of deleterious DPYD gene sequence variants to fluoropyrimidine toxicity in British cancer patients
    Aathavan Loganayagam
    Department of Gastroenterology, Guy s and St Thomas Hospital NHS Foundation Trust, College House, St Thomas Hospital, London, UK
    Cancer Chemother Pharmacol 65:403-6. 2010
    ..The study aim was to assess the contribution of deleterious DPYD sequence variants to fluoropyrimidine toxicity amongst British cancer patients...
  8. doi request reprint Adenylosuccinate lyase deficiency in the United Kingdom pediatric population: first three cases
    Claire T Lundy
    Department of Paediatric Neurology, Evelina Children s Hospital, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Pediatr Neurol 43:351-4. 2010
    ..Reported here are the cases of the only three children diagnosed to date in the United Kingdom with adenylosuccinate lyase deficiency, to further delineate the clinical phenotype and to raise awareness of this disorder...