Genomes and Genes
J K Ma
Affiliation: King's College
- Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humansJ K Ma
Department of Immunology, United Medical and Dental Schools, Guy s Hospital, London, UK
Nat Med 4:601-6. 1998..These findings could be extended to the immunotherapeutic prevention of other mucosal infections in humans and animals...
- A synthetic peptide adhesion epitope as a novel antimicrobial agentC G Kelly
Department of Immunology, United Medical and Dental Schools of Guy s and St Thomas Hospitals, London, UK
Nat Biotechnol 17:42-7. 1999..This novel antimicrobial strategy, applying competitive peptide inhibitors of adhesion, may be used against other microorganisms in which adhesins mediate colonization of mucosal surfaces...
- A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in miceD Chargelegue
Guy s, King s and St Thomas School of Medicine and Dentistry, Department of Oral Medicine and Pathology, Guy s Hospital, London, UK
Transgenic Res 9:187-94. 2000..These results have a direct relevance for the application of plant recombinant proteins as therapeutic agents and vaccines in humans...
- Sequencing and characterization of the 185 kDa cell surface antigen of Streptococcus mutansC Kelly
Department of Immunology, United Medical School, Guy s Hospital, London, England
Arch Oral Biol 35:33S-38S. 1990..N-terminal sequencing of purified antigens I and II components indicated that antigen I extends from the amino-terminus of the intact Mr 185,000 surface antigen while antigen II extends from residue 996...
- An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutansJ K Ma
Department of Immunology, United Medical and Dental School, Guy s Hospital, London, United Kingdom
Infect Immun 58:3407-14. 1990..mutans but are not consistent with the suggestion that S. sanguis or veillonella take over the niche vacated by S. mutans, unless the shift in the proportion of these organisms cannot be detected by the method used...
- Assembly and plasma membrane targeting of recombinant immunoglobulin chains in plants with a murine immunoglobulin transmembrane sequenceN D Vine
Department of Oral Medicine, Guy's Hospital, London, UK
Plant Mol Biol 45:159-67. 2001..This approach of localising and accumulating recombinant antibody in cell membranes may have a number of applications, including passive immunisation against plant pathogens...
- Conservation of the gene encoding streptococcal antigen I/II in oral streptococciJ K Ma
Department of Immunology, United Medical School, Guy s Hospital, London, United Kingdom
Infect Immun 59:2686-94. 1991..This suggests that a family of cell surface proteins which, by analogy with the 185,000-Mr SA I/II of S. mutans, could be involved in bacterial adhesion might exist...