S Lovestone

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Biomarkers in Alzheimer's disease
    S Lovestone
    Department of Old Age Psychiatry and Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    J Nutr Health Aging 10:118-22. 2006
  2. doi request reprint Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
    Raya Al-Shawi
    Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK
    Eur J Neurosci 27:2103-14. 2008
  3. pmc The GSK3 hypothesis of Alzheimer's disease
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    J Neurochem 104:1433-9. 2008
  4. pmc School students as Drosophila experimenters
    Faiza Siyad
    PLoS Biol 3:e246. 2005
  5. pmc Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
    Richard Killick
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Biochem Biophys Res Commun 386:257-62. 2009
  6. ncbi request reprint Acetylcholinesterase treatment--modelling potential demand and auditing practice
    S Lovestone
    Department of Psychological Medicine, Institute of Psychiatry, London
    Int J Geriatr Psychiatry 16:1136-42. 2001
  7. ncbi request reprint Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers
    Simon Lovestone
    Institute of Psychiatry, MRC Centre for Neurodegeneration Research and NIHR Biomedical Research Centre, KCL, London, UK
    Expert Rev Proteomics 4:227-38. 2007
  8. ncbi request reprint Schizophrenia as a GSK-3 dysregulation disorder
    Simon Lovestone
    Departments of Psychological Medicine and Neuroscience Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Trends Neurosci 30:142-9. 2007
  9. pmc Protein aggregates and dementia: is there a common toxicity?
    S Lovestone
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Neurol Neurosurg Psychiatry 72:152-61. 2002
  10. ncbi request reprint Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:727-31. 2008

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Biomarkers in Alzheimer's disease
    S Lovestone
    Department of Old Age Psychiatry and Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    J Nutr Health Aging 10:118-22. 2006
  2. doi request reprint Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
    Raya Al-Shawi
    Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK
    Eur J Neurosci 27:2103-14. 2008
    ..From these data we propose that selective age-related neuronal atrophy and neurodegeneration may be mediated by increased sortilin expression in neurons, together with elevated levels of proNGF expression in some targets...
  3. pmc The GSK3 hypothesis of Alzheimer's disease
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    J Neurochem 104:1433-9. 2008
    ..If our 'GSK3 hypothesis of AD' is substantiated and GSK3 is indeed a causal mediator of AD then inhibitors of GSK3 would provide a novel avenue for therapeutic intervention in this devastating disorder...
  4. pmc School students as Drosophila experimenters
    Faiza Siyad
    PLoS Biol 3:e246. 2005
  5. pmc Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
    Richard Killick
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Biochem Biophys Res Commun 386:257-62. 2009
    ..However, as these effects are accompanied by improvement in behavioural deficits, our findings suggest a novel protective effect of disrupting IRS2 signalling in AD which may be a useful therapeutic strategy for this condition...
  6. ncbi request reprint Acetylcholinesterase treatment--modelling potential demand and auditing practice
    S Lovestone
    Department of Psychological Medicine, Institute of Psychiatry, London
    Int J Geriatr Psychiatry 16:1136-42. 2001
    ..Acetylcholinesterase inhibitors represent an entirely novel treatment option for patients with Alzheimer's disease (AD). As such they represent a significant change in practice and a significant cost pressure on funding bodies...
  7. ncbi request reprint Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers
    Simon Lovestone
    Institute of Psychiatry, MRC Centre for Neurodegeneration Research and NIHR Biomedical Research Centre, KCL, London, UK
    Expert Rev Proteomics 4:227-38. 2007
    ....
  8. ncbi request reprint Schizophrenia as a GSK-3 dysregulation disorder
    Simon Lovestone
    Departments of Psychological Medicine and Neuroscience Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Trends Neurosci 30:142-9. 2007
    ..If, as we suggest, GSK-3 regulation is crucial to schizophrenia, the Wnt and insulin signalling pathways become targets for therapy...
  9. pmc Protein aggregates and dementia: is there a common toxicity?
    S Lovestone
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Neurol Neurosurg Psychiatry 72:152-61. 2002
    ....
  10. ncbi request reprint Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:727-31. 2008
    ..024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls. These results would not survive correction for multiple testing but warrant attempts at confirmation in independent samples...
  11. doi request reprint Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease
    S J Furney
    National Institute for Health Research Biomedical Research Centre for Mental Health, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 16:1130-8. 2011
    ..6 × 10(-8); corrected P-value=1.7 × 10(-7)). Gene-wide scoring also highlighted PICALM as the most significant gene associated with entorhinal cortical thickness (P-value=6.7 × 10(-6))...
  12. ncbi request reprint Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
    A Mudher
    Departments of Neuroscience and Psychiatry, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom
    J Neurosci 21:4987-95. 2001
    ..Furthermore, we show that human dvl-1 and wnt-1 also reduce the phosphorylation of tau by GSK-3beta. Therefore, both APP metabolism and tau phosphorylation are potentially linked through wnt signaling...
  13. ncbi request reprint Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry
    G M Gibb
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 485:99-103. 2000
    ..Additionally, of the 15 peptides phosphorylated in the presence or absence of apoE, subtle differences, some isoform-specific, in the relative amounts of phosphorylation were observed...
  14. doi request reprint Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease
    D Whitehead
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, UK
    Int Psychogeriatr 24:99-107. 2012
    ..We investigated the neuroanatomical correlates of paranoid delusions in a cohort of AD patients, using magnetic resonance imaging (MRI) to measure regional volume and regional cortical thickness...
  15. ncbi request reprint Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, UK
    Am J Med Genet B Neuropsychiatr Genet 150:61-4. 2009
    ..027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD...
  16. ncbi request reprint The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis
    C Russ
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 314:92-6. 2001
    ....
  17. doi request reprint Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study
    F Beacher
    Institute of Psychiatry, Kings College, London SE5 8AF, UK
    Psychol Med 40:611-9. 2010
    ..People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing...
  18. ncbi request reprint Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells
    T G Mack
    Department of Neuroscience and Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroscience 108:701-12. 2001
    ..We conclude that the missense tau mutations primarily result in an excess of neuronal tau, which may interfere with important cellular functions such as axonal transport...
  19. ncbi request reprint Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia
    C Beasley
    Department of Neuropathology, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK
    Neurosci Lett 302:117-20. 2001
    ..This provides further evidence for an abnormality of the Wnt signalling pathway in schizophrenia...
  20. ncbi request reprint Early diagnosis and the clinical genetics of Alzheimer's disease
    S Lovestone
    Institute of Psychiatry, London, UK
    J Neurol 246:69-72. 1999
    ..For late-onset AD significant problems remain to be overcome before the advances in molecular genetics have a direct clinical application..
  21. ncbi request reprint Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease
    C Russ
    Department of Neuroscience, Institute of Psychiatry, London SE5 8AF, UK
    Mol Psychiatry 7:104-9. 2002
    ..However further analysis of regulatory regions may lead to the identification of other sequence variations which may be implicated in AD...
  22. ncbi request reprint Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, London, United Kingdom
    Neurobiol Aging 16:389-97; discussion 398-402. 1995
    ..These results suggest that aberrant regulation of GSK-3 alpha/beta may be a pathogenic mechanism in Alzheimer's disease...
  23. ncbi request reprint Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease
    R Sims
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF144XN, UK
    Neurosci Lett 461:54-9. 2009
    ..Significant evidence for association of psychotic symptoms within cases was identified for two SNPs, rs762237 (allelic P=0.002, OR=1.42, corrected P=0.019) and rs2834072 (allelic P=0.004, OR=1.41, corrected P=0.05)...
  24. ncbi request reprint The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease
    C Russ
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 299:156-8. 2001
    ..We therefore investigated whether either the tau H1 or H2 haplotype was associated with PiD. Our results indicate a slight increase in H2H2 frequency in Pick's cases which is not statistically significant...
  25. ncbi request reprint Long-term predictors of cognitive outcome in a cohort of older people with hypertension
    J A Cervilla
    Institute of Psychiatry, London
    Br J Psychiatry 177:66-71. 2000
    ..Deteriorating cognitive function in late life substantially increases the risk for dementia, for other non-cognitive morbidity, for dependency, and early death...
  26. ncbi request reprint Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK SE5 8AF
    Mol Med Today 6:54-9. 2000
    ..Recent genetic discoveries provide some clues, suggesting that components of two developmentally important signalling pathways, Notch and wingless, or the vertebrate homologue of wingless, Wnt, are involved...
  27. ncbi request reprint Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau
    D A Latimer
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 365:42-6. 1995
    ..The findings imply that GSK-3 beta may be a stronger candidate than MAP kinase for inducing tau hyperphosphorylation in vivo...
  28. doi request reprint A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD)
    P Proitsi
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neurobiol Aging 32:434-42. 2011
    ..Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little investigated...
  29. doi request reprint Apathy and cortical atrophy in Alzheimer's disease
    C Tunnard
    MRC Centre for Neurodegeneration, King s College London, Institute of Psychiatry, De Crespigny Park, UK
    Int J Geriatr Psychiatry 26:741-8. 2011
    ..The aim of the current study was to investigate structural correlates of apathy in AD using magnetic resonance imaging (MRI) regional volume and regional cortical thickness measures...
  30. ncbi request reprint Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 144:762-70. 2007
    ..Two SNPs in SGPL1 demonstrated marginal evidence of association, with uncorrected P values of 0.042 and 0.056, suggesting that variation in SGPL1 may confer susceptibility to LOAD...
  31. ncbi request reprint Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease
    C Russ
    Department of Neuroscience, Institute of Psychiatry, London SE5 8AF, UK
    Mol Psychiatry 6:320-4. 2001
    ..Sequencing of the GSK3 beta coding region revealed no variations. This would suggest that the aberrant phosphorylation of tau by GSK3 beta in AD is not due to sequence variations in the gene or its promoter...
  32. pmc Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease
    D Liolitsa
    Department of Neuroscience and Department of Old Age Psychiatry, Institute of Psychiatry, Denmark Hill, SE5 8AF, London, UK
    J Neurol Neurosurg Psychiatry 73:261-6. 2002
    ....
  33. ncbi request reprint 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease
    C Holmes
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Hum Mol Genet 7:1507-9. 1998
    ....
  34. ncbi request reprint Depression, APOE genotype and subjective memory impairment: a cross-sectional study in an African-Caribbean population
    R Stewart
    Section of Old Age Psychiatry, Institute of Psychiatry, London
    Psychol Med 31:431-40. 2001
    ..Other factors suggested to be associated with SMI include poor physical health and the apolipoprotein E (APOE) epsilon4 allele. Studies of SMI have been predominantly confined to white Caucasian populations...
  35. pmc Premorbid cognitive testing predicts the onset of dementia and Alzheimer's disease better than and independently of APOE genotype
    J Cervilla
    Institute of Psychiatry, King s College London, UK
    J Neurol Neurosurg Psychiatry 75:1100-6. 2004
    ..To determine whether a cognitive test package can predict the onset of dementia up to 11 years later, and the extent to which this prediction is independent of that provided by APOE genotype...
  36. pmc Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH
    R Killick
    King s College London, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 533:96-9. 2013
    ..These observations provide a starting point for further attempts to determine the role of CR1 in the neuropathological process driving Alzheimer's disease...
  37. doi request reprint The role of premorbid personality and cognitive factors in awareness of illness, memory, and behavioural functioning in Alzheimer's disease
    J Gilleen
    Psychological Medicine, Department of Old Age Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 17:227-45. 2012
    ..Moreover, the study aims to contrast the strength of the relationship of premorbid personality and awareness with that of cognitive factors...
  38. ncbi request reprint Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
    R Abraham
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Hum Genet 109:646-52. 2001
    ..We conclude that IDE does not make a substantial contribution to the aetiology of LOAD and therefore cannot account for the linkage between LOAD and 10q...
  39. ncbi request reprint Proteome-based plasma biomarkers for Alzheimer's disease
    A Hye
    King s College London, MRC Centre for Neurodegeneration Research London, UK
    Brain 129:3042-50. 2006
    ..These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as alpha-2M may be a specific markers of this illness...
  40. ncbi request reprint GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
    A Mudher
    Department of Neuroscience and Old Age Psychiatry, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Mol Psychiatry 9:522-30. 2004
    ....
  41. ncbi request reprint Biomarkers for disease modification trials--the innovative medicines initiative and AddNeuroMed
    S Lovestone
    S Lovestone, NIHR Biomedical Research Centre, South London and Maudsley NHS Trust and King s College London, London SE5 8AF, UK
    J Nutr Health Aging 11:359-61. 2007
  42. ncbi request reprint Presenilin 1 independently regulates beta-catenin stability and transcriptional activity
    R Killick
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    J Biol Chem 276:48554-61. 2001
    ....
  43. doi request reprint Insight, cognition and quality of life in Alzheimer's disease
    C S Hurt
    King s College London, Institute of Psychiatry, Department of Psychology PO77, De Crespigny Park, London SE5 8AF, UK
    J Neurol Neurosurg Psychiatry 81:331-6. 2010
    ..It remains unclear what impact, if any, impaired insight has upon a patient's HRQL. The present study aimed to investigate the relationship between insight and HRQL in a sample of patients with Alzheimer's disease (AD) and their carers...
  44. ncbi request reprint Genetic risk of Alzheimer's disease: advising relatives
    M B Liddell
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 178:7-11. 2001
    ..Clinicians are increasingly asked by relatives of patients with Alzheimer's disease to advise on their genetic risk of developing Alzheimer's disease in later life. Many clinicians find this a difficult question to answer...
  45. ncbi request reprint Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease
    N Tunstall
    Department of Psychiatry, Institute of Psychiatry, London
    Br J Psychiatry 176:156-9. 2000
    ..Alzheimer's disease manifests considerable heterogeneity, the cause of which is unknown...
  46. ncbi request reprint Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells
    M C Ljungberg
    Department of Neuroscience, Institute of Psychiatry, King s College London, Denmark Hill De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 341:69-73. 2003
    ..In order to further examine the intracellular fate of apoE we demonstrate that apoE-Enhanced green fluorescent protein chimeric protein can be taken up from medium by recipient cells and tracked within these cells for extended periods...
  47. ncbi request reprint Midlife Neuroticism and the age of onset of Alzheimer's disease
    N Archer
    Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
    Psychol Med 39:665-73. 2009
    ..We aimed to examine whether midlife Neuroticism was associated with earlier age of onset of Alzheimer's disease (AD)...
  48. ncbi request reprint Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension
    D Liolitsa
    Department of Neuroscience, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    J Hum Hypertens 15:335-9. 2001
    ..The silent T102C polymorphism in the 5-HT(2A) gene is in absolute linkage disequilibrium with a polymorphism in the promoter and may contribute to genetic predisposition possibly by modifying the transcription of the gene...
  49. pmc Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication
    S Fleminger
    Lishman Brain Injury Unit, Maudsley Hospital, London, UK
    J Neurol Neurosurg Psychiatry 74:857-62. 2003
    ..To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer's disease. We sought to replicate the findings of the meta-analysis of Mortimer et al (1991)...
  50. ncbi request reprint Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes
    J W Connell
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    FEBS Lett 493:40-4. 2001
    ..The findings imply that the R406W mutation in tau exerts long-range conformational effects on the structure of tau...
  51. ncbi request reprint Alzheimer's disease and Down's syndrome: an in vivo MRI study
    F Beacher
    Institute of Psychiatry, King s College, London, UK
    Psychol Med 39:675-84. 2009
    ..Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD...
  52. pmc Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF
    Br J Pharmacol 134:1335-43. 2001
    ..5. The membrane steroid transporters that regulate access of glucocorticoids to the brain in vivo, like the multiple drug resistance p-glycoprotein, could be a fundamental target for antidepressant action...
  53. ncbi request reprint Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population
    R Stewart
    Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
    Dement Geriatr Cogn Disord 12:251-6. 2001
    ..However, it may be accounted for by vascular comorbidity. The different patterns of association between epsilon2 and epsilon4 alleles suggest different pathways of effect...
  54. ncbi request reprint Diagnosing Alzheimer's disease--non-clinicians and computerised algorithms together are as accurate as the best clinical practice
    Catherine M L Foy
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    Int J Geriatr Psychiatry 22:1154-63. 2007
    ..Obtaining such a clinical diagnosis in epidemiological studies and clinical trials that recruit large numbers of patients is time consuming...
  55. ncbi request reprint Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci
    Gillian Hamilton
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:508-16. 2007
    ..In particular, our data suggest that the effect of variants within these genes might be influenced by gender...
  56. ncbi request reprint Premorbid personality and behavioral and psychological symptoms in probable Alzheimer disease
    Nicola Archer
    King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    Am J Geriatr Psychiatry 15:202-13. 2007
    ....
  57. ncbi request reprint Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
    Andrew Grupe
    Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 16:865-73. 2007
    ..This is a missense mutation in the galanin-like peptide precursor gene (P = 0.00005, OR = 1.2, false positive rate = 0.87)...
  58. pmc The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 415:135-9. 2007
    ..These findings have ramifications for nuclear architecture and gene transcription...
  59. ncbi request reprint GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
    ..In the light of these findings GSK3alpha warrants further investigation regarding its involvement in Wnt signalling and tauopathies such as Alzheimer's disease...
  60. ncbi request reprint Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease
    Gillian Hamilton
    MRC Centre for Neurodegeneration, Institute for Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK
    Neuromolecular Med 9:331-4. 2007
    ..However, it remains possible that another variant in this gene may modify susceptibility for late-onset Alzheimer's disease...
  61. ncbi request reprint Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4
    Petroula Proitsi
    Department of Psychological Medicine, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 63:13-6. 2008
    ..This diverse evidence suggests that wnt signaling genes, defined as pathway participants, modifiers or targets, are good candidates as susceptibility factors...
  62. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  63. pmc SORL1 variants and risk of late-onset Alzheimer's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA, USA
    Neurobiol Dis 29:293-6. 2008
    ..035); however, this result does not remain significant when accounting for multiple comparisons. Further validation in other sample sets will be required to assess the true effects of SORL1 variants in LOAD...
  64. ncbi request reprint Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
    ..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
  65. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  66. ncbi request reprint Alzheimer's disease-do tauists and baptists finally shake hands?
    Amritpal Mudher
    Depts of Neuroscience and Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    Trends Neurosci 25:22-6. 2002
    ..One alternative possibility is that some common factor, loss of wnt signalling for example, might induce both plaques and tangles...
  67. ncbi request reprint Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease
    Yonghong Li
    Celera Diagnostics, Alameda, California 94502, USA
    Hum Mutat 25:270-7. 2005
    ..43 [95% CI: 1.61-3.67]; OR(het)=2.15 [95% CI: 1.46-3.17]; P=0.00006) in the combined sample set. Our data raise the possibility that genetic variations in APBB2 may affect LOAD susceptibility...
  68. ncbi request reprint Do antidepressants regulate how cortisol affects the brain?
    Carmine M Pariante
    Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK
    Psychoneuroendocrinology 29:423-47. 2004
    ..Enhanced cortisol action in the brain might prove to be a successful approach to maximise therapeutic antidepressant effects...
  69. ncbi request reprint Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella
    Naushaba Nayeem
    Department of Neurodegenerative Disease and MRC Prion Unit, Institute of Neurology, University College, London WC1N 3BG, UK
    Mol Cell Neurosci 34:400-8. 2007
    ....
  70. ncbi request reprint TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK
    J Neurochem 99:989-99. 2006
    ..Collectively, these findings may have ramifications for neurodevelopment, neurodegeneration and oncogenesis...
  71. ncbi request reprint Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 136:62-8. 2005
    ..Although our results are not universally negative, we were unable to replicate the results of previous studies and conclude that common variants or haplotypes of these variants in IDE are not major risk factors for LOAD...
  72. ncbi request reprint Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease
    Peter Holmans
    Biostatistics and Bioinformatics Unit, Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:24-32. 2005
    ..08) and chromosome 9 (max LOD = 3.34). The previously reported genome-wide linkage of AD to chromosome 10 was not influenced by any of the covariates studied...
  73. ncbi request reprint Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study
    Lynnette J Cook
    Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Am J Med Genet B Neuropsychiatr Genet 132:5-8. 2005
    ..Replication analyses of these two loci failed to detect any significant association for disease in our case-control samples...
  74. ncbi request reprint Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH89JZ, UK
    Neurosci Lett 373:110-4. 2005
    ..The possibility that this result might be a selection effect was not supported by the samples being in Hardy-Weinberg equilibrium with respect to the distribution of NCSTN genotypes...
  75. pmc Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Proc Natl Acad Sci U S A 101:15688-93. 2004
    ..Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis...
  76. ncbi request reprint Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study
    Yonghong Li
    Celera Diagnostics, Alameda, CA, USA
    Neurosci Lett 366:268-71. 2004
    ..Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study...
  77. ncbi request reprint Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
    Victoria Busby
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuromolecular Med 5:133-46. 2004
    ..None of these SNPs was associated with disease. Although an excellent candidate, we conclude that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10...
  78. ncbi request reprint Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease
    Lynnette J Cook
    Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Neurosci Lett 358:142-6. 2004
    ..70, 95% confidence interval=0.52-0.95, P=0.019). These data suggest that this variant warrants further examination in large case-control series...
  79. ncbi request reprint Genes related to vascular disease (APOE, VLDL-R, DCP-1) and other vascular factors in late-life depression
    Jorge Cervilla
    Sections of Epidemiological Psychiatry and Old Age Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King s College, University of London, UK
    Am J Geriatr Psychiatry 12:202-10. 2004
    ..The authors asked whether polymorphic variation at three genes related to vascular disease, and other vascular disease risk factors, determine late-life depression...
  80. ncbi request reprint Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD
    Amanda J Myers
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Med Genet B Neuropsychiatr Genet 124:29-37. 2004
    ..Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data...
  81. ncbi request reprint The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones
    Carmine M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 28:1553-61. 2003
    ..This work further supports the hypothesis that membrane steroid transporters regulating the access of glucocorticoids to the brain in vivo are a fundamental target for antidepressant action...
  82. ncbi request reprint Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
    Hum Genet 113:258-67. 2003
    ..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
  83. ncbi request reprint Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
    Clive Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 119:40-3. 2003
    ..In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele...
  84. ncbi request reprint Truncated apoE forms tangle-like structures in a neuronal cell line
    M Cecilia Ljungberg
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 13:867-70. 2002
    ..Further understanding of the basis of this cell specificity might add to understanding of the cell specificity of tangles in AD...
  85. ncbi request reprint Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease
    Abdul Hye
    Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE 58 AF, UK
    Neurosci Lett 373:1-4. 2005
    ....
  86. ncbi request reprint DAPK1 variants are associated with Alzheimer's disease and allele-specific expression
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Hum Mol Genet 15:2560-8. 2006
    ..015 to <0.0001). These data suggest that genetic variation in DAPK1 modulates susceptibility to LOAD...
  87. ncbi request reprint Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
  88. ncbi request reprint The NEO-FFI is a reliable measure of premorbid personality in patients with probable Alzheimer's disease
    Nicola Archer
    Section of Old Age Psychiatry, King s College London, Institute of Psychiatry, Section of Old Age Psychiatry, Denmark Hill, London, UK
    Int J Geriatr Psychiatry 21:477-84. 2006
    ..To assess the inter-informant reliability, intra-informant reliability and internal consistency of the NEO-FFI as a measure of premorbid personality in patients with Alzheimer's Disease (AD)...
  89. ncbi request reprint PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
    Fiona Kerr
    King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London SE5 8AF, United Kingdom
    FEBS Lett 580:3121-8. 2006
    ..Our studies provide evidence for an effect of PTEN on the phosphorylation of tau in AD pathogenesis, and provide some insight into the mechanisms through which deregulation of PTEN may contribute towards the progression of tauopathy...
  90. ncbi request reprint TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 401:30-4. 2006
    ..These findings have ramifications for microtubule dynamics associated with axonal growth during development and for neuronal death associated with Alzheimer's disease and other tauopathies...
  91. ncbi request reprint Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease
    Gillian Hamilton
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 401:77-80. 2006
    ..Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD...
  92. pmc p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 418:34-7. 2007
    ..Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies...
  93. pmc A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
    Andrew Grupe
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 78:78-88. 2006
    ..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder...
  94. ncbi request reprint Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease
    Scott Smemo
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Ann Neurol 59:21-6. 2006
    ..We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD...
  95. ncbi request reprint Dynamic properties of APC-decorated microtubules in living cells
    Rejith Dayanandan
    Department of Neuroscience, Institute of Psychiatry, King s College London, United Kingdom
    Cell Motil Cytoskeleton 54:237-47. 2003
    ....
  96. ncbi request reprint Glycogen synthase kinase-3 inhibition is integral to long-term potentiation
    Claudie Hooper
    MRC Centre for Neurodegeneration Research, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur J Neurosci 25:81-6. 2007
    ..It follows that this role of GSK-3beta in LTP might underlie some of the cognitive dysfunction in diseases where GSK-3 dysfunction has been implicated, including Alzheimer's and other dementias...
  97. ncbi request reprint Genetics and dementia nosology
    Deborah Blacker
    Department of Psychiatry, Mass General Hospital Harvard Medical School, Boston, MA, USA
    J Geriatr Psychiatry Neurol 19:186-91. 2006
    ..In addition, a separate section reviews the relationship of genetic findings and mild cognitive impairment, a boundary zone between normal aging and dementia, particularly Alzheimer's disease...
  98. ncbi request reprint Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications
    Clive Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton SO30 3JB, UK
    Age Ageing 32:200-4. 2003
    ..However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice...
  99. ncbi request reprint Full genome screen for Alzheimer disease: stage II analysis
    Amanda Myers
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 114:235-44. 2002
    ..Of the seven markers we tested in family-based and case control samples, the only nominally positive association we found was with the 167 bp allele of marker D10S1217 (chi-square=7.11, P=0.045, df=1)...
  100. ncbi request reprint The clinical phenotype of familial and sporadic late onset Alzheimer's disease
    Clive Holmes
    University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Int J Geriatr Psychiatry 17:146-9. 2002
    ..To date, most studies have focussed on familial influences upon age of onset or duration of illness and few studies have compared the frequency of non-cognitive symptoms between familial and sporadic LOAD...