C M Lewis

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease: a randomised controlled trial assessing impact upon stopping smoking
    Sophia C L Whitwell
    Health Psychology Section, Department of Psychology, King s College London, Guy s Campus, London, UK
    BMC Public Health 11:44. 2011
  2. ncbi Exome localization of complex disease association signals
    Benjamin Lehne
    King s College London, Department of Medical and Molecular Genetics, 8th Floor Tower Wing, Guy s Hospital, London SE19RT, UK
    BMC Genomics 12:92. 2011
  3. ncbi Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
    Martyn C Byng
    Division of Genetics and Development, Guy s, King s and St, Thomas School of Medicine, 8th Floor, Guy s Tower, Guy s Hospital, London, United Kingdom
    BMC Genet 4:S4. 2003
  4. ncbi Genome-wide association study of major recurrent depression in the U.K. population
    Cathryn M Lewis
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Psychiatry 167:949-57. 2010
  5. ncbi Genetic association studies: design, analysis and interpretation
    Cathryn M Lewis
    Division of Medical and Molecular Genetics, Guy s Hospital, London, UK
    Brief Bioinform 3:146-53. 2002
  6. ncbi Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease
    C M Lewis
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, UK
    J Med Genet 44:689-94. 2007
  7. ncbi Sequence variation, linkage disequilibrium and association with Crohn's disease on chromosome 5q31
    C Onnie
    Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK
    Genes Immun 7:359-65. 2006
  8. ncbi A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population
    N J Prescott
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, GKT School of Medicine, King s College London, London, UK
    Tissue Antigens 66:318-20. 2005
  9. ncbi Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis
    C J W Stock
    Centre for Paediatric and Adolescent Rheumatology, Windeyer Institute for Medical Sciences, University College London, London, UK
    Genes Immun 9:349-57. 2008
  10. ncbi Genetic variation at the chromosome 16 chemokine gene cluster: development of a strategy for association studies in complex disease
    S A Fisher
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Ann Hum Genet 67:377-90. 2003

Detail Information

Publications95

  1. ncbi Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease: a randomised controlled trial assessing impact upon stopping smoking
    Sophia C L Whitwell
    Health Psychology Section, Department of Psychology, King s College London, Guy s Campus, London, UK
    BMC Public Health 11:44. 2011
    ....
  2. ncbi Exome localization of complex disease association signals
    Benjamin Lehne
    King s College London, Department of Medical and Molecular Genetics, 8th Floor Tower Wing, Guy s Hospital, London SE19RT, UK
    BMC Genomics 12:92. 2011
    ....
  3. ncbi Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
    Martyn C Byng
    Division of Genetics and Development, Guy s, King s and St, Thomas School of Medicine, 8th Floor, Guy s Tower, Guy s Hospital, London, United Kingdom
    BMC Genet 4:S4. 2003
    ..Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP...
  4. ncbi Genome-wide association study of major recurrent depression in the U.K. population
    Cathryn M Lewis
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Psychiatry 167:949-57. 2010
    ..K. and 1,594 comparison subjects screened negative for psychiatric disorders...
  5. ncbi Genetic association studies: design, analysis and interpretation
    Cathryn M Lewis
    Division of Medical and Molecular Genetics, Guy s Hospital, London, UK
    Brief Bioinform 3:146-53. 2002
    ..The transmission disequilibrium test is provided as an alternative family-based test, which is robust to population stratification. The relative benefits of each analysis are summarised...
  6. ncbi Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease
    C M Lewis
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, UK
    J Med Genet 44:689-94. 2007
    ..Progress has been made in identifying mutations that confer susceptibility to complex diseases, with the prospect that these genetic risks might be used in determining individual disease risk...
  7. ncbi Sequence variation, linkage disequilibrium and association with Crohn's disease on chromosome 5q31
    C Onnie
    Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK
    Genes Immun 7:359-65. 2006
    ..Other as yet undiscovered SNPs in this region may therefore modulate gene expression and contribute to the risk of CD, and perhaps of other inflammatory phenotypes...
  8. ncbi A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population
    N J Prescott
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, GKT School of Medicine, King s College London, London, UK
    Tissue Antigens 66:318-20. 2005
    ..No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD...
  9. ncbi Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis
    C J W Stock
    Centre for Paediatric and Adolescent Rheumatology, Windeyer Institute for Medical Sciences, University College London, London, UK
    Genes Immun 9:349-57. 2008
    ..These results indicate that there may be aberrant control of the activity of the IL-1 family in sJIA patients causing the increased susceptibility to the disease...
  10. ncbi Genetic variation at the chromosome 16 chemokine gene cluster: development of a strategy for association studies in complex disease
    S A Fisher
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Ann Hum Genet 67:377-90. 2003
    ..We describe an efficient experimental design from SNP screening to association testing. This strategy can be used to test candidate genes for involvement in susceptibility to complex disease...
  11. ncbi Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease
    K King
    Department of Medical and Molecular Genetics, Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, King s College London, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Eur J Immunogenet 30:187-90. 2003
    ..The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders...
  12. ncbi Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease
    M A Smith
    Department of Gastroenterology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Aliment Pharmacol Ther 30:375-84. 2009
    ..Azathioprine (AZA) pharmacogenetics are complex and much studied. Genetic polymorphism in TPMT is known to influence treatment outcome. Xanthine oxidase/dehydrogenase (XDH) and aldehyde oxidase (AO) compete with TPMT to inactivate AZA...
  13. ncbi SNP subset selection for genetic association studies
    M C Byng
    Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, London, UK
    Ann Hum Genet 67:543-56. 2003
    ..These methods are illustrated using eleven SNPs in the MMP2 gene...
  14. ncbi SNP selection for association studies: maximizing power across SNP choice and study size
    F Pardi
    Department of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, UK
    Ann Hum Genet 69:733-46. 2005
    ..We compare the performance of these two algorithms on different chromosomal regions and show that, as expected, the selected SNPs reflect the LD pattern: the optimal SNP density varies dramatically between chromosomal regions...
  15. ncbi Methyl-CpG-binding protein 2 polymorphisms and vulnerability to autism
    C S Loat
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Genes Brain Behav 7:754-60. 2008
    ....
  16. ncbi Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population
    Alexandra V Pearce
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Int J Colorectal Dis 22:419-24. 2007
    ....
  17. ncbi Power of genetic association studies in the presence of linkage disequilibrium and allelic heterogeneity
    Sheila A Fisher
    Division of Genetics and Molecular Medicine, Institute of Psychiatry, King s College London, London, UK
    Hum Hered 66:210-22. 2008
    ....
  18. ncbi Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations
    M Ameen
    St John s Institute of Dermatology, Kings College, London, UK
    Clin Exp Dermatol 30:414-8. 2005
    ....
  19. ncbi Cancer risks in women with 2 breast or ovarian cancers: clues to genetic cancer susceptibility
    H S Evans
    Thames Cancer Registry, Division of Medicine, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Int J Cancer 94:758-9. 2001
    ..We also found significantly increased risks of myeloid leukaemia (probably due to radiotherapy) and of cancer of the corpus uteri (which may be due to hormonal factors)...
  20. ncbi Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    Muddassar M Mirza
    Division of Medical and Molecular Genetics, Guy s, King s, and Thomas s School of Medicine, King s College London, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 72:1018-22. 2003
    ..0019). These findings suggest that genetic variants at the 5q31 (IBD5) locus may hasten the onset of Crohn disease and cooperate with CARD15 in disease causation...
  21. ncbi Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn's disease gene CARD15
    S Steer
    Molecular Immunogenetics, Department of Rheumatology, Division of Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Hospital Campus, King s College, London, UK
    Rheumatology (Oxford) 42:304-7. 2003
    ..Recently, common variation in the CARD15 (NOD2) gene on chromosome 16q12 has been associated with Crohn's disease (CD) in several independent populations. CARD15 is an excellent functional and positional candidate gene for RA...
  22. ncbi Detecting population outliers and null alleles in linkage data: application to GAW12 asthma studies
    S A Fisher
    Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, 8th Floor, Guy's Tower, Guy's Hospital, London SE1 9RT, UK
    Genet Epidemiol 21:S18-23. 2001
    ..In the CSGA data, a significant excess of homozygous individuals is found at D8S1106, suggestive of a null allele at this marker with an estimated frequency of 0.17 (African-American) and 0.20 (Caucasian)...
  23. ncbi The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families
    Emma M Ogilvie
    University College London, London, UK
    Arthritis Rheum 48:3202-6. 2003
    ..The significant excess transmission to patients with age at onset >5 years but not to those with age at onset < or =5 years suggests that there may be genetic heterogeneity between the 2 groups...
  24. ncbi A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Gastroenterology 132:1665-71. 2007
    ..We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis...
  25. ncbi Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15
    Kathy King
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Hum Mutat 27:44-54. 2006
    ..The strategy developed here may have general application to the assessment of mutation pathogenicity and genetic models in other complex disorders...
  26. ncbi Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  27. ncbi Mutation in the ITPA gene predicts intolerance to azathioprine
    A M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology, Guy s and St Thomas Hospital, London, UK
    Nucleosides Nucleotides Nucleic Acids 23:1393-7. 2004
    ..2, CI 1.1-32.6, p = 0.0485). Polymorphism in the ITPA gene thus predicts AZA intolerance. Alternative immunosuppressive drugs, particularly 6-thioguanine, should be considered for AZA-intolerant patients with ITPase deficiency...
  28. ncbi Controlling misdiagnosis errors in preimplantation genetic diagnosis: a comprehensive model encompassing extrinsic and intrinsic sources of error
    C M Lewis
    Division of Medical and Molecular Genetics, Guy's, King's and St Thomas' School of Medicine, London SE1 9RT, UK
    Hum Reprod 16:43-50. 2001
    ..Genotypes from two biopsied cells are required to ensure that a high proportion of unaffected embryos are eligible for replacement. This model can be used as a clinical tool to prioritize embryos for transfer in a PGD cycle...
  29. ncbi Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    Hum Mutat 27:778-85. 2006
    ....
  30. ncbi Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease
    Clive M Onnie
    Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Eur J Gastroenterol Hepatol 20:37-45. 2008
    ..We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD...
  31. ncbi Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus
    P Forabosco
    Department of Medical and Molecular Genetics, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK
    Genes Immun 7:609-14. 2006
    ....
  32. ncbi Meta-analysis of four rheumatoid arthritis genome-wide linkage studies: confirmation of a susceptibility locus on chromosome 16
    S A Fisher
    Guy s Hospital, London, UK
    Arthritis Rheum 48:1200-6. 2003
    ..We applied a genome-search meta-analysis to 4 RA genome searches to assess linkage across studies, using published results...
  33. ncbi Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, London SE1 7EH, UK
    Br J Dermatol 144:334-8. 2001
    ..Abnormal photosensitivity is a common feature of many forms of lupus erythematosus (LE)...
  34. ncbi Polymorphic light eruption and the HLA DRB1*0301 extended haplotype are independent risk factors for cutaneous lupus erythematosus
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, London, UK
    Lupus 10:473-9. 2001
    ..They form a basis for examining the genetic architecture of photosensitivity, some aspects of which may be common to both cutaneous LE and PLE...
  35. ncbi A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 145:229-36. 2001
    ....
  36. ncbi Penetrance for copy number variants associated with schizophrenia
    Evangelos Vassos
    Institute of Psychiatry, MRC SGDP Centre, King s College London, London, UK
    Hum Mol Genet 19:3477-81. 2010
    ..Thus, although CNVs are still far from being clinically useful or relevant to genetic counselling for specific disorders, their detection may hold an important clinical value in predicting negative developmental outcomes...
  37. ncbi Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method
    Paola Forabosco
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Hum Hered 64:74-81. 2007
    ..Ranks are then summed across studies, with high summed ranks potentially showing evidence for linkage in the meta-analysis...
  38. ncbi Testing for genetic heterogeneity in the genome search meta-analysis method
    Cathryn M Lewis
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, Guy s Hospital, London, UK
    Genet Epidemiol 30:348-55. 2006
    ..Although testing for heterogeneity in the GSMA is of interest, the currently available method provides little additional information to that provided by the summed rank statistic...
  39. ncbi Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study
    Clive M Onnie
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, UK
    Inflamm Bowel Dis 12:263-71. 2006
    ....
  40. ncbi Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
    Rudolf Uher
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, SE5 8AF, London, United Kingdom
    Am J Psychiatry 167:555-64. 2010
    ..The authors performed a genome-wide association analysis of improvement of depression severity with two antidepressant drugs...
  41. ncbi The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    Andrew P Cuthbert
    Division of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, England, United Kingdom
    Gastroenterology 122:867-74. 2002
    ....
  42. ncbi Genetic predictors of response to antidepressants in the GENDEP project
    Rudolf Uher
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 9:225-33. 2009
    ..The single marker associations explained only a small proportion of variance in response to antidepressants, indicating a need for a multivariate approach to prediction...
  43. ncbi Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6
    Sheila A Fisher
    Division of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, UK
    Eur J Hum Genet 10:259-65. 2002
    ..The existence of sex-specific linkage is further evidence of the complex mechanisms involved in IBD and will facilitate future studies to identify susceptibility genes...
  44. ncbi Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians
    Anthony M Marinaki
    Purine Research and Department of Gastroenterology, Guy s and St Thomas Hospital, London SE1 9RT, UK
    Pharmacogenetics 13:97-105. 2003
    ..Here we present the allele frequencies of genetic modifiers of TPMT activity in a British Asian population, as well as the concordance between intermediate TPMT activity and ORF and VNTR genotypes in a predominantly Caucasian population...
  45. ncbi Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project
    Nader Perroud
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College Lodon, London, UK
    Neuropsychopharmacology 34:2517-28. 2009
    ..Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality...
  46. ncbi Genetics of inflammatory bowel disease: progress and prospects
    Christopher G Mathew
    Division of Genetics and Development, Guy s King s and St Thomas School of Medicine, King s College London, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 13:R161-8. 2004
    ..Although important obstacles to further progress will need to be overcome, the successes of the past 2 years suggest that a detailed description of the genetic basis of inflammatory bowel disease is a realistic goal...
  47. ncbi Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q
    Benedetta D Chiodini
    Division of Genetics and Development, Guy s, King s, and St Thomas School of Medicine, London, England
    Arterioscler Thromb Vasc Biol 23:1863-8. 2003
    ..Results from these studies are inconclusive. We performed a meta-analysis to identify genetic regions that show evidence for susceptibility genes across studies...
  48. ncbi Meta-analysis of linkage studies for Alzheimer's disease--a web resource
    Amy W Butler
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Neurobiol Aging 30:1037-47. 2009
    ..iop.kcl.ac.uk/) to present additional GSMA analyses with different study selection criteria, facilitate the reanalysis of genome-wide linkage data and provide open access to the GSMA data...
  49. ncbi Meta-analysis of genome scans of age-related macular degeneration
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Hum Mol Genet 14:2257-64. 2005
    ..Several of the regions identified here showed only weak evidence for linkage in the individual studies. These results will help prioritize regions for future positional and functional candidate gene studies in AMD...
  50. ncbi Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 19:1828-39. 2010
    ....
  51. ncbi Genome-wide association analysis of copy number variation in recurrent depressive disorder
    J J H Rucker
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 18:183-9. 2013
    ..This may suggest that the absence of deletion CNVs, especially in genes, is associated with resilience to recurrent depression...
  52. ncbi Methotrexate polyglutamates as a marker of patient compliance and clinical response in psoriasis: a single-centre prospective study
    R T Woolf
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    Br J Dermatol 167:165-73. 2012
    ..MTXPG(1-5) inhibit enzymes of the folate-purine-pyrimidine pathways, and longer-chain MTXPG(3-5) species are more active...
  53. ncbi Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis
    I C Scott
    Department of Rheumatology, Guy s Hospital, Great Maze Pond, London, UK
    Best Pract Res Clin Rheumatol 25:447-68. 2011
    ..We will also focus on how this knowledge of risk factors for RA may be implemented in the future to identify individuals at a high risk of disease development in whom preventative strategies may be undertaken...
  54. ncbi Linkage studies in dominant optic atrophy, Kjer type: possible evidence for heterogeneity
    M J Seller
    Division of Medical and Molecular Genetics, Guy s Hospital, London, UK
    J Med Genet 34:967-72. 1997
    ..In addition, analysis of recombinants has enabled us to order the 12 markers along chromosome 3...
  55. ncbi Standardization and statistical approaches to therapeutic trials in the R6/2 mouse
    Emma Hockly
    Department of Medical and Molecular Genetics, King s College London, Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Brain Res Bull 61:469-79. 2003
    ..Here we investigate the sources of phenotypic variability in R6/2, and make recommendations for the future use of such models in therapeutic trials...
  56. ncbi Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q
    Deborah M Ruddy
    Department of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, United Kingdom
    Am J Hum Genet 73:390-6. 2003
    ..5 Mb on the Marshfield map. Bioinformatic analysis of the region has identified 18 known genes and 70 predicted genes in this region, and sequencing of candidate genes has now begun...
  57. ncbi Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder
    Kaixin Zhou
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1392-8. 2008
    ..In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes...
  58. ncbi Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    Anthony M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology and Department of Gastroenterology, Guy s and St Thomas Hospital, London, UK
    Pharmacogenetics 14:181-7. 2004
    ..5, 95% CI 1.4-21.3, P = 0.0206). Polymorphism in the ITPA gene predicts AZA intolerance. Alternative immunosuppressive drugs, particularly 6-thioguanine, should be considered for AZA-intolerant patients with ITPase deficiency...
  59. ncbi Ectopic maxillary canines: segregation analysis and a twin study
    S Camilleri
    Department of Orthodontics, Kings College London, Dental Institute, Guy s Tower, London, UK
    J Dent Res 87:580-3. 2008
    ..The low concordance rate is consistent with the low penetrance determined by the segregation analysis and further supports the existence of environmental factors...
  60. ncbi Meta-analysis of 32 genome-wide linkage studies of schizophrenia
    M Y M Ng
    King s College London, Department of Medical and Molecular Genetics, London, UK
    Mol Psychiatry 14:774-85. 2009
    ..Therefore, the regions supported by this meta-analysis deserve close attention in future studies...
  61. ncbi Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy's, King's and St Thomas' School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  62. ncbi Determination of the genetic status of cleavage-stage human embryos by microsatellite marker analysis following multiple displacement amplification
    Pamela J Renwick
    1 Guy s and St Thomas Centre for PGD, Guy s and St Thomas NHS Foundation Trust, London, UK
    Prenat Diagn 27:206-15. 2007
    ..To analyse genotype information from cleavage-stage human embryos and assess the chromosomal status and feasibility of performing aneuploidy screening by microsatellite analysis...
  63. ncbi Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity
    Monica Arenas
    Purine Research Laboratory, Department of Chemical Pathology, Guy's and St. Thomas' Hospital NHS Trust, London, UK
    Clin Chem 51:2371-4. 2005
  64. ncbi Visual analysis of geocoded twin data puts nature and nurture on the map
    O S P Davis
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Mol Psychiatry 17:867-74. 2012
    ..More broadly, our experience demonstrates the potential for collaborative exploratory visualization to act as a lingua franca for large-scale interdisciplinary research...
  65. ncbi Depressive disorder moderates the effect of the FTO gene on body mass index
    M Rivera
    MRC SGDP Centre, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Mol Psychiatry 17:604-11. 2012
    ..This finding suggests that FTO is involved in the mechanism underlying the association between mood disorders and obesity...
  66. ncbi Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England
    H S Evans
    Thames Cancer Registry, Division of Oncology, Guy s, King s and St Thomas School of Medicine, Kings College, London, UK
    Br J Cancer 84:435-40. 2001
    ..Some of these associations are consistent with the effects of known inherited cancer susceptibility genes, shared environmental factors, or therapy...
  67. ncbi Effect of ethnicity on the hypnotic and cardiovascular characteristics of propofol induction
    A Natarajan
    Guy s and St Thomas NHS Foundation Trust, London, UK
    Anaesthesia 66:15-9. 2011
    ..1 (12.6) % and 7.5 (14.0) % (p = 0.015). Other differences were non-significant. The dose of propofol required for loss of verbal response, but not for suppression of bispectral index to 50, is lower in black than in white patients...
  68. ncbi Outcome in patients with end-stage renal disease following heart or heart--lung transplantation receiving peritoneal dialysis
    S D Jayasena
    Department of Nephrology, Middlesex Hospital, UCLH Trust, London, UK
    Nephrol Dial Transplant 16:1681-5. 2001
    ..Nevertheless, for patients with severely impaired cardiac function, PD may still offer therapeutic advantage...
  69. ncbi Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study
    Benedetta D Chiodini
    Division of Genetics and Molecular Medicine, King s College London, London, UK
    Eur Heart J 28:1977-83. 2007
    ..we investigated the relationship between apoe, mortality and the response to treatment in Mediterranean myocardial infarction (mi) survivors...
  70. ncbi Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method
    Jane Hermanowski
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Eur J Hum Genet 15:703-10. 2007
    ..These regions may provide targets to focus candidate gene studies or to prioritise results from genome-wide association studies...
  71. ncbi Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
    Emma Hockly
    Division of Medical and Molecular Genetics, GKT School of Medicine, King s College London, UK
    Ann Neurol 51:235-42. 2002
    ..Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease...
  72. ncbi Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
    Aleksey Shatunov
    King s College London, Medical Research Council Centre for Neurodegeneration Research, Department of Clinical Neuroscience, Institute of Psychiatry, London, UK
    Lancet Neurol 9:986-94. 2010
    ....
  73. ncbi GSMA: software implementation of the genome search meta-analysis method
    Fabio Pardi
    Department of Medical and Molecular Genetics, King's College London, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom
    Bioinformatics 21:4430-1. 2005
    ..The genome search meta-analysis (GSMA) method is widely used for this analysis, and a computer program is now available to implement the GSMA...
  74. ncbi Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis
    Emanuela Campalani
    King s College, Skin Therapy Research Unit, St John s Institute of Dermatology, London, UK
    J Invest Dermatol 127:1860-7. 2007
    ..We have demonstrated preliminary evidence that specific polymorphisms of enzymes involved in folate, pyrimidine, and purine metabolism could be useful in predicting clinical response to methotrexate in patients with psoriasis...
  75. ncbi The risk of subsequent primary cancers after colorectal cancer in southeast England
    H S Evans
    Thames Cancer Registry, Division of Oncology, Guy's, King's, and St Thomas' School of Medicine, King's College, London, UK
    Gut 50:647-52. 2002
    ..CONCLUSIONS: Patients with colorectal cancer are at increased risk of developing cancer at a number of other sites. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes...
  76. ncbi Meta-analysis of genome-wide linkage studies in celiac disease
    Paola Forabosco
    King s College London, Department of Medical and Molecular Genetics, London, UK
    Hum Hered 68:223-30. 2009
    ..A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies...
  77. ncbi Meta-analysis of genome-wide linkage studies across autoimmune diseases
    Paola Forabosco
    King s College London School of Medicine, Department of Medical and Molecular Genetics, London, UK
    Eur J Hum Genet 17:236-43. 2009
    ..This study illustrates the concept that linkage and association studies have power to identify very different types of disease-predisposing variants...
  78. ncbi Meta-analysis of genome-wide linkage studies in BMI and obesity
    Catherine L Saunders
    King s College London, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Obesity (Silver Spring) 15:2263-75. 2007
    ..The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis...
  79. ncbi A common Fanconi anemia mutation in black populations of sub-Saharan Africa
    Neil V Morgan
    Department of Medical and Molecular Genetics, Guy s Hospital, 8th Floor, Guy s Tower, London SE1 9RT, United Kingdom
    Blood 105:3542-4. 2005
    ..Diagnostic screening is now possible by means of a simple DNA test...
  80. ncbi Association of DLG5 R30Q variant with inflammatory bowel disease
    Mark J Daly
    The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
    Eur J Hum Genet 13:835-9. 2005
    ..This study provides support for the hypothesis that DLG5 constitutes a true IBD risk factor of modest effect...
  81. ncbi Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, , Lund University, SE 205 02 Malm, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  82. ncbi Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    David A van Heel
    Department of Gastoenterology, Imperial College London, UK
    Hum Mol Genet 13:763-70. 2004
    ..Clustering of adjacent bins was observed for chromosomes 6p, 16, 19p. The meta-analysis has identified novel loci and prioritized genomic regions for further gene identification studies...
  83. ncbi Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
    Mark S Fife
    Centre of Pediatric and Adolescent Rheumatology, Windeyer Institute for Medical Sciences, University College London, Cleveland Street, London W1T 4JF, UK
    Arthritis Res Ther 8:R148. 2006
    ..The two marker 'A-T' haplotype confers an odds ratio of 2.24 for sJIA. This positive association suggests an important role for these cytokines in sJIA pathogenesis...
  84. ncbi Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  85. ncbi IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
    Mark Tremelling
    IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    Gastroenterology 132:1657-64. 2007
    ..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
  86. ncbi Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  87. ncbi Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  88. ncbi Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  89. ncbi Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer
    Jane M McGregor
    Department of Photobiology, St Johns Institute of Dermatology, Guy s, Kings and St Thomas School of Medicine, St Thomas Hospital, London, U K
    J Invest Dermatol 119:84-90. 2002
    ..016), irrespective of the mutant status of the concomitant allele. Together these data infer functional differences between polymorphic forms of p53 that are likely to be relevant to skin carcinogenesis...
  90. ncbi An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms
    Jean Deguara
    Academic Department of Surgery, Cardiovascular Division, King s College London, St Thomas Hospital London SE1 7EH, UK
    Hum Mol Genet 16:3002-7. 2007
    ..009 when corrected for age and sex and P = 0.043 when corrected for aneurysm size). It appears that an abnormality in the MMP3 gene is part of the genetic profile that predisposes to aneurysmal disease...
  91. ncbi Combined evidence from three large British Association studies rejects TUCAN/CARD8 as an IBD susceptibility gene
    Sheila A Fisher
    Gastroenterology 132:2078-80. 2007
  92. ncbi Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  93. ncbi Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)
    Carmel Apicella
    Centre for Genetic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia
    Breast Cancer Res 5:R206-16. 2003
    ..The aim of this study was to develop a simple algorithm to estimate the probability that an Ashkenazi Jewish woman carries an ancestral mutation, based on multiple predictive factors...
  94. ncbi Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis
    Douglas F Levinson
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104 3309, USA
    Am J Hum Genet 73:17-33. 2003
    ..The results suggest that GSMA can detect linkage across multiple genome scans...
  95. ncbi Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...