Affiliation: King's College London
- Clinical practice. Food allergyGideon Lack
Department of Paediatric Allergy, King's College London, and the Children's Allergy Service, Guy's and St. Thomas' National Health Service Foundation Trust, London
N Engl J Med 359:1252-60. 2008
- Factors associated with the development of peanut allergy in childhoodGideon Lack
Department of Paediatric Allergy and Immunology, St. Mary's Hospital at Imperial College, London, United Kingdom
N Engl J Med 348:977-85. 2003..Confirmation of these risk factors in future studies could lead to new strategies to prevent sensitization in infants who are at risk for subsequent peanut allergy...
- Preventing food allergyAbbas Khakoo
Department of Paediatric Allergy, Asthma and Immunology, Imperial College London at St Mary's Hospital, Salton House, St Mary's Hospital, Praed Street, London W2 1NY, UK
Curr Allergy Asthma Rep 4:36-42. 2004..Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy...
- The concept of oral tolerance induction to foodsGideon Lack
Paediatric Unit, Department of Medicine, King s College London, Guys and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London, UK
Nestle Nutr Workshop Ser Pediatr Program 59:63-8; discussion 68-72. 2007..New strategies to prevent food allergy in infants need to be put to test in randomized controlled interventional studies...
- Can food allergy be prevented? The current evidenceGeorge Du Toit
Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas National Health Service Foundation Trust, Medical Research Council, London, UK
Pediatr Clin North Am 58:481-509, xii. 2011..Prevention strategies need to be tested using randomized controlled study designs that account for the numerous methodological challenges, safety concerns, and necessary ethical limitations...
- Update on risk factors for food allergyGideon Lack
MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s and St Thomas NHS Foundation Trust, Children s Allergies Department, St Thomas Hospital, London, United Kingdom
J Allergy Clin Immunol 129:1187-97. 2012..Novel interventional strategies to prevent the development of FA are also discussed...
- The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroidsGideon Lack
Children s Allergy Department, King s College London, Guy s and St Thomas NHS Foundation Trust, London, UK
Pediatr Allergy Immunol 22:258-66. 2011..Benefits of considering medical treatment in patients with OME prior to surgery include both the potential reductions in allergic inflammation and the naturally occurring spontaneous resolution of OME in these patients...
- Epidemiologic risks for food allergyGideon Lack
Kings College London, St Thomas Hospital, Children s Allergies Department, London, United Kingdom
J Allergy Clin Immunol 121:1331-6. 2008..This hypothesis provides a possible explanation for the close link between eczema and the development of food allergies. It also suggests novel interventional strategies to prevent the development of food allergies...
- Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening studyGeorge Du Toit
King s College London, King s Health Partners, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, and Department of Paediatric Allergy, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
J Allergy Clin Immunol 131:135-43.e1-12. 2013..Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction...
- Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergyGeorge Du Toit
King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
J Allergy Clin Immunol 122:984-91. 2008..Despite guidelines recommending avoidance of peanuts during infancy in the United Kingdom (UK), Australia, and, until recently, North America, peanut allergy (PA) continues to increase in these countries...
- Assessing Peanut Consumption in a Population of Mothers and Their Children in the UKAikaterini Sofianou-Katsoulis
Institute of Child Health, M Asias 76, GR 11527, Athens, Greece St Mary s Hospital, Paediatric Department, QEQM Building, Praed Street, W2 1NY, London, UK
World Allergy Organ J 4:38-44. 2011..The aim was to validate a 50-item FFQ for use in peanut protein sensitization studies...
- Early feeding practices and development of food allergiesGideon Lack
Children s Allergies Department, St Thomas Hospital, Kings College London, London, UK
Nestle Nutr Workshop Ser Pediatr Program 68:169-83; discussion 183-6. 2011..Novel interventional strategies to prevent the development of food allergies are also discussed...
- Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanutsVictor Turcanu
Department of Paediatrics, Imperial College Faculty of Medicine, London, United Kingdom
J Clin Invest 111:1065-72. 2003..In conclusion, food allergic status is characterized by a Th2 response whereas Th1-skewed responses underlie oral tolerance...
- The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort studyMichael R Perkin
Department of Child Health, St George s, University of London, London, UK
Pediatr Allergy Immunol 17:118-24. 2006..5% and a specificity of 95.8%. Although significant differences in early life IgE measurements were seen, the extent of overlap was great, such that the overall performance of IgE at 12 months as a screening test for atopy was poor...
- IgE-mediated facilitated antigen presentation underlies higher immune responses in peanut allergyV Turcanu
Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in the Allergic Mechanisms of Asthma, King s College London, London, UK
Allergy 65:1274-81. 2010..To explore the immunological mechanisms that underlie peanut allergy and tolerance, we compared the peanut-specific responses of peanut-allergic (PA) and nonallergic (NA) individuals...
- Identifying and managing cow's milk protein allergyGeorge Du Toit
King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Allergy and Lung Biology, Guy s and St Thomas NHS Foundation Trust, UK
Arch Dis Child Educ Pract Ed 95:134-44. 2010..This review is intended to highlight the broad spectrum of manifestations of CMP allergy and to offer an approach to the diagnosis and treatment thereof...
- Clinical features and natural history of physical urticaria in childrenGulamabbas Khakoo
Department of Paediatric Allergy, Asthma and Immunology, St Mary s Hospital, London, UK
Pediatr Allergy Immunol 19:363-6. 2008..A history of allergic conditions and more frequent episodes of urticaria were associated with a poorer prognosis...
- Household peanut consumption as a risk factor for the development of peanut allergyAdam T Fox
King s College London, the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
J Allergy Clin Immunol 123:417-23. 2009..Most children with peanut allergy (PA) react on first known oral exposure to peanut. Recent data suggest cutaneous exposure as a route of sensitization...
- Food allergy and asthma--what is the link?Graham Roberts
Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, E1 1BB, London, UK
Paediatr Respir Rev 4:205-12. 2003..The co-existence of food allergy should be considered in any child with asthma. Where food allergy is confirmed, steps should be taken to avoid these foods as this may considerably improve asthma control...
- Development of a quality-of-life assessment for the allergic child or teenager with multisystem allergic diseaseGraham Roberts
Pediatric Allergy, Asthma, and Immunology, Imperial College School of Medicine at St Mary's, London, United Kingdom
J Allergy Clin Immunol 111:491-7. 2003....
- Diagnosing peanut allergy with skin prick and specific IgE testingGraham Roberts
Paediatric Allergy, Asthma and Immunology, Imperial College at St. Mary's, St. Mary's Hospital, Praed Street, London W2 1NY, UK
J Allergy Clin Immunol 115:1291-6. 2005....
- New visions for food allergy: an iPAC summary and future trendsPhilippe A Eigenmann
Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
Pediatr Allergy Immunol 19:26-39. 2008....
- Food challenges: a review and auditTina Torr
Asthma and Immunology Department, St Mary's Hospital, London
Paediatr Nurs 14:30-4. 2002
- Clinical risk assessment of GM foodsGideon Lack
Department of Paediatric Allergy and Immunology, Imperial College at St Mary s Hospital, Praed Street, London W2 1NY, UK
Toxicol Lett 127:337-40. 2002..We need to proceed cautiously in the future, assessing individual GM foods on the basis of their individual merits and risks prior to introducing them into the market...
- Relevance of inhalational exposure to food allergensGraham Roberts
Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, London
Curr Opin Allergy Clin Immunol 3:211-5. 2003..The similar pathophysiology of allergic and occupational asthma and the ability of inhaled food allergens to cause the latter raises the question as to whether aerosolized food could play a role in the pathogenesis of childhood asthma...
- Egg allergy and MMR vaccinationAdam Fox
Department of Paediatric Allergy and Immunology, St Mary's Hospital, London
Br J Gen Pract 53:801-2. 2003
- Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled studyGraham Roberts
Department of Paediatric Allergy and Clinical Immunology, St Mary's Hospital, London
J Allergy Clin Immunol 112:168-74. 2003..More intensive management of this high-risk group of children might help to reduce future morbidity and mortality...
- Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxisPeter Vadas
Department of Medicine, Division of Allergy and Clinical Immunology, St Michael s Hospital, Toronto, ON, Canada
N Engl J Med 358:28-35. 2008..The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported...
- Early nutrition and immunity - progress and perspectivesPhilip C Calder
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 96:774-90. 2006..This report summarizes the content of the lectures and the subsequent discussions...
- Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthmaGraham Roberts
University Child Health, University of Southampton, Hants, UK
J Allergy Clin Immunol 117:263-8. 2006..Few studies have investigated the use of specific immunotherapy (SIT) for childhood seasonal allergic asthma...
- New developments in food allergy: old questions remainGideon Lack
J Allergy Clin Immunol 114:127-30. 2004
- Factors affecting the determination of threshold doses for allergenic foods: how much is too much?Steve L Taylor
University of Nebraska, Food Allergy Research and Resource Program, Lincoln 68583 0919, USA
J Allergy Clin Immunol 109:24-30. 2002..Are these very low, residual quantities hazardous to allergic consumers? How much of the offending food is too much? Very little quantitative information exists to allow any risk assessments to be conducted by the food industry...