Gideon Lack

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Clinical practice. Food allergy
    Gideon Lack
    Department of Paediatric Allergy, King s College London, and the Children s Allergy Service, Guy s and St Thomas National Health Service Foundation Trust, London
    N Engl J Med 359:1252-60. 2008
  2. ncbi request reprint Factors associated with the development of peanut allergy in childhood
    Gideon Lack
    Department of Paediatric Allergy and Immunology, St Mary s Hospital at Imperial College, London, United Kingdom
    N Engl J Med 348:977-85. 2003
  3. ncbi request reprint Preventing food allergy
    Abbas Khakoo
    Department of Paediatric Allergy, Asthma and Immunology, Imperial College London at St Mary s Hospital, Salton House, St Mary s Hospital, Praed Street, London W2 1NY, UK
    Curr Allergy Asthma Rep 4:36-42. 2004
  4. ncbi request reprint The concept of oral tolerance induction to foods
    Gideon Lack
    Paediatric Unit, Department of Medicine, King s College London, Guys and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London, UK
    Nestle Nutr Workshop Ser Pediatr Program 59:63-8; discussion 68-72. 2007
  5. doi request reprint Epidemiologic risks for food allergy
    Gideon Lack
    Kings College London, St Thomas Hospital, Children s Allergies Department, London, United Kingdom
    J Allergy Clin Immunol 121:1331-6. 2008
  6. doi request reprint Update on risk factors for food allergy
    Gideon Lack
    MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s and St Thomas NHS Foundation Trust, Children s Allergies Department, St Thomas Hospital, London, United Kingdom
    J Allergy Clin Immunol 129:1187-97. 2012
  7. doi request reprint The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids
    Gideon Lack
    Children s Allergy Department, King s College London, Guy s and St Thomas NHS Foundation Trust, London, UK
    Pediatr Allergy Immunol 22:258-66. 2011
  8. doi request reprint Peanut protein in household dust is related to household peanut consumption and is biologically active
    Helen A Brough
    Department of Paediatric Allergy, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King s College London, United Kingdom
    J Allergy Clin Immunol 132:630-8. 2013
  9. ncbi request reprint Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants
    Carsten Flohr
    1 St John s Institute of Dermatology, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK 2 Children s Allergies Department, Division of Asthma, Allergy and Lung Biology, King s College London, Dundee, UK
    J Invest Dermatol 134:345-50. 2014
  10. doi request reprint Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study
    George Du Toit
    King s College London, King s Health Partners, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, and Department of Paediatric Allergy, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 131:135-43.e1-12. 2013

Detail Information

Publications39

  1. doi request reprint Clinical practice. Food allergy
    Gideon Lack
    Department of Paediatric Allergy, King s College London, and the Children s Allergy Service, Guy s and St Thomas National Health Service Foundation Trust, London
    N Engl J Med 359:1252-60. 2008
  2. ncbi request reprint Factors associated with the development of peanut allergy in childhood
    Gideon Lack
    Department of Paediatric Allergy and Immunology, St Mary s Hospital at Imperial College, London, United Kingdom
    N Engl J Med 348:977-85. 2003
    ..The prevalence of peanut allergy appears to have increased in recent decades. Other than a family history of peanut allergy and the presence of atopy, there are no known risk factors...
  3. ncbi request reprint Preventing food allergy
    Abbas Khakoo
    Department of Paediatric Allergy, Asthma and Immunology, Imperial College London at St Mary s Hospital, Salton House, St Mary s Hospital, Praed Street, London W2 1NY, UK
    Curr Allergy Asthma Rep 4:36-42. 2004
    ..Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy...
  4. ncbi request reprint The concept of oral tolerance induction to foods
    Gideon Lack
    Paediatric Unit, Department of Medicine, King s College London, Guys and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London, UK
    Nestle Nutr Workshop Ser Pediatr Program 59:63-8; discussion 68-72. 2007
    ..New strategies to prevent food allergy in infants need to be put to test in randomized controlled interventional studies...
  5. doi request reprint Epidemiologic risks for food allergy
    Gideon Lack
    Kings College London, St Thomas Hospital, Children s Allergies Department, London, United Kingdom
    J Allergy Clin Immunol 121:1331-6. 2008
    ..This hypothesis provides a possible explanation for the close link between eczema and the development of food allergies. It also suggests novel interventional strategies to prevent the development of food allergies...
  6. doi request reprint Update on risk factors for food allergy
    Gideon Lack
    MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s and St Thomas NHS Foundation Trust, Children s Allergies Department, St Thomas Hospital, London, United Kingdom
    J Allergy Clin Immunol 129:1187-97. 2012
    ..Novel interventional strategies to prevent the development of FA are also discussed...
  7. doi request reprint The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids
    Gideon Lack
    Children s Allergy Department, King s College London, Guy s and St Thomas NHS Foundation Trust, London, UK
    Pediatr Allergy Immunol 22:258-66. 2011
    ..Benefits of considering medical treatment in patients with OME prior to surgery include both the potential reductions in allergic inflammation and the naturally occurring spontaneous resolution of OME in these patients...
  8. doi request reprint Peanut protein in household dust is related to household peanut consumption and is biologically active
    Helen A Brough
    Department of Paediatric Allergy, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King s College London, United Kingdom
    J Allergy Clin Immunol 132:630-8. 2013
    ....
  9. ncbi request reprint Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants
    Carsten Flohr
    1 St John s Institute of Dermatology, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK 2 Children s Allergies Department, Division of Asthma, Allergy and Lung Biology, King s College London, Dundee, UK
    J Invest Dermatol 134:345-50. 2014
    ..76, P=0.05). AD is the main skin-related risk factor for food sensitization in young infants. In exclusively breastfed children, this suggests that allergic sensitization to foods can be mediated by cutaneous antigen-presenting cells. ..
  10. doi request reprint Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study
    George Du Toit
    King s College London, King s Health Partners, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, and Department of Paediatric Allergy, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 131:135-43.e1-12. 2013
    ..Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction...
  11. doi request reprint Can food allergy be prevented? The current evidence
    George Du Toit
    Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas National Health Service Foundation Trust, Medical Research Council, London, UK
    Pediatr Clin North Am 58:481-509, xii. 2011
    ..Prevention strategies need to be tested using randomized controlled study designs that account for the numerous methodological challenges, safety concerns, and necessary ethical limitations...
  12. doi request reprint Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy
    George Du Toit
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 122:984-91. 2008
    ..Despite guidelines recommending avoidance of peanuts during infancy in the United Kingdom (UK), Australia, and, until recently, North America, peanut allergy (PA) continues to increase in these countries...
  13. doi request reprint Is there an association between microbial exposure and food allergy? A systematic review
    Tom Marrs
    Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London, London, UK
    Pediatr Allergy Immunol 24:311-320.e8. 2013
    ..Factors influencing microbial exposure may be partly responsible for rising FA burden, but further prospective studies using double-blind placebo controlled food challenges as an outcome are required...
  14. doi request reprint Distribution of peanut protein in the home environment
    Helen A Brough
    Department of Paediatric Allergy, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King s College London, United Kingdom
    J Allergy Clin Immunol 132:623-9. 2013
    ..High household peanut consumption used as an indirect marker of environmental peanut exposure is associated with the development of peanut allergy...
  15. doi request reprint Food allergy and anaphylaxis in pediatrics: update 2010-2012
    Alexandra F Santos
    Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
    Pediatr Allergy Immunol 23:698-706. 2012
    ..Current research into the epidemiology and immunological mechanisms of FA and tolerance will enable us to devise strategies to both prevent and treat food allergies...
  16. pmc Assessing Peanut Consumption in a Population of Mothers and Their Children in the UK
    Aikaterini Sofianou-Katsoulis
    Institute of Child Health, M Asias 76, GR 11527, Athens, Greece St Mary s Hospital, Paediatric Department, QEQM Building, Praed Street, W2 1NY, London, UK
    World Allergy Organ J 4:38-44. 2011
    ..The aim was to validate a 50-item FFQ for use in peanut protein sensitization studies...
  17. doi request reprint Early feeding practices and development of food allergies
    Gideon Lack
    Children s Allergies Department, St Thomas Hospital, Kings College London, London, UK
    Nestle Nutr Workshop Ser Pediatr Program 68:169-83; discussion 183-6. 2011
    ..Novel interventional strategies to prevent the development of food allergies are also discussed...
  18. ncbi request reprint The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort study
    Michael R Perkin
    Department of Child Health, St George s, University of London, London, UK
    Pediatr Allergy Immunol 17:118-24. 2006
    ..5% and a specificity of 95.8%. Although significant differences in early life IgE measurements were seen, the extent of overlap was great, such that the overall performance of IgE at 12 months as a screening test for atopy was poor...
  19. pmc Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts
    Victor Turcanu
    Department of Paediatrics, Imperial College Faculty of Medicine, London, United Kingdom
    J Clin Invest 111:1065-72. 2003
    ..In conclusion, food allergic status is characterized by a Th2 response whereas Th1-skewed responses underlie oral tolerance...
  20. doi request reprint IgE-mediated facilitated antigen presentation underlies higher immune responses in peanut allergy
    V Turcanu
    Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in the Allergic Mechanisms of Asthma, King s College London, London, UK
    Allergy 65:1274-81. 2010
    ..To explore the immunological mechanisms that underlie peanut allergy and tolerance, we compared the peanut-specific responses of peanut-allergic (PA) and nonallergic (NA) individuals...
  21. doi request reprint Commentary on 'glucocorticoids for the treatment of anaphylaxis'
    Alexandra F Santos
    Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
    Evid Based Child Health 8:1295-6. 2013
    ..Glucocorticoids for the treatment of anaphylaxis. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD007596. DOI: 10.1002/14651858.CD007596.pub3. ..
  22. doi request reprint Why do few food-allergic adolescents treat anaphylaxis with adrenaline?--Reviewing a pressing issue
    Tom Marrs
    Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College, London, UK
    Pediatr Allergy Immunol 24:222-9. 2013
    ..Further research is warranted to identify cognitive patterns associated with high-risk behaviour, and to design appropriate interventions for the augmentation of adolescent self-management skills...
  23. doi request reprint Clinical features and natural history of physical urticaria in children
    Gulamabbas Khakoo
    Department of Paediatric Allergy, Asthma and Immunology, St Mary s Hospital, London, UK
    Pediatr Allergy Immunol 19:363-6. 2008
    ..A history of allergic conditions and more frequent episodes of urticaria were associated with a poorer prognosis...
  24. doi request reprint Identifying and managing cow's milk protein allergy
    George Du Toit
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Allergy and Lung Biology, Guy s and St Thomas NHS Foundation Trust, UK
    Arch Dis Child Educ Pract Ed 95:134-44. 2010
    ..This review is intended to highlight the broad spectrum of manifestations of CMP allergy and to offer an approach to the diagnosis and treatment thereof...
  25. ncbi request reprint Food allergy and asthma--what is the link?
    Graham Roberts
    Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, E1 1BB, London, UK
    Paediatr Respir Rev 4:205-12. 2003
    ..The co-existence of food allergy should be considered in any child with asthma. Where food allergy is confirmed, steps should be taken to avoid these foods as this may considerably improve asthma control...
  26. doi request reprint Household peanut consumption as a risk factor for the development of peanut allergy
    Adam T Fox
    King s College London, the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
    J Allergy Clin Immunol 123:417-23. 2009
    ..Most children with peanut allergy (PA) react on first known oral exposure to peanut. Recent data suggest cutaneous exposure as a route of sensitization...
  27. ncbi request reprint Development of a quality-of-life assessment for the allergic child or teenager with multisystem allergic disease
    Graham Roberts
    Pediatric Allergy, Asthma, and Immunology, Imperial College School of Medicine at St Mary s, London, United Kingdom
    J Allergy Clin Immunol 111:491-7. 2003
    ..Health-related quality of life (HRQOL) questionnaires currently being used to evaluate allergic disease are organ-specific. They therefore fail to take account of the systemic aspects of allergic disease...
  28. ncbi request reprint Diagnosing peanut allergy with skin prick and specific IgE testing
    Graham Roberts
    Paediatric Allergy, Asthma and Immunology, Imperial College at St Mary s, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Allergy Clin Immunol 115:1291-6. 2005
    ..Food allergy is common in childhood. It has been suggested that the magnitude of a skin prick test or specific IgE result can improve diagnostic usefulness, but this has been addressed in only a few tertiary challenge-based studies...
  29. doi request reprint New visions for food allergy: an iPAC summary and future trends
    Philippe A Eigenmann
    Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Allergy Immunol 19:26-39. 2008
    ....
  30. ncbi request reprint Relevance of inhalational exposure to food allergens
    Graham Roberts
    Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, London
    Curr Opin Allergy Clin Immunol 3:211-5. 2003
    ..This review discusses the inhalational route as a clinically important route of exposure to food allergens...
  31. ncbi request reprint Clinical risk assessment of GM foods
    Gideon Lack
    Department of Paediatric Allergy and Immunology, Imperial College at St Mary s Hospital, Praed Street, London W2 1NY, UK
    Toxicol Lett 127:337-40. 2002
    ..We need to proceed cautiously in the future, assessing individual GM foods on the basis of their individual merits and risks prior to introducing them into the market...
  32. ncbi request reprint Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study
    Graham Roberts
    Department of Paediatric Allergy and Clinical Immunology, St Mary s Hospital, London
    J Allergy Clin Immunol 112:168-74. 2003
    ..No objective clinical risk factors exist for pediatric life-threatening asthma...
  33. ncbi request reprint Food challenges: a review and audit
    Tina Torr
    Asthma and Immunology Department, St Mary s Hospital, London
    Paediatr Nurs 14:30-4. 2002
  34. pmc Egg allergy and MMR vaccination
    Adam Fox
    Department of Paediatric Allergy and Immunology, St Mary s Hospital, London
    Br J Gen Pract 53:801-2. 2003
  35. ncbi request reprint New developments in food allergy: old questions remain
    Gideon Lack
    J Allergy Clin Immunol 114:127-30. 2004
  36. ncbi request reprint Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma
    Graham Roberts
    University Child Health, University of Southampton, Hants, UK
    J Allergy Clin Immunol 117:263-8. 2006
    ..Few studies have investigated the use of specific immunotherapy (SIT) for childhood seasonal allergic asthma...
  37. ncbi request reprint Early nutrition and immunity - progress and perspectives
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 96:774-90. 2006
    ..This report summarizes the content of the lectures and the subsequent discussions...
  38. doi request reprint Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis
    Peter Vadas
    Department of Medicine, Division of Allergy and Clinical Immunology, St Michael s Hospital, Toronto, ON, Canada
    N Engl J Med 358:28-35. 2008
    ..The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported...
  39. ncbi request reprint Factors affecting the determination of threshold doses for allergenic foods: how much is too much?
    Steve L Taylor
    University of Nebraska, Food Allergy Research and Resource Program, Lincoln 68583 0919, USA
    J Allergy Clin Immunol 109:24-30. 2002
    ..Are these very low, residual quantities hazardous to allergic consumers? How much of the offending food is too much? Very little quantitative information exists to allow any risk assessments to be conducted by the food industry...