Genomes and Genes
Affiliation: King's College London
- Design and analysis of association studies using pooled DNA from large twin samplesJo Knight
Institute of Psychiatry, King s College London, London, UK
Behav Genet 36:665-77. 2006....
- Human chromosome 17 in essential hypertensionJ Knight
Clinical Pharmacology, The William Harvey Research Institute Bart s and The London Queen Mary, University of London Charterhouse Square, UK
Ann Hum Genet 67:193-206. 2003..However, results of ongoing fine mapping and candidate gene studies in both rodents and man are eagerly awaited...
- Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative traitJo Knight
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
BMC Genet 4:S74. 2003....
- A comparison of association statistics between pooled and individual genotypesJo Knight
Social Genetic and Developmental Psychiatry MRC Centre, Institute of Psychiatry, Kings College London, London, UK
Hum Hered 67:219-25. 2009..Markers for individual genotyping can be selected using quantitative genotyping of pooled DNA. This strategy saves time and money...
- A survey of current software for genetic power calculationsJo Knight
Social Genetic and Developmental Psychiatry Research Centre, Box P080, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Hum Genomics 1:225-7. 2004..There are a number of web-based tools and programs freely available to enable geneticists to perform power calculations, and the specifics of some of these are discussed here...
- CLUMPHAP: a simple tool for performing haplotype-based association analysisJo Knight
Social Genetic and Developmental Psychiatry MRC Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
Genet Epidemiol 32:539-45. 2008..Our results show that CLUMPHAP tends to have greater power than the omnibus haplotype test and is comparable in power to multiple regression locus-coding approaches...
- A genome-wide significant linkage for severe depression on chromosome 3: the depression network studyGerome Breen
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London
Am J Psychiatry 168:840-7. 2011..The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample...
- DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for associationXiaohui Xu
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
- A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancyKeeley Joanne Brookes
Medical Research Council Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, London, England
Arch Gen Psychiatry 63:74-81. 2006..The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets...
- Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1BJonathan Mill
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005....
- Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's diseaseGillian Hamilton
MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK
Neurosci Lett 401:77-80. 2006..Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD...
- DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkageWai Chen
MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 147:1450-60. 2008..In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings...
- Software for generating liability distributions for pedigrees conditional on their observed disease states and covariatesDesmond D Campbell
Department of Biostatistics, Institute of Psychiatry, King s College London, United Kingdom
Genet Epidemiol 34:159-70. 2010..We apply this program to a specimen disease pedigree, and discuss the results produced, comparing its results with those generated under a more naïve model. We also detail simulation studies that validate the software's operation...
- The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorderSarah Cohen-Woods
Institute of Psychiatry, King s College London, MRC SGDP Centre, London, UK
Am J Med Genet B Neuropsychiatr Genet 153:1298-304. 2010..We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD...
- Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorderSarah Cohen-Woods
MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
Hum Mol Genet 18:1504-9. 2009..It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences...
- SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 childrenLee M Butcher
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
Hum Mol Genet 14:1315-25. 2005..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
- Whole genome linkage scan of recurrent depressive disorder from the depression network studyPeter McGuffin
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
Hum Mol Genet 14:3337-45. 2005..Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined...
- Association of the serotonin transporter gene, neuroticism and smoking behavioursColin O'Gara
MRC Social Genetic and Developmental Psychiatry Research Centre, King s College London, Institute of Psychiatry, London, UK
J Hum Genet 53:239-46. 2008..Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings...
- An investigation of candidate regions for association with bipolar disorderJo Knight
Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
Am J Med Genet B Neuropsychiatr Genet 153:1292-7. 2010..02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP...
- A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studiesDavid Curtis
Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
BMC Genet 8:20. 2007..However if hundreds of thousands of markers are typed then inevitably very large numbers of such results will occur by chance and those from candidate regions may attract no special attention...
- Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysisJo Knight
Department of Medical and Molecular Genetics, King s College London School of Medicine, London, United Kingdom
PLoS ONE 6:e14808. 2011..For GWAS studies, our analyses suggest the use of a Bayes Factor of about 4 for cis eQTL SNPs within regions of open chromatin, 3 for nsSNPs and 2 for promoter SNPs...
- Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsyBarry Chioza
Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
Eur J Hum Genet 10:857-64. 2002..The functionally significant variant(s) are unlikely to be exonic and suggests an effect on expression or alternative splicing...
- A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigreesDavid Curtis
Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
Psychiatr Genet 15:181-7. 2005..Here, we describe a new method for LOD score analysis of quantitative traits which does not require specification of a mode of inheritance...
- Homing in on depression genesPeter McGuffin
Am J Psychiatry 164:195-7. 2007