Affiliation: King's College London
- Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infectionEmma Murray
MRC Immunochemistry Unit, Oxford, United Kingdom
Infect Immun 70:1481-7. 2002..SP-D may therefore play a significant role in the innate immune response to H. pylori infection...
- Helicobacter infection in the surfactant protein D-deficient mouseWafa Khamri
Faculty of Medicine, Imperial College, St Mary s Campus, London, UK
Helicobacter 12:112-23. 2007..SP-D binds to Helicobacter in vitro, suggesting the involvement of SP-D in Helicobacter-induced immune responses. The aim of this study was to determine the role of SP-D in gastric epithelial defense in vivo...
- Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytesWafa Khamri
Immunoregulation Laboratory, Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy s Hospital Campus, King s College London School of Medicine at Guy s, London SE1 9RT, United Kingdom
Infect Immun 78:845-53. 2010..Altogether, we can conclude that DCs are potent inducers of IL-23/IL-17 expression following H. pylori stimulation. IL-1/IL-23 as well as H. pylori virulence factors seem to play an important role in mediating this response...
- TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scanAmy E Anderson
Gastroenterology and Hepatology Research, Division of Medicine, Faculty of Medicine, Imperial College London, London, UK
Eur J Immunol 37:1548-61. 2007..Regulation of TLR9 expression and signalling therefore appears to play an important role in the control of lymphocyte responses to Helicobacter and potentially other luminal microorganisms...
- Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 developmentPeter Mitchell
Department of Immunology, Division of Medicine, Faculty of Medicine, Imperial College at Hammersmith Hospital, London, United Kingdom
Infect Immun 75:810-9. 2007..Our results raise the possibility that in chronic H. pylori infection DCs become exhausted after prolonged antigen exposure leading to suboptimal Th1 development. This effect may contribute to persistence of H. pylori infection...
- Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein DWafa Khamri
Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, United Kingdom
Infect Immun 73:7677-86. 2005..SP-D binding organisms are predominant in mucus in vivo (P = 0.02), suggesting that SP-D facilitates physical elimination. Phase variation to evade SP-D contributes to the persistence of this common gastric pathogen...
- Expression of complement components, receptors and regulators by human dendritic cellsKe Li
King s College London, MRC Centre for Transplantation, NIHR Comprehensive Biomedical Research Centre, Guy s Hospital, London, UK
Mol Immunol 48:1121-7. 2011..It acts as a resource that allows further understanding and exploitation of role of complement in human health and immune mediated diseases...
- Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failureCharalambos Gustav Antoniades
Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
Hepatology 59:1564-76. 2014..Conclusion: SLPI is a pivotal mediator of anti-inflammatory responses in AALF through modulation of monocyte/macrophage function, which may account for the susceptibility to sepsis in AALF...
- CD14, CD16 and HLA-DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA-DR expression by CD14(hi) /CD16(neg) monocytes: Expansion of CD14(hi) /CD16(pos) and contraction of CD14(lo) /CD16(pos) monocytes in aRobin Daniel Abeles
Department of Transplantation, Immunology and Mucosal Biology, Institute of Liver Studies and Transplantation, King s College London School of Medicine at King s College Hospital, Denmark Hill, London, United Kingdom
Cytometry A 81:823-34. 2012..Understanding the changes in monocyte pheontype in ALF and similar clinico-pathological diseases may allow the development of novel biomarkers or therapeutic strategies...
- Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharideAnthony P Moran
Department of Microbiology, National University of Ireland, Galway, Ireland
J Endotoxin Res 11:357-62. 2005..pylori lipopolysaccharide. Furthermore, evidence indicates that H. pylori varies LPS O-chain structure to evade SP-D binding which is speculated aids persistence of this chronic infection...