F J Kelly

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants
    Ian S Mudway
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Arch Biochem Biophys 423:200-12. 2004
  2. ncbi request reprint Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 89:1452-8. 2004
  3. pmc Particulate matter oxidative potential from waste transfer station activity
    Krystal J Godri
    Environmental Research Group, MRC HPA Centre for Environmental Health, School of Biomedical and Health Sciences, King s College London, London, United Kingdom
    Environ Health Perspect 118:493-8. 2010
  4. doi request reprint Monitoring air pollution: use of early warning systems for public health
    Frank J Kelly
    MRC HPA Centre for Environment and Health, School of Biomedical Sciences, King s College London, London, UK
    Respirology 17:7-19. 2012
  5. pmc In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project
    Maaike Steenhof
    Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, PO Box 80177, 3508 TD Utrecht, The Netherlands
    Part Fibre Toxicol 8:26. 2011
  6. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
  7. ncbi request reprint Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease
    Frank J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Proc Nutr Soc 64:510-26. 2005
  8. ncbi request reprint Air pollution and the elderly: oxidant/antioxidant issues worth consideration
    F J Kelly
    Environmental Sciences Research Group, School of Health and Life Sciences, King s College London, London, UK
    Eur Respir J Suppl 40:70s-75s. 2003
  9. pmc Oxidative stress: its role in air pollution and adverse health effects
    Frank J Kelly
    Environmental Research Group, School of Health and Life Science, King s College London, UK
    Occup Environ Med 60:612-6. 2003
  10. ncbi request reprint Protein oxidation at the air-lung interface
    F J Kelly
    Air Pollution and Health Research Group, School of Health and Life Sciences, King s College London, London, United Kingdom
    Amino Acids 25:375-96. 2003

Detail Information

Publications56

  1. ncbi request reprint An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants
    Ian S Mudway
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Arch Biochem Biophys 423:200-12. 2004
    ..We interpret these findings as being indicative that the antioxidant network at the air-lung interface in healthy subjects is capable of dealing with the oxidative challenge posed by DE at ambient concentrations...
  2. ncbi request reprint Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 89:1452-8. 2004
    ..This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established...
  3. pmc Particulate matter oxidative potential from waste transfer station activity
    Krystal J Godri
    Environmental Research Group, MRC HPA Centre for Environmental Health, School of Biomedical and Health Sciences, King s College London, London, United Kingdom
    Environ Health Perspect 118:493-8. 2010
    ..The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household waste...
  4. doi request reprint Monitoring air pollution: use of early warning systems for public health
    Frank J Kelly
    MRC HPA Centre for Environment and Health, School of Biomedical Sciences, King s College London, London, UK
    Respirology 17:7-19. 2012
    ....
  5. pmc In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project
    Maaike Steenhof
    Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, PO Box 80177, 3508 TD Utrecht, The Netherlands
    Part Fibre Toxicol 8:26. 2011
    ..This study investigated the in vitro toxicity of ambient PM collected at different sites in the Netherlands in relation to PM composition and oxidative potential...
  6. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
    ..abstract:..
  7. ncbi request reprint Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease
    Frank J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Proc Nutr Soc 64:510-26. 2005
    ..dietary modification, in order to achieve a therapeutic effect will be discussed...
  8. ncbi request reprint Air pollution and the elderly: oxidant/antioxidant issues worth consideration
    F J Kelly
    Environmental Sciences Research Group, School of Health and Life Sciences, King s College London, London, UK
    Eur Respir J Suppl 40:70s-75s. 2003
    ..Given these possibilities, a better understanding of respiratory tract lining fluid antioxidant defences in the aged lung is warranted...
  9. pmc Oxidative stress: its role in air pollution and adverse health effects
    Frank J Kelly
    Environmental Research Group, School of Health and Life Science, King s College London, UK
    Occup Environ Med 60:612-6. 2003
  10. ncbi request reprint Protein oxidation at the air-lung interface
    F J Kelly
    Air Pollution and Health Research Group, School of Health and Life Sciences, King s College London, London, United Kingdom
    Amino Acids 25:375-96. 2003
    ..In this review we focus primarily on the soluble protein components of within the surface liquid layer in the lung and the consequence of their undue oxidation...
  11. ncbi request reprint London air quality: a real world experiment in progress
    Frank J Kelly
    Environmental Research Group, School of Biomedical and Health Sciences, King s College London, London, UK
    Biomarkers 14:5-11. 2009
    ..Together, it is hoped that these measures will lead to an improvement in air quality and provide a direct health benefit to Londoners. Research underway is charting the progress of this real world experiment...
  12. ncbi request reprint Inter- and intra-individual vitamin E uptake in healthy subjects is highly repeatable across a wide supplementation dose range
    Frank J Kelly
    School of Health and Life Sciences, King s College London, London SE1 9NN, United Kingdom
    Ann N Y Acad Sci 1031:22-39. 2004
    ..51, P = 0.02 [100 vs. 200] and tau, 0.49, P = 0.03 [100 vs. 400] and tau, 0.56, P = 0.005 [200 vs. 400]. Together these data support the contention that alpha-tocopherol uptake is a stable individual phenotype under genetic regulation...
  13. ncbi request reprint Dietary antioxidants and environmental stress
    Frank J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, 150 Stamford Street, London SE19NN, UK
    Proc Nutr Soc 63:579-85. 2004
    ..However, many questions remain unanswered in relation to inter-individual sensitivity to ambient air pollution, and extent to which this sensitivity is modified by airway antioxidant defences...
  14. doi request reprint Air pollution and airway disease
    F J Kelly
    MRC HPA Centre for Environment and Health, King s College, London, 150 Stamford Street, London SE1 9NH, UK
    Clin Exp Allergy 41:1059-71. 2011
    ....
  15. ncbi request reprint Hypothermic preservation of isolated rat lungs in modified bicarbonate buffer, EuroCollins solution or St Thomas' Hospital cardioplegic solution
    R L Featherstone
    Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, UK
    Eur J Cardiothorac Surg 14:508-15. 1998
    ..Here we report the effects of hypothermic storage in EuroCollins solution, St Thomas' Hospital cardioplegic solution and a modified bicarbonate buffer solution...
  16. ncbi request reprint Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects
    I S Mudway
    School of Health and Life Sciences, Kings' College London, London, UK
    Free Radic Biol Med 31:962-74. 2001
    ..These responses and variations in basal antioxidant defense were not, however, useful predictive markers of group or individual responsiveness to ozone...
  17. ncbi request reprint Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase
    P A MacCarthy
    Department of Cardiology, Guy's King's and St Thomas' Schools of Medicine and Biomedical Sciences, King's College London, UK
    Circulation 104:2967-74. 2001
    ..These are the first data to potentially link increased NADPH oxidase-derived ROS with a defect in cardiac contractile function in a pathological setting...
  18. ncbi request reprint Air pollution, oxidative stress, and allergic response
    F J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Lancet 363:95-6. 2004
  19. ncbi request reprint gamma-Tocopherol biokinetics and transformation in humans
    Francesco Galli
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Free Radic Res 37:1225-33. 2003
    ..The uptake and biotransformation of gamma-tocopherol (gamma-T) in humans is largely unknown. Using a stable isotope method we investigated these aspects of gamma-T biology in healthy volunteers and their response to gamma-T supplementation...
  20. ncbi request reprint Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial
    L Poston
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Lancet 367:1145-54. 2006
    ..Our aim was to investigate the potential benefit of these antioxidants in a cohort of women with a range of clinical risk factors...
  21. ncbi request reprint Cloning of guinea pig surfactant protein A defines a distinct cellular distribution pattern within the lung
    H T Yuan
    Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Physiol 273:L900-6. 1997
    ..This distinct expression pattern suggests that the guinea pig lung will be a useful model in which to study expression of transcription factors implicated in the regulation of SP genes...
  22. ncbi request reprint Vitamin supplementation does not protect against symptoms in ozone-responsive subjects
    Ian S Mudway
    Lung Biology, Pharmaceutical Sciences Research Division, Franklin Wilkins Building, Kings College London, London, UK
    Free Radic Biol Med 40:1702-12. 2006
    ..These data do not therefore support the contention that acute ozone-induced symptoms can be attenuated through the use of dietary antioxidants in well-nourished individuals...
  23. ncbi request reprint Alpha- and gamma-tocopherol plasma and urinary biokinetics following alpha-tocopherol supplementation
    Judith C P Eichhorn
    Department of Life Sciences, King s College London, 150 Stamford Street, London, SE1 9NN, UK
    Ann N Y Acad Sci 1031:339-40. 2004
  24. doi request reprint Proinflammatory doses of diesel exhaust in healthy subjects fail to elicit equivalent or augmented airway inflammation in subjects with asthma
    Annelie F Behndig
    Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Thorax 66:12-9. 2011
    ..Here the hypothesis that this heightened sensitivity reflects an augmentation of the transient inflammatory response previously reported in healthy adults exposed to diesel exhaust is examined...
  25. ncbi request reprint Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes
    D Darko
    Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Clin Sci (Lond) 103:339-44. 2002
    ..Thus treatment with vitamin C (1.5 g daily) for 3 weeks does not significantly improve oxidative stress, blood pressure or endothelial function in patients with Type II diabetes...
  26. ncbi request reprint Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function
    Lucy C Chappell
    Maternal and Fetal Research Unit, Department of Obstetrics and Gynaecology and Centre for Cardiovascular Biology and Medicine, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Am J Obstet Gynecol 187:777-84. 2002
    ..In this study, we determined whether supplementation in the same cohort was associated with an improvement in indices of placental dysfunction and oxidative stress toward values determined in women who were at low risk of preeclampsia...
  27. ncbi request reprint Chronic alpha-tocopherol supplementation in rats does not ameliorate either chronic or acute alcohol-induced changes in muscle protein metabolism
    Michael Koll
    Department of Nutrition and Dietetics, King s College London, Franklin Wilkins Building, Stamford Street, London SE1 9NN, UK
    Clin Sci (Lond) 104:287-94. 2003
    ..alpha-Tocopherol supplementation is not protective against the deleterious effects of alcohol on protein metabolism in skeletal muscle...
  28. ncbi request reprint Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs
    R L Featherstone
    Cardiovascular Research and Cardiac Surgical Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 162:850-6. 2000
    ..05). Of the selective PDE inhibitors tested, rolipram (type IV inhibitor) was most effective. However, the nonselective agent, theophylline, provided the best protection of function after storage and reperfusion of rat lungs...
  29. ncbi request reprint Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development
    H T Yuan
    Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, UK
    Biochim Biophys Acta 1305:163-71. 1996
    ....
  30. ncbi request reprint An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults
    Ian S Mudway
    Lung Biology, School of Health and Life Sciences, King s College London, University of London, United Kingdom
    Am J Respir Crit Care Med 169:1089-95. 2004
  31. pmc Comparison of oxidative properties, light absorbance, total and elemental mass concentration of ambient PM2.5 collected at 20 European sites
    Nino Kunzli
    Working Group Air Pollution, European Community Respiratory Health Survey, London, United Kingdom
    Environ Health Perspect 114:684-90. 2006
    ..The objective was to examine how these toxicologically relevant measures were related to other PM characteristics, such as total and elemental mass concentration and light absorbance...
  32. pmc An approach for estimating the health effects of changes over time in air pollution: an illustration using cardio-respiratory hospital admissions in London
    Cathryn Tonne
    London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 67:422-7. 2010
    ....
  33. ncbi request reprint A longitudinal study of biochemical variables in women at risk of preeclampsia
    Lucy C Chappell
    Maternal and Fetal Research Unit, Department Cardiovascular Research, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Am J Obstet Gynecol 187:127-36. 2002
    ....
  34. ncbi request reprint Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype
    Adriana Zatterale
    Department of Genetics, Elena d Aosta Hospital, I 80136 Naples, Italy
    Clin Biochem 40:1100-3. 2007
    ..To evaluate an association of Bloom syndrome (BS) phenotype with an in vivo prooxidant state...
  35. ncbi request reprint Multiple evidence for an early age pro-oxidant state in Down Syndrome patients
    Federico V Pallardo
    Department of Physiology, University of Valencia, E 46010, Valencia, Spain
    Biogerontology 7:211-20. 2006
    ..The evidence for a multiple pro-oxidant state in young DS patients supports the role of oxidative stress in DS phenotype, with relevant distinctions according to patients' ages...
  36. ncbi request reprint Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects
    Sarah Aldred
    Life and Health Sciences, Aston University, Birmingham, UK
    Proteomics 6:1695-703. 2006
    ..01 after 28 days supplementation with 268 mg AT/day). These data demonstrate the time and dose sensitivity of the plasma proteome to AT supplementation...
  37. ncbi request reprint Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma
    Francesco Galli
    Dept of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy corrected
    Free Radic Biol Med 32:333-40. 2002
    ..This GC/MS method provides a versatile and accurate mean for assessing carboxyethyl-hydroxychroman metabolites of vitamin E in plasma...
  38. ncbi request reprint The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    ..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have...
  39. ncbi request reprint Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients
    Giovanni Pagano
    Italian National Cancer Institute, G Pascale Foundation, Via M Semmola 12, I 80131 Naples, Italy
    Carcinogenesis 25:1899-909. 2004
    ..The results suggest a gender- and age-related modulation of oxidative stress in FA patients. The observed increase in urinary 8-OHdG in untransplanted FA patients suggests a proficient removal of oxidized DNA bases...
  40. ncbi request reprint Effect of acute airway inflammation on the pulmonary antioxidant status
    Christopher M Deaton
    Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, UK
    Exp Lung Res 31:653-70. 2005
    ..001) when both groups were combined. In conclusion, acute neutrophilic airway inflammation does not result in significant evidence of oxidative stress in horses affected by recurrent airway obstruction...
  41. ncbi request reprint Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype
    Giovanni Pagano
    Centre for Research, Innovation and Technological Transfer in Oncology and Life Sciences, Mercogliano AV, Italy
    Eur J Haematol 75:93-100. 2005
    ..FA may thus represent a unique model disease in testing the integration between the acquisition of macromolecular damage as a result of oxidative stress and the ability of the mammalian cell to respond effectively to such damage...
  42. ncbi request reprint Vitamins E and C are safe across a broad range of intakes
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC, USA
    Am J Clin Nutr 81:736-45. 2005
    ....
  43. ncbi request reprint Bioavailability and metabolism
    Wilhelm Stahl
    Institut fur Physiologische Chemie I, Dusseldorf, Germany
    Mol Aspects Med 23:39-100. 2002
  44. ncbi request reprint In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes
    Giovanni Pagano
    Italian National Cancer Institute, I 80131, Naples, Italy
    Free Radic Res 39:529-33. 2005
    ..Further investigations on more extensive study populations are warranted to verify the relevance of an in vivo prooxidant state in WS patients...
  45. ncbi request reprint Pulmonary bioavailability of ascorbic acid in an ascorbate-synthesising species, the horse
    Christopher M Deaton
    Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk CB8 7UU, UK
    Free Radic Res 37:461-7. 2003
    ..In conclusion, the concentration of lung lining fluid ascorbic acid is increased following ascorbic acid supplementation (20 mg/kg body weight) in an ascorbate-synthesising species...
  46. ncbi request reprint Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction
    Christopher M Deaton
    Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK
    Am J Vet Res 65:80-7. 2004
    ..To determine the pulmonary epithelial lining fluid (ELF) concentrations and degree of oxidation of ascorbic acid in horses affected by recurrent airway obstruction (RAO) in the presence and absence of neutrophilic airway inflammation...
  47. ncbi request reprint Multiple involvement of oxidative stress in Werner syndrome phenotype
    Giovanni Pagano
    Italian National Cancer Institute, G Pascale Foundation, I 80131 Naples, Italy
    Biogerontology 6:233-43. 2005
    ....
  48. ncbi request reprint Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse
    Christopher M Deaton
    Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk CB8 7UU, UK
    Free Radic Res 38:201-8. 2004
    ..80, p < 0.0001). We conclude that the concentration of H2O2 in breath condensate influences the ELF ascorbic acid concentration and provides a non-invasive diagnostic indicator of the severity of neutrophilic airway inflammation...
  49. ncbi request reprint Changes in circulatory antioxidant status in horses during prolonged exercise
    David J Marlin
    Center for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK
    J Nutr 132:1622S-7S. 2002
    ..622; P = 0.0004). Although there were increases in creatine phosphokinase (CK), aspartate aminotransferase (AST) and TBARS and a loss of TGSH, this study failed to demonstrate evidence of classical oxidative stress...
  50. ncbi request reprint Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases
    Ana Lloret
    Department of Physiology, University of Valencia, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    Free Radic Biol Med 44:495-503. 2008
    ..The UA and AA levels were significantly increased in WS and DS patients, but not in AT, FA, BS, nor XP patients. Rationale for chemoprevention trials is discussed...
  51. ncbi request reprint Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles
    Miriam E Gerlofs-Nijland
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Inhal Toxicol 19:1055-69. 2007
    ..It is likely that the toxicological responses of SH rats were associated with specific PM components derived from brake wear (copper and barium), tire wear (zinc), and wood smoke (potassium)...
  52. ncbi request reprint Vitamin E biotransformation in humans
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Italy
    Vitam Horm 76:263-80. 2007
    ..The hypothesis of a transformation-dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation...
  53. pmc Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma
    Seif O Shaheen
    Respiratory Epidemiology and Public Health Group, NHLI at Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK
    Thorax 62:483-90. 2007
    ..The only previous trial of selenium supplementation in adults with asthma found no objective evidence of benefit but involved only 24 participants...
  54. ncbi request reprint Antioxidant supplementation in horses affected by recurrent airway obstruction
    Christopher M Deaton
    Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK
    J Nutr 134:2065S-2067S. 2004
  55. ncbi request reprint Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, UmeƄ SE 901 85, Sweden
    Respir Med 98:821-5. 2004
    ..1 (1.35-4.88) Md (Q1-Q3) vs. air 0.94 (0.53-1.23); P = 0.009. No significant changes were seen in IL-10 and IL-18 expression. This finding suggests an TH2-inflammatory response in the airways of non-atopic healthy individuals...
  56. ncbi request reprint Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways
    Jamshid Pourazar
    Dept of Respiratory Medicine and Allergy, Univ Hospital, SE 901 85 Umea, Sweden
    Am J Physiol Lung Cell Mol Physiol 289:L724-30. 2005
    ..05). These observations demonstrate that DE activates redox-sensitive transcription factors in vivo consistent with oxidative stress triggering the increased synthesis of proinflammatory cytokines...