Robert Keers

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project
    R Keers
    MRC SGDP, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 11:138-45. 2011
  2. doi request reprint Gene-environment interaction in major depression and antidepressant treatment response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry at King s College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, England, UK
    Curr Psychiatry Rep 14:129-37. 2012
  3. doi request reprint Pharmacogenetics of antidepressant response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry at King s College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Expert Rev Neurother 11:101-25. 2011
  4. doi request reprint Gender differences in antidepressant drug response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, 16 De Crespigny Park, Denmark Hill, London, UK
    Int Rev Psychiatry 22:485-500. 2010
  5. doi request reprint Variation in GNB3 predicts response and adverse reactions to antidepressants
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Psychopharmacol 25:867-74. 2011
  6. doi request reprint Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP
    Robert Keers
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 127:337-42. 2010
  7. doi request reprint Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression
    Karim Malki
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenet Genomics 22:765-76. 2012
  8. doi request reprint Changes in body weight during pharmacological treatment of depression
    Rudolf Uher
    Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 14:367-75. 2011
  9. doi request reprint The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression
    Robert A Power
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychiatr Res 47:1032-5. 2013
  10. pmc Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression
    Helen L Fisher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 136:189-93. 2012

Detail Information

Publications16

  1. doi request reprint Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project
    R Keers
    MRC SGDP, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 11:138-45. 2011
    ..Gene-environment interactions including life events may therefore be important not only in the aetiology of depression, but also in predicting response to antidepressant medication...
  2. doi request reprint Gene-environment interaction in major depression and antidepressant treatment response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry at King s College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, England, UK
    Curr Psychiatry Rep 14:129-37. 2012
    ..These findings suggest that the dissection of etiological pathways to depression may provide the key to understanding and predicting response to antidepressants...
  3. doi request reprint Pharmacogenetics of antidepressant response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry at King s College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Expert Rev Neurother 11:101-25. 2011
    ....
  4. doi request reprint Gender differences in antidepressant drug response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, 16 De Crespigny Park, Denmark Hill, London, UK
    Int Rev Psychiatry 22:485-500. 2010
    ..Future studies should therefore consider genotypes of the mother, foetus and infant in antidepressant response...
  5. doi request reprint Variation in GNB3 predicts response and adverse reactions to antidepressants
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Psychopharmacol 25:867-74. 2011
    ..Our results are consistent with previous associations with GNB3 and emphasize the importance of signalling genes in antidepressant response...
  6. doi request reprint Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP
    Robert Keers
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 127:337-42. 2010
    ..There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically...
  7. doi request reprint Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression
    Karim Malki
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenet Genomics 22:765-76. 2012
    ....
  8. doi request reprint Changes in body weight during pharmacological treatment of depression
    Rudolf Uher
    Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 14:367-75. 2011
    ..While treatment with nortriptyline may be recommended in underweight subjects with typical neurovegetative symptoms, escitalopram is a suitable alternative for subjects at risk of weight gain...
  9. doi request reprint The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression
    Robert A Power
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychiatr Res 47:1032-5. 2013
    ....
  10. pmc Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression
    Helen L Fisher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 136:189-93. 2012
    ....
  11. doi request reprint Dissecting the genetic heterogeneity of depression through age at onset
    Robert A Power
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 159:859-68. 2012
    ..04). This study provides the first focussed analysis of the genetic contribution to AAO in depression, and establishes a statistical framework that can be applied to a quantitative trait underlying any disorder...
  12. doi request reprint Genetic predictors of antidepressant side effects: A grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study
    Karen Hodgson
    1Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 28:142-50. 2014
    ....
  13. doi request reprint Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains
    Karim Malki
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Proteomics 12:2355-65. 2012
    ....
  14. doi request reprint Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5HTTLPR and their interaction
    Helena M S Zavos
    Institute of Psychiatry, King s College London, United Kingdom
    Depress Anxiety 29:400-8. 2012
    ..In light of this, we looked at the association between stressful life events, the serotonin transporter gene polymorphism (5HTTLPR), and anxiety sensitivity in a longitudinal sample of adolescents...
  15. pmc Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 7:e38263. 2012
    ..One such mutant, after hours (Afh), an ENU-derived mutant with a mutation in a recently identified circadian clock gene Fbxl3, results in a disturbed (long) circadian rhythm of approximately 27 hours...
  16. doi request reprint Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
    Georgina M Hosang
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 125:345-9. 2010
    ..The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder...