L Kalra

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Randomized controlled study of stroke unit care versus stroke team care in different stroke subtypes
    Andrew Evans
    Department of Medicine, Guy s, King s, and St Thomas s School of Medicine, London, UK
    Stroke 33:449-55. 2002
  2. ncbi request reprint Homocysteine, migration and early vascular impairment in people of African descent
    L Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Heart 94:1171-4. 2008
  3. doi request reprint An observational study of thrombolysis outcomes in wake-up ischemic stroke patients
    Dulka Manawadu
    Department of Stroke Medicine, King s College Hospital, London, United Kingdom
    Stroke 44:427-31. 2013
  4. pmc Antithrombotic treatment in atrial fibrillation
    L Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Heart 93:39-44. 2007
  5. pmc Advances in stroke regenerative medicine 2007
    Lalit Kalra
    King s College London School of Medicine, Bessemer Road, London, United Kingdom
    Stroke 39:273-5. 2008
  6. pmc Training carers of stroke patients: randomised controlled trial
    Lalit Kalra
    Department of Medicine, Guy s, King s and St Thomas s School of Medicine, London SE5 9PJ
    BMJ 328:1099. 2004
  7. ncbi request reprint An international matched cohort study of the contribution of metabolic impairments to subclinical atherosclerosis in United Kingdom and Jamaican African-Caribbeans
    Lalit Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Atherosclerosis 199:95-101. 2008
  8. doi request reprint Stroke rehabilitation 2009: old chestnuts and new insights
    Lalit Kalra
    Department of Stroke Medicine, Academic Neurosciences Centre, King s College London, London, England
    Stroke 41:e88-90. 2010
  9. ncbi request reprint Facilitating recovery: evidence for organized stroke care
    Lalit Kalra
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    J Rehabil Med 39:97-102. 2007
  10. ncbi request reprint Ethnic differences in arterial responses and inflammatory markers in Afro-Caribbean and Caucasian subjects
    Lalit Kalra
    Cardiovascular Division, Guy s, King s, and St Thomas s School of Medicine, King s College, London, UK
    Arterioscler Thromb Vasc Biol 25:2362-7. 2005

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Randomized controlled study of stroke unit care versus stroke team care in different stroke subtypes
    Andrew Evans
    Department of Medicine, Guy s, King s, and St Thomas s School of Medicine, London, UK
    Stroke 33:449-55. 2002
    ..A post hoc analysis of the influence of stroke subtype on stroke unit effectiveness was undertaken by using prospective data collected in a randomized controlled trial...
  2. ncbi request reprint Homocysteine, migration and early vascular impairment in people of African descent
    L Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Heart 94:1171-4. 2008
    ..A gradient of increased vascular risk with migration exists across the African diaspora. We investigated the hypothesis that differences in homocysteine/folic acid status contribute to this increased risk...
  3. doi request reprint An observational study of thrombolysis outcomes in wake-up ischemic stroke patients
    Dulka Manawadu
    Department of Stroke Medicine, King s College Hospital, London, United Kingdom
    Stroke 44:427-31. 2013
    ..Wake-up ischemic stroke (WUIS) patients are not eligible for thrombolysis; the a priori hypothesis was that thrombolysis of selected WUIS patients who meet clinical and imaging criteria for treatment is associated with better outcomes...
  4. pmc Antithrombotic treatment in atrial fibrillation
    L Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Heart 93:39-44. 2007
  5. pmc Advances in stroke regenerative medicine 2007
    Lalit Kalra
    King s College London School of Medicine, Bessemer Road, London, United Kingdom
    Stroke 39:273-5. 2008
  6. pmc Training carers of stroke patients: randomised controlled trial
    Lalit Kalra
    Department of Medicine, Guy s, King s and St Thomas s School of Medicine, London SE5 9PJ
    BMJ 328:1099. 2004
    ..Informal care givers support disabled stroke patients at home but receive little training for the caregiving role...
  7. ncbi request reprint An international matched cohort study of the contribution of metabolic impairments to subclinical atherosclerosis in United Kingdom and Jamaican African-Caribbeans
    Lalit Kalra
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Atherosclerosis 199:95-101. 2008
    ..A gradient of increased vascular risk exists across the African diaspora. We hypothesised that increased insulin resistance with environmental transition contributes to this risk...
  8. doi request reprint Stroke rehabilitation 2009: old chestnuts and new insights
    Lalit Kalra
    Department of Stroke Medicine, Academic Neurosciences Centre, King s College London, London, England
    Stroke 41:e88-90. 2010
    ....
  9. ncbi request reprint Facilitating recovery: evidence for organized stroke care
    Lalit Kalra
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    J Rehabil Med 39:97-102. 2007
    ..Finally, some key challenges have been identified for stroke units in improving rehabilitation outcomes over the next decade and for healthcare planners in investing adequately in organized stroke services...
  10. ncbi request reprint Ethnic differences in arterial responses and inflammatory markers in Afro-Caribbean and Caucasian subjects
    Lalit Kalra
    Cardiovascular Division, Guy s, King s, and St Thomas s School of Medicine, King s College, London, UK
    Arterioscler Thromb Vasc Biol 25:2362-7. 2005
    ..Small vessel disease is more common in Afro-Caribbeans than Caucasians. We investigated underlying differences in metabolic, inflammatory, and vascular responses that may predispose Afro-Caribbeans to small vessel pathology...
  11. ncbi request reprint Recent advances in stroke rehabilitation 2006
    Lalit Kalra
    Department of Stroke Medicine, King s College London School of Medicine, Denmark Hill Campus, Bessemer Rd, London SE5 9PJ, UK
    Stroke 38:235-7. 2007
  12. ncbi request reprint Alternative strategies for stroke care: a prospective randomised controlled trial
    L Kalra
    Department of Medicine, Guy s, King s and St Thomas s School of Medicine, London, UK
    Lancet 356:894-9. 2000
    ..Organised specialist care for stroke improves outcome, but the merits of different methods of organisation are in doubt. This study compares the efficacy of stroke unit with stroke team or domiciliary care...
  13. ncbi request reprint The role of inheritance and environment in predisposition to vascular disease in people of African descent
    Lalit Kalra
    Cardiovascular Division, King s College London School of Medicine, London, United Kingdom
    J Am Coll Cardiol 47:1126-33. 2006
    ..This study sought to compare vascular reactivity and carotid intima media thickness (CIMT) between Afro-Caribbean people in the United Kingdom (UK) and the West Indies and Afro-Caribbean and Caucasian people in the UK...
  14. pmc Prospective cohort study to determine if trial efficacy of anticoagulation for stroke prevention in atrial fibrillation translates into clinical effectiveness
    L Kalra
    Department of Medicine, Guy s, King s, and St Thomas s School of Medicine, London SE5 9PJ
    BMJ 320:1236-9. 2000
    ..To determine whether trial efficacy of prophylaxis with warfarin for patients with atrial fibrillation at high risk of stroke translates into effectiveness in clinical practice...
  15. ncbi request reprint Should stroke subtype influence anticoagulation decisions to prevent recurrence in stroke patients with atrial fibrillation?
    A Evans
    Department of Medicine, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Stroke 32:2828-32. 2001
    ..Although the role of warfarin in cardioembolic stroke is established, it may not prevent recurrence in other stroke subtypes, even in the presence of atrial fibrillation...
  16. ncbi request reprint Risk assessment and anticoagulation for primary stroke prevention in atrial fibrillation
    L Kalra
    Orpington Stroke Unit, Clinical and Health Services Studies Unit, King s College School of Medicine and Dentistry, London, UK
    Stroke 30:1218-22. 1999
    ..Risk assessment before anticoagulation is important for effective stroke prevention in atrial fibrillation (AF)...
  17. ncbi request reprint Secondary stroke prevention in atrial fibrillation: lessons from clinical practice
    A Evans
    Department of Medicine, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Stroke 31:2106-11. 2000
    ..The purpose of the study was to determine whether trial efficacy of anticoagulation for secondary prevention could be replicated in clinical practice in strokes of different etiology...
  18. doi request reprint Acute ischaemic hemispheric stroke is associated with impairment of reflex in addition to voluntary cough
    K Ward
    Division of Asthma, Allergy and Lung Biology, Dept of Respiratory Medicine, King s College London School of Medicine, London, UK
    Eur Respir J 36:1383-90. 2010
    ..VC and RC are both impaired in hemispheric stroke patients, despite preserved expiratory muscle strength. Cough coordination is probably cortically modulated and affected by hemispheric stroke...
  19. ncbi request reprint A randomised controlled comparison of alternative strategies in stroke care
    L Kalra
    Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas School of Medicine, London, UK
    Health Technol Assess 9:iii-iv, 1-79. 2005
    ..To describe organisational aspects of individual strategies of stroke care and to evaluate cost-effectiveness of each strategy and its acceptability to patients, carers and professionals...
  20. ncbi request reprint Are the results of randomized controlled trials on anticoagulation in patients with atrial fibrillation generalizable to clinical practice?
    A Evans
    Department of Diabetes, Endocrinology, and Internal Medicine, Guy s, King s and St Thomas School of Medicine, Denmark Hill Campus, Bessemer Road, London SE5 8PJ, England
    Arch Intern Med 161:1443-7. 2001
    ..The reluctance to treat all eligible patients with anticoagulants may be due to studies in clinical practice showing variable risk-benefit, raising concerns about application to general medical practice...
  21. ncbi request reprint Can differences in management processes explain different outcomes between stroke unit and stroke-team care?
    A Evans
    Department of Medicine, Guy s, King s and St Thomas s School of Medicine, London, UK
    Lancet 358:1586-92. 2001
    ..We have compared differences in management and complications of patients with acute stroke who were admitted to a stroke unit or to a general ward as part of a previously reported randomised trial...
  22. doi request reprint Cognitive function and hypertension
    J Birns
    King s College London, Department of Stroke Medicine, Academic Neurosciences Centre, Institute of Psychiatry, London, UK
    J Hum Hypertens 23:86-96. 2009
    ....
  23. doi request reprint Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease
    J Birns
    Department of Stroke Medicine, Academic Neurosciences Centre, PO41, Institute of Psychiatry, King s College London, London, UK
    J Neurol Neurosurg Psychiatry 80:1093-8. 2009
    ..Adequate perfusion of the deep white matter of the brain depends on the relationships between blood pressure (BP), cerebral vasoreactivity and autoregulation...
  24. doi request reprint Transcranial magnetic stimulation study of expiratory muscle weakness in acute ischemic stroke
    F Harraf
    Department of Stroke Medicine, King s College London, London, UK
    Neurology 71:2000-7. 2008
    ..Expiratory muscle weakness due to cerebral infarction may contribute to reduced airway clearance in stroke patients...
  25. ncbi request reprint Blood pressure and vascular cognitive impairment: the debate continues
    J Birns
    Department of Stroke Medicine, Guy s, King s and St Thomas s School of Medicine, Denmark Hill Campus, Bessemer Road, London, UK
    J Hum Hypertens 20:1-3. 2006
  26. pmc Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial
    Leo H Bonati
    Stroke Research Group, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 8:908-17. 2009
    ..We aimed to investigate the long-term risks of restenosis in patients included in CAVATAS...
  27. doi request reprint Ethnic differences in the cerebrovascular impact of hypertension
    Jonathan Birns
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    Cerebrovasc Dis 25:408-16. 2008
    ....
  28. ncbi request reprint The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials
    Jonathan Birns
    Department of Stroke Medicine, Guy s, King s and St Thomas School of Medicine, New Medical School, London, UK
    J Hypertens 24:1907-14. 2006
    ..To review systematically and synthesize quantitatively the evidence from completed randomized, controlled trials of blood pressure reduction on cognitive performance...
  29. ncbi request reprint Can pulse oximetry or a bedside swallowing assessment be used to detect aspiration after stroke?
    Deborah J C Ramsey
    Department of Stroke Medicine, King s College London School of Medicine, Bessemer Road, London, SE5 9PJ UK
    Stroke 37:2984-8. 2006
    ..Desaturation during swallowing may help to identify aspiration in stroke patients. This study investigated pulse oximetry, bedside swallowing assessment (BSA), and videofluoroscopy as tests for detecting aspiration after stroke...
  30. doi request reprint Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 39:2943-9. 2008
    ..We determined the association between homocysteine and stroke subtypes, especially SVD, in a well-phenotyped UK cohort of black stroke patients compared to community controls...
  31. ncbi request reprint Differences in stroke subtypes between black and white patients with stroke: the South London Ethnicity and Stroke Study
    Hugh S Markus
    Centre for Clinical Neuroscience, St George s University of London, London, SW17 ORE, UK
    Circulation 116:2157-64. 2007
    ..Determining whether the distribution of stroke subtypes differs between ethnic groups is important in understanding the mechanisms of the increased stroke incidence in black patients...
  32. doi request reprint Early cerebrovascular impairment: new insights and controversies
    Jonathan Birns
    Department of Stroke Medicine, King s College London School of Medicine, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    Int J Stroke 3:167-8. 2008
  33. ncbi request reprint What's new in stroke rehabilitation: back to basics
    Robert W Teasell
    Physical Medicine and Rehabilitation, St Joseph s Health Care, London, Ontario, Canada
    Stroke 36:215-7. 2005
  34. pmc Training care givers of stroke patients: economic evaluation
    Anita Patel
    Centre for the Economics of Mental Health, Institute of Psychiatry, London SE5 8AF
    BMJ 328:1102. 2004
    ..Training care givers reduces their burden and improves psychosocial outcomes in care givers and patients at one year. However, the cost effectiveness of this approach has not been investigated...
  35. ncbi request reprint What's new in stroke rehabilitation
    Robert W Teasell
    Physical Medicine and Rehabilitation, St Joseph s Health Care, London, Ontario, Canada
    Stroke 35:383-5. 2004
  36. ncbi request reprint Alternative strategies for stroke care: cost-effectiveness and cost-utility analyses from a prospective randomized controlled trial
    Anita Patel
    Centre for the Economics of Mental Health, Health Services Research Department, David Goldberg Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF UK
    Stroke 35:196-203. 2004
    ..Although stroke units reduce mortality and institutionalization, their comparative cost-effectiveness is unknown...
  37. ncbi request reprint Ethnic differences in markers of thrombophilia: implications for the investigation of ischemic stroke in multiethnic populations: the South London Ethnicity and Stroke Study
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 34:1821-6. 2003
    ..This study estimated ethnic-specific reference ranges in a community population to determine the prevalence of thrombophilic states in a multiethnic stroke population...
  38. ncbi request reprint Early assessments of dysphagia and aspiration risk in acute stroke patients
    Deborah J C Ramsey
    Department of Stroke Medicine, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Stroke 34:1252-7. 2003
    ..Dysphagia is common after stroke and is a marker of poor prognosis. Early identification is important. This article reviews the merits and limitations of various assessment methods available to clinicians...
  39. ncbi request reprint The economic burden of stroke in the United Kingdom
    Penny Youman
    Fourth Hurdle Consulting Ltd, Holborn, London, UK
    Pharmacoeconomics 21:43-50. 2003
    ..To estimate the cost of treating stroke in the UK...
  40. ncbi request reprint Integrated care pathways and quality of life on a stroke rehabilitation unit
    David Sulch
    Guy s, King s, and St Thomas School of Medicine, King s College, and Department of Adult Medicine, Queen Elizabeth Hospital, London, UK
    Stroke 33:1600-4. 2002
    ..Their potential to improve patient heath status or satisfaction with care is not known...
  41. ncbi request reprint Are cost benefits of anticoagulation for stroke prevention in atrial fibrillation underestimated?
    Paul S J Miller
    AstraZeneca, HEOR Clinical Science, Parklands FE2 D 4, Alderley Park, SK10 4TG UK
    Stroke 36:360-6. 2005
    ..The objective of this study was to evaluate whether the cost benefits of anticoagulation for stroke prevention in AF may currently be underestimated by existing economic models that do not distinguish between different stroke outcomes...
  42. ncbi request reprint Blood pressure reduction for vascular risk: is there a price to be paid?
    Jonathan Birns
    Department of Stroke Medicine, Guy s King s and St Thomas School of Medicine, King s College London, Bessemer Road, London SE5 9PJ, United Kingdom
    Stroke 36:1308-13. 2005
    ..This will help to direct appropriate protective strategies and treatments in a vulnerable group of people, many of whom have hypertension and cerebrovascular disease at the same time...
  43. ncbi request reprint Determinants of caregiving burden and quality of life in caregivers of stroke patients
    Emily McCullagh
    Department of Stroke Medicine, Guy s, King s, and St Thomas s School of Medicine, King s College, London, UK
    Stroke 36:2181-6. 2005
    ..A large proportion of disabled stroke survivors live at home and are supported by informal caregivers. Identification of determinants of caregiver burden will help to target caregiver interventions...
  44. ncbi request reprint Is the gag reflex useful in the management of swallowing problems in acute stroke?
    Deborah Ramsey
    Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Dysphagia 20:105-7. 2005
    ..We conclude that the gag reflex is as specific as but less sensitive than the BSA in detecting dysphagia in acute stroke patients. An intact gag may be protective against longer-term swallowing problems and the need for enteral feeding...
  45. ncbi request reprint The vascular effects of metabolic impairment clusters in subjects of different ethnicities
    Curtis Rambaran
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Atherosclerosis 192:354-62. 2007
    ..Although metabolic syndrome affects vascular function, the impact of individual impairments and their clustering is unclear...
  46. ncbi request reprint Silent aspiration: what do we know?
    Deborah Ramsey
    Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Dysphagia 20:218-25. 2005
    ..The phenomenon of silent aspiration is poorly understood and further research is needed to improve methods of detection and thereby better define its prevalence and prognostic significance...
  47. pmc Assessment of endothelial function: comparison of the pulse wave response to beta 2-adrenoceptor stimulation with flow mediated dilatation
    Curtis Rambaran
    Cardiovascular Division, King s College London School of Medicine, London, UK
    Br J Clin Pharmacol 65:238-43. 2008
    ....
  48. ncbi request reprint Does an integrated care pathway improve processes of care in stroke rehabilitation? A randomized controlled trial
    David Sulch
    Department of Adult Medicine, Queen Elizabeth Hospital, Stadium Road, Woolwich, London SE18 4QH, UK
    Age Ageing 31:175-9. 2002
    ..to evaluate whether integrated care pathways improve the processes of care in stroke rehabilitation...
  49. ncbi request reprint Thrombolysis for stroke in clinical practice: are we doing enough?
    Lalit Kalra
    Natl Med J India 19:119-22. 2006
  50. pmc A multicentre observational study of presentation and early assessment of acute stroke
    Farzaneh Harraf
    Department of Medicine, Guy s King s, and St Thomas s Medical School, London SE5 9PJ
    BMJ 325:17. 2002
    ..To investigate delays in the presentation to hospital and evaluation of patients with suspected stroke...
  51. ncbi request reprint Scoring systems for the differential diagnosis of ischaemic and haemorrhagic stroke
    Lalit Kalra
    Natl Med J India 16:1-3. 2003
  52. ncbi request reprint A randomized controlled trial of an enhanced balance training program to improve mobility and reduce falls in elderly patients
    Jayne Steadman
    Department of Physiotherapy, Orpington Hospital, Bromley Hospitals NHS Trust, Orpington, United Kingdom
    J Am Geriatr Soc 51:847-52. 2003
    ..To evaluate the effectiveness of an enhanced balance training program in improving mobility and well-being of elderly people with balance problems...
  53. pmc Prism adaptation aftereffects in stroke patients with spatial neglect: pathological effects on subjective straight ahead but not visual open-loop pointing
    Margarita Sarri
    UCL Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, UK
    Neuropsychologia 46:1069-80. 2008
    ..Future studies of possible rehabilitative impact from prisms upon neglect may need to consider carefully how to measure prism adaptation per se, separately from any impact of such adaptation upon manifestations of neglect...
  54. ncbi request reprint Acute treatment and long-term management of stroke in developing countries
    Michael Brainin
    Centre of Clinical Neurosciences, Department of Clinical Medicine and Preventive Medicine, Danube University, Austria
    Lancet Neurol 6:553-61. 2007
    ..On the basis of available studies, largely from developed countries, we discuss the need to develop basic organised stroke-unit care in developing countries...
  55. ncbi request reprint Benefits of occupational therapy in stroke rehabilitation
    Paran Govender
    Department of Occupational Therapy, King s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
    Expert Rev Neurother 7:1013-9. 2007
    ..Several promising new rehabilitation approaches, based on neuropsychology and technological advances, have been developed to complement therapy inputs and exploit the brain's capacity to recover from stroke...
  56. ncbi request reprint Prism adaptation changes perceptual awareness for chimeric visual objects but not for chimeric faces in spatial neglect after right-hemisphere stroke
    Margarita Sarri
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, UK
    Neurocase 12:127-35. 2006
    ..Prism therapy dramatically improved awareness for the identity of the left side of chimeric non-face objects, but had no effect on judging expressions for chimeric faces. The latter may thus be unique in showing no prism benefit...