Guo Cai Huang

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint The development of new density gradient media for purifying human islets and islet-quality assessments
    Guo Cai Huang
    Department of Diabetes, Endocrinology and Internal Medicine, King s College GKT Medical School, London, UK
    Transplantation 77:143-5. 2004
  2. pmc Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells
    Min Zhao
    Diabetes Research Group, King s College London School of Medicine, London, United Kingdom
    PLoS ONE 3:e2666. 2008
  3. ncbi request reprint The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis
    Bo Liu
    Diabetes Research Group, Division of Diabetes and Nutritional Sciences, School of Medicine, 2 9N Hodgkin Building, King s College London, Guy s Campus, London, SE1 1UL, UK
    Diabetologia 56:2467-76. 2013
  4. ncbi request reprint Evidence for the presence of stem cell-like progenitor cells in human adult pancreas
    Min Zhao
    Department of Diabetes, Endocrinology and Internal Medicine, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, UK
    J Endocrinol 195:407-14. 2007
  5. doi request reprint Function and expression of melatonin receptors on human pancreatic islets
    Reshma D Ramracheya
    Beta Cell Development and Function Group, School of Biomedical and Health Sciences, King s College London, London, UK
    J Pineal Res 44:273-9. 2008
  6. pmc Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity
    Robin R Knight
    Department of Immunobiology, King s College London, London, United Kingdom
    Diabetes 62:205-13. 2013
  7. ncbi request reprint Costus pictus extracts stimulate insulin secretion from mouse and human islets of Langerhans in vitro
    Altaf Al-Romaiyan
    Diabetes Research Group, King s College London, London, United Kingdom
    Cell Physiol Biochem 26:1051-8. 2010
  8. ncbi request reprint The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans
    Shanta J Persaud
    Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology, and Development, King s College London, UK
    Diabetes 56:197-203. 2007
  9. ncbi request reprint Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression
    Dany Muller
    Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King s College London, London SE1 1UL, UK
    Diabetes 55:2835-42. 2006
  10. doi request reprint Conversion of non-endocrine human pancreatic cells to insulin-producing cells for treatment of diabetes
    Min Zhao
    Department of Diabetes and Endocrinology, King s College London School of Medicine, London, UK
    Methods Mol Biol 806:73-85. 2012

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The development of new density gradient media for purifying human islets and islet-quality assessments
    Guo Cai Huang
    Department of Diabetes, Endocrinology and Internal Medicine, King s College GKT Medical School, London, UK
    Transplantation 77:143-5. 2004
    ..The new medium enhances yield, purity, and viability of human islet preparations for clinical islet transplantation...
  2. pmc Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells
    Min Zhao
    Diabetes Research Group, King s College London School of Medicine, London, United Kingdom
    PLoS ONE 3:e2666. 2008
    ..We explored the potential for human MSCs (hMSCs) to be differentiated into glucose-responsive cells through a non-viral genetic reprogramming approach...
  3. ncbi request reprint The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis
    Bo Liu
    Diabetes Research Group, Division of Diabetes and Nutritional Sciences, School of Medicine, 2 9N Hodgkin Building, King s College London, Guy s Campus, London, SE1 1UL, UK
    Diabetologia 56:2467-76. 2013
    ..GPR75 is coupled to Gq to elevate intracellular calcium, so we investigated whether islets express this receptor and whether its activation by CCL5 increases beta cell calcium levels and insulin secretion...
  4. ncbi request reprint Evidence for the presence of stem cell-like progenitor cells in human adult pancreas
    Min Zhao
    Department of Diabetes, Endocrinology and Internal Medicine, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, UK
    J Endocrinol 195:407-14. 2007
    ..The numbers of Oct4(+ve) and Sox2(+ve) cells varied among donors and were approximately 1-200 and 1-30 per 100 000 pancreatic cells respectively...
  5. doi request reprint Function and expression of melatonin receptors on human pancreatic islets
    Reshma D Ramracheya
    Beta Cell Development and Function Group, School of Biomedical and Health Sciences, King s College London, London, UK
    J Pineal Res 44:273-9. 2008
    ..This study also indicates that the effects of melatonin are species-specific with primarily an inhibitory role in rodent beta-cells and a stimulatory effect in human islets...
  6. pmc Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity
    Robin R Knight
    Department of Immunobiology, King s College London, London, United Kingdom
    Diabetes 62:205-13. 2013
    ..The study highlights the regulation of β-cell killing as a potential point for therapeutic control, including the possibility of blocking autoreactive CD8 T-cell function without impacting upon general immune competence...
  7. ncbi request reprint Costus pictus extracts stimulate insulin secretion from mouse and human islets of Langerhans in vitro
    Altaf Al-Romaiyan
    Diabetes Research Group, King s College London, London, United Kingdom
    Cell Physiol Biochem 26:1051-8. 2010
    ..CP extracts may provide an affordable and inexpensive alternative for treating patients with T2DM...
  8. ncbi request reprint The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans
    Shanta J Persaud
    Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology, and Development, King s College London, UK
    Diabetes 56:197-203. 2007
    ....
  9. ncbi request reprint Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression
    Dany Muller
    Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King s College London, London SE1 1UL, UK
    Diabetes 55:2835-42. 2006
    ..Defects in this regulation may accentuate the metabolic dysfunction associated with type 2 diabetes...
  10. doi request reprint Conversion of non-endocrine human pancreatic cells to insulin-producing cells for treatment of diabetes
    Min Zhao
    Department of Diabetes and Endocrinology, King s College London School of Medicine, London, UK
    Methods Mol Biol 806:73-85. 2012
    ....
  11. ncbi request reprint GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia
    Rachel E Roberts
    King s College London School of Medicine, London SE1 1UL, United Kingdom
    J Clin Endocrinol Metab 97:3039-45. 2012
    ..GLP-1 secretion causing hypoglycemia has been described once from an ovarian neuroendocrine tumor (NET) but has not been reported from a pancreatic NET (pNET)...
  12. ncbi request reprint Expression and function of cyclooxygenase and lipoxygenase enzymes in human islets of Langerhans
    Shanta J Persaud
    Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, King s College London, London, UK
    Arch Physiol Biochem 113:104-9. 2007
    ..This short review examines cPLA2, COX and LOX expression and function in insulin- secreting cell lines and rodent and human islets...
  13. pmc CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    Ania Skowera
    Department of Immunobiology, King s College London, London, United Kingdom
    J Clin Invest 118:3390-402. 2008
    ..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...