O D Howes

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging
    O D Howes
    PET Psychiatry MRC Clinical Sciences Centre, Imperial College Hammersmith Campus, Hammersmith Hospital, London, UK
    Curr Pharm Des 15:2550-9. 2009
  2. pmc The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients
    Oliver D Howes
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    J Clin Psychopharmacol 26:629-31. 2006
  3. pmc Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder
    Oliver D Howes
    Institute of Psychiatry, De Crespigny Park, London, UK
    J Clin Psychiatry 68:361-7. 2007
  4. doi request reprint Elevated striatal dopamine function linked to prodromal signs of schizophrenia
    Oliver D Howes
    Section of Neuroimaging, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 66:13-20. 2009
  5. pmc Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment
    Oliver D Howes
    The Institute of Psychiatry, London SE5 8AF, UK
    J Clin Psychopharmacol 25:259-61. 2005
  6. pmc The effect of clozapine on factors controlling glucose homeostasis
    Oliver D Howes
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    J Clin Psychiatry 65:1352-5. 2004
  7. ncbi request reprint Diabetic keto-acidotic (DKA) coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine
    O D Howes
    The Institute of Psychiatry, De Crespigny Park, London, UK
    J Psychopharmacol 18:435-7. 2004
  8. ncbi request reprint Pathways to schizophrenia: the impact of environmental factors
    Oliver D Howes
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Int J Neuropsychopharmacol 7:S7-S13. 2004
  9. pmc Street slang and schizophrenia
    Oliver D Howes
    Institute of Psychiatry, London SE5 8AF
    BMJ 335:1294. 2007
  10. doi request reprint Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group PO67, Institute of Psychiatry, De Crespigny Park, London SE58AF, England
    Arch Gen Psychiatry 67:683-91. 2010

Detail Information

Publications24

  1. pmc Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging
    O D Howes
    PET Psychiatry MRC Clinical Sciences Centre, Imperial College Hammersmith Campus, Hammersmith Hospital, London, UK
    Curr Pharm Des 15:2550-9. 2009
    ..Finally, we discuss the implications of these PET and SPECT findings for new avenues of drug development...
  2. pmc The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients
    Oliver D Howes
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    J Clin Psychopharmacol 26:629-31. 2006
    ..To determine if prolactin levels are associated with glucose-insulin homeostasis in antipsychotic-treated patients with schizophrenia...
  3. pmc Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder
    Oliver D Howes
    Institute of Psychiatry, De Crespigny Park, London, UK
    J Clin Psychiatry 68:361-7. 2007
    ..To determine rates of sexual dysfunction and hypogonadism and establish the relationship between gonadal hormone levels and sexual function in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder...
  4. doi request reprint Elevated striatal dopamine function linked to prodromal signs of schizophrenia
    Oliver D Howes
    Section of Neuroimaging, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 66:13-20. 2009
    ....
  5. pmc Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment
    Oliver D Howes
    The Institute of Psychiatry, London SE5 8AF, UK
    J Clin Psychopharmacol 25:259-61. 2005
    ..BMD was correlated with body mass index but there was no correlation with prolactin. BMD was not correlated with prolactin levels and showed no clinically significant reduction. The low BMD in black males warrants further investigation...
  6. pmc The effect of clozapine on factors controlling glucose homeostasis
    Oliver D Howes
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    J Clin Psychiatry 65:1352-5. 2004
    ..This prospective study examines the effect of clozapine on factors determining glucose homeostasis...
  7. ncbi request reprint Diabetic keto-acidotic (DKA) coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine
    O D Howes
    The Institute of Psychiatry, De Crespigny Park, London, UK
    J Psychopharmacol 18:435-7. 2004
    ..The case highlights that changes in antipsychotic treatment may be associated with large changes in glucose tolerance, and that it is possible to continue antipsychotic treatment with appropriate diabetic care...
  8. ncbi request reprint Pathways to schizophrenia: the impact of environmental factors
    Oliver D Howes
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Int J Neuropsychopharmacol 7:S7-S13. 2004
    ..Thus, stresses, such as drug use and social adversity, in adolescence or early adult life may propel the neurodevelopmentally impaired individual over a threshold into frank psychosis...
  9. pmc Street slang and schizophrenia
    Oliver D Howes
    Institute of Psychiatry, London SE5 8AF
    BMJ 335:1294. 2007
  10. doi request reprint Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group PO67, Institute of Psychiatry, De Crespigny Park, London SE58AF, England
    Arch Gen Psychiatry 67:683-91. 2010
    ..Alterations in dopaminergic neurotransmission and function of the prefrontal cortex are thought to be central to the pathophysiology of schizophrenia, but the relationship between these factors in the development of psychosis is unclear...
  11. doi request reprint Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis
    P Fusar-Poli
    Department of Psychological Medicine, Neuroimaging Section, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 16:67-75. 2011
    ..These changes reflect an increased vulnerability to psychosis and predate the first episode of frank psychosis...
  12. doi request reprint Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding
    Alice Egerton
    Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, United Kingdom
    Synapse 64:301-12. 2010
    ....
  13. pmc A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance
    Oliver D Howes
    Division of Psychological Medicine, Insitute of Psychiatry, London, UK
    Am J Psychiatry 161:361-3. 2004
    ..This prospective study examines the effect of clozapine on glucose control and insulin sensitivity...
  14. doi request reprint Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 50:260-6. 2010
    ..These findings have important implications for understanding the mechanism of action underlying bupropions' therapeutic efficacy and for the development of novel treatments for addiction and depression...
  15. doi request reprint The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Neuroimage 50:524-31. 2010
    ..This information can be used to optimize the experimental design of future studies investigating changes in brain dopaminergic function with 18F-DOPA...
  16. pmc The dopaminergic basis of human behaviors: A review of molecular imaging studies
    Alice Egerton
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, United Kingdom
    Neurosci Biobehav Rev 33:1109-32. 2009
    ....
  17. doi request reprint Striatal dopamine synthesis capacity in twins discordant for schizophrenia
    P Shotbolt
    Psychiatric Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, UK
    Psychol Med 41:2331-8. 2011
    ..Relatives of patients with schizophrenia are themselves at increased risk of developing the condition. In this study we examined striatal dopamine synthesis capacity in both members of twin pairs discordant for schizophrenia...
  18. pmc A comprehensive review and model of putative prodromal features of bipolar affective disorder
    O D Howes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College Hammersmith Campus, London, UK
    Psychol Med 41:1567-77. 2011
    ..This review addresses two key questions: Is there a bipolar prodrome? And, if there is, what are its characteristic features?..
  19. doi request reprint The effect of ageing on grey and white matter reductions in schizophrenia
    Subrata K Bose
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Schizophr Res 112:7-13. 2009
    ..This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders...
  20. doi request reprint Functional neuroimaging in schizophrenia: diagnosis and drug discovery
    Philip McGuire
    Sections of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park 16, London, UK
    Trends Pharmacol Sci 29:91-8. 2008
    ..Here, we focus on the potential for the use of these techniques in the diagnosis of schizophrenia and in the development of new drugs for its treatment...
  21. ncbi request reprint Comments on "Prolactin levels and erectile function in patients treated with risperidone" (J Clin Psychopharmacol 2004;24:161-166)
    Oliver D Howes
    J Clin Psychopharmacol 25:393-4. 2005
  22. ncbi request reprint Serum glutamic acid decarboxylase 65 antibody levels in people with schizophrenia and their families
    Fiona Gaughran
    Schizophr Res 73:379-81. 2005
  23. ncbi request reprint Comment on Hyperprolactinaemia and antipsychotic therapy in schizophrenia
    Oliver D Howes
    Curr Med Res Opin 20:1649. 2004
  24. pmc Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis
    Oliver D Howes
    Br J Psychiatry Suppl 51:s13-8. 2007
    ....