Claudie Hooper

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Neurosci Lett 413:227-32. 2007
  2. pmc p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 418:34-7. 2007
  3. doi request reprint Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides
    Christopher M Davenport
    Cell Signalling Laboratory, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Neurochem 112:552-63. 2010
  4. ncbi request reprint TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK
    J Neurochem 99:989-99. 2006
  5. pmc The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 415:135-9. 2007
  6. doi request reprint Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage
    Claudie Hooper
    Kings College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    J Neurochem 109:694-705. 2009
  7. ncbi request reprint GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
  8. doi request reprint Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones
    Claudie Hooper
    MRC Centre for Neurodegenerative Research, Institute of Psychiatry, King s College London, London, UK
    J Neurochem 118:512-20. 2011
  9. pmc Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
    Richard Killick
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Biochem Biophys Res Commun 386:257-62. 2009
  10. pmc Wnt3a induces exosome secretion from primary cultured rat microglia
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    BMC Neurosci 13:144. 2012

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Neurosci Lett 413:227-32. 2007
    ..These findings provide insights into the way microglia are activated by CgA and the microglial signalling mechanisms associated with neurological disorders such as Alzheimer's disease...
  2. pmc p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 418:34-7. 2007
    ..Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies...
  3. doi request reprint Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides
    Christopher M Davenport
    Cell Signalling Laboratory, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Neurochem 112:552-63. 2010
    ..Inhibiting p53 mediated microglial apoptosis prevented microglial neurotoxicity suggesting targeting of p53-mediated pathways in microglia may have therapeutic benefit in Alzheimer's disease...
  4. ncbi request reprint TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK
    J Neurochem 99:989-99. 2006
    ..Collectively, these findings may have ramifications for neurodevelopment, neurodegeneration and oncogenesis...
  5. pmc The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 415:135-9. 2007
    ..These findings have ramifications for nuclear architecture and gene transcription...
  6. doi request reprint Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage
    Claudie Hooper
    Kings College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    J Neurochem 109:694-705. 2009
    ..Thus, exposure of microglia in the brain to albumin may contribute to neuronal damage following blood-brain barrier breakdown and point to resident microglia rather than infiltrating macrophages as therapeutic targets...
  7. ncbi request reprint GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
    ..In the light of these findings GSK3alpha warrants further investigation regarding its involvement in Wnt signalling and tauopathies such as Alzheimer's disease...
  8. doi request reprint Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones
    Claudie Hooper
    MRC Centre for Neurodegenerative Research, Institute of Psychiatry, King s College London, London, UK
    J Neurochem 118:512-20. 2011
    ..The overlapping transcriptional response was not attributable to Wnt3a activating Akt. These findings have ramifications for neurodevelopment and neurological diseases, in which the Wnt and insulin signalling pathways are implicated...
  9. pmc Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
    Richard Killick
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Biochem Biophys Res Commun 386:257-62. 2009
    ..However, as these effects are accompanied by improvement in behavioural deficits, our findings suggest a novel protective effect of disrupting IRS2 signalling in AD which may be a useful therapeutic strategy for this condition...
  10. pmc Wnt3a induces exosome secretion from primary cultured rat microglia
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    BMC Neurosci 13:144. 2012
    ..Here we describe the inducible release of exosomes from primary cultured rat microglia following treatment with recombinant carrier-free Wnt3a...
  11. pmc The GSK3 hypothesis of Alzheimer's disease
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    J Neurochem 104:1433-9. 2008
    ..If our 'GSK3 hypothesis of AD' is substantiated and GSK3 is indeed a causal mediator of AD then inhibitors of GSK3 would provide a novel avenue for therapeutic intervention in this devastating disorder...
  12. ncbi request reprint Glycogen synthase kinase-3 inhibition is integral to long-term potentiation
    Claudie Hooper
    MRC Centre for Neurodegeneration Research, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur J Neurosci 25:81-6. 2007
    ..It follows that this role of GSK-3beta in LTP might underlie some of the cognitive dysfunction in diseases where GSK-3 dysfunction has been implicated, including Alzheimer's and other dementias...
  13. ncbi request reprint Pure albumin is a potent trigger of calcium signalling and proliferation in microglia but not macrophages or astrocytes
    Claudie Hooper
    Cell Signalling Laboratory, Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
    J Neurochem 92:1363-76. 2005
    ....
  14. ncbi request reprint TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism
    Claudie Hooper
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neurosci Lett 401:30-4. 2006
    ..These findings have ramifications for microtubule dynamics associated with axonal growth during development and for neuronal death associated with Alzheimer's disease and other tauopathies...