Lars Holmberg

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Predictors of early death in female patients with breast cancer in the UK: a cohort study
    Ceilidh Stapelkamp
    Bazian Ltd, 10 Fitzroy Square, London, UK
    BMJ Open 1:e000247. 2011
  2. ncbi request reprint The biology and natural history of prostate cancer: a short introduction
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University Regional Cancer Center University Hospital, Uppsala, Sweden
    Recent Results Cancer Res 202:1-7. 2014
  3. pmc Evaluation of prediction models for decision-making: beyond calibration and discrimination
    Lars Holmberg
    Regional Cancer Center Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 10:e1001491. 2013
  4. pmc Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study
    L Holmberg
    King s College London, Medical School, Division of Cancer Studies, London SE1 9RT, UK
    Br J Cancer 108:812-9. 2013
  5. pmc Results from the Scandinavian Prostate Cancer Group Trial Number 4: a randomized controlled trial of radical prostatectomy versus watchful waiting
    Lars Holmberg
    Division of Cancer Studies, Guy s Hospital, King s College London, St Thomas Street, London, UK
    J Natl Cancer Inst Monogr 2012:230-3. 2012
  6. doi request reprint A comparison of prostate cancer survival in England, Norway and Sweden: a population-based study
    L Holmberg
    King s College London, Medical School, Division of Cancer Studies, Section of Cancer Epidemiology, SE1 9RT London, UK
    Cancer Epidemiol 36:e7-12. 2012
  7. doi request reprint National comparisons of lung cancer survival in England, Norway and Sweden 2001-2004: differences occur early in follow-up
    Lars Holmberg
    Division of Cancer Studies, King s College London, School of Medicine, Research Oncology, 3rd Floor Bermondsey Wing, Guy s Hospital, London SE1 9RT, UK
    Thorax 65:436-41. 2010
  8. doi request reprint Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast
    Lars Holmberg
    Division of Cancer Studies, Thomas Guy House, 3rd Floor, King s College London, Guy s Campus, London SE1 9RT, United Kingdom
    J Clin Oncol 26:1247-52. 2008
  9. doi request reprint Increased risk of recurrence after hormone replacement therapy in breast cancer survivors
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    J Natl Cancer Inst 100:475-82. 2008
  10. ncbi request reprint Differences in endpoints between the Swedish W-E (two county) trial of mammographic screening and the Swedish overview: methodological consequences
    L Holmberg
    Research Oncology, 3rd Floor Bermondsey Wing, Guy s Hospital, Divison of Cancer Studies, Guy s Campus, King s College London, SE1 9RT London, UK
    J Med Screen 16:73-80. 2009

Detail Information

Publications92

  1. pmc Predictors of early death in female patients with breast cancer in the UK: a cohort study
    Ceilidh Stapelkamp
    Bazian Ltd, 10 Fitzroy Square, London, UK
    BMJ Open 1:e000247. 2011
    ..The study identifies a group of women with a particularly poor prognosis for whom interventions aiming at early detection may be targeted...
  2. ncbi request reprint The biology and natural history of prostate cancer: a short introduction
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University Regional Cancer Center University Hospital, Uppsala, Sweden
    Recent Results Cancer Res 202:1-7. 2014
    ..The understanding of prostate cancer aetiology and natural history has progressed slowly. However, the current situation is positively challenging and opens up possibilities for fruitful research. ..
  3. pmc Evaluation of prediction models for decision-making: beyond calibration and discrimination
    Lars Holmberg
    Regional Cancer Center Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 10:e1001491. 2013
    b>Lars Holmberg and Andrew Vickers discuss the importance of ensuring prediction models lead to better decision making in light of new research into breast, endometrial, and ovarian cancer risk by Ruth Pfeiffer and colleagues...
  4. pmc Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study
    L Holmberg
    King s College London, Medical School, Division of Cancer Studies, London SE1 9RT, UK
    Br J Cancer 108:812-9. 2013
    ..We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast...
  5. pmc Results from the Scandinavian Prostate Cancer Group Trial Number 4: a randomized controlled trial of radical prostatectomy versus watchful waiting
    Lars Holmberg
    Division of Cancer Studies, Guy s Hospital, King s College London, St Thomas Street, London, UK
    J Natl Cancer Inst Monogr 2012:230-3. 2012
    ..These questionnaire studies show an intricate pattern of symptoms evolving after surgery, hormonal treatments, signs of tumor progression, and also from natural aging. This article discusses some of the main findings of the SPCG-4 study...
  6. doi request reprint A comparison of prostate cancer survival in England, Norway and Sweden: a population-based study
    L Holmberg
    King s College London, Medical School, Division of Cancer Studies, Section of Cancer Epidemiology, SE1 9RT London, UK
    Cancer Epidemiol 36:e7-12. 2012
    ..The objective of the study was to compare patterns of survival 2001-2004 in prostate cancer patients from England, Norway and Sweden in relation to age and period of follow-up...
  7. doi request reprint National comparisons of lung cancer survival in England, Norway and Sweden 2001-2004: differences occur early in follow-up
    Lars Holmberg
    Division of Cancer Studies, King s College London, School of Medicine, Research Oncology, 3rd Floor Bermondsey Wing, Guy s Hospital, London SE1 9RT, UK
    Thorax 65:436-41. 2010
    ..Future improvements in lung cancer management may be seen early in follow-up...
  8. doi request reprint Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast
    Lars Holmberg
    Division of Cancer Studies, Thomas Guy House, 3rd Floor, King s College London, Guy s Campus, London SE1 9RT, United Kingdom
    J Clin Oncol 26:1247-52. 2008
    ..Evaluate the effects of radiotherapy after sector resection for ductal carcinoma in situ of the breast (DCIS) in patient groups as defined by age, size of the lesion, focality, completeness of excision and mode of detection...
  9. doi request reprint Increased risk of recurrence after hormone replacement therapy in breast cancer survivors
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    J Natl Cancer Inst 100:475-82. 2008
    ..We present results after extended follow-up...
  10. ncbi request reprint Differences in endpoints between the Swedish W-E (two county) trial of mammographic screening and the Swedish overview: methodological consequences
    L Holmberg
    Research Oncology, 3rd Floor Bermondsey Wing, Guy s Hospital, Divison of Cancer Studies, Guy s Campus, King s College London, SE1 9RT London, UK
    J Med Screen 16:73-80. 2009
    ....
  11. doi request reprint Season of diagnosis and prognosis in breast and prostate cancer
    Lars Holmberg
    Regional Oncologic Center and Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Cancer Causes Control 20:663-70. 2009
    ..Patients with breast or prostate cancer diagnosed during the summer season have been observed to have better survival. The extent to which this is due to biological and/or health care system related factors is unclear...
  12. doi request reprint Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 364:1708-17. 2011
    ..In 2008, we reported that radical prostatectomy, as compared with watchful waiting, reduces the rate of death from prostate cancer. After an additional 3 years of follow-up, we now report estimated 15-year results...
  13. pmc Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    J Natl Cancer Inst 100:1144-54. 2008
    ..In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up...
  14. ncbi request reprint Radical prostatectomy or watchful waiting in early prostate cancer
    Anna Bill-Axelson
    From the Departments of Surgical Sciences A B A, M H and Immunology, Genetics, and Pathology C B, and the Regional Cancer Center Uppsala Örebro L H, H G, Uppsala University Hospital, Uppsala, The School of Health and Medical Sciences, Örebro University and Department of Urology, Orebro University Hospital, Örebro S O A, O A, J E J, The Department of Urology, Linkoping University Hospital, Linköping A S, the Department of Oncology and Pathology, Division of Clinical Cancer Epidemiology G S, and Department of Medical Epidemiology and Biostatistics J P, H O A, Karolinska Institutet, Stockholm, and the Division of Clinical Cancer Epidemiology, Sahlgrenska Academy, Gothenburg G S all in Sweden King s College London, School of Medicine, Division of Cancer Studies, London L H, H G Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School J R R, and the Department of Epidemiology, Harvard School of Public Health J R R, H O A all in Boston and the Department of Urology, Helsinki University Central Hospital K T, Chinese Academy of Preventive Medicine
    N Engl J Med 370:932-42. 2014
    ..Radical prostatectomy reduces mortality among men with localized prostate cancer; however, important questions regarding long-term benefit remain...
  15. ncbi request reprint Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 352:1977-84. 2005
    ..In 2002, we reported the initial results of a trial comparing radical prostatectomy with watchful waiting in the management of early prostate cancer. After three more years of follow-up, we report estimated 10-year results...
  16. doi request reprint Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
    Eva Johansson
    Department of Surgical Sciences, University Hospital of Uppsala, Uppsala, Sweden
    Lancet Oncol 12:891-9. 2011
    ..We report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) after a median follow-up of more than 12 years...
  17. doi request reprint Thromboembolic events following surgery for prostate cancer
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK
    Eur Urol 63:354-63. 2013
    ..Prostate cancer (PCa) and surgery are both associated with increased risk of thromboembolic diseases (TED)...
  18. doi request reprint Multiple events of fractures and cardiovascular and thromboembolic disease following prostate cancer diagnosis: results from the population-based PCBaSe Sweden
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK
    Eur Urol 61:690-700. 2012
    ..To date, adverse events of prostate cancer (PCa) treatment have only been studied as a single event, and little is known about the risk of subsequent adverse events...
  19. doi request reprint Prognosis of metachronous contralateral breast cancer: importance of stage, age and interval time between the two diagnoses
    Voralak Vichapat
    Cancer Epidemiology Group, Division of Cancer Studies, School of Medicine, King s College London, London, UK
    Breast Cancer Res Treat 130:609-18. 2011
    ..The occurrence of CBC implies a new surveillance and therapeutic situation...
  20. pmc Iron metabolism and risk of cancer in the Swedish AMORIS study
    Anjali Gaur
    Division of Cancer Studies, Research Oncology, School of Medicine, King s College London, Guy s Hospital, London, UK
    Cancer Causes Control 24:1393-402. 2013
    ..We assessed the link between serum iron (SI), total-iron binding capacity (TIBC), and risk of cancer by levels of C-reactive protein (CRP) in a large population-based study (n = 220,642)...
  21. pmc Serum glucose and fructosamine in relation to risk of cancer
    Wahyu Wulaningsih
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom
    PLoS ONE 8:e54944. 2013
    ..We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer...
  22. doi request reprint Lipid profiles and risk of breast and ovarian cancer in the Swedish AMORIS study
    Jennifer C Melvin
    1King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:1381-4. 2012
    ..Perturbed lipid metabolism often accompanies obesity; we therefore ascertained the associations between lipid components and breast and ovarian cancer risk in a prospective cohort study...
  23. doi request reprint Risk of prostate cancer is not associated with levels of C-reactive protein and other commonly used markers of inflammation
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom
    Int J Cancer 129:1485-92. 2011
    ..This indicates need for international consensus on appropriate inflammatory markers in the context of cancer that may be practically applied in large studies...
  24. doi request reprint Absolute and relative risk of cardiovascular disease in men with prostate cancer: results from the Population-Based PCBaSe Sweden
    Mieke Van Hemelrijck
    King s College London, London, United Kingdom
    J Clin Oncol 28:3448-56. 2010
    ..Cardiovascular disease (CVD) is a potential adverse effect of endocrine treatment (ET) for prostate cancer (PC). We investigated absolute and relative CVD risk in 76,600 patients with PC undergoing ET, curative treatment, or surveillance...
  25. pmc Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
    Wahyu Wulaningsih
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, UK
    BMC Cancer 13:257. 2013
    ..Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi and risk of cancer in humans...
  26. doi request reprint Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation
    Johan Botling
    Departments of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Clin Cancer Res 19:194-204. 2013
    ..So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap...
  27. doi request reprint Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: the Randomized Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) clinical trial
    Eva Johansson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    Eur Urol 55:422-30. 2009
    ..Quality-of-life outcomes are important in the choice of treatment strategy for men with localized prostate cancer...
  28. doi request reprint The interplay between lipid profiles, glucose, BMI and risk of kidney cancer in the Swedish AMORIS study
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK
    Int J Cancer 130:2118-28. 2012
    ..This detailed analysis of lipid components only showed a consistent relation between TG levels and kidney cancer risk. Further mechanistic studies are required to assess links between lipid abnormalities and kidney cancer...
  29. doi request reprint Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer
    Patrick Micke
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Thorac Oncol 6:1833-40. 2011
    ..To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups...
  30. doi request reprint Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, Research Oncology, Bermondsey Wing, Guy s Hospital, London, SE1 9RT, UK
    Cancer Causes Control 22:1011-9. 2011
    ..Since several etiological pathways have been proposed for PCa and lipids, we aimed to study this in a large Swedish cohort with 1,469 primary prostate cancers...
  31. pmc Risk of thromboembolic diseases in men with prostate cancer: results from the population-based PCBaSe Sweden
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK
    Lancet Oncol 11:450-8. 2010
    ..We investigated the risk of thromboembolic disease in men with prostate cancer who were receiving endocrine treatment, curative treatment, or surveillance...
  32. doi request reprint Serum calcium and incident and fatal prostate cancer in the Swedish AMORIS study
    Mieke Van Hemelrijck
    Cancer Epidemiology Group, Research Oncology, Division of Cancer Studies, School of Medicine, Guy s Hospital, King s College London, UK
    Cancer Causes Control 23:1349-58. 2012
    ..We studied the association between serum calcium and PCa while also accounting for levels of albumin, a protein to which calcium is bound...
  33. ncbi request reprint Tumor stage affects risk and prognosis of contralateral breast cancer: results from a large Swedish-population-based study
    Voralak Vichapat
    Division of Cancer Studies, King s College London, London, United
    J Clin Oncol 30:3478-85. 2012
    ..The number of breast cancer survivors at risk of developing contralateral breast cancer (CBC) is increasing. However, ambiguity remains regarding risk factors and prognosis for women with CBC...
  34. doi request reprint Colorectal cancer survival in socioeconomic groups in England: variation is mainly in the short term after diagnosis
    Henrik Møller
    King s College London, Thames Cancer Registry, 1st Floor Capital House, 42 Weston Street, London SE1 3QD, UK
    Eur J Cancer 48:46-53. 2012
    ..The objective of this study was to examine differences in cancer survival between socioeconomic groups in England, with particular attention to survival in the short term of follow-up...
  35. pmc Association between levels of C-reactive protein and leukocytes and cancer: three repeated measurements in the Swedish AMORIS study
    Mieke Van Hemelrijck
    Cancer Epidemiology Group, Division of Cancer Studies, School of Medicine, King s College London, 3rd Floor, Bermondsey Wing, Guy s Hospital, London SE1 9RT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 20:428-37. 2011
    ..To study levels of C-reactive protein (CRP) and leukocytes, as inflammatory markers, in the context of cancer risk...
  36. doi request reprint Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, United Kingdom
    Cancer 117:2086-95. 2011
    ..In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose...
  37. ncbi request reprint Long-term distress after radical prostatectomy versus watchful waiting in prostate cancer: a longitudinal study from the Scandinavian Prostate Cancer Group-4 randomized clinical trial
    Anna Bill-Axelson
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Eur Urol 64:920-8. 2013
    ..Yet, overcoming patient selection forces is a formidable challenge for observational studies comparing treatment groups...
  38. ncbi request reprint Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study
    Wahyu Wulaningsih
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK
    BMC Public Health 13:663. 2013
    ..Meanwhile, limited data on the link between serum calcium and cancer risk is available. We investigated the relation between serum calcium and risk of different gastrointestinal cancers in a prospective study...
  39. doi request reprint Recent childbirth is an adverse prognostic factor in breast cancer and melanoma, but not in Hodgkin lymphoma
    Henrik Møller
    Cancer Epidemiology and Population Health, King s Health Partners Integrated Cancer Centre, Research Oncology, Bermondsey Wing, 3rd Floor, Guy s Hospital, Great Maze Pond, London SE1 9RT, UK Electronic address
    Eur J Cancer 49:3686-93. 2013
    ..The relationship between gestation, childbirth and cancer prognosis is unknown for most cancers (e.g. Hodgkin lymphoma), whereas a body of evidence exists for melanoma and breast cancer...
  40. doi request reprint Breast cancer survival in England, Norway and Sweden: a population-based comparison
    Henrik Møller
    King s College London, Division of Cancer Studies, Thames Cancer Registry, London, United Kingdom
    Int J Cancer 127:2630-8. 2010
    ..Our findings emphasise the importance of awareness of symptoms and early detection as the main strategy to improve breast cancer survival in the United Kingdom...
  41. doi request reprint Social differences in breast cancer survival in relation to patient management within a National Health Care System (Sweden)
    Sonja Eaker
    Department of Surgery, Uppsala University, Uppsala, Sweden
    Int J Cancer 124:180-7. 2009
    ....
  42. doi request reprint Primary cancers before and after prostate cancer diagnosis
    Mieke Van Hemelrijck
    Cancer Epidemiology Group, Division of Cancer Studies, School of Medicine, King s College London, London, United Kingdom
    Cancer 118:6207-16. 2012
    ..The occurrence of multiple cancers may indicate common etiology; and, although some studies have investigated the risk of second primary cancers after prostate cancer (PCa), there are no studies on cancers before PCa...
  43. pmc Gamma-glutamyl transferase and C-reactive protein as alternative markers of metabolic abnormalities and their associated comorbidites: a prospective cohort study
    Jennifer C Melvin
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group London, UK Regional Oncologic Centre, Uppsala University Uppsala, Sweden
    Int J Mol Epidemiol Genet 3:276-85. 2012
    ..We assessed the link between GGT, CRP and common metabolic abnormalities, as well their link to related diseases, such as cancer and cardiovascular disease (CVD)...
  44. pmc Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:431. 2011
    ..We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se...
  45. doi request reprint Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons - the Swedish AMORIS study
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, UK
    Eur J Cancer 47:2033-41. 2011
    ..We aimed to study the association between GGT and cancer in a large Swedish cohort with 37,809 primary cancers...
  46. ncbi request reprint Prognostic markers under watchful waiting and radical prostatectomy
    Lars Holmberg
    Regional Oncologic Center, University Hospital, Uppsala, Sweden
    Hematol Oncol Clin North Am 20:845-55. 2006
    ..Because overall prognostic information obtained by these parameters or by tumor stage was not provided in our publication, we now present these data in the two study arms separately...
  47. ncbi request reprint Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Obstetrics and Gynecology, Akademiska University Hospital, Uppsala, Sweden
    Gynecol Oncol 105:166-71. 2007
    ..Origin of metastases and time of detection in relation to surgery were recorded. Age at diagnosis, survival for ovarian metastasis compared to ovarian cancer and prognostic factors were evaluated...
  48. doi request reprint Cyclin B is an immunohistochemical proliferation marker which can predict for breast cancer death in low-risk node negative breast cancer
    Anthoula Koliadi
    Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden
    Acta Oncol 49:816-20. 2010
    ..Cyclin B is a proliferative marker easily assessed by immunohistochemistry. We wanted to examine cyclin B as a prognostic factor in low-risk breast cancer patients...
  49. doi request reprint Immunoglobulin E and cancer: a meta-analysis and a large Swedish cohort study
    Mieke Van Hemelrijck
    Cancer Epidemiology Group, King s College London, London, UK
    Cancer Causes Control 21:1657-67. 2010
    ..Our findings suggest the need for prospective studies studying IgE and cancer. Measurements of IgE should be combined with other information, e.g., bio-banked samples containing other key immunological discriminators...
  50. doi request reprint Sector resection with or without postoperative radiotherapy for stage I breast cancer: 20-year results of a randomized trial
    Asa Wickberg
    Åsa Wickberg, Anders Magnuson, Kenneth Villman, Göran Liljegren, Orebro University Hospital, Örebro Lars Holmberg, Uppsala University, Uppsala Hans Olov Adami, Karolinska Institutet, Stockholm, Sweden Lars Holmberg, King s College, London, United Kingdom Hans Olov Adami, Harvard School of Public Health, Boston, MA
    J Clin Oncol 32:791-7. 2014
    ..To investigate how radiotherapy (XRT) adds to tumor control using a standardized surgical technique with meticulous control of surgical margins in a randomized trial with 20 years of follow-up...
  51. pmc Mortality following Hip Fracture in Men with Prostate Cancer
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 8:e74492. 2013
    ..Hip fractures are associated with increased mortality and are a known adverse effect of androgen deprivation therapy (ADT) for prostate cancer (PCa). It was our aim to evaluate how mortality after hip fracture is modified by PCa and ADT...
  52. ncbi request reprint A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer
    Lars Holmberg
    Regional Oncologic Center, University Hospital, Uppsala, Sweden
    N Engl J Med 347:781-9. 2002
    ..Radical prostatectomy is widely used in the treatment of early prostate cancer. The possible survival benefit of this treatment, however, is unclear. We conducted a randomized trial to address this question...
  53. ncbi request reprint Borderline ovarian tumors in Sweden 1960-2005: trends in incidence and age at diagnosis compared to ovarian cancer
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Int J Cancer 123:1897-901. 2008
    ....
  54. doi request reprint Differences according to socioeconomic status in the management and mortality in men with high risk prostate cancer
    Anders Berglund
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 48:75-84. 2012
    ..Outcomes for many cancer forms are associated with socioeconomic status (SES).We investigated if SES was associated with management and mortality in men with high risk prostate cancer...
  55. doi request reprint Causes of death in men with prostate cancer: an analysis of 50,000 men from the Thames Cancer Registry
    Simon Chowdhury
    Department of Medical Oncology, Guy s Hospital, King s College London, London, UK
    BJU Int 112:182-9. 2013
    ..To investigate causes of death in a UK cohort of patients with prostate cancer...
  56. pmc Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS Study
    Wahyu Wulaningsih
    Cancer Epidemiology Group, Division of Cancer Studies, School of Medicine, King s College London, London, UK
    J Cancer Epidemiol 2012:792034. 2012
    ..Conclusion. The persistent link between TC and rectal cancer risk as well as between TG and oesophageal and colon cancer risk in normoglycaemic individuals may imply their substantiality in gastrointestinal carcinogenesis...
  57. doi request reprint Experiences of randomization: interviews with patients and clinicians in the SPCG-IV trial
    Anna Bill-Axelson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    Scand J Urol Nephrol 42:358-63. 2008
    ..This study investigated patients' and clinicians' experiences of randomization with the aim of facilitating trial participation in the future...
  58. doi request reprint Season of cancer diagnosis exerts distinct effects upon short- and long-term survival
    Rahul Roychoudhuri
    Thames Cancer Registry, Division of Cancer Studies, King s College London, Capital House, London, United Kingdom
    Int J Cancer 124:2436-41. 2009
    ..However, the distinct mortality reduction observed in the long term amongst those diagnosed in the autumn, especially amongst breast cancer patients, may indicate the presence of a seasonally variable protective mechanism...
  59. doi request reprint Dietary patterns and prostate cancer risk: report from the population based ULSAM cohort study of swedish men
    Erika Ax
    a Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Nutr Cancer 66:77-87. 2014
    ..In this study, a LCHP diet was associated with lower prostate cancer incidence. Relations emerged in adequate reporters, underscoring the importance of high-quality dietary data. ..
  60. doi request reprint Distribution of coronary artery stenosis after radiation for breast cancer
    Greger Nilsson
    Uppsala University, University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Oncol 30:380-6. 2012
    ..To study distribution of coronary artery stenosis among patients with breast cancer (BC) and to assess correlation between radiotherapy (RT) and location of stenosis...
  61. doi request reprint CD99 is a novel prognostic stromal marker in non-small cell lung cancer
    Karolina Edlund
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Int J Cancer 131:2264-73. 2012
    ..The results support the concept that stromal properties have an important impact on tumour progression...
  62. doi request reprint Hospital volume, proportion resected and mortality from oesophageal and gastric cancer: a population-based study in England, 2004-2008
    Victoria H Coupland
    King s College London, Thames Cancer Registry, 42, Weston Street, London SE1 3QD, UK
    Gut 62:961-6. 2013
    ..This study assessed the associations between hospital volume, resection rate and survival of oesophageal and gastric cancer patients in England...
  63. pmc Birth outcome in women with previously treated breast cancer--a population-based cohort study from Sweden
    Kristina Dalberg
    Department of Surgery and the Regional Oncologic Centre, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 3:e336. 2006
    ..The aim of this study was to assess the risk of adverse birth outcomes in women previously treated for invasive breast cancer compared with the general population of mothers...
  64. doi request reprint Regional differences in treatment and outcome in non-small cell lung cancer: a population-based study (Sweden)
    Gunnar Myrdal
    Department of Thoracic and Cardiovascular Surgery, Uppsala University Hospital, Uppsala, Sweden
    Lung Cancer 63:16-22. 2009
    ..Despite common guidelines there were marked differences in treatment activity between the counties. Treatment activity was associated with survival. Survival benefits may follow improvement in compliance to guidelines...
  65. ncbi request reprint No increased prostate cancer incidence after negative transrectal ultrasound guided multiple biopsies in men with increased prostate specific antigen and/or abnormal digital rectal examination
    Anna Bill-Axelson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    J Urol 170:1180-3. 2003
    ..We investigated the incidence of prostate cancer after negative transrectal ultrasound (TRUS) guided multiple biopsies. Our secondary aim was to calculate the sensitivity of the extended protocol used...
  66. pmc The occurrence of invasive cancers following a diagnosis of breast carcinoma in situ
    D Robinson
    Thames Cancer Registry, Division of Cancer Studies, King s College London, 1st Floor Capital House, 42 Weston Street, London SE1 3QD, UK
    Br J Cancer 99:611-5. 2008
    ..97 (95% ci 1.84-4.80)...
  67. pmc Serum lipid profiles and cancer risk in the context of obesity: four meta-analyses
    Jennifer C Melvin
    Cancer Epidemiology Group, Division of Cancer Studies, King s College London, School of Medicine, 3rd Floor, Bermondsey Wing, Guy s Hospital, London SE1 9RT, UK Regional Cancer Centre, Uppsala University Hospital, 751 85 Uppsala, Sweden
    J Cancer Epidemiol 2013:823849. 2013
    ..Future intervention studies involving lifestyle modification would provide insight into the potential biological role of lipid metabolism in tumorigenesis...
  68. doi request reprint Risk factors for metachronous contralateral breast cancer suggest two aetiological pathways
    Voralak Vichapat
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London SE1 9RT, UK
    Eur J Cancer 47:1919-27. 2011
    ..It may also imply that some CBCs are metastases from the first primary tumour, particularly in patients who present with recurrent disease before CBC...
  69. pmc The metabolic syndrome and the risk of prostate cancer under competing risks of death from other causes
    Birgitta Grundmark
    Regional Oncologic Centre, Uppsala University Hospital, Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 19:2088-96. 2010
    ..Using the National Cholesterol Education Program Adult Treatment panel III (NCEP) and International Diabetes Federation (IDF) definitions of the MetS, we investigated such associations taking competing risks of death into consideration...
  70. ncbi request reprint Neoadjuvant cisplatin-methotrexate chemotherapy for invasive bladder cancer -- Nordic cystectomy trial 2
    Amir Sherif
    Department of Urology, Akademiska University Hospital, Uppsala, Sweden
    Scand J Urol Nephrol 36:419-25. 2002
    ..The aim of this study was to investigate if solely neoadjuvant chemotherapy could influence survival in patients with advanced urothelial bladder cancer undergoing cystectomy...
  71. pmc Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival
    Helgi Birgisson
    Department of Surgical Sciences, Colorectal Surgery, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:438. 2011
    ..The aim of this study was to compare different survival endpoints in patients with primary colorectal cancer (CRC) and to understand the effect of second primary other cancer on disease-free survival (DFS) calculations...
  72. ncbi request reprint Ductal carcinoma in situ of the breast: a new phenotype classification system and its relation to prognosis
    F Warnberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Breast Cancer Res Treat 73:215-21. 2002
    ....
  73. pmc Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data
    Hanna Göransson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e6057. 2009
    ..Since tumor tissue invariably contains genetically normal stromal cells, this may lead to a failure to detect aberrations in the tumor cells...
  74. doi request reprint Plasma vitamin D and mortality in older men: a community-based prospective cohort study
    Karl Michaelsson
    Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:841-8. 2010
    ..Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death...
  75. pmc Failure to detect early breast cancer using in vitro nuclear magnetic resonance spectroscopy of plasma
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 68:389-92. 1993
    ..7 Hz). In vitro NMR spectroscopy in our hands was thus not a useful diagnostic tool in patients with early breast cancer...
  76. ncbi request reprint Trends in childhood and adolescent cancer survival in Sweden 1960 through 1984
    H O Adami
    Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden
    Acta Oncol 31:1-10. 1992
    ..Our data reflect the remarkable therapeutic improvements that have occurred for cancer in the young and indicate that these improvements have rapidly become available in Sweden...
  77. ncbi request reprint Preoperative serum levels of follicle stimulating hormone (FSH) and prognosis in invasive breast cancer
    M Eskelinen
    Regional Oncologic Center and Department of Surgery, University of Uppsala, Uppsala, Sweden
    Eur J Surg Oncol 30:495-500. 2004
    ..We investigated the association between preoperative serum levels of follicle stimulating hormone (FSH) and the prognosis in women with invasive breast cancer...
  78. doi request reprint Follow-up may not be beneficial after treatment of grade 1 breast cancer
    M Kontos
    Breast Unit, Guy s Hospital, London, UK
    Br J Surg 96:999-1004. 2009
    ..This study investigated the risk of locoregional recurrence and contralateral breast cancer in women treated for grade 1 breast cancer...
  79. ncbi request reprint Sector resection with and without radiotherapy in early breast cancer. Presentation of two ongoing prospective multicenter studies in Sweden. Uppsala/Orebro Breast Cancer Study Group
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 28:927-9. 1989
    ..Overall 5% of the women in the conservatively treated group and 22% of the mastectomized women are still suffering substantial psychosocial disturbance after 13 months...
  80. ncbi request reprint Role of surgery in invasive breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 34:625-8. 1995
    ....
  81. pmc Prognosis in bilateral breast cancer. Effects of time interval between first and second primary tumours
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 58:191-4. 1988
    ..The results indicate that the two tumours contribute independently to the patient's excess risk of dying and thus occur as two seemingly biologically unrelated events with respect to the tumour-host relationship and metastatic behaviour...
  82. ncbi request reprint Breast-conserving surgery without radiotherapy
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 34:681-3. 1995
    ..4) If the long-term--positive and negative--effects of radiotherapy were better quantified. Until we have new information, postoperative radiotherapy after breast conservation remains the standard...
  83. pmc Defining a high mortality risk group among women with primary breast cancer
    T Norden
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 69:520-4. 1994
    ..Women with no involved nodes and with three or four negative factors had a risk of dying from breast cancer similar to that of node-positive women with fewer than three...
  84. ncbi request reprint Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers
    S Sjogren
    Department of Oncology, Akademiska sjukhuset, Uppsala University, Sweden
    J Clin Oncol 16:462-9. 1998
    ..To investigate the prognostic and predictive value of c-erbB-2 overexpression in breast cancer in relation to other prognostic markers...
  85. pmc Population based case-control study of sick leave in postmenopausal women before diagnosis of hyperparathyroidism
    E Lundgren
    Department of Surgery, Uppsala University, S 751 85 Uppsala, Sweden
    BMJ 317:848-51. 1998
    ..To analyse sick leave in women at risk of primary hyperparathyroidism before its diagnosis...
  86. ncbi request reprint Intensified primary cancer care: a randomized study of home care nurse contacts
    B Johansson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Adv Nurs 30:1137-46. 1999
    ....
  87. ncbi request reprint Reduced utilisation of specialist care among elderly cancer patients: a randomised study of a primary healthcare intervention
    B Johansson
    Department of Public Health and Caring Sciences, Uppsala University, S 751 83 Uppsala, Sweden
    Eur J Cancer 37:2161-8. 2001
    ..The conclusion is that older cancer patients' utilisation of specialist care may be reduced by intensified primary healthcare services...
  88. ncbi request reprint Five-node biopsy of the axilla: an alternative to axillary dissection of levels I-II in operable breast cancer
    J Ahlgren
    Department of Oncology, University Hospital, Uppsala, S 751 85, Sweden
    Eur J Surg Oncol 28:97-102. 2002
    ..Less invasive ways to establish the axillary nodal status are therefore of interest, especially in women with low risk of nodal metastases...
  89. ncbi request reprint Pre-operative oestradiol levels - relation to survival in breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, MA, S 751 85, Sweden
    Eur J Surg Oncol 27:152-6. 2001
    ..However, few studies have information on plasma levels of hormones pre-operatively...
  90. pmc Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke
    G Nilsson
    Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden
    Br J Cancer 100:811-6. 2009
    ..Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke...
  91. doi request reprint Does immediate breast reconstruction using free flaps lead to delay in the administration of adjuvant chemotherapy for breast cancer?
    M Kontos
    Breast Unit, Guy s Hospital, London, UK
    Eur J Surg Oncol 36:745-9. 2010
    ..However, these are complex surgical procedures with more complications and longer recovery time, which can potentially delay adjuvant treatment. Our aim is to investigate the impact of free flap IBR on the timing of adjuvant treatment...
  92. ncbi request reprint Age as a determinant of axillary node involvement in invasive breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 31:533-8. 1992
    ..The findings indicate that the parallelism between the establishment of metastases in lymph nodes and at distant sites may vary with age. The prognostic value of nodal status may therefore depend on age at diagnosis...