A R Hipkiss

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi On the "struggle between chemistry and biology during aging"--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention
    A R Hipkiss
    Division of Biomolecular Sciences, Henriette Raphael House, GKT School of Biomedical Sciences, King s College London, UK
    Biogerontology 2:173-8. 2001
  2. ncbi Carnosine protects proteins against methylglyoxal-mediated modifications
    A R Hipkiss
    Molecular Biology and Biophysics Group, King s College London, United Kingdom
    Biochem Biophys Res Commun 248:28-32. 1998
  3. ncbi Pluripotent protective effects of carnosine, a naturally occurring dipeptide
    A R Hipkiss
    Molecular Biology and Biophysics Group, King s College London, Strand, United Kingdom
    Ann N Y Acad Sci 854:37-53. 1998
  4. ncbi A possible new role for the anti-ageing peptide carnosine
    A R Hipkiss
    Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, UK
    Cell Mol Life Sci 57:747-53. 2000
  5. ncbi Carnosine and protein carbonyl groups: a possible relationship
    A R Hipkiss
    Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, London SE1 1UL, UK
    Biochemistry (Mosc) 65:771-8. 2000
  6. ncbi Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
    A R Hipkiss
    Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Mech Ageing Dev 122:1431-45. 2001
  7. ncbi Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?
    A R Hipkiss
    Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, Guy s Campus London Bridge, London EC1 1UL, UK
    Biogerontology 1:217-23. 2000
  8. ncbi Reaction of carnosine with aged proteins: another protective process?
    Alan R Hipkiss
    GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, United Kingdom
    Ann N Y Acad Sci 959:285-94. 2002
  9. ncbi Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine
    J E Preston
    Institute of Gerontology, King s College London, UK
    Neurosci Lett 242:105-8. 1998
  10. ncbi Accumulation of altered proteins and ageing: causes and effects
    Alan R Hipkiss
    Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Experimental Therapeutics, Charterhouse Square, London EC1M 6BQ, UK
    Exp Gerontol 41:464-73. 2006

Detail Information

Publications21

  1. ncbi On the "struggle between chemistry and biology during aging"--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention
    A R Hipkiss
    Division of Biomolecular Sciences, Henriette Raphael House, GKT School of Biomedical Sciences, King s College London, UK
    Biogerontology 2:173-8. 2001
    ..These observations suggest that pluripotency may be a necessary pre-requisite for effective anti-ageing activity...
  2. ncbi Carnosine protects proteins against methylglyoxal-mediated modifications
    A R Hipkiss
    Molecular Biology and Biophysics Group, King s College London, United Kingdom
    Biochem Biophys Res Commun 248:28-32. 1998
    ..Our results show that carnosine can inhibit protein modification induced by a lysine-MG-AGE; this suggests a second intervention site for carnosine and emphasizes its potential as a possible non-toxic modulator of diabetic complications...
  3. ncbi Pluripotent protective effects of carnosine, a naturally occurring dipeptide
    A R Hipkiss
    Molecular Biology and Biophysics Group, King s College London, Strand, United Kingdom
    Ann N Y Acad Sci 854:37-53. 1998
    ....
  4. ncbi A possible new role for the anti-ageing peptide carnosine
    A R Hipkiss
    Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, UK
    Cell Mol Life Sci 57:747-53. 2000
    ..The various possible cellular fates of the carnosinylated proteins are discussed. These proposals may help explain anti-ageing actions of carnosine and its presence in non-mitotic cells of long-lived mammals...
  5. ncbi Carnosine and protein carbonyl groups: a possible relationship
    A R Hipkiss
    Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, London SE1 1UL, UK
    Biochemistry (Mosc) 65:771-8. 2000
    ..It is proposed that the anti-ageing and rejuvenating effects of carnosine are more readily explainable by its ability to react with protein carbonyls than its well-documented antioxidant activity...
  6. ncbi Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
    A R Hipkiss
    Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Mech Ageing Dev 122:1431-45. 2001
    ....
  7. ncbi Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?
    A R Hipkiss
    Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, Guy s Campus London Bridge, London EC1 1UL, UK
    Biogerontology 1:217-23. 2000
    ..The proposal may point to a hitherto unrecognised mechanism by which cells/organisms normally defend themselves against protein carbonyls...
  8. ncbi Reaction of carnosine with aged proteins: another protective process?
    Alan R Hipkiss
    GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, United Kingdom
    Ann N Y Acad Sci 959:285-94. 2002
    ....
  9. ncbi Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine
    J E Preston
    Institute of Gerontology, King s College London, UK
    Neurosci Lett 242:105-8. 1998
    ..Carnosine may therefore be a useful therapeutic agent...
  10. ncbi Accumulation of altered proteins and ageing: causes and effects
    Alan R Hipkiss
    Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Experimental Therapeutics, Charterhouse Square, London EC1M 6BQ, UK
    Exp Gerontol 41:464-73. 2006
    ..Other possible explanations for the age-related changes in the defence systems, enzymatic and non-enzymatic, which normally counter generation of altered proteins are also discussed...
  11. ncbi Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Biogerontology 9:49-55. 2008
    ..Variation in mitochondrial DNA composition and consequent mutation rate, arising from dietary-controlled differences in DNA precursor ratios, could also contribute to tissue differences in age-related mitochondrial dysfunction...
  12. ncbi Could carnosine or related structures suppress Alzheimer's disease?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 6BQ, UK
    J Alzheimers Dis 11:229-40. 2007
    ..These observations suggest that carnosine and related structures should be explored for therapeutic potential towards AD and other neurodegenerative disorders...
  13. ncbi On why decreasing protein synthesis can increase lifespan
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 128:412-4. 2007
    ..This increased availability of proteolytic and chaperone functions may thereby contribute to the observed increase in organism stress resistance and lifespan...
  14. ncbi Dietary restriction, glycolysis, hormesis and ageing
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1 6BQ, UK
    Biogerontology 8:221-4. 2007
    ..It is proposed that periods of fasting might be a more acceptable approach than permanent undernutrition in our attempts to slow human ageing, although timing of meals may prove important...
  15. ncbi Would carnosine or a carnivorous diet help suppress aging and associated pathologies?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
    Ann N Y Acad Sci 1067:369-74. 2006
    ..Olfactory administration of carnosine could provide a direct route to compromised tissue, avoiding serum carnosinases...
  16. ncbi Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, UK
    Biogerontology 6:147-9. 2005
    ..It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration...
  17. ncbi Glycation, ageing and carnosine: are carnivorous diets beneficial?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 126:1034-9. 2005
    ..The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed...
  18. ncbi Is carnosine a naturally occurring suppressor of oxidative damage in olfactory neurones?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Rejuvenation Res 7:253-5. 2004
    ..Should the peptide prove beneficial, olfactory carnosine administration could provide a direct route to compromised tissue, avoiding serum carnosinases...
  19. ncbi Do developmentally-related changes in constitutive proteolysis affect aberrant protein accumulation and generation of the aged phenotype?
    Alan R Hipkiss
    Department of Experimental Therapeutics, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 124:575-9. 2003
    ..It is proposed that developmentally-regulated diminution of constitutive proteolytic activities contribute to the onset of age-relate pathologies...
  20. ncbi Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain?
    Alan R Hipkiss
    Neurobiol Aging 23:645-6. 2002
  21. ncbi On methionine restriction, suppression of mitochondrial dysfunction and aging
    Alan R Hipkiss
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
    Rejuvenation Res 11:685-8. 2008
    ..Changes in SAM levels may also affect gene silencing. All the above may help explain, at least in part, the beneficial effects of MetR...