Michael A Heneghan

Summary

Affiliation: King's College Hospital
Country: UK

Publications

  1. ncbi Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, London, SE5 9RS, UK
    Int J Gastrointest Cancer 34:19-26. 2003
  2. ncbi Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis
    Michael A Heneghan
    Department of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    J Hepatol 45:584-91. 2006
  3. doi Increased model for end-stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs
    Matthew R Foxton
    Institute of Liver Studies, Kings College Hospital, London, UK
    Liver Transpl 16:668-77. 2010
  4. ncbi The association of pretransplant ferritin level with waiting list and post-transplant survival. Does ferritin actually predict outcome?
    Mohammad A B Al-Freah
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 26:1070-9. 2013
  5. doi The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 33:53-61. 2013
  6. ncbi Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival
    Timothy J S Cross
    Institute of Liver Studies, King s College Hospital, London, England
    Liver Transpl 13:1382-8. 2007
  7. doi Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration
    Alberto Quaglia
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 14:1437-48. 2008
  8. ncbi Impact of gender on the long-term outcome and survival of patients with autoimmune hepatitis
    Thawab Al-Chalabi
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    J Hepatol 48:140-7. 2008
  9. doi Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten-eleven translocation 2 mutations in Budd-Chiari syndrome and their impact on thrombotic complications post liver transplantation
    Rachel H Westbrook
    Institute of Liver Studies, King s College Hospital, National Health Service Foundation Trust, London, United Kingdom
    Liver Transpl 18:819-27. 2012
  10. doi Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience
    William Bernal
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 50:306-13. 2009

Collaborators

Detail Information

Publications48

  1. ncbi Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, London, SE5 9RS, UK
    Int J Gastrointest Cancer 34:19-26. 2003
    ..The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Genomic DNA was available from 98 patients with HCC, 77 familial controls, 97 controls from Hong Kong and 96 Northern European controls (NECs)...
  2. ncbi Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis
    Michael A Heneghan
    Department of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    J Hepatol 45:584-91. 2006
    ..Our aims were to evaluate the role of TPMT genotyping and phenotyping and to examine 6-TG and 6-MMP metabolite levels in patients with AIH...
  3. doi Increased model for end-stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs
    Matthew R Foxton
    Institute of Liver Studies, Kings College Hospital, London, UK
    Liver Transpl 16:668-77. 2010
    ..Use of MELD as a method of organ allocation results in significant increase in ICU cost after LT. Using TISS as surrogate marker for ICU costs reveals that the cost implications are related to the need for RRT and prolonged ICU stay...
  4. ncbi The association of pretransplant ferritin level with waiting list and post-transplant survival. Does ferritin actually predict outcome?
    Mohammad A B Al-Freah
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 26:1070-9. 2013
    ..030). Presence of graft siderosis (15.8% of patients) was not associated with survival. In conclusion, we found a limited role for SF as a prognostic indicator for pre- or post-transplant survival...
  5. doi The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 33:53-61. 2013
    ..An association between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) is well recognized. However, the disease course of IBD following liver transplantation (LT) for PSC remains ill-defined...
  6. ncbi Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival
    Timothy J S Cross
    Institute of Liver Studies, King s College Hospital, London, England
    Liver Transpl 13:1382-8. 2007
    ..In addition, patients over 65 yr experience less rejection, with good graft survival. Thus, LT should not be denied to patients>65 yr on the basis of age alone, once a comprehensive screen for comorbidity has been undertaken...
  7. doi Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration
    Alberto Quaglia
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 14:1437-48. 2008
    ..The likelihood of histological recovery appears to be minimal in livers with total hepatocyte loss at the time of ALT...
  8. ncbi Impact of gender on the long-term outcome and survival of patients with autoimmune hepatitis
    Thawab Al-Chalabi
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, UK
    J Hepatol 48:140-7. 2008
    ..Autoimmune hepatitis (AIH) predominantly affects women. Reasons for this are unclear and few series have assessed long-term outcomes of men with AIH...
  9. doi Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten-eleven translocation 2 mutations in Budd-Chiari syndrome and their impact on thrombotic complications post liver transplantation
    Rachel H Westbrook
    Institute of Liver Studies, King s College Hospital, National Health Service Foundation Trust, London, United Kingdom
    Liver Transpl 18:819-27. 2012
    ..005). In conclusion, the presence of JAK2V617F predicts hepatic and extrahepatic thrombotic complications after LT. Testing for TET2 mutations can identify another 7% of idiopathic BCS patients with molecular MPDs...
  10. doi Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience
    William Bernal
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 50:306-13. 2009
    ..Though emergency liver transplantation (ELT) is an established treatment for severe acute liver failure (ALF), outcomes are inferior to elective surgery. Despite prioritization, many patients deteriorate, becoming unsuitable for ELT...
  11. doi Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: Implications for follow-up and screening
    Andrew D Yeoman
    Institute of Liver Studies, King s College Hospital National Health Service NHS Foundation Trust, Denmark Hill, London, UK
    Hepatology 48:863-70. 2008
    ..5 months, range 12-195 months. Median survival in patients whose HCC was diagnosed on surveillance was 19 months (range 6-36 months) compared with 2 months (range 0-14 months) for patients presenting symptomatically (P = 0.042)...
  12. doi Liver transplantation in human immunodeficiency virus-infected patients: procoagulant, but is antithrombotic prophylaxis required?
    P Thomas Cherian
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Liver Transpl 18:82-8. 2012
    ..2%, P = 0.016 (Fisher's exact test)]. The minimization of complex arterial reconstruction, coagulopathy screening, and risk-adapted antithrombotic chemoprophylaxis appear to be reasonable precautions...
  13. doi Sclerosing cholangitis with granulocytic epithelial lesion: a benign form of sclerosing cholangiopathy
    Yoh Zen
    Institute of Liver Studies, GI and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
    Am J Surg Pathol 36:1555-61. 2012
    ..Although rare, the diagnosis of sclerosing cholangitis with GEL is important in view of its excellent and apparently sustained response to immunosuppressive treatment...
  14. doi Early predictors of corticosteroid treatment failure in icteric presentations of autoimmune hepatitis
    Andrew D Yeoman
    Institute of Liver Studies, Kings College Hospital NHS Trust Foundation Trust, Denmark Hill, London, UK
    Hepatology 53:926-34. 2011
    ..In total, four patients died in the treatment failure group compared with one in the responder group (4/13 = 31% versus 1/59 = 1.7%, P = 0.003)...
  15. ncbi Chronic mesenteric venous thrombosis: evaluation and determinants of survival during long-term follow-up
    David W Orr
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, England
    Clin Gastroenterol Hepatol 5:80-6. 2007
    ..Therapeutic options are limited, and are directed at the prevention of variceal bleeding and the control of abdominal pain related to gastrointestinal hyperemia...
  16. ncbi Change in model for end-stage liver disease score on the transplant waiting list predicts survival in patients undergoing liver transplantation
    Matthew R Foxton
    Institute of Liver Studies, Kings College Hospital, London, UK
    Transpl Int 19:988-94. 2006
    ....
  17. ncbi Pregnancy outcome after liver transplantation: a single-center experience of 71 pregnancies in 45 recipients
    Vimala Christopher
    Institute of Liver Studies, King s College Hospital, London, England
    Liver Transpl 12:1138-43. 2006
    ..However, delaying pregnancy until after 1-year post-LT is advisable, since doing so maybe associated with a lower risk of prematurity...
  18. ncbi Effects of serum aspartate aminotransferase levels in patients with autoimmune hepatitis influence disease course and outcome
    Thawab Al-Chalabi
    Institute of Liver Studies, King s College Hospital, London, England
    Clin Gastroenterol Hepatol 6:1389-95; quiz 1287. 2008
    ..This study evaluated whether serum AST levels of patients, determined at presentation, are associated with disease course or outcome...
  19. ncbi Hepatic dysfunction in sickle cell disease: a new system of classification based on global assessment
    Philip A Berry
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Clin Gastroenterol Hepatol 5:1469-76; quiz 1369. 2007
    ..Because previous attempts to describe patterns of liver disease have not reflected clinical experience, we aimed to characterize the presentation, clinicopathologic findings, and natural history of such patients...
  20. doi Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension
    Mark J Austin
    Institute of Liver Studies, King s College Hospital, London, England
    Liver Transpl 14:287-91. 2008
    ..This regimen may enable LT in similar patients in the future, without long-term consequences...
  21. doi Model for end-stage liver disease score predicts outcome in cirrhotic patients during pregnancy
    Rachel H Westbrook
    Institute of Liver Studies, King s College Hospital, NHS Foundation Trust, Denmark Hill, London, United Kingdom
    Clin Gastroenterol Hepatol 9:694-9. 2011
    ..Pregnancy is rare among patients with cirrhosis, and data about complications and outcomes are sparse. We evaluated the utility of prognostic models of severity of cirrhosis in determining outcomes in pregnant women with cirrhosis...
  22. ncbi Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group (IAIHG) criteria in acute and chronic liver disease
    Andrew D Yeoman
    Institute of Liver Studies, King s College Hospital NHS Foundation Trust, London, UK
    Hepatology 50:538-45. 2009
    ..The frequency of an overall diagnosis of AIH (probable or definite AIH) among the 70 patients with fulminant liver failure was 24% for simplified criteria and 40% for 1999 criteria, respectively...
  23. ncbi Autoimmune hepatitis (AIH) in the elderly: a systematic retrospective analysis of a large group of consecutive patients with definite AIH followed at a tertiary referral centre
    Thawab Al-Chalabi
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 45:575-83. 2006
    ..A few reports have suggested that AIH may be less severe in the elderly and may be underdiagnosed, but there is a paucity of data...
  24. doi Liver disease in pregnancy
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 375:594-605. 2010
    ..Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options...
  25. doi Outcomes of pregnancy in women with autoimmune hepatitis
    Rachel H Westbrook
    Institute of Liver Studies, King s College Hospital NHS Foundation Trust, London, United Kingdom
    J Autoimmun 38:J239-44. 2012
    ..We therefore reviewed all patients with AIH who reported pregnancy at our centre to identify any pre-conception factors that might predict adverse outcomes...
  26. ncbi De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant
    Michael A Heneghan
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 3:634-8. 2003
    ..No viable tumor was identified in the explanted liver. This case establishes that long-term complications associated with PSC and biliary-enteric surgery such as CCA may become apparent in new grafts post-transplant...
  27. doi Neutrophil gelatinase--associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation
    Andrew J Portal
    Institute of Liver Studies, Denmark Hill, London, England
    Liver Transpl 16:1257-66. 2010
    ..In conclusion, a combination of NGAL and APACHE II predicts AKI with high sensitivity and specificity after LT...
  28. ncbi HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study
    Peter T Donaldson
    School of Clinical Medical Sciences Hepatology, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, and Institute of Liver Studies, Kings College Hospital, London, UK
    Hepatology 44:667-74. 2006
    ..042, OR=0.65 in the UK patients; and 10% versus 31%, P=.00092, OR=0.25 in the Italian patients). In conclusion, a complex relationship exists between HLA and PBC, and some genetic associations may be population specific...
  29. ncbi Cost-effectiveness of pharmacotherapy for autoimmune hepatitis
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Expert Opin Pharmacother 7:145-56. 2006
    ..Moreover, the exact role of pharmacogenomics and genotyping of thiopurine methyltransferase in patients with autoimmune hepatitis needs to be fully defined...
  30. doi Spontaneous rupture of hepatocellular carcinoma: a Western experience
    Narendra Battula
    Institute of Liver Studies, King s College London School of Medicine, King s College Hospital, Denmark Hill, Camberwell, London, UK
    Am J Surg 197:164-7. 2009
    ..The reported overall mortality is < or =50% in Asian countries, where the incidence is 12% to 14%. The aim of this study was to report a single center's experience of patients with ruptured HCC during a 11-year period...
  31. ncbi Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection
    Steven L Condron
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    Transplantation 80:145-8. 2005
    ..Recent studies from selected centers have suggested that older donor age is associated with worse outcomes after transplantation for HCV...
  32. doi Autoimmune hepatitis
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital NHS Foundation Trust, Denmark Hill, London, UK Electronic address
    Lancet 382:1433-44. 2013
    ..Variant or overlapping syndromes are worthy of consideration when unexpected disease features arise. ..
  33. doi Management of hepatitis C in patients with chronic kidney disease
    Mohammad A B Al-Freah
    Institute of Liver Studies, King s College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, United Kingdom
    Curr Gastroenterol Rep 14:78-86. 2012
    ..However, this combination is challenging in patients with ESRD due to its tolerability. We describe in this review relevant issues in epidemiology, diagnosis and management of CHC in ESRD, HD and renal transplant recipients...
  34. doi Normal neurological outcome in two infants treated with exchange transfusions born to mothers with Crigler-Najjar Type 1 disorder
    Simon Hannam
    Department of Child Health, Kings College Hospital, London, SE5 9RS, UK
    Eur J Pediatr 168:427-9. 2009
    ..We propose that this intervention might have improved the neurological outcome of these infants...
  35. ncbi Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome
    Raj K Patel
    Department of Haematological Medicine, King s College Hospital, London, England
    Gastroenterology 130:2031-8. 2006
    ..A clonal mutation in JAK2 tyrosine kinase (JAK2V617F) occurs in a high proportion of patients with MPD and is of use in the characterization of latent MPD in BCS...
  36. ncbi An evaluation of long-term outcomes after liver transplantation for cryptogenic cirrhosis
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London, England
    Liver Transpl 9:921-8. 2003
    ..053, P =.0015). These results suggest that CC is a favorable indication for OLT and that although a proportion of patients develop inflammation in the liver allograft, this does not result in significant graft dysfunction or loss...
  37. ncbi The current status of living donor liver transplantation
    Janet E Tuttle-Newhall
    Liver Transplant Program, Duke University Medical Center, Durham, North Carolina, USA
    Curr Probl Surg 42:144-83. 2005
    ..He/she should also be assigned advocates who constantly promote the donor's best interest. Failure to adhere to strict donor evaluation protocols and standardized operative techniques could result in disastrous consequences...
  38. ncbi Current and novel immunosuppressive therapy for autoimmune hepatitis
    Michael A Heneghan
    Division of Gastroenterology, Duke University Medical Center, Durham NC 27710, USA
    Hepatology 35:7-13. 2002
    ..In this review we examine current management strategies of AIH, and evaluate available data pertaining to the use of novel immunosuppressive agents in this condition...
  39. ncbi An open pilot study of the effects of a human fibrin glue for endoscopic treatment of patients with acute bleeding from gastric varices
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SF5 9PJ, England
    Gastrointest Endosc 56:422-6. 2002
    ..Other agents, such as cyanoacrylate, have significant complication rates and can damage endoscopic equipment. The risk of prior-associated disease has caused concern regarding the use of bovine thrombin...
  40. ncbi Novel approaches to assessing renal function in cirrhotic liver disease
    Andrew J Portal
    Institute of Liver Studies, King s College Hospital, London, UK
    Hepatol Res 37:667-72. 2007
    ..This article reviews novel markers of renal function and their potential use in patients with liver disease...
  41. ncbi An examination of factors predicting prioritization for liver transplantation
    Andrew J Muir
    Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Liver Transpl 8:957-61. 2002
    ..In conclusion, these data show the wide range of practice patterns with the use of status 2A, and these findings suggest that certain patient groups might have received preference in the previous liver transplant allocation system...
  42. ncbi Transjugular biopsy of the liver in pediatric and adult patients using an 18-gauge automated core biopsy needle: a retrospective review of 410 consecutive procedures
    Tony P Smith
    Department of Radiology, Rm 1502, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    AJR Am J Roentgenol 180:167-72. 2003
    ..The aim of our study was to evaluate the safety and efficacy of transjugular biopsy of the liver in a large population of patients using an 18-gauge automated core biopsy needle...
  43. ncbi Fulminant hepatic failure
    Michael A Heneghan
    Duke University Medical Center, Durham, NC 27710, USA
    Semin Gastrointest Dis 14:87-100. 2003
    ..Also examined are management issues pertinent to these complex situations and the role of liver transplantation and liver assist devices are considered...
  44. ncbi Autoimmune hepatitis in men: examining the gender gap
    Michael A Heneghan
    Am J Gastroenterol 97:1870-2. 2002
  45. ncbi Type 1 autoimmune hepatitis in Turkish patients: absence of association with HLA B8
    Yasemin Kosar
    Gastroenterology Department, the Turkiye Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey
    J Clin Gastroenterol 35:185-90. 2002
    ..There is very little information about autoimmune hepatitis (AIH) in populations other than of white European or Japanese descent...
  46. ncbi Remission in autoimmune hepatitis: what is it, and can it ever be achieved?
    Thawab Al-Chalabi
    Am J Gastroenterol 102:1013-5. 2007
    ..The results illustrate the difficulties in relation to defining remission and relapse in patients with AIH and highlight the need for consistency in terminology...
  47. ncbi Of mice and women: toward a mouse model of autoimmune hepatitis
    Michael A Heneghan
    Hepatology 42:17-20. 2005
  48. ncbi Management of cirrhosis and ascites
    James P O'Beirne
    N Engl J Med 351:300-1; author reply 300-1. 2004