Adrian Hayday

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 065420, USA
    J Exp Med 198:747-55. 2003
  2. pmc Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite
    Elizabeth Ramsburg
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Exp Med 198:1403-14. 2003
  3. doi request reprint A long-playing CD about the γδ TCR repertoire
    Adrian Hayday
    Peter Gorer Department of Immunobiology, King s College London, London SE1 9RT, UK London Research Institute, Cancer Research UK, London WC2A 3LY, UK Medical Research Council Centre for Transplantation Biology, London SE1 9RT, UK Comprehensive Biomedical Research Centre of Guy s and St Thomas Hospitals and King s College London, London SE1 9RT, UK Electronic address
    Immunity 39:994-6. 2013
  4. pmc The biological activity of natural and mutant pTalpha alleles
    D Gibbons
    Guy s King s St Thomas Medical School, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
    J Exp Med 194:695-703. 2001
  5. ncbi request reprint gammadelta cells and the regulation of mucosal immune responses
    A C Hayday
    Peter Gorer Department of Immunobiology, Guy s, King s, and St Thomas Medical School, University of London, London, United Kingdom
    Am J Respir Crit Care Med 162:S161-3. 2000
  6. doi request reprint The habitual, diverse and surmountable obstacles to human immunology research
    Adrian C Hayday
    National Institute of Health Research Comprehensive Biomedical Research Centre, Guy s and St Thomas Hospitals Foundation Trust, and King s College London, UK
    Nat Immunol 9:575-80. 2008
  7. ncbi request reprint Immunoregulation in the tissues by gammadelta T cells
    Adrian Hayday
    Peter Gorer Department of Immunobiology, Guy s, King s and StThomas Medical School, King s College, London SE1 9RT, UK
    Nat Rev Immunol 3:233-42. 2003
  8. ncbi request reprint Gammadelta T cells and the lymphoid stress-surveillance response
    Adrian C Hayday
    London Research Institute, Cancer Research UK, Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunity 31:184-96. 2009
  9. pmc Brokering the peace: the origin of intestinal T cells
    A Hayday
    Peter Gorer Department of Immunobiology, King s College School of Medicine at Guy s Hospital, London, UK
    Mucosal Immunol 1:172-4. 2008
  10. ncbi request reprint Intraepithelial lymphocytes: exploring the Third Way in immunology
    A Hayday
    Peter Gorer Department of Immunobiology, GKT School of Medicine, University of London, Third floor New Guy s House, Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 2:997-1003. 2001

Collaborators

Detail Information

Publications53

  1. pmc The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 065420, USA
    J Exp Med 198:747-55. 2003
    ..As is likely to be the case in humans, this study also shows that the contribution of T cells to tumor immunosurveillance is regulated by modifier genes...
  2. pmc Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite
    Elizabeth Ramsburg
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Exp Med 198:1403-14. 2003
    ..This notwithstanding, the development of effective, pathogen-specific immunity in young mice requires alphabeta T cells, just as it does in adult mice...
  3. doi request reprint A long-playing CD about the γδ TCR repertoire
    Adrian Hayday
    Peter Gorer Department of Immunobiology, King s College London, London SE1 9RT, UK London Research Institute, Cancer Research UK, London WC2A 3LY, UK Medical Research Council Centre for Transplantation Biology, London SE1 9RT, UK Comprehensive Biomedical Research Centre of Guy s and St Thomas Hospitals and King s College London, London SE1 9RT, UK Electronic address
    Immunity 39:994-6. 2013
    ..2013) provides structural evidence for direct interactions of human Vδ1(+) T cell receptors with CD1d, capping a long trail of evidence that CD1 might be a major influence on γδ T cell biology...
  4. pmc The biological activity of natural and mutant pTalpha alleles
    D Gibbons
    Guy s King s St Thomas Medical School, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
    J Exp Med 194:695-703. 2001
    ..These data support a hypothesis that the primary role of pTalpha is to stabilize the pre-TCR, and that much of the conserved structure of pTalpha probably plays a critical regulatory role...
  5. ncbi request reprint gammadelta cells and the regulation of mucosal immune responses
    A C Hayday
    Peter Gorer Department of Immunobiology, Guy s, King s, and St Thomas Medical School, University of London, London, United Kingdom
    Am J Respir Crit Care Med 162:S161-3. 2000
    ..This has obvious implications for susceptibility to Th2-type allergic responses...
  6. doi request reprint The habitual, diverse and surmountable obstacles to human immunology research
    Adrian C Hayday
    National Institute of Health Research Comprehensive Biomedical Research Centre, Guy s and St Thomas Hospitals Foundation Trust, and King s College London, UK
    Nat Immunol 9:575-80. 2008
  7. ncbi request reprint Immunoregulation in the tissues by gammadelta T cells
    Adrian Hayday
    Peter Gorer Department of Immunobiology, Guy s, King s and StThomas Medical School, King s College, London SE1 9RT, UK
    Nat Rev Immunol 3:233-42. 2003
    ..In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells...
  8. ncbi request reprint Gammadelta T cells and the lymphoid stress-surveillance response
    Adrian C Hayday
    London Research Institute, Cancer Research UK, Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunity 31:184-96. 2009
    ....
  9. pmc Brokering the peace: the origin of intestinal T cells
    A Hayday
    Peter Gorer Department of Immunobiology, King s College School of Medicine at Guy s Hospital, London, UK
    Mucosal Immunol 1:172-4. 2008
    ..When this homeostasis is disrupted, IELs may also contribute to inflammatory and wound-healing responses. Given this, a strong interest in their origin is appropriate...
  10. ncbi request reprint Intraepithelial lymphocytes: exploring the Third Way in immunology
    A Hayday
    Peter Gorer Department of Immunobiology, GKT School of Medicine, University of London, Third floor New Guy s House, Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 2:997-1003. 2001
    ..An improved characterization of IELs would seem essential if we are to understand how immune responses and immunopathologies develop at body surfaces...
  11. ncbi request reprint [gamma][delta] cells: a right time and a right place for a conserved third way of protection
    A C Hayday
    Department of Immunobiology, Guy s King s St Thomas Medical School, King s College, University of London, United Kingdom
    Annu Rev Immunol 18:975-1026. 2000
    ..We conclude by considering which gammadelta cell functions may be most critical...
  12. ncbi request reprint The ins and outs of body surface immunology
    A Hayday
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas Medical School, University of London, Guy s Hospital, London, SE1 9RT, UK
    Science 290:97-100. 2000
    ..In some instances, these responses occur purely within the local body surface tissue, yet in other cases both local and systemic responses are elicited...
  13. ncbi request reprint Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development
    Angela Denzel
    Department of Immunobiology, New Guy s House, Guy s, King s and St Thomas s School of Medicine, London, United Kingdom
    J Immunol 171:519-23. 2003
    ..It can obviate the generation of multiple lines of mice expressing different levels of kinase transgenes and should permit specific biological effects to be associated with defined biochemical activities...
  14. pmc The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy
    Jessica Strid
    London Research Institute, Cancer Research UK, London WC2A 3LY, UK
    Science 334:1293-7. 2011
    ..These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis...
  15. pmc Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma
    Badri G Modi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 335:104-8. 2012
    ..Thus, tissue-associated DC can enhance chemical carcinogenesis via PAH metabolism, highlighting the complex relation between immune cells and carcinogenesis...
  16. pmc An NKG2D-mediated human lymphoid stress surveillance response with high interindividual variation
    Seema Shafi
    Peter Gorer Department of Immunobiology, King s College London, London SE19 RT, UK
    Sci Transl Med 3:113ra124. 2011
    ..These individual variations in LSS tuning may help explain patient-specific differences in tumor immune surveillance, transplant rejection, and inflammation, as well as provide insight into immune evasion and immunosuppression...
  17. doi request reprint Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, Research Oncology, Bermondsey Wing, Guy s Hospital, London, SE1 9RT, UK
    Cancer Causes Control 22:1011-9. 2011
    ..Since several etiological pathways have been proposed for PCa and lipids, we aimed to study this in a large Swedish cohort with 1,469 primary prostate cancers...
  18. ncbi request reprint Immunoglobulin E and cancer: a meta-analysis and a large Swedish cohort study
    Mieke Van Hemelrijck
    Cancer Epidemiology Group, King s College London, London, UK
    Cancer Causes Control 21:1657-67. 2010
    ..Our findings suggest the need for prospective studies studying IgE and cancer. Measurements of IgE should be combined with other information, e.g., bio-banked samples containing other key immunological discriminators...
  19. doi request reprint Suppression of airway inflammation by a natural acute infection of the intestinal epithelium
    D L Gibbons
    Programme in Infection and Immunity, Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, UK
    Mucosal Immunol 2:144-55. 2009
    ..They strongly support the hypothesis that airway allergies are naturally suppressed by both acute and chronic mucosal pathogens, but by different mechanisms...
  20. pmc Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: initiation via direct platelet signaling
    Tyler S Durazzo
    Department of Dermatology, Yale University, School of Medicine, New Haven, CT, USA
    Transfus Apher Sci 50:370-8. 2014
    ..These findings clarify how ECP directly stimulates DC maturation; suggest a new clinically applicable approach to the obtainment of DC; and identify a novel mechanism that may reflect physiological induction of DC. ..
  21. pmc Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway
    Pierre Vantourout
    Peter Gorer Department of Immunobiology, King s College London, London SE19RT, UK
    Sci Transl Med 6:231ra49. 2014
    ..Thus, therapeutics designed to limit cancer cell growth should also be considered in terms of their impact on immunosurveillance. ..
  22. pmc Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
    John Cardone
    Division of Immunology, Infection and Inflammatory Diseases, King s College London, Medical Research Council Centre for Transplantation, Guy s Hospital, London, UK
    Nat Immunol 11:862-71. 2010
    ..Nonetheless, coengagement of T cell antigen receptor (TCR) gammadelta and CD46 suppressed effector cytokine production, establishing that CD46 uses distinct mechanisms to regulate different T cell subsets during an immune response...
  23. pmc Six-of-the-best: unique contributions of γδ T cells to immunology
    Pierre Vantourout
    London Research Institute, Cancer Research UK, London WC2A 3LY, UK
    Nat Rev Immunol 13:88-100. 2013
    ..This underpins a revised perspective on lymphocyte biology and the regulation of immunogenicity...
  24. pmc Epithelial decision makers: in search of the 'epimmunome'
    Mahima Swamy
    London Research Institute, Cancer Research UK, London, UK
    Nat Immunol 11:656-65. 2010
    ..In this context, a research goal should be to identify all molecules used by epithelial cells to instruct immune cells. We term this the 'epimmunome'...
  25. ncbi request reprint The 5th EFIS Tatra Immunology Conference on 'Molecular determinants of T cell immunity' held in the High Tatra Mountains, Slovakia, September 7-11, 2002
    Angela Denzel
    Peter Gorer Department of Immunobiology, Guy s, King s and St Thomas Medical School, King s College, London, 3rd Floor New Guy s House, Guy s Hospital, London SE1 9RT, UK
    Immunol Lett 86:1-6. 2003
  26. pmc Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells
    P Chandler
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Immunology 85:531-7. 1995
    ....
  27. doi request reprint Risk of prostate cancer is not associated with levels of C-reactive protein and other commonly used markers of inflammation
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom
    Int J Cancer 129:1485-92. 2011
    ..This indicates need for international consensus on appropriate inflammatory markers in the context of cancer that may be practically applied in large studies...
  28. ncbi request reprint Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE)
    J Shires
    Peter Gorer Department of Immunobiology, Guy's, King's, and St. Thomas' Medical School, King's College, University of London, London Bridge, London SE1 9RT, United Kingdom
    Immunity 15:419-34. 2001
    ..Differentially expressed genes readily identify heterogeneity among TCRalphabeta+ IELs, whereas differences between resident TCRgammadelta+ IELs and TCRalphabeta+ IELs are less obvious...
  29. ncbi request reprint Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells
    K L Philpott
    Imperial Cancer Research Fund, London, United Kingdom
    Science 256:1448-52. 1992
    ..The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells...
  30. pmc Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells
    J L Viney
    Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 91:11948-52. 1994
    ....
  31. pmc T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment
    L Dianda
    Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 150:91-7. 1997
    ....
  32. ncbi request reprint Regulation of cutaneous malignancy by gammadelta T cells
    M Girardi
    Department of Dermatology and Yale Skin Diseases Research Core Center, King s College, London SE1 9RT, UK
    Science 294:605-9. 2001
    ..Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy...
  33. ncbi request reprint Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors
    Bruno Silva-Santos
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas Medical School, King s College, Guy s Hospital, London SE1 9RT, UK
    Science 307:925-8. 2005
    ..This finding provokes a revised view of the thymus, in which lymphoid tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages...
  34. ncbi request reprint Gammadelta T cell development--having the strength to get there
    Daniel J Pennington
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas Medical School, King s College, Guy s Hospital, London SE1 9RT, UK
    Curr Opin Immunol 17:108-15. 2005
    ..Studies on T cell receptor-mediated selection of gammadelta cells have supported the view that these unconventional T cells are positively rather than negatively selected on cognate self antigen...
  35. ncbi request reprint Key factors in the organized chaos of early T cell development
    Adrian C Hayday
    King s College School of Medicine at Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 8:137-44. 2007
    ..We also review new findings on the positive selection of gammadelta T cells and on extrathymic T cell development...
  36. ncbi request reprint Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant
    Julia M Lewis
    Department of Dermatology and Yale Skin Disease Research Core Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Nat Immunol 7:843-50. 2006
    ....
  37. pmc Anti-inflammatory effects in the skin of thymosin-beta4 splice-variants
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, Connecticut 06520, USA
    Immunology 109:1-7. 2003
    ..Thus, the activation-responsive expression of the lymph-specific form of Tbeta4 may be one mechanism by which DETC, and possibly other IELs, down-regulate local inflammation...
  38. ncbi request reprint Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage
    Cesar Trigueros
    Laboratory of Lymphocyte Molecular Biology, Cancer Research UK, London, England, UK
    Eur J Immunol 33:1968-77. 2003
    ....
  39. pmc Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520, USA
    J Exp Med 195:855-67. 2002
    ....
  40. pmc Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
    Diana Bellavia
    Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Proc Natl Acad Sci U S A 99:3788-93. 2002
    ..Together, these results suggest that the combined expression of Notch3 and pTalpha sustains T cell leukemogenesis and may represent pathognomonic molecular features of human T-ALL...
  41. ncbi request reprint The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells
    Daniel J Pennington
    Peter Gorer Department of Immunobiology, Guy s King s Saint Thomas Medical School, Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 4:991-8. 2003
    ..Thus, normal gammadelta cell development is dependent on the development of conventional alphabeta T cells...
  42. ncbi request reprint Genomics and immunology
    Adrian C Hayday
    Semin Immunol 15:201-8. 2003
  43. ncbi request reprint Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Invest Dermatol 122:699-706. 2004
    ..Collectively, these data illustrate which components of the alphabeta T cell response against SCC have protective potential, and indicate which aspects of tumor physiology may be most susceptible to their activities...
  44. ncbi request reprint Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Invest Dermatol 126:808-14. 2006
    ....
  45. ncbi request reprint Early events in the thymus affect the balance of effector and regulatory T cells
    Daniel J Pennington
    Peter Gorer Department of Immunobiology, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Nature 444:1073-7. 2006
    ..Unexpectedly, we found that the propensity of early TCR-alphabeta+ progenitors to differentiate into Foxp3+ Tr cells is also regulated in trans by CD4+CD8+ T-cell progenitor cells, before agonist selection...
  46. ncbi request reprint Reduced circulating CD4+CD25+ cell populations in Guillain-Barré syndrome
    Jane Pritchard
    Department of Clinical Neuroscience, King s College London School of Medicine, Guy s Campus, London SE1 1UL, UK
    J Neuroimmunol 183:232-8. 2007
    ..4%, 95% CI 1.1-1.8%, p=0.005. Since CD4+CD25+ cells include cells with special immunoregulatory functions, further investigation of this phenomenon and its relation to possible loss of regulatory T cell function in GBS is warranted...
  47. ncbi request reprint The integration of conventional and unconventional T cells that characterizes cell-mediated responses
    Daniel J Pennington
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas School of Medicine, King s College, University of London, London SE1 9RT, United Kingdom
    Adv Immunol 87:27-59. 2005
    ..Highlighting the fundamental nature of T-cell integration, we also review emerging data that the development of conventional and unconventional T cells is also highly integrated...
  48. pmc Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy
    David Vermijlen
    Peter Gorer Department of Immunobiology, Guy s, King s and St Thomas Medical School, King s College London, London, UK
    J Immunol 178:4304-14. 2007
    ....
  49. pmc Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    Francesco Dieli
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Cancer Res 67:7450-7. 2007
    ..Moreover, gammadelta cell phenotypes and possibly serum TRAIL may constitute novel biomarkers of prognosis upon therapy with zoledronate + IL-2 in metastatic carcinoma...
  50. ncbi request reprint Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
    Jessica Strid
    Peter Gorer Department of Immunobiology, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 9:146-54. 2008
    ..These results provide unique insight into the early phases of tissue immunosurveillance and indicate that acute changes in NKG2D ligands may alone initiate a rapid, multifaceted immunosurveillance response in vivo...
  51. pmc Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, 333 Cedar St, SHM I 308, New Haven, Connecticut 06510, USA
    Nat Genet 40:656-62. 2008
    ..Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes. These findings define a new family of proteins mediating key epithelial-immune interactions...
  52. pmc Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells
    Matthias Eberl
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Immunology 112:364-8. 2004
  53. ncbi request reprint Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    David E Oppenheim
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
    Nat Immunol 6:928-37. 2005
    ..Thus, NKG2D engagement is a natural mediator of immunosurveillance, which can be compromised by locally sustained ligand expression but potentially restored by innate immune activation...