Claire M A Haworth

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
  2. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
  3. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
  4. pmc Developmental origins of low mathematics performance and normal variation in twins from 7 to 9 years
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Twin Res Hum Genet 10:106-17. 2007
  5. doi request reprint Sex differences and science: the etiology of science excellence
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1113-20. 2009
  6. pmc The etiology of science performance: decreasing heritability and increasing importance of the shared environment from 9 to 12 years of age
    Claire M A Haworth
    SGDP Centre P080, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Child Dev 80:662-73. 2009
  7. pmc Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    J Am Acad Child Adolesc Psychiatry 49:783-93. 2010
  8. doi request reprint Generalist genes and high cognitive abilities
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre P080, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:437-45. 2009
  9. doi request reprint Increasing heritability of BMI and stronger associations with the FTO gene over childhood
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:2663-8. 2008
  10. doi request reprint Childhood obesity: genetic and environmental overlap with normal-range BMI
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:1585-90. 2008

Detail Information

Publications33

  1. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
    ..The purpose of the present study was to test the developmental origins of some of these associations in a large longitudinal sample of children...
  2. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  3. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...
  4. pmc Developmental origins of low mathematics performance and normal variation in twins from 7 to 9 years
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Twin Res Hum Genet 10:106-17. 2007
    ..We conclude that, despite the considerable differences in mathematics curricula from 7 to 9 years, the same genetic effects largely operate at the two ages...
  5. doi request reprint Sex differences and science: the etiology of science excellence
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1113-20. 2009
    ....
  6. pmc The etiology of science performance: decreasing heritability and increasing importance of the shared environment from 9 to 12 years of age
    Claire M A Haworth
    SGDP Centre P080, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Child Dev 80:662-73. 2009
    ..Understanding what these increasingly important shared environmental influences are could lead to interventions that encourage engagement in science throughout the lifespan...
  7. pmc Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    J Am Acad Child Adolesc Psychiatry 49:783-93. 2010
    ..We focus on findings that go beyond merely estimating heritability. We use learning abilities and disabilities as examples...
  8. doi request reprint Generalist genes and high cognitive abilities
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre P080, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:437-45. 2009
    ..However, a smaller proportion of the phenotypic intercorrelations appears to be explained by genetic influences for high abilities...
  9. doi request reprint Increasing heritability of BMI and stronger associations with the FTO gene over childhood
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:2663-8. 2008
    ..01 at age 11. These findings suggest that expression of FTO may become stronger throughout childhood. Increases in heritability may also be due to children increasingly selecting environments correlated with their genetic propensities...
  10. doi request reprint Childhood obesity: genetic and environmental overlap with normal-range BMI
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Obesity (Silver Spring) 16:1585-90. 2008
    ..To understand the overlap between the etiology of obesity and normal variation in BMI in children...
  11. ncbi request reprint Internet cognitive testing of large samples needed in genetic research
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 10:554-63. 2007
    ..We conclude that Internet testing can be reliable and valid for collecting cognitive test data on large samples even for children as young as 10 years...
  12. pmc Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 50:1318-25. 2009
    ..Here we assess whether this finding extends to language and general cognitive disabilities, as well as replicating the earlier finding for reading and mathematics in an older and larger sample...
  13. pmc Learning abilities and disabilities: generalist genes in early adolescence
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Cogn Neuropsychiatry 14:312-31. 2009
    ..A surprising finding emerging from multivariate quantitative genetic studies across diverse learning abilities is that most genetic influences are shared: they are "generalist", rather than "specialist"...
  14. pmc Socioeconomic status (SES) and children's intelligence (IQ): in a UK-representative sample SES moderates the environmental, not genetic, effect on IQ
    Ken B Hanscombe
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 7:e30320. 2012
    ..The evidence however is inconsistent. Other studies have reported an effect in the opposite direction (higher heritability in lower SES), or no moderation of the genetic effect on intelligence...
  15. pmc Added value measures in education show genetic as well as environmental influence
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, King s College London, London, United Kingdom
    PLoS ONE 6:e16006. 2011
    ..The pervasiveness of genetic influence in how and how much children learn is compatible with an active view of learning in which children create their own educational experiences in part on the basis of their genetic propensities...
  16. pmc First genome-wide association study on anxiety-related behaviours in childhood
    Maciej Trzaskowski
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e58676. 2013
    ....
  17. doi request reprint Dramatic increase in heritability of cognitive development from early to middle childhood: an 8-year longitudinal study of 8,700 pairs of twins
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Psychol Sci 20:1301-8. 2009
    ..57 and a shared environmental correlation of .65. These findings set constraints on how genetic and environmental variation affects the developing brain...
  18. pmc Common DNA markers can account for more than half of the genetic influence on cognitive abilities
    Robert Plomin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Sci 24:562-8. 2013
    ..66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities...
  19. pmc Chaotic homes and children's disruptive behavior: a longitudinal cross-lagged twin study
    Sara R Jaffee
    Institute of Psychiatry, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, King s College London, England
    Psychol Sci 23:643-50. 2012
    ..However, genetic influences on disruptive behavior did not explain why household chaos was heritable...
  20. pmc A twin study of the genetics of high cognitive ability selected from 11,000 twin pairs in six studies from four countries
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 39:359-70. 2009
    ..41-0.60). Shared environmental influences were moderate (0.28, 0.19-0.37). We conclude that genetic variation contributes substantially to high g in Australia, the Netherlands, the United Kingdom and the United States...
  21. pmc Chaotic homes and school achievement: a twin study
    Ken B Hanscombe
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 52:1212-20. 2011
    ....
  22. pmc Mathematical ability of 10-year-old boys and girls: genetic and environmental etiology of typical and low performance
    Yulia Kovas
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Learn Disabil 40:554-67. 2007
    ..We conclude that low mathematical performance is the quantitative extreme of the same genetic and environmental factors responsible for variation throughout the distribution...
  23. pmc Genetics of callous-unemotional behavior in children
    Essi Viding
    King s College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    PLoS ONE 8:e65789. 2013
    ..This GCTA ceiling is very low for CU in our study, despite its high twin study heritability estimate. The gap between GCTA and twin study heritabilities will make it challenging to identify genes responsible for the heritability of CU. ..
  24. pmc Twins Early Development Study (TEDS): a genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood
    Claire M A Haworth
    Institute of Psychiatry, King s College London, London, UK
    Twin Res Hum Genet 16:117-25. 2013
    ..TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond...
  25. pmc Stable genetic influence on anxiety-related behaviours across middle childhood
    Maciej Trzaskowski
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box PO80, De Crespigny Park, London SE5 8AF, UK
    J Abnorm Child Psychol 40:85-94. 2012
    ..In contrast, though more varied, heterotypic continuity between some traits (i.e. the change from one type of anxiety-related behaviour into another over time) was mainly due to shared-environmental factors...
  26. ncbi request reprint Genetic and environmental influences on children's food neophobia
    Lucy J Cooke
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Clin Nutr 86:428-33. 2007
    ..The design of effective interventions to improve children's diets would be facilitated by a better understanding of the determinants of neophobia...
  27. doi request reprint Common disorders are quantitative traits
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Nat Rev Genet 10:872-8. 2009
    ..Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits...
  28. pmc Strong Genetic Influence on a UK Nationwide Test of Educational Achievement at the End of Compulsory Education at Age 16
    Nicholas G Shakeshaft
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 8:e80341. 2013
    ....
  29. pmc A novel approach to genetic and environmental analysis of cross-lagged associations over time: the cross-lagged relationship between self-perceived abilities and school achievement is mediated by genes as well as the environment
    Yu L L Luo
    National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China
    Twin Res Hum Genet 13:426-36. 2010
    ..We discuss implications of finding that genetic factors contribute to the cross-lag between self-perceived abilities at age 9 and school achievement at age 12...
  30. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  31. ncbi request reprint The genetic and environmental origins of learning abilities and disabilities in the early school years
    Yulia Kovas
    Goldsmiths College, University of London, London, UK
    Monogr Soc Res Child Dev 72:vii, 1-144. 2007
    ..These conclusions have far-reaching implications for education and child development as well as for molecular genetics and neuroscience...
  32. pmc The genetic and environmental origins of learning abilities and disabilities in the early school years
    Yulia Kovas
    Goldsmiths College, University of London and SGDP Centre, Institute of Psychiatry
    Monogr Soc Res Child Dev 72:vii, 1-144. 2007
    ..These conclusions have far-reaching implications for education and child development as well as for molecular genetics and neuroscience...
  33. doi request reprint Obesity associated genetic variation in FTO is associated with diminished satiety
    Jane Wardle
    Health Behavior Research Centre, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 93:3640-3. 2008
    ..However, to date, it is not known whether the association between genetic variation in FTO and obesity is mediated through effects on energy intake or energy expenditure...