Deborah J Hart

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
  2. ncbi request reprint The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study
    Deborah J Hart
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 46:92-9. 2002
  3. ncbi request reprint Kellgren & Lawrence grade 1 osteophytes in the knee--doubtful or definite?
    D J Hart
    The Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Osteoarthritis Cartilage 11:149-50. 2003
  4. ncbi request reprint Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 54:533-9. 2006
  5. doi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
  6. doi request reprint The UK Adult Twin Registry (TwinsUK Resource)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Twin Res Hum Genet 16:144-9. 2013
  7. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
  8. pmc The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Ann Rheum Dis 70:1556-61. 2011
  9. ncbi request reprint Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Spine (Phila Pa 1976) 30:2445-51. 2005
  10. pmc Longitudinal study of variation in body mass index in middle-aged UK females
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital, London, SE1 7EH, UK
    Age (Dordr) 34:1285-94. 2012

Collaborators

Detail Information

Publications21

  1. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  2. ncbi request reprint The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study
    Deborah J Hart
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 46:92-9. 2002
    ..This study was undertaken to examine the association of bone mass with incident and progressive disease and to determine whether prior fractures influence the development of OA...
  3. ncbi request reprint Kellgren & Lawrence grade 1 osteophytes in the knee--doubtful or definite?
    D J Hart
    The Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Osteoarthritis Cartilage 11:149-50. 2003
    ..So called 'doubtful' osteophytes appear to be 'real' and significantly related to OA knee and therefore cannot be ignored or classified as normal...
  4. ncbi request reprint Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 54:533-9. 2006
    ....
  5. doi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
    ..We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women...
  6. doi request reprint The UK Adult Twin Registry (TwinsUK Resource)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Twin Res Hum Genet 16:144-9. 2013
    ..The scientific community now can freely access parts of the phenotype data from the 'TwinsUK', and interested researchers are encouraged to contact us via our Web site (www.twinsuk.ac.uk) for future collaborations...
  7. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
    ..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee...
  8. pmc The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Ann Rheum Dis 70:1556-61. 2011
    ..To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA)...
  9. ncbi request reprint Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Spine (Phila Pa 1976) 30:2445-51. 2005
    ..A candidate gene association study in a longitudinal cohort...
  10. pmc Longitudinal study of variation in body mass index in middle-aged UK females
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital, London, SE1 7EH, UK
    Age (Dordr) 34:1285-94. 2012
    ..Therefore, simply combining all individuals into groups by any other criteria (age, sex, etc.) and overlooking the distinctive patterns of BMI change may lead to biased inferences in epidemiologic and etiologic research of the future...
  11. doi request reprint Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
    Guangju Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Ann Rheum Dis 69:1227-31. 2010
    ..There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach...
  12. pmc Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study
    Gregory Livshits
    King s College London, London, UK
    Arthritis Rheum 60:2037-45. 2009
    ....
  13. doi request reprint Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
    Arthritis Rheum 62:2347-52. 2010
    ..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans...
  14. pmc Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 70:349-55. 2011
    ..It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component...
  15. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  16. pmc Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity
    Theodosios Kyriakou
    Nutritional Sciences Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, UK
    J Hum Genet 53:718-27. 2008
    ..2 kb of the ADIPOQ promoter region was cloned in a luciferase reporter plasmid, and the four haplotypes were transfected in differentiated 3T3-L1 adipocytes. No significant allelic effects on promoter activity were found...
  17. ncbi request reprint Association study of candidate genes for the prevalence and progression of knee osteoarthritis
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 50:2497-507. 2004
    ..We examined the role of 26 single-nucleotide polymorphisms (SNPs) from 24 candidate genes in OA susceptibility and progression...
  18. doi request reprint Effects of age on genetic influence on bone loss over 17 years in women: the Healthy Ageing Twin Study (HATS)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    J Bone Miner Res 27:2170-8. 2012
    ..Whereas genetic factors appear to have an important role in bone loss in early postmenopausal women, nongenetic mechanisms become more important determinants of bone loss with advanced age...
  19. pmc Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis
    Ben H Mullin
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia
    Am J Hum Genet 82:1262-9. 2008
    ..In conclusion, genetic variation in ARHGEF3 plays a role in the determination of bone density in Caucasian women. This data implicates the RhoGTPase-RhoGEF pathway in osteoporosis...
  20. ncbi request reprint Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study
    Paolo Bettica
    Procter and Gamble Pharmaceuticals, Staines, UK
    Arthritis Rheum 46:3178-84. 2002
    ....
  21. pmc Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19
    Gregory Livshits
    Tel Aviv University, Tel Aviv, Israel
    Ann Rheum Dis 66:623-7. 2007
    ..The purpose of this study was to conduct a whole-genome linkage scan to identify susceptibility loci for idiopathic hand OA in a large, population-based sample of females...