Research Topics
| Matthew S GrubbSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Building and maintaining the axon initial segmentMatthew S Grubb
MRC Centre for Developmental Neurobiology, King s College London, 4th Floor, New Hunt s House, Guy s Campus, London SE1 1UL, UK
Curr Opin Neurobiol 20:481-8. 2010....
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitabilityMatthew S Grubb
MRC Centre for Developmental Neurobiology, King s College London, 4th Floor, New Hunt s House, Guy s Campus, London SE1 1UL, UK
Nature 465:1070-4. 2010..This novel form of activity-dependent plasticity may fine-tune neuronal excitability during development...
Channelrhodopsin-2 localised to the axon initial segmentMatthew S Grubb
Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
PLoS ONE 5:e13761. 2010....
Short- and long-term plasticity at the axon initial segmentMatthew S Grubb
MRC Centre for Developmental Neurobiology, King s College London, London SE11UL, United Kingdom
J Neurosci 31:16049-55. 2011..Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction...
Multi-site optical excitation using ChR2 and micro-LED arrayNir Grossman
Institute of Biomedical Engineering, Imperial College, London, UK Devision of Neuroscience, Imperial College, London, UK
J Neural Eng 7:16004. 2010..We first describe the design and fabrication of the system and characterize its capabilities. We then demonstrate its capacity to elicit precise electrophysiological responses in cultured and slice neurons expressing ChR2...
Photocycles of channelrhodopsin-2Konstantin Nikolic
Institute of Biomedical Engineering, Imperial College London, London, UK
Photochem Photobiol 85:400-11. 2009..The crucial insight provided by the analysis of the new model is that it reveals an adaptation mechanism of the ChR2 molecule. Hence very simple organisms expressing ChR2 can use this form of light adaptation...
