Hannah J Gould

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells
    Sophia N Karagiannis
    Randall Division of Cell and Molecular Biophysics, King s College London, Room 3 8, New Hunt s House, Guy s Campus, St Thomas s Street, London, SE1 1UL, UK
    Cancer Immunol Immunother 57:247-63. 2008
  2. pmc Cytokinergic IgE Action in Mast Cell Activation
    Heather J Bax
    Randall Division of Cell and Molecular Biophysics, King s College London London, UK
    Front Immunol 3:229. 2012
  3. doi request reprint IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
  4. ncbi request reprint The allergic march from Staphylococcus aureus superantigens to immunoglobulin E
    Hannah J Gould
    Divisions of Cell and Molecular Biophysics and Allergy, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College, London, UK
    Chem Immunol Allergy 93:106-36. 2007
  5. ncbi request reprint Germinal-centre reactions in allergic inflammation
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, King s College London, UK
    Trends Immunol 27:446-52. 2006
  6. ncbi request reprint The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
  7. ncbi request reprint IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells
    Sophia N Karagiannis
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London, United Kingdom
    J Immunol 179:2832-43. 2007
  8. pmc Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E
    Daopeng Yuan
    King s College London and the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London, SE1 1UL, United Kingdom
    J Biol Chem 288:21667-77. 2013
  9. pmc Conformational plasticity at the IgE-binding site of the B-cell receptor CD23
    Balvinder Dhaliwal
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London SE1 1UL, UK MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK Electronic address
    Mol Immunol 56:693-7. 2013
  10. pmc Soluble CD23 controls IgE synthesis and homeostasis in human B cells
    Alison M Cooper
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London SE1 9RT, UK
    J Immunol 188:3199-207. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells
    Sophia N Karagiannis
    Randall Division of Cell and Molecular Biophysics, King s College London, Room 3 8, New Hunt s House, Guy s Campus, St Thomas s Street, London, SE1 1UL, UK
    Cancer Immunol Immunother 57:247-63. 2008
    ..Harnessing IgE receptors to target tumor cells suggests the potential of tumor-specific IgE antibodies to activate effector cells in immunotherapy of ovarian cancer...
  2. pmc Cytokinergic IgE Action in Mast Cell Activation
    Heather J Bax
    Randall Division of Cell and Molecular Biophysics, King s College London London, UK
    Front Immunol 3:229. 2012
    ..We consider also the important implications that the existence of cytokinergic IgE may have for a fuller understanding of adaptive immunity and of the action of IgE in asthma and other diseases...
  3. doi request reprint IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    ..The information that has emerged suggests new therapeutic directions for combating allergic disease...
  4. ncbi request reprint The allergic march from Staphylococcus aureus superantigens to immunoglobulin E
    Hannah J Gould
    Divisions of Cell and Molecular Biophysics and Allergy, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College, London, UK
    Chem Immunol Allergy 93:106-36. 2007
    ..Moreover, S. aureus superantigens inhibit the activity of T regulatory cells that normally control inflammation, and generate a state of steroid resistance that confounds treatment of allergic disorders and airway disease...
  5. ncbi request reprint Germinal-centre reactions in allergic inflammation
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, King s College London, UK
    Trends Immunol 27:446-52. 2006
    ..Germinal-centre-like reactions are well-documented in the target organs of autoimmune diseases. Here, we review recent evidence that they also occur at sites of allergic inflammation...
  6. ncbi request reprint The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
    ..Effective mechanisms ensure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic anaphylaxis...
  7. ncbi request reprint IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells
    Sophia N Karagiannis
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London, United Kingdom
    J Immunol 179:2832-43. 2007
    ..These results demonstrate that IgE Abs can engage cell surface IgE receptors and activate effector cells against ovarian tumor cells. Our findings offer a framework for an improved immunotherapeutic strategy for combating solid tumors...
  8. pmc Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E
    Daopeng Yuan
    King s College London and the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London, SE1 1UL, United Kingdom
    J Biol Chem 288:21667-77. 2013
    ..Taken together, these results suggest that binding of Ca(2+) brings an extra degree of modulation to CD23 function. ..
  9. pmc Conformational plasticity at the IgE-binding site of the B-cell receptor CD23
    Balvinder Dhaliwal
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London SE1 1UL, UK MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK Electronic address
    Mol Immunol 56:693-7. 2013
    ..We have determined the structures of the C-type lectin "head" domain of CD23 from seven crystal forms. The thirty-five independent structures reveal extensive conformational plasticity in two loops that are critical for IgE binding...
  10. pmc Soluble CD23 controls IgE synthesis and homeostasis in human B cells
    Alison M Cooper
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London SE1 9RT, UK
    J Immunol 188:3199-207. 2012
    ..We interpret these results with the aid of a model for the upregulation of IgE by sCD23...
  11. ncbi request reprint Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
    Heather A Coker
    The Randall Division of Cell and Molecular Biophysics, King s College London, London
    J Allergy Clin Immunol 116:445-52. 2005
    ..The expressed IgE VH genes also undergo somatic hypermutation in situ to generate clonal families. The antigenic driving force behind these events is unknown...
  12. ncbi request reprint Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI
    James Hunt
    Randall Division of Cell and Molecular Biophysics and the Division of Asthma, Allergy and Lung Biology, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 280:16808-14. 2005
    ....
  13. pmc Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction
    Susmita Borthakur
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 287:31457-61. 2012
    ..The mutually inhibitory nature of receptor binding provides a degree of autonomy for the individual activities mediated by IgE-FcεRI and IgE-CD23 interactions...
  14. ncbi request reprint Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
    Pooja Takhar
    The Randall Division, King s College London, London, United Kingdom
    J Immunol 174:5024-32. 2005
    ..These results demonstrate that allergen stimulates local CSR to IgE, revealing a potential target for topical therapies in allergic rhinitis...
  15. ncbi request reprint Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma
    Pooja Takhar
    Randall Division of Cell and Molecular Biophysics, King s College London, UK
    J Allergy Clin Immunol 119:213-8. 2007
    ..It is generally believed that class switch recombination occurs in lymphoid tissue, but it was recently shown that class switching to IgE occurs in the nasal mucosa in allergic rhinitis...
  16. ncbi request reprint Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells
    Natalie McCloskey
    Medical Research Council Asthma UK Centre in Allergic Mechanisms of Asthma and the Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 282:24083-91. 2007
    ..We show that the monomers inhibit and the oligomer stimulates IgE synthesis in human B cells after heavy chain switching to IgE. CD23 fragments could be targets for therapeutic intervention in allergic disease...
  17. pmc Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo
    James Hunt
    King s College London, Medical Research Council, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 283:29882-7. 2008
    ..We have therefore demonstrated that the high affinity of IgE for FcepsilonRI is critical to the allergic response, and that even moderate attenuation of this affinity has a substantial effect in vivo...
  18. doi request reprint Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application
    Sophia N Karagiannis
    NIHR Biomedical Research Centre at Guy s and St Thomas s Hospitals and King s College London, London, UK
    Cancer Immunol Immunother 61:1547-64. 2012
    ..On-going efficacy, safety evaluations and future first-in-man clinical studies of IgE therapeutics constitute key metrics for this concept, providing new scope for antibody immunotherapies for solid tumours...
  19. pmc Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells
    Panagiotis Karagiannis
    Cutaneous Medicine and Immunotherapy Unit, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Tower, Guy s Hospital, London, UK
    Cancer Immunol Immunother 58:915-30. 2009
    ..These functional characteristics of trastuzumab IgE, some distinct from those of trastuzumab, indicate its potential to complement or improve upon the existing clinical benefits of trastuzumab...
  20. pmc Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
    Mary D Holdom
    King s College London, Randall Division of Cell and Molecular Biophysics, London, UK
    Nat Struct Mol Biol 18:571-6. 2011
    ....
  21. doi request reprint Avian IgY binds to a monocyte receptor with IgG-like kinetics despite an IgE-like structure
    Alexander I Taylor
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 283:16384-90. 2008
    ..Whatever the function of this extra domain pair in avian IgY, it has persisted for at least 310 million years and has been co-opted in mammalian IgE to generate a uniquely slow dissociation rate and high affinity...
  22. pmc Structural determinants of unique properties of human IgG4-Fc
    Anna M Davies
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, United Kingdom Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 9RT, United Kingdom Electronic address
    J Mol Biol 426:630-44. 2014
    ..These Fc-Fc interactions are compatible with intact IgG4 molecules and may provide a model for the formation of aggregates of IgG4 that can cause disease pathology in the absence of antigen...
  23. pmc Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI
    Balvinder Dhaliwal
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 109:12686-91. 2012
    ..We demonstrate experimentally the reciprocal inhibition of CD23 and FcεRI binding in solution and suggest that the mutual exclusion of receptor binding allows IgE to function independently through its two receptors...
  24. ncbi request reprint Three-colour flow cytometric method to measure antibody-dependent tumour cell killing by cytotoxicity and phagocytosis
    Marguerite Bracher
    Randall Division of Cell and Molecular Biophysics, Kings College London, New Hunts House, London, United Kingdom
    J Immunol Methods 323:160-71. 2007
    ..We illustrate the new method by analysing human monocyte-mediated cytotoxic and phagocytic cell killing of IGROV1 ovarian tumour cells by the ovarian tumour antigen-specific anti-folate binding protein monoclonal antibody, MOv18 IgE...
  25. ncbi request reprint The crystal structure of IgE Fc reveals an asymmetrically bent conformation
    Tommy Wan
    The Randall Centre, King s College London, New Hunt s House, London SE1 1UL, UK
    Nat Immunol 3:681-6. 2002
    ..This may be the basis of the exceptionally slow dissociation rate of the IgE-Fc epsilon RI complex and, thus, of the ability of IgE to cause persistent allergic sensitization of mast cells...
  26. pmc Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
    Muslima Chowdhury
    Randall Division of Cell and Molecular Biophysics, King s College London, St Thomas Street, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 105:15872-7. 2008
    ..These data demonstrates that the Ig locus is maintained with a complex pattern of both positive and negative histone marks and suggest that some of these marks may have dual functions...
  27. ncbi request reprint Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells
    Sophia N Karagiannis
    The Randall Centre, King s College London, London, GB
    Eur J Immunol 33:1030-40. 2003
    ..We observed phagocytosis of tumor cells by the monocytes in vitro. Our results suggest that tumor-specific IgE antibodies may be exploited for immunotherapy of cancer...
  28. ncbi request reprint Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy
    Louisa K James
    Randall Division of Cell and Molecular Biophysics, King s College London, London, United Kingdom
    J Allergy Clin Immunol 130:663-670.e3. 2012
    ....
  29. ncbi request reprint Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination
    David J Fear
    The Randall Center, King s College London, United Kingdom
    J Immunol 173:4529-38. 2004
    ..We have also found that the levels of germline gene transcription cannot fully account for the levels of secretion of the different Ig isotypes, and that secretion of IgE, in particular, is suppressed relative to that of IgG...
  30. ncbi request reprint Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
    Heather A Coker
    The Randall Centre, King s College London, London, United Kingdom
    J Immunol 171:5602-10. 2003
    ....
  31. pmc A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene
    Georgina Lang
    The Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, UK
    Immunology 114:25-36. 2005
    ..Interaction of B-Myb with HSS8 may enhance bcl-2 gene expression by co-operating with positive regulatory elements (e.g. previously identified B-Myb response elements) or silencing negative response elements in the bcl-2 gene promoter...
  32. ncbi request reprint Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding
    Graham A Mackay
    Randall Centre, New Hunt s House, King s College London, Guy s Campus, London, United Kingdom
    J Immunol 168:1787-95. 2002
    ....
  33. doi request reprint Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange
    Anna M Davies
    King s College London, Randall Division of Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom
    Mol Immunol 54:1-7. 2013
    ..This suggests a mechanism by which Arg409 weakens the C(H)3 interface in IgG4, predisposing this human antibody subclass to Fab-arm exchange...
  34. ncbi request reprint Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics
    Duncan R Wilson
    Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 165:22-6. 2002
    ..These data indicate that allergen provocation results in a selective local accumulation of isotype-specific and allergen-specific IgE antibody within the bronchi, independent of alterations in circulating IgE...
  35. pmc Comprehensive FISH probe design tool applied to imaging human immunoglobulin class switch recombination
    Jakub Nedbal
    Randall Division of Cell and Molecular Biophysics, King s College London, London, United Kingdom
    PLoS ONE 7:e51675. 2012
    ..This novel technique offers the possibility of gaining unprecedented insight into the molecular mechanisms involved in class switch recombination...
  36. pmc Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies
    Amy E Gilbert
    Cutaneous Medicine and Immunotherapy Unit, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy s and St Thomas s Hospitals and King s College London, King s College London School of Medicine, St John s Institute of Dermatology, Guy s Hospital, King s College London, London, United Kingdom
    PLoS ONE 6:e19330. 2011
    ....
  37. pmc The structure of human CD23 and its interactions with IgE and CD21
    Richard G Hibbert
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England, UK
    J Exp Med 202:751-60. 2005
    ..The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease...
  38. ncbi request reprint Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus
    Rengasamy Asokan
    Department of Medicine and Department of Immunology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:383-94. 2006
    ....