Genomes and Genes
Affiliation: King's College London
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010..Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated...
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsJerome Cros
U838 INSERM, Universite Paris Descartes, Paris, France
Immunity 33:375-86. 2010..Thus, CD14(dim) cells are bona fide monocytes involved in the innate local surveillance of tissues and the pathogenesis of autoimmune diseases...
- Unravelling mononuclear phagocyte heterogeneityFrederic Geissmann
King s College London, Guy s Campus, London SE1 1UL, UK
Nat Rev Immunol 10:453-60. 2010..Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research...
- A lineage of myeloid cells independent of Myb and hematopoietic stem cellsChristian Schulz
Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 336:86-90. 2012..These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny...
- Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cellsGina J Walter
King s College London, London, UK
Arthritis Rheum 65:627-38. 2013....
- Development and homeostasis of "resident" myeloid cells: the case of the microgliaElisa Gomez Perdiguero
Centre for Molecular and Cellular Biology of Inflammation, King s College London, Great Maze Pond, London, United Kingdom
Glia 61:112-20. 2013..This suggests the existence of tissue resident macrophage "stem cells" within tissues such as the brain, and opens a new era for the molecular and cellular understanding of myeloid cells responses during acute and chronic inflammation...
- Development and homeostasis of 'resident' myeloid cells: the case of the Langerhans cellLaurent Chorro
Centre for Molecular and Cellular Biology of Inflammation CMCBI, New Hunt s House, King s College London, Great Maze Pond, SE1 1UL, London, UK
Trends Immunol 31:438-45. 2010..Beyond LC biology, we propose that YS and HSCs can contribute to the development of distinct subsets of macrophages and DCs...
- Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC networkLaurent Chorro
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
J Exp Med 206:3089-100. 2009..This mechanism may be relevant in locations where leukocyte trafficking is limited...
- Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromesJacqueline M Tabler
Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King s College London, London SE1 9RT, UK
Dev Cell 25:623-35. 2013..Thus, our findings elucidate the etiology for a common craniofacial anomaly and identify links between two classes of human disease: FGF-hyperactivation syndromes and ciliopathies. ..
- Nr4a1-Dependent Ly6C(low) Monocytes Monitor Endothelial Cells and Orchestrate Their DisposalLeo M Carlin
Centre for Molecular and Cellular Biology of Inflammation, King s College London, London SE1 1UL, UK Peter Gorer Department of Immunobiology, King s College London, London SE1 1UL, UK
Cell 153:362-75. 2013..Therefore, Ly6C(low) monocytes are intravascular housekeepers that orchestrate the necrosis by neutrophils of endothelial cells that signal a local threat sensed via TLR7 followed by the in situ phagocytosis of cellular debris...
- FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cellsAnn L Jagger
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
J Autoimmun 38:29-38. 2012....
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010....
- Monocytes control natural killer cell differentiation to effector phenotypesKatrina Soderquest
Medical Research Council Centre for Transplantation, King s College London, London, UK
Blood 117:4511-8. 2011..Together, these data reveal a novel, unrecognized role for Txb21 expression in monocytes in promoting NK-cell development and help appreciate how various NK-cell subsets are generated and participate in antitumor immunity...