Genomes and Genes
Affiliation: King's College London
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010..Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated...
- B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric diseaseTakeshi Satoh
School of Medicine, Centre for Molecular and Cellular Biology of Inflammation CMCBI, King s College London, London, United Kingdom
PLoS ONE 7:e33891. 2012..Here we confirm their findings and report the identification of two novel B-RAF mutations detected in LCH patients...
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsJerome Cros
U838 INSERM, Universite Paris Descartes, Paris, France
Immunity 33:375-86. 2010..Thus, CD14(dim) cells are bona fide monocytes involved in the innate local surveillance of tissues and the pathogenesis of autoimmune diseases...
- Unravelling mononuclear phagocyte heterogeneityFrederic Geissmann
King s College London, Guy s Campus, London SE1 1UL, UK
Nat Rev Immunol 10:453-60. 2010..Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research...
- CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammationCedric Auffray
Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Santé et de la Recherche Médicale U838, Universite Paris Descartes, 75015 Paris, France
J Exp Med 206:595-606. 2009..CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs...
- A lineage of myeloid cells independent of Myb and hematopoietic stem cellsChristian Schulz
Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 336:86-90. 2012..These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny...
- Blood monocytes: development, heterogeneity, and relationship with dendritic cellsCedric Auffray
INSERM U838, Universite Paris Descartes, 75015 Paris, France
Annu Rev Immunol 27:669-92. 2009..Functional characterization of monocytes is in progress in humans and rodents and will provide a better understanding of the pathophysiology of inflammation...
- Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunityCheng Lung Ku
Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
J Exp Med 204:2407-22. 2007..Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria...
- A clonogenic bone marrow progenitor specific for macrophages and dendritic cellsDarin K Fogg
INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
Science 311:83-7. 2006..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS...
- Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cellsGina J Walter
King s College London, London, UK
Arthritis Rheum 65:627-38. 2013....
- Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorCedric Auffray
Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
Science 317:666-70. 2007....
- Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient miceJana Pachlopnik Schmid
Institut National de la Sante et de la Recherche Medicale, Unité U768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Paris, France
EMBO Mol Med 1:112-24. 2009..These data strongly suggest that neutralization of IFNgamma could be used in humans to safely alleviate the clinical manifestations of haemophagocytosis...
- Development and homeostasis of "resident" myeloid cells: the case of the microgliaElisa Gomez Perdiguero
Centre for Molecular and Cellular Biology of Inflammation, King s College London, Great Maze Pond, London, United Kingdom
Glia 61:112-20. 2013..This suggests the existence of tissue resident macrophage "stem cells" within tissues such as the brain, and opens a new era for the molecular and cellular understanding of myeloid cells responses during acute and chronic inflammation...
- Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responsesFrederic Geissmann
INSERM U838, Paris, France
Immunol Cell Biol 86:398-408. 2008..We will discuss here the potential roles of monocytes in the immune response, the existence of functional subsets and their relationship with other myeloid cells, including dendritic cells...
- Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skinClare L Bennett
Transplantation Immunology Group, Department of Haematology, Division of Cancer Studies, University College London, London, United Kingdom
Blood 117:7063-9. 2011..These data demonstrate a novel regulatory role for epidermal LCs during the effector phase of an inflammatory immune response in the skin...
- Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to virusesKun Yang
Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
Immunity 23:465-78. 2005..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
- Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposalLeo M Carlin
Centre for Molecular and Cellular Biology of Inflammation, King s College London, London SE1 1UL, UK
Cell 153:362-75. 2013..Therefore, Ly6C(low) monocytes are intravascular housekeepers that orchestrate the necrosis by neutrophils of endothelial cells that signal a local threat sensed via TLR7 followed by the in situ phagocytosis of cellular debris...
- Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiencyLaure Gineau
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U980, Paris, France
J Clin Invest 122:821-32. 2012..Thus, partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency...
- A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH)Jana Pachlopnik Schmid
Institut National de la Santé et de la Recherche Médicale U768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Paris, France
Eur J Immunol 38:3219-25. 2008..This study demonstrates that LCMV-infected Rab27a-deficient C57BL/6 mice develop features consistent with HLH and, therefore, represent a murine model of HLH in human Griscelli syndrome type 2...
- Development and homeostasis of 'resident' myeloid cells: the case of the Langerhans cellLaurent Chorro
Centre for Molecular and Cellular Biology of Inflammation CMCBI, New Hunt s House, King s College London, Great Maze Pond, SE1 1UL, London, UK
Trends Immunol 31:438-45. 2010..Beyond LC biology, we propose that YS and HSCs can contribute to the development of distinct subsets of macrophages and DCs...
- Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC networkLaurent Chorro
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
J Exp Med 206:3089-100. 2009..This mechanism may be relevant in locations where leukocyte trafficking is limited...
- Expansion of regulatory T cells in patients with Langerhans cell histiocytosisBrigitte Senechal
INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France
PLoS Med 4:e253. 2007..The present study was designed to further investigate the nature of proliferating cells and the immune mechanisms involved in the LCH granulomas...
- Herpes-virus infection in patients with Langerhans cell histiocytosis: a case-controlled sero-epidemiological study, and in situ analysisEric Jeziorski
Laboratory of Biology of the Mononuclear Phagocyte System, INSERM U838, University Paris Descartes, Paris, France
PLoS ONE 3:e3262. 2008..Epstein-barr virus (EBV, HHV-4), & Cytomegalovirus (CMV, HHV-5) can infect Langerhans cells, and EBV, CMV and HHV-6 have been proposed to be associated with LCH based on the detection of these viruses in clinical samples...
- TNF-α blockade induces IL-10 expression in human CD4+ T cellsHayley G Evans
1 Centre for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK 2
Nat Commun 5:3199. 2014..Our data demonstrate that TNF-α blockade induces IL-10 in CD4+ T cells including Th17 cells and suggest a role for the transcription factor Aiolos in the regulation of IL-10 in CD4+ T cells. ..
- Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromesJacqueline M Tabler
Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King s College London, London SE1 9RT, UK
Dev Cell 25:623-35. 2013..Thus, our findings elucidate the etiology for a common craniofacial anomaly and identify links between two classes of human disease: FGF-hyperactivation syndromes and ciliopathies. ..
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010....
- Monocytes control natural killer cell differentiation to effector phenotypesKatrina Soderquest
Medical Research Council Centre for Transplantation, King s College London, London, UK
Blood 117:4511-8. 2011..Together, these data reveal a novel, unrecognized role for Txb21 expression in monocytes in promoting NK-cell development and help appreciate how various NK-cell subsets are generated and participate in antitumor immunity...
- Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitorsElisa Gomez Perdiguero
Centre for Molecular and Cellular Biology of Inflammation CMCBI, King s College London, London SE1 1UL, UK
Nature 518:547-51. 2015..Our fate-mapping experiments identify, in the fetal liver, a sequence of yolk sac EMP-derived and HSC-derived haematopoiesis, and identify yolk sac EMPs as a common origin for tissue macrophages. ..
- X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 productionOrchidée Filipe-Santos
Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes Institut National de la Santé et de la Recherche Médicale INSERM U 550, Necker Medical School, Paris, France
J Exp Med 203:1745-59. 2006..They also demonstrate the importance of the T cell- and CD40L-triggered, CD40-, and NEMO/NF-kappaB/c-Rel-mediated induction of IL-12 by monocyte-derived cells for protective immunity to mycobacteria in humans...
- FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cellsAnn L Jagger
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
J Autoimmun 38:29-38. 2012....
- Roles of lymphoid cells in the differentiation of Langerhans dendritic cells in miceBouchra Asli
Faculty de Médecine Necker Pathology Department and CNRS UMR 8603, Equipe Avenir Inserm, Service d Anatomie Pathologique, Universite Paris V, Paris, France
Immunobiology 209:209-21. 2004..We conclude that the presence of T cells is not required for the differentiation and migration of resident skin DC but is critical for the maintenance of DC and LC migrating into the LNs...
- Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunityYiqi Guo
1St Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA Laboratory of Human Genetics of Infectious Diseases, National Institute of Health and Medical Research, Paris, France Necker Medical School, Paris Descartes University, Paris 75015, France
J Exp Med 208:2083-98. 2011....
- Myb-independent macrophages: a family of cells that develops with their tissue of residence and is involved in its homeostasisElisa Gomez Perdiguero
Centre for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunity, Infection, and Inflammatory Diseases, King s College London, London WC2R 2LS, United Kingdom
Cold Spring Harb Symp Quant Biol 78:91-100. 2013....
- Severe FOXP3+ and naïve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiencyJulien Zuber
Unité du Développement des Lymphocytes, Institut Pasteur, Paris, France
Gastroenterology 132:1694-704. 2007..We hypothesized that this syndrome combined a deficit of FOXP3(+) cells and other lymphocyte populations...
- Multiple TGF-β superfamily signals modulate the adult Drosophila immune responseRebecca I Clark
Centre for the Molecular and Cellular Biology of Inflammation and Peter Gorer Department of Immunobiology, King s College London School of Medicine, London SE1 1UL, UK
Curr Biol 21:1672-7. 2011..Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response...
- Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3Genevieve De Saint Basile
Unité Développement Normal et Pathologique du Système Immunitaire, INSERM U 429, Paris, France
J Clin Invest 114:1512-7. 2004..e., CD3epsilon deficiency, and emphasize the essential roles played by the CD3epsilon and CD3delta subunits in human thymocyte development, since these subunits associate with both the pre-TCR and the TCR...